STUDY PROGRAM 2018/2019 Elective and Optional...

UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2018/2019

1

University of Pécs Faculty of Pharmacy

PHARMACY Major

STUDY PROGRAM 2018/2019

Elective and Optional subjects


2

1st semester

OPE-BFA-T Physical Basis of Biophysics _____________________________________________________________________ 5

OPE-BO1-T Biophysics Seminars 1 __________________________________________________________________________ 7

OPE-GOM-T Poisonous Mushrooms __________________________________________________________________________ 8

OPE-HPR-T Health Promotion _____________________________________________________________________________ 10

OPE-KP1-T Basics of Chemistry 1 _________________________________________________________________________ 13

OPE-SKS-T Inorganic Chemistry Calculations ________________________________________________________________ 15

OPF-BBM-T Introduction to Biometrics ______________________________________________________________________ 17

OPF-BFM-T Problem Solving in Biometrics __________________________________________________________________ 19

OPF-DME-T Cancer is Preventable! _________________________________________________________________________ 21

OPF-FEA-T Basics of Infectious Disease Epidemiology _________________________________________________________ 23

OPF-H1A-T Medical Hungarian 1A - Communication Skills _____________________________________________________ 25

OPF-H1B-T Medical Hungarian 1B - Language Points __________________________________________________________ 27

OPF-HB1-T How to Achieve Better Grade in Organic Chemistry 1 ________________________________________________ 29

OPF-N06-T Medical Terminology _________________________________________________________________________ 31

OPF-NS1-T Nobel Prize Awarded Cell Biology I ______________________________________________________________ 33

OPF-OTT-T History of Medicine ___________________________________________________________________________ 35

2nd semester

OPE-ABI-T Applied Biometrics ___________________________________________________________________________ 38

OPE-BO2-T Biophysics Seminars 2 _________________________________________________________________________ 40

OPE-ETI-T Pharmacy Ethics _____________________________________________________________________________ 41

OPE-FKS-T Physical Chemistry Problem Solving Seminar ______________________________________________________ 42

OPE-GKT-T History of Manufacture of Medicines _____________________________________________________________ 43

OPE-JEA-T Diseases of Signal Transduction _________________________________________________________________ 45

OPE-KP2-T Basics of Chemistry 2 _________________________________________________________________________ 47

OPE-QAS-T Quantitative Analytical Chemistry Calculation ______________________________________________________ 49

OPF-BAL-T Mineral and Spa Waters, Balneology _____________________________________________________________ 51

OPF-BMK-T Methods and Experiments in Molecular Biology ____________________________________________________ 53

OPF-H2A-T Medical Hungarian 2A - Communication Skills _____________________________________________________ 54

OPF-H2B-T Medical Hungarian 2B - Language Points __________________________________________________________ 56

OPF-HB2-T How to Achieve Better Grade in Organic Chemistry 2 ________________________________________________ 58

OPF-IZM-T Molecular Basis of Muscle Function ______________________________________________________________ 60

OPF-MGY-T Medicinal Plants in the Mecsek Mountain - Field Study 1 _____________________________________________ 62

OPF-N04-T Anatomical Terminology _______________________________________________________________________ 64

OPF-NS2-T Nobel Prize Awarded Cell Biology II _____________________________________________________________ 66

OPF-PLH-T The Placebo Effect ____________________________________________________________________________ 68

OPF-VVE-T Vaccination, Anti-Vaccination Movements: Do More Harm than Good ___________________________________ 70

3rd semester

OPE-BEE-T Basics of Epidemiology ________________________________________________________________________ 72

OPE-EHS-T Hunger, Satiety and Disturbances of Body Weight Regulation __________________________________________ 74

OPE-HOS-T Hormonal Regulatory Mechanisms in Health and Disease _____________________________________________ 76

OPE-TSA-T Statistical Analysis of Thesis and Student Research Projects ___________________________________________ 78

OPE-TSS-T Medical Applications of Mass Spectrometry ________________________________________________________ 80

OPE-WMI-T Weak Molecular Interactions ____________________________________________________________________ 82

OPF-DRD-T Drug Design _________________________________________________________________________________ 85

OPF-EBK-T Food Safety and Crisis Situations ________________________________________________________________ 87


3

OPF-GMS-T Genetically Modified Organisms and Our Health ____________________________________________________ 89

OPF-H3A-T Medical Hungarian 3A - Basics of Medical Communication for Students of Pharmacy _______________________ 91

OPF-H3B-T Medical Hungarian 3B - Medical Communication in Practice for Students of Pharmacy ______________________ 93

OPF-IPM-T Innovation and Project Management from a Business Perspective _______________________________________ 95

OPF-MGE-T Molecular Gerontology ________________________________________________________________________ 97

OPF-SSG-T Histology Seminar for Pharmacy Students _________________________________________________________ 99

OPF-TG1-T Student Project Research for Students of Pharmaceutist Programme 1 ___________________________________ 101

OPF-TMB-T Molecular Biology of Tumors __________________________________________________________________ 102

4th semester

OPE-BKM-T Basic Methods of Scientific Research ____________________________________________________________ 104

OPE-EMM-T Molecular Basis of Endocrine Diseases ___________________________________________________________ 106

OPE-GMO-T Modelling the Structure and Interactions of Bioactive Molecules _______________________________________ 108

OPE-PPP-T Proteins and Peptides in Pharmacology ___________________________________________________________ 110

OPE-SME-T Spectrometric Identification of Organic Compounds ________________________________________________ 112

OPE-TIZ-T Central Regulation of Feeding and Metabolism. New Approaches ______________________________________ 114

OPF-CSU-T Miracles of Living Materials ("Realistic" Biochemistry) _____________________________________________ 116

OPF-GMI-T Gyógyszerészek a mindennapokban _____________________________________________________________ 118

OPF-H4A-T Medical Hungarian 4A - Basics of Medical Communication for Students of Pharmacy ______________________ 119

OPF-H4B-T Medical Hungarian 4B - Medical Communication in Practice for Students of Pharmacy _____________________ 121

OPF-MAS-T Instrumental Analysis - Seminar ________________________________________________________________ 123

OPF-MMR-T Nuclear Magnetic Resonance for Dummies _______________________________________________________ 124

OPF-QBI-T Quantum Biology: Quantum Phenomena in Biological Processes ______________________________________ 126

OPF-SKI-T Basics of Chemical Informatics _________________________________________________________________ 129

OPF-TG2-T Student Project Research for Students of Pharmaceutist Programme 2 ___________________________________ 131

OPF-VAA-T Iron Metabolism: from Molecular Mechanisms to Clinical Consequences ________________________________ 132

5th semester

OPE-EFA-T Ethnopharmacobotany ________________________________________________________________________ 134

OPE-GMK-T Qualitative and Quantitative Analysis of Drugs from Human Tissue ____________________________________ 136

OPE-KMS-T Seminars in Pharmaceutical Sciences - Research Perspectives _________________________________________ 138

OPE-TG3-T Student Project Research for Students of Pharmaceutist Programme 3 ___________________________________ 140

ATT5-T Physical Education 5 _________________________________________________________________________ 141

OPF-EGZ-T Egzotic Medicinal Plants ______________________________________________________________________ 142

OPF-GKG-T Gas Chromatography _________________________________________________________________________ 144

OPF-GLK-T Bioinorganic Chemistry for Pharmacy Students ____________________________________________________ 146

OPF-GMT-T Drug Metabolism and Drug Toxicity _____________________________________________________________ 148

OPF-HVS-T Synthesis of Heterocyclic Compounds and Their Application in Therapy ________________________________ 150

OPF-MME-T Molecular Medicine __________________________________________________________________________ 152

OPF-MOD-T Molecular Diagnostics ________________________________________________________________________ 154

OPF-MOT-T Molecular Therapies _________________________________________________________________________ 156

6th semester

OPE-ASZ-T The Antimicrobial Drugs and their Clinical Use ____________________________________________________ 158

OPE-GFK-T Physico-Chemical Bases of Drug Action __________________________________________________________ 160

OPE-KPR-T Chemoprevention ____________________________________________________________________________ 162

OPE-STK-T Basics of Stereochemistry _____________________________________________________________________ 164

OPE-TG4-T Student Project Research for Students of Pharmaceutist Programme 4 ___________________________________ 166


4

OPE-VFM-T Business Development and Management _________________________________________________________ 167

OPF-DTS-T The Role of Drug Transporters _________________________________________________________________ 169

OPF-EXT-T Extraction and Chromatographic Techniques in Medicinal Plant Analysis ________________________________ 172

OPF-KNH-T Drug Plants and Hallucinogenes ________________________________________________________________ 174

OPF-MMG-T Nuclear Magnetic Resonance in Drug Development _________________________________________________ 176

OPF-PNT-T Pharmaceutical Nanotechnology ________________________________________________________________ 178

OPF-SNA-T Carbon Nanostructures _______________________________________________________________________ 181

7th semester

OPE-FM2-T Data Analysis 2 _____________________________________________________________________________ 183

OPE-FMA-T Data Analysis 1 _____________________________________________________________________________ 185

OPE-SHK-T Design and Industrial Manufacture of Medicines ___________________________________________________ 187

OPE-T2F-T Pharmaceutical Biotechnology and its links to Biopharmaceuticals _____________________________________ 189

OPF-KIA-T Essential Oils and Clinical Aromatherapy _________________________________________________________ 191

OPF-XES-T The Fate of Drug ____________________________________________________________________________ 194

8th semester

OPE-FAJ-T Pain and Analgesics __________________________________________________________________________ 196

OPE-MGT-T Pharmaceutical Technology of Modified Drug Release ______________________________________________ 198

OPF-GTH-T Gene Therapy ______________________________________________________________________________ 200

OPF-IVF-T Infections and Immunity ______________________________________________________________________ 202

9th semester

OPE-GSI-T Pharmaceutical Informatics ____________________________________________________________________ 204

OPE-GST-T Special Fields of Pharmacology_________________________________________________________________ 206

OPF-SUO-T Emergency Medicine _________________________________________________________________________ 208


5

OPE-BFA-T PHYSICAL BASIS OF BIOPHYSICS

Course director: DR. EMŐKE BÓDIS, assistant professor

Department of Biophysics

2 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ both semesters ▪ recommended semester: 1

Number of hours/semester: 0 lectures + 0 practices + 28 seminars = total of 28 hours

Course headcount limitations (min.-max.): 5 – 100 Prerequisites: none

Topic

The course addresses the chapters of physics which are necessary for a proper understanding of Biophysics (lecture and practicals).

Beyond theoretical discussions, example problems are solved.

Conditions for acceptance of the semester

Maximum 3 absence is allowed.

Mid-term exams

Making up for missed classes

There is no option.

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

Course related information can be found on the website of the Department of Biophysics (http://biofizika.aok.pte.hu).

- Recommended literature

As a base, any secondary school physics book is useful.

