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I N T E R N AT I ON A L
SCIENCE & ENGINEERING
V I S U A L I Z A T I O N
C H A L L E N G E
Call for Entries
ENTRY DEADLINE:
SEPTEMBER 30, 2013
science & engineering’s
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You are invited to submit an entry to this year’s International Science
& Engineering Visualization Challenge, cosponsored by the National
Science Foundation and AAA’s journal Science.
Entry categories include: Photography, Illustration,
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Winning entries will be published in a special
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ENTRY DEADLINE: SEPTEMBER 30, 2013
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• Photography
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Adjacent to Tokyo International (Haneda) Airport lies a unique 40-hect-
are science and technology innovation hub, the Kawasaki INnovation
Gateway (KING) SKYFRONT.The mission of this futuristic facility is to
find actionable solutions to issues in regenerative medicine, cancer treat-
ment, and the prevention ofëlifestyleí diseases such as obesity. Important-
ly, the Japanese government has designated the KING SKYFRONT to be
a special zone for international competitiveness development, bestowing
it special privileges including reduced corporate taxes and government-
backed financial support for projects launched there.
ìKING SKYFRONT is the first important step in establishing the To-
nomachi area of Kawasaki City as Asiaís Silicon Valley,î says Nobuhide
Kobayashi, executive director of the Coastal Area International Strategy
Office, Kawasaki City. ìWe are confident that the easy access provided by
Haneda Airport, in conjunction with the excellent research and develop-
ment infrastructure, will form the basis for unprecedented business op-
portunities growing out of innovative science, medicine, and technology.î
Kobayashi has reason to be confident. Kawasaki City, with its 1.4 million
inhabitants, is already home to many blue chip companies including Aji-
Kawasaki City: The KING SKYFRONT InnovationHub for 21st Century Life Science
ADVERTORIAL
intractable diseases. Notably, NanoCarrier is listed on theMothers (market
of the high-growth and emerging stocks) section of theTokyo Stock Ex-
change and valued at •100 billion (US$985 million).
Underscoring Kataokaís internationally recognized contributions to
innovative research in nanobiotechnology, he recently received support
from Japanís prestigious national Funding Program forWorld-Leading In-
novative Research and Development on Science andTechnology (FIRST)
program.With funding of •3.6 billion (US$35.7 million) over five years,Kataokaís team will address the following topics: (1)Treatment of cancer
stem cells using targeted drug delivery systems in which nanometer-sized
drug carriers are able to selectively bind to cancer cells; (2) Treatment
of neurological diseases such as Alzheimerís disease using functionalized
micelles capable of passing through the blood-brain barrier; (3) Develop-
ment of nanovaccines that can be stored for long periods of time at room
temperature; (4) Fusion of drug delivery platforms with medical devices
for minimally invasive ìchemical surgeryîósuch as ultrasonic waves that
activate drugs at specific places in the bodyóto reduce the length of hos-
pital stays for patients; and (5) Development of point-of-care diagnostic
devices, such as the use of portable nanofabricated systems to detect mi-
croRNAs and specific enzymes.
Kataoka emphasizes the importance of what he calls ësmart healthcare.í
ìReducing the time a patient stays in hospital would be a tremendous
contribution to society. I am confident that research at iCON can achieve
this.î As an example of how nanomedicine may eventually be used by
millions of people, Kataoka describes the development of the advanced
technology necessary to produce hybrid cars. ìThese cars require a lot of
expensive technology. But mass production has enabled cost reductions to
within the price range of millions of people worldwide. I predict a similar
scenario for nanomedicine.î
nomoto, Toshiba, Fujitsu, and NEC as well as other global brands that
have played a central role in the growth of Japanís economy over the last
century.
