Supplementary Fig. 1
description
Transcript of Supplementary Fig. 1
Supplementary Fig. 1
Placental RLN3 ancestorMarsupial RLN3Monotreme RFLCIAmphibian RFLCITeleost RFLC ancestor
AncRFLC (alternative)
GHSIYGVKLCGREFIRAVIFTCGGSRW DVVVGLSNACCKWGCSKSEISSLCYPSFYGVKLCGREFIRAVIFTCGGSRW DVVVGLSNACCKWGCSKSEISSLCYPSFYGVKLCGREFIRAVIFTCGGSRW DVVVGLSNACCKWGCSKSEISSLCDDPIYGVKLCGREFIRAVIFTCGGSRW DVVVGLSNACCKWGCSKSEISSLCAGPSYGVKLCGREFIRAVIFTCGGSRW DVVVGLSNACCKWGCSKGEISSLCRVPTFGVKLCGTEFIRAVIFTCGGSRW EAALGLSKTCCKWGCSKSQISSLCRVPTFGVKLCGREFIRAVIFTCGGSRW EAALGLSNTCCKWGCSKSQISSLC
RPSTYGVKLCGREFIRAVIFTCGGSRW DVVVGLSNACCKWGCSKSEISSLC
RAAPYGVKLCGREFIRAVIFTCGGSRW DVLAGLSSSCCKWGCSKSEISSLCRTSPYAVKLCGREFIRAVIFTCGGSRW DVLAGVSSNCCKWGCSKTEISSLCRSPSYGMKLCGREFIRAVIFTCGGSRW DVLAGLSSNCCKWGCSKSEISSLCRVPTFGVKLCGREFIRAVIFTCGGSRW EAALGLSNTCCKWGCSKSQISSLCDDPIYGVKLCGREFIRAVIFTCGGSRW DVVVGLSNACCKWGCSKSEISSLC
RAPTYGVKLCGREFIRAVIFTCGGSRW DVVVGLSNACCKWGCSKSEISSLC
A chainB chainD. rerio T. rubripes T. nigroviridisT. rubripes D. rerio X. laevis X. tropicalis
AncRFLC
RFLC1RFLC1RFLC1RFLC2RFLC2RFLCIRFLCI
zRFLC
1zR
FLC1
RB12HzR
FLC
2zR
FLC2
RB12HAncR
FL
CAncR
FLC
RB12H
RLN3 RB12 H
RLN3
RLN3 RB12 A
RLN3 FB20 R
RLN3 SB25 P
INSL3
INSL3 H
B12 R
INSL3 H
B12 A
AncRFLC
AncRFLC V
VA3,4 LA
AncRFLC N
AA8,9 SS
RLN3 LA
A3,4 VV
RLN3 SSA8,9 NA
RLN3
RLN3
oINSL3
INSL3
pRFLCI
pRFLCII
4
66
10
4
66
10
kDa kDa kDa
kDa kDa kDa
Nonreducing
4
66
10
Nonreducing
Reducing
4
66
10
Reducing4
66
10
4
66
10
Supplementary Fig. 2
Human INSL3
Platypus RFLCII
Supplementary Fig. 3
Therian mammals
Monotreme
Human INSL3Chimp INSL3Mouse Insl3Rat Insl3Cow INSL3Dog INSL3Opossum INSL3
Platypus RFLCII
E K L C G H H F V R A L VGAGAAGTTGTGCGGCCACCACTTCGTACGCGCGCTAGTGGAGAAGTTGTGCGGCCACCACTTCGTACGCGCGCTGGTGGCCAAGCTCTGCGGCCACCACCTGGTGCGCACGCTGGTGGCCAAGCTCTGTGGTCACCACCTGGTGCGTGCGCTGGTGGAGAAACTGTGTGGCCACCACTTCGTGCGCGCGCTCGTGGAGAAGCTGTGTGGCCACCACTTCGTGCGGGCGCTGGTGCAGAAACTCTGTGCCCACCGCTTCATCCGGGCCCTCGTC
GTGAAGCTGTGTGGGCGGGAGTTCATCCGTGCTCTGATTV K L C G R E F I R A L I