Lectures

Practices

Seminars

1 Mathematical basics. Scalars and vectors

2 Physical quantities and units

3 Newton's laws

4 Conservation of momentum. Collisions

5 Motion on a straight line. Kinetics

6 Motion on a straight line. Dynamics

7 Circular motion, rotation

8 Oscillations

9 Work and energy. Friction

10 The work-energy theorem. Conservation of mechanical energy

11 Hydrostatics

12 Hydrodynamics

13 First and second law of thermodynamics

14 Thermodynamic potentials

15 Electrostatics

16 Ohm's law, Kirchhoff's laws

17 Magnetostatics

18 Magnetic induction

19 Waves

20 Wave- and geometrical optics

21 Atom- and nuclear physics

22 Radioactivity

23 Radiations (radioactive, electromagnetic)

24 Electromagnetic waves

25 Radiation-matter interaction

26 Special radiation-matter interactions

http://biofizika.aok.pte.hu/


6

27 Test writing

28 Test writing

Exam topics/questions

Can be found on the website of the Department of Biophysics (http://biofizika.aok.pte.hu)

The seminar strengthens physics theoretical background and provide further understanding through evaluation of exercises (calculations)

hence the written test at the end of the semester includes theoretical questions and exercises.

Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject

Participants

Dr. Szabó-Meleg Edina (MEEDAA.T.JPTE), Dr. Talián Csaba Gábor (TACRAAO.PTE), Leipoldne Víg Andrea Teréz

(VIAFAAO.PTE), Szatmári Dávid (SZDHAAT.PTE), Takács-Kollár Veronika Tünde (KOVGACT.PTE), Tóth Mónika Ágnes

(TOMIAAT.PTE)



7

OPE-BO1-T BIOPHYSICS SEMINARS 1

Course director: DR. ZOLTÁN UJFALUSI, assistant professor


1 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ autumn semester ▪ recommended semester: 1


Course headcount limitations (min.-max.): 5 – 40 Prerequisites: OPA-FI1 parallel

Topic

The objective of the course is to advance the acquisition of knowledge and skills related to Biophysics 1. Object-oriented discussions

and problem solving sessions are organized in interactive small-group seminars.


Maximum of three absences.

Mid-term exams

There will be no midterm test.


None. Based on previous agreement with the lecturer the student can attend the seminar with another group another day on the same

week.

Reading material



http://biofizika.aok.pte.hu

- Notes

Damjanovich et al (ed.): Medical Biophysics


Lectures

Practices

Seminars

1 Introduction

2 Diffusion

3 Osmosis. Fluid flow

4 Circulation. Cardiac biophysics. Protein folding

5 Resting membrane potential. Sensory receptors. Action potential

6 Vision. Hearing

7 Cytoskeleton. Motor proteins

8 Structure of striated muscle. Molecular basis of muscle function

9 Foundations of thermodynamics. Laws of thermodynamics

10 Thermodynamic potentials

11 The double nature of light. The structure of the atoms

12 Quantum numers. Spin. Molecular orbitals

13 Laser. X-ray

14 Test writing


Can be found on the departmental website: http://biofizika.aok.pte.hu


Participants

Dr. Futó Kinga (FUKIAAT.PTE), Dr. Huber Tamás (HUTEAB.T.JPTE), Dr. Kengyel András Miklós (KEAFACO.PTE), Dr. Szabó-

Meleg Edina (MEEDAA.T.JPTE), Szatmári Dávid (SZDHAAT.PTE), Takács-Kollár Veronika Tünde (KOVGACT.PTE)




8

OPE-GOM-T POISONOUS MUSHROOMS

Course director: DR. LORÁND BARTHÓ, professor

Department of Pharmacology and Pharmacotherapy

2 credit ▪ midsemester grade ▪ Elective subject for the Pharmaceutical module ▪ autumn semester ▪ recommended semester: 1



Topic

Family physicians may play an important role in the early identification and management of mushroom poisoning (MP).

This course:

- deals with the various types of MP and their symptoms;

- molecular mechanisms encountered with the effects of cytotoxic MPs

- morphological features of the most important toxic mushrooms/fungi and their edible counterparts.


- Attending at least 75% of the lessons, passing the oral exam

- Oral exam includes matters of poisonings, as well as recognizing the most important PMs and their edible counterparts

Mid-term exams


Individual

Reading material



CD prepared by Prof. Barthó

Most terms will be explained in the lectures.

- Notes


http://www.rogersmushrooms.com/

Lectures

1 Introduction

Dr. Barthó Loránd

2 Introduction

Dr. Barthó Loránd

3 Amanitas, Lepiotas (parasols) and their poisonings

Dr. Barthó Loránd


Dr. Barthó Loránd


Dr. Barthó Loránd


Dr. Barthó Loránd

7 Other mushrooms with white spores and their p.

Dr. Barthó Loránd


Dr. Barthó Loránd


Dr. Barthó Loránd


Dr. Barthó Loránd

http://www.rogersmushrooms.com/


9

11 Mushrooms with pink, brown or black spores

Dr. Barthó Loránd


Dr. Barthó Loránd


Dr. Barthó Loránd


Dr. Barthó Loránd


Dr. Barthó Loránd


Dr. Barthó Loránd

17 Mushrooms with tubes, pores, wrinkles or spines

Dr. Barthó Loránd

18 Mushrooms with tubes, pores, wrinkles or spines

Dr. Barthó Loránd

19 Molecular mechanisms encountered with the effects of cytotoxic MPs

Dr. Szeberényi József

20 Molecular mechanisms encountered with the effects of cytotoxic MPs

Dr. Szeberényi József

21 Morels, false morels, puff-balls, corals, etc. Pre-exam

Dr. Barthó Loránd

22 Morels, false morels, puff-balls, corals, etc.

Dr. Barthó Loránd

23 Some forensic aspects of MPs

Dr. Barthó Loránd

24 Muscarine, muscimol, ibotenic acid

Dr. Barthó Loránd

25 Coprin, orellanin, aflatoxin

Dr. Barthó Loránd

26 Reprise of poisonous mushrooms

Dr. Barthó Loránd

27 Reprise of types of poisoning; Exam

Dr. Barthó Loránd

28 Exam

Dr. Barthó Loránd

Practices

Seminars


Oral exam including matters of poisonings, as well as recognizing the most important PMs and their edible counterparts

Cytotoxic MPs

Gastrointestinal MP

Muscarine-type of MP

Psychotropic MP

Other types of MP

Tasks of the general practitioner in case of MP


Participants


10

OPE-HPR-T HEALTH PROMOTION

Course director: DR. ISTVÁN KISS, professor

Department of Public Health Medicine

2 credit ▪ midsemester grade ▪ Elective subject for the Medical/Biological module ▪ autumn semester ▪ recommended semester: 1



Topic

Health promotion is intimately related not only to preventive medicine, but to the everyday practice of physicians as well. A considerable

part of noninfectious diseases is preventable, morbidity and mortality of these illnesses are decreasable by the implementation of effective

intervention.


Maximum of 15 % absence allowed

Mid-term exams

Neptun Meet Street


There are no make-up classes

Reading material



Education material on Neptun

- Notes


Lectures

1 Definitions of health. Relationship between health status and fields of life.

Theoretical background of health promotion.

Dr. Horváth-Sarródi Andrea

2 Definitions of health. Relationship between health status and fields of life.

Theoretical background of health promotion.


3 Salutogenesis and patogenesis.

Basic documents of health proomotion.


4 Salutogenesis and patogenesis.

Basic documents of health proomotion.


5 Relationship between health promotion and health education. Differences in theory and methods.

Methods of health promotion.


6 Relationship between health promotion and health education. Differences in theory and methods.

Methods of health promotion.


7 Measuring of results in health promotion activities.

Evidence based health promotion.


8 Measuring of results in health promotion activities.

Evidence based health promotion.



11

9 Health promotion and health policy.

Lalonde-model. Health in all policies (HiAP).


10 Health promotion and health policy.

Lalonde-model. Health in all policies (HiAP).


11 Multisectorality. Stakeholders.

Health Impact Assessment (HIA) I.


12 Multisectorality. Stakeholders.

Health Impact Assessment (HIA) I.


13 Health Impact Assessment (HIA) II.

Health promotion in communities.


14 Health Impact Assessment (HIA) II.

Health promotion in communities.


15 Method of health planning.

SWOT-analysis.


16 Method of health planning.

SWOT-analysis.


17 Personal health planning.

Effective health promotion in settings (school).


18 Personal health planning.

Effective health promotion in settings (school).


19 Effective health promotion in settings(workplace).

Health Promoting Universities.


20 Effective health promotion in settings(workplace).

Health Promoting Universities.


21 Possibilities of application and actualities in the concept of Health Promoting Universities.

Methods of mental health promotion.


22 Possibilities of application and actualities in the concept of Health Promoting Universities.

Methods of mental health promotion.


23 Promotion of positive mental health and possibilities of prevention of mental disorders.

Mental health policy.


24 Promotion of positive mental health and possibilities of prevention of mental disorders.

Mental health policy.


25 Role of physicians in the primary, secondary and tertiary levels of prevention.

Multiplicating effect of the physicians in the society.


26 Role of physicians in the primary, secondary and tertiary levels of prevention.

Multiplicating effect of the physicians in the society.



12

27 Complex health promotion programs.

Examples for good practices in health promotion.

Lee Andrew

28 Complex health promotion programs.

Examples for good practices in health promotion.

Lee Andrew

Practices

Seminars


Neptun Meet Street


Participants


13

OPE-KP1-T BASICS OF CHEMISTRY 1

Course director: DR. PÁL PERJÉSI, professor

Department of Pharmaceutical Chemistry




Topic

Based on the previously acquired high school knowledge the course provides an overview on the basic laws of Chemistry concentrating

on those that are ubiquitous in the chemistry-related subjects of the basic modules of the health related curriculums. The course helps

understanding the chemistry-related compulsory subjects of the modules.


Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation in the lectures is obligatory.

Maximum three absences can be accepted both from lectures and practices. Two midterm tests will be written during the semester on the

7th and the 12th weeks. The result of both tests should be above 60%. One re-take chance is allowed after both tests.

Mid-term exams


There is no opportunity to make up missed classes.

Reading material


Ebbing D.D., Gammon S.D.: General Chemistry, Houghton Miffilin Co., Boston, 2009


Almási A., Kuzma M., Perjési P.: General and Inorganic Chemistry - Laboratory Techniques and Practices, electronic educational

material, University of Pécs, 2014

- Notes


en.wikibooks.org/wiki/General_Chemistry

Lectures

1 The electronic structure of atom. Elements.

Dr. Perjési Pál

2 The electronic structure of atom. Elements.

Dr. Perjési Pál

3 Chemical bonds. Geometry of molecules.

Dr. Perjési Pál

4 Chemical bonds. Geometry of molecules.

Dr. Perjési Pál

5 Kinetic theory of gases. Gas laws.

Dr. Perjési Pál

6 Kinetic theory of gases. Gas laws.

Dr. Perjési Pál

7 Liquids and solutions. Concentrations.

Dr. Perjési Pál

8 Liquids and solutions. Concentrations.

Dr. Perjési Pál

9 Colligative properties.

Dr. Perjési Pál

10 Colligative properties.

Dr. Perjési Pál

11 Chemical thermodynamics I.

Dr. Perjési Pál

12 Chemical thermodynamics I.

Dr. Perjési Pál


14

13 Chemical kinetics.

Dr. Perjési Pál

14 Chemical kinetics.

Dr. Perjési Pál

15 Chemical equilibrium I. Homogeneous equilibria.

Dr. Perjési Pál

16 Chemical equilibrium I. Homogeneous equilibria.

Dr. Perjési Pál

17 Chemical equilibrium II. Acid-base equilibriums in solution.

Dr. Perjési Pál

18 Chemical equilibrium II. Acid-base equilibriums in solution.

Dr. Perjési Pál

19 Chemical equilibrium III. Heterogeneous equilibria.

Dr. Perjési Pál

20 Chemical equilibrium III. Heterogeneous equilibria.

Dr. Perjési Pál

21 Chemical equilibrium IV. Chemical thermodynamics II.

Dr. Perjési Pál

22 Chemical equilibrium IV. Chemical thermodynamics II.

Dr. Perjési Pál

23 Electrochemistry I. Conductivity of electrolytes.

Dr. Perjési Pál

24 Electrochemistry I. Conductivity of electrolytes.

Dr. Perjési Pál

25 Electrochemistry II. Electrode potential. Galvanic cells.

Dr. Perjési Pál

26 Electrochemistry II. Electrode potential. Galvanic cells.

Dr. Perjési Pál

27 Electrochemistry III. Electrolysis.

Dr. Perjési Pál

28 Electrochemistry III. Electrolysis.

Dr. Perjési Pál

Practices

Seminars


Written tests covering the topics of the lectures.