The KING SKYFRONT is at the heart of the Keihin Industrial Re-
gion, encompassing areas ofTokyo and Kanagawa Prefecture, and Haneda
Airport. This location offers unprecedented land, sea, and air access to
cities within Japan, and the international airport connects the area to
Asia, North America, and Europe. ìLife science is one of the strategic
areas for KING SKYFRONT,î says Kobayashi. ìWe envisage that visit-
ing scientists, medical doctors, and business people will be able to ar-
rive at Haneda in the morning, go directly from the airport to KING
SKYFRONT, participate in meetings, and return to their country on an
evening flight.î
In addition to the excellent technological infrastructure and access,
KING SKYFRONT is located within commuting distance of international
schools and medical clinics run by English-speaking cliniciansóimpor-
tant factors to consider for creating long-term collaborations with over-
seas partners.
Launch of the innovation
Center Of Nanomedicine
The innovation Center Of Nanomed-
icine (iCON) is set to be the flagship
of the KING SKYFRONT devel-
opment. With government startup
funding of approximately •3.5 bil-
lion (US$34.7 million), constructionon the project is due to start in 2013,
with a formal launch in 2014. Re-
search at the centerócarried out by groups from academia, industry, and
governmentówill address such diverse issues as the medico-economic
impact of aging populations, curbing the increasing cost of medical care,
improving point of care treatment, and establishing new medical markets
in developing countries.
Translation of research ideas to the marketplace and fabrication/manu-
facture are two of the main strategic pillars of the center, emphasizes Pro-
fessor Kazunori Kataoka of the University ofTokyo, who will be director
of research in nanomedicine at the center. ìThe KING SKYFRONT will
offer an open-innovation approach to meet our targets,î says Kataoka.
ìThe proximity of Haneda Airport, the availability of clean rooms and
related infrastructure for nanofabrication, industrial participation, and
professionals to advise on the commercial aspects of research are essential
ingredients for taking creative ideas from the laboratory to the market-
place. KING SKYFRONT can be viewed as a highly condensed version
of SiliconValley.î
Kataoka is no stranger to big ideas and translational research, having
launched the company NanoCarrier in 1996 to commercialize nanosized
micelles for targeted drug delivery for the treatment of cancer and other
Kazunori Kataoka
Laying the Foundations for a Global Innovation Hub
The Central Institute for Experimental Animals (CIEA)óinternationally
recognized for research on the use of induced pluripotent stem cells for
the treatment of spinal cord injuries and Alzheimerís diseaseówas the
first major research institute to move to KING SKYFRONT, transferring
its facilities in July 2011.
March 2013 saw the opening of the Life Science and Environment Re-
search Center (LiSE) to promote collaborative research in the life sci-
ences, and consisting of a multipurpose facility housing laboratories from
both Kawasaki City and the private sector.
In 2016, the Japanese National Institute of Health Sciences (NIHS) will
move from Tokyo to the KING SKYFRONT. The NIHS plays a central
role in regulatory science in Japan and at KING SKYFRONT it will es-
tablish global standards for new drugs and medical technology developed
by researchers there.
KING SKYFRONT has attracted attention from overseas companies
including Johnson and Johnson, which will establish an R&D and training
center onsite.
ìThe worldís life sciences community will
continue to ëorganicallyí lay the foundations for
a global innovation hub for research,î says Ko-
bayashi. ìItís an exciting time at Kawasaki City
as KING SKYFRONT evolves into a global base
for research in the 21st century.î
From Lab to Market
Technology transfer at iCON will be managed by two professors
from the University of Tokyo: Hiromichi Kimura, in charge of Phar-
maco-Business Innovation at the Graduate School of Pharmaceuti-
cal Sciences, and Tomohiro Anzai, a member of the Translational
Research Initiative.
Kimuraís academic background is in biochemistry. After graduat-
ing from the University of Tokyo, he joined a major life sciences-based
company in Japan before moving to the U.S. to complete an Master of
BusinessAdministration and Ph.D. at Stanford University. ìI now have my
own consultancy company as well as the post at the University ofTokyo,î
says Kimura. Anzai is also a graduate of the University of Tokyo where
he trained as a molecular biologist. He spent some time at a consultancy
company, because he ìwas interested in the commercialization of research
ideas,î before joining KING SKYFRONT.Anzai also works with the Uni-
versity ofTokyo Hospital on technology transfer.