Participants


15

OPE-SKS-T INORGANIC CHEMISTRY CALCULATIONS

Course director: DR. BEÁTA LEMLI, assistant professor





Topic

This subject is based on the acquired theoretical knowledge on General and Inorganic Chemistry, with adaptation of the principles to

solve chemical problems. The aim of this course to solve chemical calculations related to the lessons of General and Inorganic Chemistry

1 and give a support for easier understanding of the subject.


According to the Code of Studies and Examinations (see on the homepage). During the semester maximum 3 missed classes are

acceptable. Two midterm tests will be written during the semester on the 7th and the 12th weeks. The result of both tests should be above

60%. One re-take chance is allowed after both tests.

Mid-term exams

Two written exams during the semester.



Reading material


Ebbing D.D., Gammon S.D.: General Chemistry, Houghton Miffilin Co., Boston, 2009.


Almási A., Kuzma M., Perjési P.: General and Inorganic Chemistry - Laboratory Techniques and Calculations, electronic educational

material, University of Pécs, 2014

- Notes



Lectures

Practices

Seminars

1 Introduction to the calculations on inorganic chemistry (basis of chemistry). Stochiometric calculations.

2 Introduction to the calculations on inorganic chemistry (basis of chemistry). Stochiometric calculations.

3 Stochiometric calculations. Calculation of concentrations.

4 Stochiometric calculations. Calculation of concentrations.

5 Calculation of concentrations, Solubility.

6 Calculation of concentrations, Solubility.

7 Electrolytic dissociation.

8 Electrolytic dissociation.

9 Kolligative properites.

10 Kolligative properites.

11 Thermochemistry (Hess’ Law).

12 Thermochemistry (Hess’ Law).

13 Chemical kinetics. Test 1

14 Chemical kinetics. Test 1

15 pH calculations I.: Hydrolysis of salts.

16 pH calculations I.: Hydrolysis of salts.

17 pH calculations II: Buffers.

18 pH calculations II: Buffers.

19 Solubility equilibria.

20 Solubility equilibria.


16

21 Calculations based on the balancing of redox equations I

22 Calculations based on the balancing of redox equations I

23 Calculations based on the balancing of redox equations II

24 Calculations based on the balancing of redox equations II

25 Calculations on electrochemistry I. Test 2

26 Calculations on electrochemistry I. Test 2

27 Calculations on electrochemistry II

28 Calculations on electrochemistry II


The final grade is established based on the average of each written exams.


Participants

Dr. Kulcsár Győző Kornél (KUGDAA.T.JPTE), Dr. Lemli Beáta (LEBGAAF.PTE)


17

OPF-BBM-T INTRODUCTION TO BIOMETRICS

Course director: DR. LÁSZLÓ PÓTÓ, associate professor

Institute of Bioanalysis

1 credit ▪ midsemester grade ▪ Optional subject ▪ both semesters ▪ recommended semester: 1



Topic

Exploring data (using graphs and numbers) are usually handled as one-lesson ‘first chapter’ by basic statistical courses. This is, because

a first course in statistics introduces many new skills. It also introduces some new ideas, that all are ‘hard to understand’ for students.

The new approach is to make a solid foundation to learn statistics by a more thorough introduction to those: The course tries to make

clear a few of these fundamental ideas of statistics - limited to understanding and working with data. An improved skill for exploring

data is useful not only at your classes and your future job but in the everyday life as well.


Maximum one missed class.

Mid-term exams

Active participation at the classes.


One extra class

Reading material



- Notes

László Pótó: Biometrics, workbook, Pécs, 2018


1, Moore, D. S.: The Basic Practice of Statistics, 7th edition, 2015

2, Moore, David S., McCabe, George P.: Introduction to the Practice of Statistics, 5th edition, W.H. Freeman, 2005

and

Yates, Dan, Moore, David S., Starnes, Daren S.: The Practice of Statistics (TI-83/89 Graphing Calculator Enhanced) 2/e, W.H.

Freeman, 2003 or

3, Rees, W. G.: Essential Statistics, Chapman and Hall, 1992

Lectures

Practices

1 Probability examples 1

2 Probability examples 1

3 Probability examples 2 - discrete distributions

4 Probability examples 2 - discrete distributions

5 Exploring data by graphs - 1




9 Exploring data by numbers - sample measures 1




13 The normal distribution

14 The normal distribution

Seminars


No exam - but active participation on the classes is a must.


18


Participants

Dr. Pótó László (POLGABO.PTE)


19

OPF-BFM-T PROBLEM SOLVING IN BIOMETRICS






The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

Give a chance to have more practice to solve problems in Biometrics using PC and the SPSS software in the computer room. This was a

regular need of the students earlier since the special way how a MD should handle the typical medical problems (special way of thinking)

was not founded by the secondary school education. This foundation is an important focus point of the Biometrics course. It seems, the

weekly 1+1 lectures were not enough for most of the students for completing this important goal: To develop some brand new skills.

This course offers an organized way for that extra practices. It offers also some ‘brushing up’ chances for those who has completed

Biometrics earlier.


Maximum one missed class

Mid-term exams

Active participation on the classes.


One extra class

Reading material



- Notes

László Pótó: Biometrics, workbook, Pécs, 2018.


1, Moore, D. S.: The Basic Practice of Statistics, 7th edition, 2015.

or

2, Moore, David S., McCabe, George P.: Introduction to the Practice of Statistics, 5th edition, W.H. Freeman, 2005

and

Yates, Dan, Moore, David S., Starnes, Daren S.: The Practice of Statistics (TI-83/89 Graphing Calculator Enhanced) 2/e, W.H.

Freeman, 2003 or

3, Rees, W. G.: Essential Statistics, Chapman and Hall, 1992

Lectures

Practices

1 The Confidence Interval of the expected value

2 The Confidence Interval of the expected value

3 The one sample (and the paired samples) t test

4 The one sample (and the paired samples) t test

5 The CI and the hypothesis testing - the type one and type two errors.

6 The CI and the hypothesis testing - the type one and type two errors. MDM basics 1.

7 The independent samples t test

8 The independent samples t test

9 The linear regression

10 The linear regression

11 The contingency tables - the chi squares test

12 The contingency tables - the chi squares test

13 The nonparametric tests

14 The nonparametric tests. MDM basics 2.


20

Seminars


No exam but active participation on the classes is a must.


Participants



21

OPF-DME-T CANCER IS PREVENTABLE!



2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 1



Topic

One of the major challenges for the health care system of the 21st century is the high number of cancer caused deaths. Over the past

decades, despite a significant development on the field of medicine, the prognosis of this disease is still not satisfactory. Thus prevention

has a key role in in the fight against cancer. The course gives a description on the different types of cancer their major risk factors for a

more detailed understanding. Methods of cancer prevention will be described and emphasized - including theoretical knowledge and a

practical guide as well. During the course the results of most recent human epidemiological studies on cancer will also be described.


Participation in lectures and practicals is obligatory which is registered. Absences should not exceed 4x45 min. Otherwise signature of

grade book is denied.

Mid-term exams


There are no make-up classes.

Reading material



Educational material uploaded on Neptun.

- Notes


Robert Weinberg (ed.): The Biology of Cancer, Garland Science 2006 ISBN 0815340788

Boffetta P., La Veccia: Neoplasms 2009. In Detels R, Beaglehole R, Lansang MA and Gulliford M (eds.) Oxford Textbook of Public

Health, 5th ed., Oxfort University Press

Lectures

1 Cancer in the 21st century

Dr. Kiss István

2 Cancer in developing and developed countries

Dr. Kiss István

3 The process of carcinogenesis I

Dr. Kiss István

4 The process of carcinogenesis II

Dr. Kiss István

5 Characteristics of cancer cells

Dr. Kiss István

6 Molecular epidemiology of cancer

Dr. Kiss István

7 The most important cancer risk factors in general I

Dr. Kiss István

8 The most important cancer risk factors in general II

Dr. Kiss István

9 Lung cancer (development, risk factors, prevention) I

Dr. Kiss István

10 Lung cancer (development, risk factors, prevention) II

Dr. Kiss István

11 Colorectal cancer (development, risk factors, prevention) I

Dr. Kiss István

12 Colorectal cancer (development, risk factors, prevention) II

Dr. Kiss István


22

13 Breast cancer (development, risk factors, prevention) I

Dr. Kiss István

14 Breast cancer (development, risk factors, prevention) II

Dr. Kiss István

15 Prostate cancer (development, risk factors, prevention)

Dr. Kiss István

16 Head and neck cancer (development, risk factors, prevention)

Dr. Kiss István

17 Pancreatic cancer (development, risk factors, prevention)

Dr. Kiss István

18 Gastric cancer (development, risk factors, prevention)

Dr. Kiss István

19 Liver cancer (development, risk factors, prevention)

Dr. Kiss István

20 Cervical cancer (development, risk factors, prevention)

Dr. Kiss István

21 Ovarian cancer (development, risk factors, prevention)

Dr. Kiss István

22 Skin cancer and melanoma malignum (development, risk factors, prevention)

Dr. Kiss István

23 Leukemia (development, risk factors, prevention)

Dr. Kiss István

24 Less frequent tumors (development, risk factors, prevention)

Dr. Kiss István

25 Genetics, genomics and epigenetics in cancer prevention I

Dr. Kiss István

26 Genetics, genomics and epigenetics in cancer prevention II

Dr. Kiss István

Practices

Seminars

1 Recommendations I

2 Recommendations II


Neptun


Participants

Dr. Kiss István (KIIFAD.A.JPTE)


23

OPF-FEA-T BASICS OF INFECTIOUS DISEASE EPIDEMIOLOGY







Topic

However the morbidity and mortality caused by infectious diseases has significantly declined in the developed countries in the last

century due to the effective prevention methods, their complete elimination is not possible, infectious diseases are still part of our

everyday life. The spread of infectious diseases could be controlled by timely identification, proper investigation and by targeted

interventions. Aim of the course is to present the special characteristics of infectious diseases, and of infectious disease epidemiology;

basics and functioning of surveillance systems, the basics and steps of an outbreak investigation, and epidemiological methods used

during the investigation.


The participation in the lectures, seminars, practises is obligatory (a catalogue should be signed), a maximum of 3x45 min absence is

acceptable, above the signature will be rejected.

Mid-term exams


None

Reading material



- Notes


Heymann (ed.): Control of Communicable Diseases Manual

Mikanatha, Lynfield, Van Beneden, de Valk (eds.): Infectious Disease Surveillance

Lectures

1 Special characteristics of infectious diseases

Dr. Prantner Ida

2 Basics of infectious disease epidemiology I

Dr. Prantner Ida

3 Basics of infectious disease epidemiology II

Dr. Prantner Ida

4 Methods used in infectious disease epidemiology

Dr. Prantner Ida

5 Basic principles of surveillance

Dr. Prantner Ida

6 Infectious disease surveillance

Dr. Prantner Ida

7 Basics and steps of outbreak investigation I

Dr. Prantner Ida

8 Basics and steps of outbreak investigation II

Dr. Prantner Ida

Practices

1 Use of epidemiological knowledge in practice I (definitions, surveillance data interpretation, analysis)

2 Use of epidemiological knowledge in practice II (Data collection, analysis, graphical interpretations)

3 Use of epidemiological knowledge in practice III (analytic studies)


24

Seminars

1 Investigation of a food-borne outbreak I

2 Investigation of a food-borne outbreak II

3 Investigation of a food-borne outbreak III


-


Participants

Dr. Prantner Ida (PRIFAAO.PTE)


25

OPF-H1A-T MEDICAL HUNGARIAN 1A - COMMUNICATION SKILLS

Course director: DR. GÁBOR RÉBÉK-NAGY, associate professor

Department of Languages for Specific Purposes



Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPE-H1B parallel

Topic

To establish basic skills in reading, writing, listening and speaking Hungarian in preparation for effective medical communication.


Participation in class work is obligatory. In case absences exceed 25% of total class time, the course will be regarded as uncompleted. In

the case of absences up to 25% of total class time, oral examination will have to be taken

Mid-term exams

-


To be discussed with the course tutor in each individual case.

Reading material



In-house course book: at the homepage of the institute:

http://aok.pte.hu/index.php?page=egyseg&egy_id=60&menu=okt_anyag&nyelv=eng

- Notes


Lectures

Practices

1 Greeting people, formality and informality

2 Greeting people, formality and informality

3 Addressing people, men and women

4 Addressing people, men and women

5 Starting conversation, the elderly and children

6 Starting conversation, the elderly and children

7 Introducing, equal and unequal relations

8 Introducing, equal and unequal relations

9 Nutritional History Taking

10 Nutritional History Taking

11 Nutrients

12 Nutrients

13 Consolidation

14 Test 1

15 Health Preservation, Sports, Addictions

16 Health Preservation, Sports, Addictions

17 Writing CV, occupation, work

18 Medical Specialties, Consulting Room and Ward

19 Medical Specialties, Consulting Room and Ward

20 Telling CV, family relations

21 Introducing family

22 Introducing family

23 Describing people - Internal and external features

24 Describing people - Internal and external features

25 Health care institutions, consolidation

26 Health care institutions, consolidation

27 Test 2

28 Course Evaluation



26

Seminars


Two written test papers and oral presentations


Participants

Dr. Hegedűs Anita (HEAAAA.B.JPTE), Dr. Rébék-Nagy Gábor (REGCAC.B.JPTE), Dr. Warta Vilmos (WAVEAB.B.JPTE), Eklicsné

Dr. Lepenye Katalin (EKLAXA.B.JPTE), Hamarné Sávay Judit (HASMAAO.PTE), Hild Gabriella (MAGAAD.B.JPTE), Horváth Lilla

Anita (HOLFABP..PTE), Kurdiné Molnár Eszter (KUMPAAK.PTE), Lokodiné Szolcsányi Judit (LOSIAAB.PTE), Mészégetőné

Halmos Éva (MEHHABE.PTE), Ronczykné Berta Anikó (BEAAAI.B.JPTE), Szántóné Dr. Csongor Alexandra (CSAAAA.B.JPTE),

Tóth Ida (TOIHABE.PTE), Váradi Katalin (VAKHAAE.PTE)


27

OPF-H1B-T MEDICAL HUNGARIAN 1B - LANGUAGE POINTS





Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPF-H1A parallel

Topic

Familiarizing foreign students with basic paradigms used in specific conversations.




Mid-term exams

-


Reading material




- Notes


Lectures

Practices

1 Basics of Hungarian Phonetics and Morphology

2 Basics of Hungarian Phonetics and Morphology

3 Personal Pronouns - formal and informal style

4 Personal Pronouns - formal and informal style

5 Constructing Questions - Question Words

6 Constructing Questions - Question Words

7 Numerals - Cardinal, Ordinal, Labels

8 Numerals - Cardinal, Ordinal, Labels

9 Verbs - Definite and Indefinite Conjugation

10 Verbs - Definite and Indefinite Conjugation

11 Expressing Frequency

12 Expressing Frequency

13 Test 1

14 Articles

15 Modality - necessity

16 Modality - necessity

17 Objective Case

18 Objective Case

19 Verbal prefixes

20 Verbal prefixes

21 Expressing Time

22 Expressing Time

23 Expressing Location - Trinity of Directions

24 Expressing Location- Trinity of Directions

25 Dative Case

26 Dative Case

27 Test 2

28 Course Evaluation



28

Seminars


-


Participants




Halmos Éva (MEHHABE.PTE), Molnár Annamária (MOAF-AC.B.JPTE), Ronczykné Berta Anikó (BEAAAI.B.JPTE), Szántóné Dr.

Csongor Alexandra (CSAAAA.B.JPTE), Váradi Katalin (VAKHAAE.PTE)


29

OPF-HB1-T HOW TO ACHIEVE BETTER GRADE IN ORGANIC CHEMISTRY 1

Course director: DR. BALÁZS BOGNÁR, assistant professor

Department of Organic and Pharmacological Chemistry



Course headcount limitations (min.-max.): 2 – 20 Prerequisites: OHA-V1E-T parallel

Topic

The aim of the course is to help the students to understand the important reaction mechanisms, and find the connections between the

different topics.

1. Reaction mechanisms in organic chemistry

2. Projection structures, radical substitution

3. Electrophilic addition

4. Electrophilic aromatic substitution

5. Nucleophilic substitution 1, alkyl halides

6. 1. test

7. Nucleophilic substitution 2, organometallics, alcohols, phenols, ethers.

8. Aromatic nucleophilic substitutions

9. Stereochemistry

10-11. Practice, design and synthetic pathway of complex compounds

12. 2. test



Mid-term exams

Nincs.


Nincs

Reading material



The worksheets will be handed on the seminar.

- Notes


Estelle K. Meislich; Herbert Meislich; Jacob Sharefkin: Schaum’s Series 3000 Solved Problems In Organic Chemistry, McGraw-

Hill, Inc., New York, 1994

T. W. Graham Solomons: Organic Chemistry, 7th edition, Wiley and Sons, New York, 2000

John McMurry, Eric Simanek: Fundamentals of Organic Chemistry, 6th edition, Thomson Brooks/Cole, Belmont, 2007

Lectures

Practices

Seminars

1 Reaction mechanisms, nucleophilic, electrophilic and radical reagents.

2 Projection structures, Fisher projection, reactions of alkanes.

3 Electrophilic addition, reactions of alkenes.

4 Electrophilic aromatic substitution, reactivity, orientation rules.

5 The two possible mechanisms of nucleophilic substitutions, synthesis and reactions of alkyl halides.

6 First test: radical, nucleophilic and electrophilic substitutions, electrophilic additions.

7 Nucleophilic substitution 2, synthesis and reactions of alcohols, phenols, ethers.

8 Aromatic nucleophilic substitutions: aryl halides, diazonium salts.

9 Stereochemistry, relative and absolute configuration.

10 First practice, design and synthetic pathways of complex compounds.

11 Second practice, design and synthetic pathways of complex compounds.

12 Second test: substitution and addition reactions, stereochemistry.


30


There is no exam.


Participants

Dr. Bognár Balázs (BOBGAAT.PTE)


31

OPF-N06-T MEDICAL TERMINOLOGY

Course director: GABRIELLA HÁBEL, language teacher





Topic

Introduction into the basics of Medical Terminology pertaining to Anatomy and clinical aspects focusing on word building and breaking

down medical terms.



Mid-term exams


To be discussed with the instructor.

Reading material



- Notes


University Script

Donáth, Tibor: Lexicon Anatomiae. Anatomical Dictionary, Semmelweis, Bp. 1999

Barbara Janson Cohen: Medical Terminology, Wolters Kluwer, Lippincott Williams and Wilkins, Baltimore 2008

This resource is also available via thePoint (http://thepoint.lww.com/cohen5e)

Jean Tannis Dennerll: Medical Terminology Made Easy, Delmar Publishers Inc., New York 1991

Lectures

1 Introduction into Medical Terminology. The importance of Medical terminology in practice.

Hábel Gabriella

2 The human body. Technical language use pertaining to anatomy and clinical practice.

Hábel Gabriella

3 Termini and clinical references pertaining to the digestive system

Hábel Gabriella

4 Termini pertaining to the respiratory system

Hábel Gabriella

5 The heart. Terminology pertaining to cardiology.

Hábel Gabriella

6 Terminology pertaining to blood and lymphatic system

Hábel Gabriella

7 Terminology pertaining to the genito-urinary system

Hábel Gabriella

8 Anatomical and clinical references pertaining to the genital organs

Hábel Gabriella

9 Sensory perception and its terminology

Hábel Gabriella

10 Characteristics of the technical language use pertaining to the brain and nervous system

Hábel Gabriella

11 Terms pertaining to bones, muscles, joints, ligaments and the relevant traumas

Hábel Gabriella

12 Terms pertaining to dentistry. Anatomy of the teeth and clinical aspects

Hábel Gabriella

13 Comparison of anatomical and clinical language usages based on authentic examples

Hábel Gabriella

http://thepoint.lww.com/cohen5e


32

14 Test paper

Hábel Gabriella

Practices

Seminars

1 Introduction. Structure of Medical Terminology. Features of anatomical and clinical language usages.

2 Parts of the human body. Anatomical directions, plates.

3 Introduction into the terminology pertaining to the digestive system, diagnoses.

4 Characteristics of the terminology pertaining to the respiratory system. Case studies from the field of pulmonology.

5 About the heart in nutshell. Symptoms, diagnoses, procedures in the field of cardiology.

6 Basic termini and diseases pertaining to blood and lymphatic system.

7 Test paper

8 Basic termini pertaining to the genito-urinary system. Diagnostic features of nephrology and urology.

9 Anatomical designations pertaining to the genitalia. Diagnostic methods, procedures, interventions in the fields of gynaecology

and andrology.

10 Sensory perception. Diagnostic procedures, making diagnosis in the fields of dermatology, ophthalmology and

otorhinolaryngology.