Kimura andAnzai stress that the interdisciplinary nature of the projects
at KING SKYFRONT and iCON will require good communication skills
between project members. ìWe will not only have people from differ-
ent academic backgrounds but there will also be people from industry as
well as government administrators,î says Kimura. ìOur biggest challenge
will be to formulate ways to ensure that physicists, medical doctors, and
chemists can communicate with investment bankers, lawyers, and patent
attorneys. They may speak different languages, but they have the same
goal of making iCON a success.î
Produced by the Science/AAAS Custom Publishing Office ADVERTORIAL
Hiromichi Kimura Tomohiro Anzai
ìWe will not only have people from different academic
backgrounds but there will also be people from industry as
well as government administrators.î óHiromichi Kimura
Academia and National InstitutesThe University ofTokyoTokyo Institute ofTechnologyTokyoWomenís Medical UniversityNational Cancer Center (Tokyo)Central Institute for Experimental AnimalsKeio University (Tokyo)
Stanford University (USA)Karolinska Institutet(Sweden)
IndustryFujifilm CorporationNikon CorporationNanoCarrier Co., Ltd.
Participants in the innovation CenterOf Nanomedicine include:
Artistís Impression of the innovation Center Of Nanomedicine (iCON)
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Want towin a ratherspecial prize in Stockholm,Sweden thisDecember?Winner’s essay published in the journal Science
$25,000 dollars grand prize
Awards held in Stockholm in December
Henrik
Trygg/Im
agebank,Sweden
Tis December a rather special prize will be awarded in Stockholm, Sweden. Te journal Science and SciLifeLab
have come together to recognize and celebrate excellence in PhD research. Te Science and SciLifeLab Prize has
been established to support young scientists at the start of their career.
“Science has never been more exciting and, as leaders in science, we need to support
and encourage young researchers today and tomorrow. Tis prize is a way of doing just that.”Professor Mathias Uhlén, Director SciLifeLab
Te grand prize winner of this major global award will have their essay published in the journal Science and receive
$25,000. Tree runners up will receive a combined total of an additional $10,000 in prize money.
Te prizes will be presented in Stockholm, Sweden in the middle of December 2013.
To enter
You must be a recent Ph.D. graduate (awarded between January 1, 2011 and December 31, 2012).
Submissions must be in the form of a 1000 word essay, in English, on your thesis, highlighting the signif-
cance of its contribution and overall implications in the feld. Te four submission areas for this prize are:
(1) Genomics / Proteomics / Systems Biology (2) Developmental Biology (3) Molecular and Cellular Biology
(4) Environmental Life Science.
Te deadline for submissions is August 15, 2013. Te overall winning essay will be published in Science.
For further details and to enter, please go to: www.sciencemag.org/scilifelabprize
For over 130 years the
journal Science has been the
world’s leading journal of
original scientifc research,
global news and commentary.
SciLifeLab is a collaboration
between four universities in
Stockholm and Uppsala, Sweden,
and is a pioneering center for
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environmental research.
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ideas in science diplomacy and receive regular updates
by following@SciDip on Twitter and registering for
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www.ScienceDiplomacy.org
Science & Diplomacy is published by the Center for Science
Diplomacy of the American Associaton for the Advancement of
Science (AAAS), the world’s largest general scientfc society.
The Leading Journal of Cell Signaling
• Peer-reviewed Research Articles and Resources
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In this BaF3 cell model of NF-kB luciferase induction, only
FuGENEÆ HD and FuGENEÆ 6 are able to create a usable assay.
10
81
8M
A
80000
RLU
FHD
F6
LTX+
L2K
60000
40000
20000
0
0–6 – 4 –2 2 4
FuGENE®
HD
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