11 Termini pertaining to the brain and neurology. Disorders of the brain, diagnoses in the field of neurology.

12 Bones, muscles, articulations, ligaments. Introduction into the language of traumatology

13 Termini pertaining to dentistry. Anatomical and clinical expressions pertaining to the buccal cavity.

14 Introduction into the technical language of pharmaceutics



Participants

Hábel Gabriella (HAGTAAP.PTE)


33

OPF-NS1-T NOBEL PRIZE AWARDED CELL BIOLOGY I

Course director: DR. MARIANNA PAP, associate professor

Department of Medical Biology




Topic

The aim of the course is to present the most important and most exciting Nobel Prize-winning molecular cell biology discoveries based

on Nobel lectures given by the winners. The background story of the awards reveals many years of research work, good ideas, good

fortune mixed with family and other personal memories. There is no single recipe for success, the road is always a bit different, and

perhaps the only common feature is the teamwork. From the presentations one might get insight of the winners’ personality as well. An

important aspect was in the selection of the topics to emphasize their significance (DNA-, RNA-structure and their synthesis, ribosome

function), their impact on current medical way of thinking (e.g. Prions) and diagnostic methods (e.g. recombinant DNA technology,

DNA sequencing), the description of their present and future medical applicability (e.g. in vitro fertilization), as well as to highlight their

potential relations to different diseases (e.g. cell cycle regulation, reprogram of differentiated cells, RNA interference, papillomaviruses,

HIV). Lectures are organized based on the topics related to the weekly schedule of the molecular cell biology course, not in chronological

order. Most of the presented discoveries and experiments are involved in the molecular cell biology course material, so hopefully their

discussion helps in the better understanding of those topics and lead to a more effective and shorter exam preparation.



Mid-term exams

2 written tests: on week 7 and on week 14.


Participation on Hungarian or German lectures is the only possibility to make-up missed lectures.

Reading material



- Notes


www.nobelprize.org

Lectures

1 History of Nobel prize, interesting facts

Dr. Pap Marianna

2 Structure of nucleic acids, catalytic RNA molecules

Dr. Pap Marianna

3 Structure of proteins

Dr. Pap Marianna

4 Prions

Dr. Pap Marianna

5 PCR

Dr. Pap Marianna

6 Targeted mutagenesis

Dr. Pap Marianna

7 Recombinant DNA technology

Dr. Pap Marianna

8 DNA sequencing

Dr. Pap Marianna

9 Inhibition of gene expresssion (KO mutation)

Dr. Pap Marianna

10 Inhibition of gene expresssion (RNA interference)

Dr. Pap Marianna

http://www.nobelprize.org/


34

11 Regulation of cell cycle

Dr. Pap Marianna

12 Regulation of cell cycle

Dr. Pap Marianna

13 DNA synthesis

Dr. Pap Marianna

14 DNA repair

Dr. Pap Marianna

15 Eukariotyc RNA synthesis

Dr. Pap Marianna

16 Eukariotyc RNA synthesis

Dr. Pap Marianna

17 Splicing

Dr. Pap Marianna

18 Splicing

Dr. Pap Marianna

19 Structure and function of ribosomes

Dr. Pap Marianna

20 Role of RNA molecules in translation

Dr. Pap Marianna

21 Genetic code

Dr. Pap Marianna

22 Genetic code

Dr. Pap Marianna

23 Gene regulation

Dr. Pap Marianna

24 Gene regulation

Dr. Pap Marianna

25 Rough endoplasmic reticulum

Dr. Pap Marianna

26 Vesicular transport

Dr. Pap Marianna

27 Receptor-mediated endocytosis

Dr. Pap Marianna

28 Receptor-mediated endocytosis, Exam

Dr. Pap Marianna

Practices

Seminars



Participants


35

OPF-OTT-T HISTORY OF MEDICINE

Course director: DR. CSILLA RÚZSÁS, associate professor

Department of Operational Medicine




Topic

The purpose of the course is to give an opportunity for reviewing the progress in medicine historically, from the ancient times up to the

present époque, on the basis of cultural background. The understanding of the fact that the contemporary medicine is the result of the

efforts of several centuries will be hopefully stimulatory for the students in the professional improvement, realizing that both the

theoretical basis and healing practice are due to the devoted work of previous generations. Accordingly, the progress from healing art to

healing science will be illustrated in relation to the culture of previous centuries.

Since the students of our University come from countries of different cultures and traditions, the progress in medicine of ancient Greek

and Persian and Islamic culture are equally reviewed, besides the European medicine where English and German relations are of

outstanding importance, as reflected by the fact that in German universities, high number of weekly hours are devoted for the history of

medicine. Accordingly, the most outstanding physicians and clinical schools, playing a prominent role in the European progress will be

reviewed.

Our aim is to demonstrate that each culture represents a value which contributes to the common treasure of humanity.


Survey of the theoretical basis of medical practice in a historical period.

Mid-term exams

-


-

Reading material



Summary of the content of each lecture (detailed description of authors and the main outlines of their activity promoting the medicine)

- Notes


Delano: The Story of Medicine, London

Benke J.: Az orvostudomány története - Hungarian ed. with English summary, Medicina, Bp. 2008.

Lectures

1 Archaic medicine

Dr. Rúzsás Csilla

2 Ancient Egypt, Mesopotamia, India, traditional Chinese medicine

Dr. Rúzsás Csilla

3 Medicine in Greece in the Antiquity

Dr. Rúzsás Csilla

4 The most outstanding medical schools; Hippocratic medicine

Dr. Rúzsás Csilla

5 Medicine in the Roman times. Galen.

Dr. Rúzsás Csilla

6 Byzantine leading doctors

Dr. Rúzsás Csilla

7 Early medieval medicine in Europe

Dr. Rúzsás Csilla

8 Monasteric medicine in medieval Europe

Dr. Rúzsás Csilla

9 The medicine under Islam

Dr. Rúzsás Csilla


36

10 The most outstanding physicians of Arabic-Islamic medicine

Dr. Rúzsás Csilla

11 Foundation of the universities in the Middle-Age

Dr. Rúzsás Csilla

12 Scholastic medicine

Dr. Rúzsás Csilla

13 Medicine in the Renaissance

Dr. Rúzsás Csilla

14 Vesal. Paracelsus.

Dr. Rúzsás Csilla

15 Medicine of the 17th century: the golden age of sciences

Dr. Rúzsás Csilla

16 Raise of natural sciences. Iatrophysics and iatrochemistry

Dr. Rúzsás Csilla

17 The age of the 18th century

Dr. Rúzsás Csilla

18 The age of enlightment. Progress in pathology.

Dr. Rúzsás Csilla

19 Beginnings of modern medicine in the 19th century

Dr. Rúzsás Csilla

20 Medical schools in Europe

Dr. Rúzsás Csilla

21 Specialisation in medicine in the 19th century

Dr. Rúzsás Csilla

22 New approaches and equipment in medicine of the 19th century

Dr. Rúzsás Csilla

23 Medicine in the first half of the 20th century

Dr. Rúzsás Csilla

24 Results of Nobel-Prize winners in medicine

Dr. Rúzsás Csilla

25 Main trends in medicine in the second half of the 20th century

Dr. Rúzsás Csilla

26 Molecular biological methods in modern medicine and related problems

Dr. Rúzsás Csilla

27 The history of the University of Pécs

Dr. Rúzsás Csilla

28 Relations with prominent European scientists

Dr. Rúzsás Csilla

Practices

Seminars


Possible themes for the essays:

Characteristics of the ancient Egyptian and Mesopotamian culture.

Medicine of ancestral Chinese civilization.

Medicine of Greece in the Antiquity.

Hippocratic medicine and the Hippocratic Collection.

Post-hippocratic medicine: The school of Athens and Alexandria.

Outstanding physicians of Persian and Arabic-Islamic medicine.

Medical education in the Middle-Ages.

The main epidemies in Europe.

The most prominent physicians in the Renaissance.

Main trends in medicine of the 19th century.

Ignatz Semmelweis, the saver of the mothers.

Most important discoveries in medicine in the 20th century.


37


Participants


38

OPE-ABI-T APPLIED BIOMETRICS

Course director: DR. KORNÉLIA FARKAS-BORBÁS, assistant professor


1 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ spring semester ▪ recommended semester: 2




Topic

Basics of biometrical methods are indispensable to understand the scientific results, to plan own research, and to evaluate data. The main

goal of the course is to expand and deepened the basic knowledge of biometrics via solving practical problems.

Object of the course is to demonstrate different type of research with most frequently applied biometrical methods, though representative

examples or with using of the data of the participants.


Problem solving, oral report

Mid-term exams

Short presentation(s) on the classes by the students


Consultation

Reading material



- Notes


Andrew F. Siegel: Statistics and Data Analysis. An introduction, John Wiley & Sons, 1988

Douglas G. Altman: Practical Statistics for Medical Research, Chapman & Hall, 1994

P. Armitage and G. Berry: Statistical Methods in Medical Research, Blackwell Science, 1994

Robert R. Sokal / F. James Rohlf: Biometry, W. H. Freeman and Company, New York, 1981

Lectures

1 Introduction to research methodology

Borbásné Dr. Farkas Kornélia

2 Refresh the bio-statistical knowledge


3 Variance analysis


4 Regression analysis


5 Correlation analysis


6 Survival analysis


7 Factor analysis


Practices

1 Refresh the bio-statistical knowledge using the SPSS

2 Exercises

3 Variance analysis, post-hoc tests

4 Linear and non-linear regression analysis

5 Parametric and non-parametric(rank-) correlation analysis

6 Survival analysis, Cox-regression analysis...

7 Factor analysis


39

Seminars



Participants

Borbásné Dr. Farkas Kornélia (FAKAAA.T.JPTE)


40

OPE-BO2-T BIOPHYSICS SEMINARS 2

Course director: DR. ZOLTÁN UJFALUSI, assistant professor




Course headcount limitations (min.-max.): 5 – 40 Prerequisites: OPA-FI2 parallel


Topic

The objective of the course is to advance the acquisition of knowledge and skills related to Biophysics 2. Object-oriented discussions

and problem solving sessions are organized in interactive small-group seminars.


Maximum of three absences.

Mid-term exams

There will be no midterm exam.


None. After previous agreement with the lecturer the student can attend the seminar with another group another day, the same week.

Reading material



Online materials on departmental website (http://biofizika.aok.pte.hu)

- Notes

Damjanovich Sándor, Fidy Judit, Szöllősi János (eds.): Medical Biophysics, Medicina, Budapest, 2008


Lectures

Practices

Seminars

1 Radioactivity. Radioactive radiations

2 Spectrophotometry

3 Infrared and Raman spectroscopy

4 Fluorescence spectroscopy

5 Fluorescence anisotropy. FRET

6 Light microscopy, fluorescence microscopy

7 Modern microscopic methods. FRAP

8 Flow cytometry.

9 NMR

10 MRI

11 X-ray diagnostics. CT

12 Gamma-camera, SPECT, PET

13 Ultrasound

14 Test writing


Can be found on the departmental website (http://biofizika.aok.pte.hu)


Participants

Dr. Futó Kinga (FUKIAAT.PTE), Dr. Huber Tamás (HUTEAB.T.JPTE), Dr. Kengyel András Miklós (KEAFACO.PTE), Dr. Lukács

András Szilárd (LUATAA0.PTE), Kilián Balázsné Raics Katalin (RAKHAAT.PTE), Takács-Kollár Veronika Tünde (KOVGACT.PTE)




41

OPE-ETI-T PHARMACY ETHICS

Course director: TIBOR SZOLCSÁNYI, assistant professor

Department of Behavioural Sciences

1 credit ▪ midsemester grade ▪ Elective subject for the Pharmaceutical module ▪ spring semester ▪ recommended semester: 2



Topic

The aim of the course is to help students gain sensitivity to the ethical issues connected to the pharmacy practice. During the course

students learn about the basic ethical principles governing the pharmacist-patient and the pharmacist-physician relationship. Students

also get acquainted with the dilemmas that are raised by the conflict between business and ethics in pharmacy. The most important

concerns of research ethics and some specific ethical issues, like the question of mind-enhancing drugs, are also discussed during the

course.



Mid-term exams

Written test taking place in the last class. To improve the grade, the test can be repeated two times in the first two weeks of the exam

period. Oral exam is also an option for that purpose.


According to the Code of Studies and Examinations

Reading material



Additional materials: Neptun MeetStreet

- Notes


Robert Veatch and Amy Haddad (eds.): Case Studies in Pharmacy Ethics, 2nd edition, Oxford University Press, New York, 2008

Lectures

Practices

Seminars

1 Introduction

2 A short history of pharmacy

3 General ethical viewpoints

4 The principle of informed consent in modern health-care

5 The ethics of patient-pharmacist relationship

6 The ethics of physician-pharmacist relationship

7 The conflict between business and ethics in pharmacy

8 The placebo effect and its ethical concerns

9 Dietary supplements, performance- and mind- enhancing drugs

10 Ethical dilemmas raised by the drug therapy of mental disorders

11 Ethical issues in animal experimentation

12 Ethical issues in clinical drug trials

13 Summarizing discussion

14 Test


-


Participants

Dr. Szolcsányi Tibor (SZTAAJ.B.JPTE)


42

OPE-FKS-T PHYSICAL CHEMISTRY PROBLEM SOLVING SEMINAR

Course director: DR. LÍVIA NAGY-ZENGŐ, senior research fellow

Faculty of Natural Sciences - Department of General and Physical Chemistry



Course headcount limitations (min.-max.): 3 – 36 Prerequisites: OPA-FZ1 parallel

Topic

This is an elective course, a lecture room practice. It helps the student understanding the ways of calculating quantitative properties of

material, extent of changes and determine important physicochemical parameters. It shows the applicability of the theoretical forms, the

proper using of units in calculations. Showing the applicability of theory it supports bringing close to understanding the principles of

basic course on physical chemistry. The practice is an informal discussion following the physical chemistry I lecturing. The students

obtain problems to solve as home work. These problems are discussed during the practice. During the semester written test are given.

The evaluation is based on the scores. Students taking this course usually can solve easier the calculating problems at the physical

chemistry I course.


One class absence can be tolerated.

Mid-term exams


Full solved problems will be handed over in written form for the absent student.

Reading material


P. Atkins, J. de Paula: Physical Chemistry, 8th edition, Oxford University Press 2006, ISBN 9780198700722


- Notes


P. Atkins, J. de Paula: Physical Chemistry, 8th edition, Oxford University Press 2006, ISBN 9780198700722

D. Freifelder: Physical Chemistry for Students of Biology and Chemistry, Science Books International Inc. ISBN 0 86720-002-2

Lectures

Practices

Seminars

1 The properties of gases: states of perfect gas, the gas laws, units.

2 Basic concepts in thermodynamics, expansion work, internal energy of a system. Application of the first law.

3 Calculation of enthalpy and calorimetry.

4 Calculation of formation enthalpy and the heat capacity (cp, cv).

5 Calculation of the changes in internal energy.

6 Problem solving of entropy, changing of entropy in different processes.

7 Test: the gas laws, the first law, change in internal energy of a system, the heat capacities and entropy

8 Problems of the kinetic model of gases, collision with walls and surfaces.

9 Calculation: First rate chemical reactions.

10 Calculation: First rate chemical reactions, determination of ages by reaction kinetic base.

11 Problem solving of second rate chemical reaction and enzyme reaction

12 Electrochemical calculations: Faraday’s laws, conductivity in electrolytes, Nernst equation, Galvan cells

13 Test: problems fom kinetic model of gases, reaction kinetics and Faraday’s laws.

14 Calculation of electrolysis and corrosion


The solved problems will be handed over in written form for the students at the end of the semester.


Participants

Dr. Nagyné Dr. Zengő Lívia (NAZLAAF.PTE)


43

OPE-GKT-T HISTORY OF MANUFACTURE OF MEDICINES

Course director: DR. SZILÁRD PÁL, assistant professor

Institute of Pharmaceutical Technology and Biopharmacy




Topic

Aim of the course is to explain the importance of the birth of Pharmaceutical Technology, introducing the manufacture of medicines

from the ancient times until the new age. Lectures will explain how first medicines were made, how the first pharmaceutical technological

equipments were created and how the mass production of drugs became more and more important. Lectures will also elaborate the birth

of famous medicines, like the quinine, aspirin, insulin and the sildenafil.



Mid-term exams

- participation on the lectures

- accepted work reports

- accepted written assessments

Students have to write an end-semester assessment from the lectures at acceptance level of 60%.


Students must fulfil requirements determined by the Code of Studies and Examinations. Student has make up for the missed lectures and

work reports.

Reading material



- Notes


Leon Shargel, A. B.C. Yu, Stamford: Applied Biopharmaceutics and Pharmacokinetics

Susanna Wu-Pong, Yon Rojanasakul: Biopharmaceutical Drug Design and Development, Humana Press

Gilbert S. Banker, Christopher T. Rhodes: Modern Pharmaceutics, Marcel Dekker Inc., New York- Basel

Michael J. Rathbone, Michael S. Roberts: Modified-Release Drug Delivery Technology, Informa Healthcare

Michael E. Aulton: The Design and Manufacture of Medicines, Churchill Livingstone

Lectures

1 Introduction

Dr. Pál Szilárd

2 introduction

Dr. Kása Péter

3 Ancient technologies (Egypt, Greece, Persian Empire)

Dr. Pál Szilárd

4 Ancient technologies (Egypt, Greece, Persian Empire)

Dr. Kása Péter

5 Influence of alchemy to the pharmaceutical technology

Dr. Pál Szilárd

6 Influence of alchemy to the pharmaceutical technology

Dr. Kása Péter

7 Middle ages

Dr. Pál Szilárd

8 Middle ages

Dr. Kása Péter


44

9 Effect of industrial revolution

Dr. Pál Szilárd

10 Effect of industrial revolution

Dr. Kása Péter

11 Development of medicines in the new age

Dr. Pál Szilárd

12 Development of medicines in the new age

Dr. Kása Péter

13 Birth of the first industrial manufacturers

Dr. Pál Szilárd

14 Birth of the first industrial manufacturers

Dr. Kása Péter

15 Evolution of community pharmacies

Dr. Pál Szilárd

16 Evolution of community pharmacies

Dr. Kása Péter

17 Drugs that changed the world

Dr. Pál Szilárd

18 Drugs that changed the world

Dr. Kása Péter

19 Invention of the quinine

Dr. Pál Szilárd

20 Invention of the aspirine

Dr. Kása Péter

21 Invention of various famous drugs

Dr. Pál Szilárd

22 Invention of the sildenafil

Dr. Kása Péter

23 Invention of the insulin

Dr. Pál Szilárd

24 Invention of the insulin

Dr. Kása Péter

25 Test

Dr. Pál Szilárd

26 Test

Dr. Kása Péter

27 Attending the Saracen Pharmacy in Pécs

Dr. Pál Szilárd

28 Attending the Saracen Pharmacy in Pécs

Dr. Kása Péter

Practices

Seminars


Students can get the test topics in the institute or download the from website of the institute.


Participants

Dr. Kása Péter (ISWPRM), Dr. Pál Szilárd (PASMAAO.PTE)


45

OPE-JEA-T DISEASES OF SIGNAL TRANSDUCTION

Course director: GYÖRGY SÉTÁLÓ DR. JR., associate professor


1 credit ▪ midsemester grade ▪ Elective subject for the Medical/Biological module ▪ spring semester ▪ recommended semester: 2


Course headcount limitations (min.-max.): 5 – 25 Prerequisites: OPO-GL1-T completed + OPO-GL2-T parallel


Topic

The topics of signal transduction will be discussed beyond the details of the compulsory course, Molecular cell biology 2. In 14 x 45

minutes special attention is paid to mechanisms that are relevant to diseases.

The course is recommended to those students who are especially interested in the signaling aspects of pathological processes.



Mid-term exams

Two multiple-choice test-exams, with 20-25 questions each, one halfway and another one at the end of the course.


It is not possible to make up for missed classes.

Reading material



Lecturers using ppt will load these up onto the intranet after their class.

- Notes


Lectures

1 Introduction to the topics. Types of inter- and intracellular signaling.

Dr. Sétáló György ifj.

2 Second messengers. The cAMP-system in cholera, pertussis and anthrax.

Dr. Palkovics Tamás

3 The PKA, PKB and phospholipase C-system. Intracellular calcium. Tumor promotion and the PKC-family.


4 Catalytic receptors and their pathological alterations in diseases.


5 Insulin signaling and its aspects in certain types of diabetes mellitus.


6 Cytokines. NFK-B and inflammation.

Dr. Mikó Éva

7 First test exam.


8 Stress signaling and the consequences of too much stress. Heatshock proteins in signaling.

Dr. Bátor Judit

9 Signaling of apoptosis and its alterations in disease.

Dr. Pap Marianna

10 Cell-cell and cell-matrix connections and their pathological relevance.


11 The role of steroids in signaling and in certain diseases.


12 Integrin signaling and metastasis

Dr. Berta Gergely

13 Signaling in development. Malformations.

Dr. Ábrahám Hajnalka Gabriella

14 Second test exam.



46

Practices

Seminars


Multiple-choice test questions based on the actually presented materials of the course.


Participants


47

OPE-KP2-T BASICS OF CHEMISTRY 2






Topic

Based on the previously acquired high school knowledge the course provides an overview on the basic laws of Chemistry concentrating

on those that are ubiquitous in the chemistry-related subjects of the basic modules of the health related curriculums. The course helps

understanding the chemistry-related compulsory subjects of the modules.



Maximum three absences can be accepted both from lectures and practices. Two midterm tests will be written during the semester on the

7th and the 12th weeks. The result of both tests should be above 60%. One re-take chance is allowed after both tests.

Mid-term exams



Reading material


Ebbing D.D., Gammon S.D.: General Chemistry, Houghton Miffilin Co., Boston, 2009


Almási A., Kuzma M., Perjési P.: General and Inorganic Chemistry - Laboratory Techniques and Practices, electronic educational

material University of Pécs, 2014

- Notes



J. McMurray, R. C. Fay: Chemistry, 5th edition

Lectures

1 The electronic structure of atom. Periodic properties.

Dr. Perjési Pál

2 The electronic structure of atom. Periodic properties.

Dr. Perjési Pál

3 Structure of molecules. The valence bond theory

Dr. Perjési Pál

4 Structure of molecules. The valence bond theory

Dr. Perjési Pál

5 Structure of molecules. The molecular-orbital theory.

Dr. Perjési Pál

6 Structure of molecules. The molecular-orbital theory.

Dr. Perjési Pál

7 Bonding in solids

Dr. Perjési Pál

8 Bonding in solids

Dr. Perjési Pál

9 Molecular spectroscopy I. UV-VIS

Dr. Perjési Pál

10 Molecular spectroscopy I. UV-VIS

Dr. Perjési Pál


48

11 Carbon: structure and reactivity

Dr. Perjési Pál

12 Carbon: structure and reactivity

Dr. Perjési Pál

13 Nitrogen: structure and reactivity.

Dr. Perjési Pál

14 Nitrogen: structure and reactivity.

Dr. Perjési Pál

15 Oxygen: structure and reactivity.

Dr. Perjési Pál

16 Oxygen: structure and reactivity.

Dr. Perjési Pál

17 Transition metals: structure and reactivity

Dr. Perjési Pál

18 Transition metals: structure and reactivity

Dr. Perjési Pál

19 Coordination compounds I. Metal-ligand bonding I

Dr. Perjési Pál

20 Coordination compounds I. Metal-ligand bonding I

Dr. Perjési Pál

21 Coordination compounds II. Metal-ligand bonding II

Dr. Perjési Pál

22 Coordination compounds II. Metal-ligand bonding II

Dr. Perjési Pál

23 Coordination compounds III. Isomerism

Dr. Perjési Pál

24 Coordination compounds III. Isomerism

Dr. Perjési Pál

25 Coordination compounds IV. Stability.

Dr. Perjési Pál

26 Coordination compounds IV. Stability.

Dr. Perjési Pál

27 Basic photochemistry

Dr. Perjési Pál

28 Basic photochemistry

Dr. Perjési Pál

Practices

Seminars


Written test covering the topics of the lectures.


Participants


49

OPE-QAS-T QUANTITATIVE ANALYTICAL CHEMISTRY CALCULATION

Course director: DR. GYŐZŐ KORNÉL KULCSÁR, assistant professor

Department of Biochemistry and Medical Chemistry




Topic

The Quantitative analytical chemistry calculation course helps students to understand the analytical (titrimetric) calculations. It makes

theoretical backgrounds more understandable.


According to the Code of Studies and Examinations (see on the homepage). During the semester maximum 3 missed classes are

acceptable. Two midterm tests will be written during the semester. The result of both tests should be above 60%.

Mid-term exams

Two written exams during the semester.


Missing written exams should be made up.

Reading material


Harris D.C.: Quantitative Chemical Analysis, 8th ed., W.H. Freeman and Co., New York, 2010


Handouts.

- Notes


Lectures

Practices

Seminars

1 Introduction - Concentrations - Concentration of standard solutions.

2 Introduction - Concentrations - Concentration of standard solutions.

3 Acid-base titrations - Methods for calculating the titration results. Calculations with molarity and normality.

4 Acid-base titrations - Methods for calculating the titration results. Calculations with molarity and normality.

5 Neutralization analysis - Standardization of a titrant. Titration curve calculations.

6 Neutralization analysis - Standardization of a titrant. Titration curve calculations.

7 Calculation of pH in titration problems I. Hydrolysis of salts.

8 Calculation of pH in titration problems I. Hydrolysis of salts.

9 Calculation of pH in titration problems II. Buffers.

10 Calculation of pH in titration problems II. Buffers.

11 Non-aqueous titration calculations.

12 Non-aqueous titration calculations.

13 Complexometry - Methods for calculating the titration results.

14 Complexometry - Methods for calculating the titration results

15 Complex chemical equilibria - Calculations with the stability constants.

16 Complex chemical equilibria - Calculations with the stability constants.

17 Redox titrations II. - Calculations based on oxidimetry.

18 Redox titrations II. - Calculations based on oxidimetry.

19 Redox titrations I. - Redox titration curve calculations.

20 Redox titrations I. - Redox titration curve calculations.

21 Redox titrations I. - Calculations based on oxidimetry.

22 Redox titrations I. - Calculations based on oxidimetry.

23 Redox titrations III. - Calculations based on reductometry.

24 Redox titrations III. - Calculations based on reductometry.


50

25 Precipitate formation titrations - Calculations for the solubility products.

26 Precipitate formation titrations - Calculations for the solubility products.

27 Gravimetry.

28 Gravimetry.


The final grade is established based on the average of each written exams.


Participants

Dr. Almási Attila (ALAFAEO.PTE), Dr. Kulcsár Győző Kornél (KUGDAA.T.JPTE)


51

OPF-BAL-T MINERAL AND SPA WATERS, BALNEOLOGY

Course director: DR. CSABA VARGA, associate professor


2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2



Topic

The main educational task of the subject initiating to form state-of-art regarding use and application of mineral and spa waters in Hungary

and EU with special respect of the prevention.

Short description of the course: Delivering up to date hydrological, hydrogeological, physical, chemical, biological knowledge for

students of medicine and other sciences.



Mid-term exams

-


-

Reading material



Neptun

- Notes


Lectures

1 Hydrogeology and balneology of mineral and spa waters

Dr. Varga Csaba

2 Hydrogeology of Hungarian mineral and spa waters

Dr. Varga Csaba

3 Correlation of the geological characteristics and the chemical composition

Dr. Varga Csaba

4 Hydrology of mineral and spa waters

Dr. Varga Csaba

5 Mineral and spa waters in Hungary and Europe

Dr. Varga Csaba

6 Chemical characteristics of mineral and spa waters

Dr. Varga Csaba

7 Inorganic analytical classification

Dr. Varga Csaba

8 Presence of microelements

Dr. Varga Csaba

9 Inorganic ions, substances and complexes in the therapeutical effect

Dr. Varga Csaba

10 Organic ions, substances and complexes in the therapeutical

Dr. Varga Csaba

11 In situ water analysis

Dr. Varga Csaba

12 Inorganic analysis

Dr. Varga Csaba

13 Hygienic microbiological analysis

Dr. Varga Csaba


52

14 Artificial mineral and medicinal waters

Dr. Varga Csaba

15 Peloids: genesis, chemical/physical/toxicological properties. Hungarian peloids.

Dr. Varga Csaba

16 Mineral and spa water products

Dr. Varga Csaba

17 Introduction to Balneology: objectives and history

Dr. Varga Csaba

18 Water and ions in the human body

Dr. Varga Csaba

19 External cure with spa waters, mode of action

Dr. Varga Csaba

20 Mechanic, thermal, chemical and psychic actions, Spa reaction.

Dr. Varga Csaba

21 Water types in cure

Dr. Varga Csaba

22 Application of spa waters to different diseases

Dr. Varga Csaba

23 Therapeutic applications of peloids

Dr. Varga Csaba

24 Internal use of mineral and medicinal waters. Drinking cure

Dr. Varga Csaba

25 Inhalation cure

Dr. Varga Csaba

26 Other natural cures: climate cure, physicotherapy, additional therapies

Dr. Varga Csaba

27 Exam

Dr. Varga Csaba

28 Exam

Dr. Varga Csaba

Practices

Seminars


Neptun


Participants


53

OPF-BMK-T METHODS AND EXPERIMENTS IN MOLECULAR BIOLOGY

Course director: DR. KATALIN SIPOS, associate professor

Department of Pharmaceutical Biology




Topic

We will analyze famous and interesting molecular biological experiments and examine the development and everyday importance of

methods used in molecular biology. We will pay special attention for experimental areas of pharmaceutical research. We hope the course

material will help the students to develop problemsolving thinking.



Mid-term exams

The course will end with a written exam.


According to personal agreement

Reading material



Scientific articles in English

- Notes


Lectures

Practices

Seminars

1 Methods to follow replication.

2 Molecular biological methods of cell cycle examinations

3 PCR

4 Array methods

5 Blotting methods

6 Labeling methods in the molecular biology

7 Gene regulation in the prokaryotes

8 Gene regulation in the eukaryotes.

9 Genetically modified animals

10 Experimental planning in pharmaceutical research I.

11 Experimental planning in pharmaceutical research II.

12 Real time PCR

13 Methods in cell culture experiments

14 Exam


No extra exam questions. The basis of the exam is the material of the seminars.


Participants

Dr. Pandur Edina (PAEFAA.T.JPTE), Dr. Sipos Katalin (SIKMAAO.PTE), Jánosa Gergely (JAGTAAT.PTE), Pap Ramóna

(PARTAAT.PTE), Poór Viktor Soma (POVFAB.T.JPTE)


54

OPF-H2A-T MEDICAL HUNGARIAN 2A - COMMUNICATION SKILLS





Course headcount limitations (min.-max.): 2 – 25 Prerequisites: OPF-H1A completed + OPF-H2B parallel


Topic

This course is meant to serve as a transition between general and specific (doctor-patient) communication skills development.




Mid-term exams

-


In the case of absences up to 25% of total class time, oral examination will have to be taken.

Reading material



http://aok.pte.hu/index.php?page=egyseg&egy_id=60&nyelv=eng&menu=okt_anyag

- Notes


Lectures

Practices

1 Logical relations, comparison

2 Logical relations, comparison

3 Giving orientation, informing people

4 Giving orientation, informing people

5 Giving descriptions, requesting and providing information

6 Giving descriptions, requesting and providing information

7 Cause and consequence

8 Cause and consequence

9 Narratives

10 Narratives

11 Giving advice

12 Giving advice

13 Expressing uncertainty

14 Expressing uncertainty

15 Test 1

16 Test 1

17 Descriptions, warning

18 Descriptions, warning

19 Polite request, command and warning

20 Polite request, command and warning

21 Parts of the human body, pain, basic symptoms

22 Parts of the human body, pain, basic symptoms

23 History taking: presenting complaints, location, direction and character of pain

24 History taking: presenting complaints, location, direction and character of pain

25 Simple examinations, diagnostic procedures

26 Simple examinations, diagnostic procedures



55

27 Test 2

28 Course evaluation

Seminars


-


Participants




Halmos Éva (MEHHABE.PTE), Nagy Gabriella (NAGMAAO.PTE), Ronczykné Berta Anikó (BEAAAI.B.JPTE), Szántóné Dr.



56

OPF-H2B-T MEDICAL HUNGARIAN 2B - LANGUAGE POINTS





Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPF-H1B completed + OPF-H2A parallel


Topic

This course is meant to provide the language basis for advanced communication between doctors and patients.




Mid-term exams

-


Reading material




- Notes


Lectures

Practices

1 Expressing possessing, genitive case

2 Expressing possessing, genitive case

3 Adjectives and nouns: eg. nátha-náthás, nominalization: eg köhög-köhögés

4 Adjectives and nouns: eg. nátha-náthás, nominalization: eg köhög-köhögés

5 Question words, concerning time and location and adverbs of time

6 Question words, concerning time and location and adverbs of time

7 Expressing cause, giving explanation

8 Expressing cause, giving explanation

9 Functions of past tense in medical Hungarian

10 Functions of past tense in medical Hungarian

11 Future tense, modality expressing ability and volition

12 Future tense, modality expressing ability and volition

13 Impersonalization

14 Impersonalization

15 Consolidation test 1

16 Test 1

17 Modality expressing necessity, possibility and prohibition

18 Modality expressing necessity, possibility and prohibition

19 Definite and indefinite conjugation, prefixed verbs

20 Definite and indefinite conjugation, prefixed verbs

21 Imperative forms

22 Imperative forms

23 Giving instructions to patients



26 Consolidation

27 Test 1




57

Seminars


-


Participants




Halmos Éva (MEHHABE.PTE), Nagy Gabriella (NAGMAAO.PTE), Ronczykné Berta Anikó (BEAAAI.B.JPTE), Szántóné Dr.



58

OPF-HB2-T HOW TO ACHIEVE BETTER GRADE IN ORGANIC CHEMISTRY 2

Course director: DR. BALÁZS BOGNÁR, assistant professor




Course headcount limitations (min.-max.): 2 – 20 Prerequisites: OPA-V2E-T parallel

Topic

The aim of the course is to help the students to understand the important reaction mechanisms, and find the connections between the

different topics.

1. Revision of addition and substitution reactions

2. Basicity and reactivity of amines

3-4. Reactions of carbonyl compounds, nucleophilic additions, condensations

5. Isomerisations in carbohydrates

6. 1. test

7. Acidity of carboxilyc acids

8. Reactions of carboxilyc acids and their derivatives

9. Aromatic substitutions of heteroaromatics

10-11 Summary of the most important reaction mechanisms with complex problems

12 2. test



Mid-term exams

Nincs.


Nincs.

Reading material



The worksheets will be granted on the seminar.

- Notes


Estelle K. Meislich; Herbert Meislich; Jacob Sharefkin: Schaum’s Series 3000 Solved Problems In Organic Chemistry, McGraw-

Hill, Inc., New York, 1994.

T. W. Graham Solomons: Organic Chemistry, 7th edition, Wiley and Sons, New York, 2000.

John McMurry, Eric Simanek: Fundamentals of Organic Chemistry, 6th edition, Thomson Brooks/Cole, Belmont, 2007.

Lectures

Practices

Seminars

1 Summary of the most important reactions from the first semester.

2 Basicity and reactivity of amines.

3 Polarity of the carbonyl bond. Reactions of carbonyl compounds, nucleophilic additions.

4 Polarity of the carbonyl bond. Reactions of carbonyl compounds, condensations.

5 Reactions of carbohydrates: oxidation, reduction, bromination.

6 First test: synthesis and reactions of amines and carbonyl compounds.

7 Acidity of carboxilyc acids, effect of electron sending or withdrawing groups.

8 Reactivity and reactions of carboxilyc acids, amides, anhydrides, esters.

9 Aromatic substitutions of heteroaromatics, reactions of five-membered and six-membered heterocycles.

10 Summary of the most important reaction mechanisms (substitutions, additions) with complex problems.

11 Summary of the most important reaction mechanisms (condensations) with complex problems.

12 Second test: carboxilic acids and their derivatives, heteroaromatics.


59


There is no exam.


Participants

Dr. Bognár Balázs (BOBGAAT.PTE)


60

OPF-IZM-T MOLECULAR BASIS OF MUSCLE FUNCTION

Course director: DR. DÉNES LŐRINCZY, professor






Topic

The structure of muscle based on light, phase contrast, polarized and electron microscopic observations. Elastic behaviour of passive and

active muscle, types of muscle contractions, muscle force-length relationship. Work done by the muscle, muscle efficiency and heat

production. Thermoelastic behaviour of muscle. Muscle models based on mechanical and structural investigations. Bioelectrical

phenomena, excitation-contraction coupling. Energetics of muscle function, structure of muscle proteins (actin, myosin etc.), analysis of

sliding model. Energetic and spectroscopic investigations in the research of molecular dynamic and thermodynamic background of

muscle function.


The applicants - in the case of more than one absence (up to maximum three absences in which must not be the consultation or test) -

should prepare and will be tested from the missed topics given by the instructor. In the case of more than three absences the course can

not be accepted.

Mid-term exams

Written test at the end of semester.


The applicants - in the case of more than one absence (up to maximum three absences in which must not be the consultation or test) -

should prepare and will be tested from the missed topics given by the instructor.

Reading material



It will be announced at the beginning of the course depending on the possibilities of libraries of Biophysical Department, Faculty of

Medicine. A permanent source could be the roaming in the Internet.

- Notes


Lectures

1 The composition of muscle.

Dr. Lőrinczy Dénes

2 The sorts of muscle.


3 The structure of muscle on the basis of light, phasecontrast and polarization microscope.


4 Structure of muscle by ELMI.


5 Sorts of muscle contraction.


6 Elastic behaviour of passive and active muscle.


7 Muscle force and length relationship, Hill`s equation.


8 Work and heat production done by a muscle, efficiency of muscle function.


9 Thermoelastic behaviour of muscle.


10 Muscle models proposed by mechanical and structural investigations.



61

11 Biochemical basis and energetics of muscle function.


12 Bioelectrical phenomena. Action potentials.


13 Nernst equation, G-H-K equation.


14 Voltage- and patch-clamp techniques.


15 Excitation-contraction coupling.


16 Structure of muscle proteins (actin and myosin, actomyosin complex).


17 Discussion of sliding model in details (x-ray diffraction).


18 Molecular dynamic background of muscle contraction (EPR spectroscopy)


19 Muscle in the sport and rehabilitation (wellness).


20 Principle of differential scanning calorimetry.


21 Thermodynamic background of muscle contraction (DSC results)


22 Muscle and levers in locomotion.


23 Free consultation from the topics of course (discussion of any problem).


24 Free consultation from the topics of course (discussion of any problem).


25 Written test.


26 Written test.


27 Discussion of the test, final evaluation of the course.


28 Discussion of the test, final evaluation of the course.


Practices

Seminars


Written test


Participants


62

OPF-MGY-T MEDICINAL PLANTS IN THE MECSEK MOUNTAIN - FIELD STUDY 1

Course director: DR. NÓRA PAPP, associate professor

Department of Pharmacognosy




Topic

The course includes 6x2 lectures and 3x4 practice (field work). The aim of the course is to practice the correct identification of medicinal

plants, knowledge of main morphological characters, habitat, collection place, and therapeutical use. The course gives a general overview

on the most frequent medicinal plants, protected and produced species, as well as various vegetation types in the Mecsek mountain and

its environment. In addition, the effect and relationship between abiotic factors and secondary metabolites of plants are also discussed,

which can provide recommendations for collection place and habitat of plants.


Maximal absences: 2 /semester.

Mid-term exams

Fulfillment of 2 tests.


http://gytk.pte.hu/en/egyseg/oktatasianyagok/1640

http://aok.pte.hu/en/egyseg/oktatasianyagok/1640

Reading material



Lectures downloaded in Neptun.

- Notes


Lectures

1 Vegetation types of medicinal plants; ecological factors in habitats I

Dr. Papp Nóra

2 Vegetation types of medicinal plants; ecological factors in habitats I

Dr. Papp Nóra

3 Vegetation types of medicinal plants; ecological factors in habitats II

Dr. Papp Nóra

4 Vegetation types of medicinal plants; ecological factors in habitats II

Dr. Papp Nóra

5 Environmental adaptation of medicinal plants (morphology, phytochemistry); relationship between medicinal plant populations

and their environment

Dr. Papp Nóra

6 Environmental adaptation of medicinal plants (morphology, phytochemistry); relationship between medicinal plant populations

and their environment

Dr. Papp Nóra

7 Vegetation types in the Mecsek mountain I: medicinal plants in beech and karst shrub forests

Dr. Papp Nóra

8 Vegetation types in the Mecsek mountain II: medicinal plants in rock grasses, swamps and alder woods

Dr. Papp Nóra

9 Medicinal plants at road edge vegetations, planted and protected plants of the Mecsek mountain I

Dr. Papp Nóra

10 Medicinal plants at road edge vegetations, planted and protected plants of the Mecsek mountain II

Dr. Papp Nóra




63

11 Identification of medicinal plants used Identification Handbooks, methods in field work I

Dr. Papp Nóra

12 Identification of medicinal plants used Identification Handbooks, methods in field work II

Dr. Papp Nóra

Practices

1 Identification of medicinal plants in rock grasses (Tettye)




5 Identification of medicinal plants in oak forest (Dömörkapu)




9 Identification of medicinal plants in swamp (Pellérd)




Seminars


According to the topics of the course.


Participants

Dr. Papp Nóra (PANAAA.T.JPTE)


64

OPF-N04-T ANATOMICAL TERMINOLOGY

Course director: GABRIELLA HÁBEL, language teacher






Topic

The course aims to mediate the basic anatomical terms supporting the studies of Anatomy.



Mid-term exams


Reading material



- Notes


University Script

Donáth, Tibor: Lexicon Anatomiae. Anatomical Dictionary, Semmelweis, Bp. 1999.

Lectures

Practices

Seminars

1 Structure of anatomical terms.

2 Structure of anatomical terms.

3 Body Planes, Anatomical Directions, Surface Features of Bones

4 Body Planes, Anatomical Directions, Surface Features of Bones

5 Anatomical Terminology of the Upper Extremity, Bones, Joints

6 Anatomical Terminology of the Upper Extremity, Bones, Joints

7 Anatomical Terminology of the Scapula and Shoulder Girdle

8 Anatomical Terminology of the Scapula and Shoulder Girdle

9 Anatomical Terminology of the Lower Extremity, Bones, Joints

10 Anatomical Terminology of the Lower Extremity, Bones, Joints

11 Anatomical Terminology of the Pelvic Girdle, Bones, Joints

12 Anatomical Terminology of the Pelvic Girdle, Bones, Joints

13 Test paper 1.

14 Test paper 1.

15 Vertebrae, Sternum, Costae. Terminology of the Vertebral Column

16 Vertebrae, Sternum, Costae. Terminology of the Vertebral Column

17 Anatomical Terminology of the Muscular System

18 Anatomical Terminology of the Muscular System

19 Anatomical Terminology of the Skull. Calvaria, Internal Cranial Base

20 Anatomical Terminology of the Skull. Calvaria, Internal Cranial Base

21 Anatomical Terminology of the Skull. External Cranial Base

22 Anatomical Terminology of the Skull. External Cranial Base

23 Anatomical Terminology of the Skull. Palatine, Sphenoid, Temporal, Occipital Bones

24 Anatomical Terminology of the Skull. Palatine, Sphenoid, Temporal, Occipital Bones

25 Anatomical Terminology of the Skull. Temporomandibular Joint. Cranial Nerves

26 Anatomical Terminology of the Skull. Temporomandibular Joint. Cranial Nerves

27 Test paper 2.

28 Test paper 2.


65



Participants

Hábel Gabriella (HAGTAAP.PTE)


66

OPF-NS2-T NOBEL PRIZE AWARDED CELL BIOLOGY II

Course director: DR. MARIANNA PAP, associate professor






Topic

The aim of the course is to present the most important and most exciting Nobel Prize-winning molecular cell biology discoveries based

on Nobel lectures given by the winners. The background story of the awards reveals many years of research work, good ideas, good

fortune mixed with family and other personal memories. There is no single recipe for success, the road is always a bit different, and

perhaps the only common feature is the teamwork. From the presentations one might get insight of the winners’ personality as well. An

important aspect was in the selection of the topics to emphasize their significance (DNA-, RNA-structure and their synthesis, ribosome

function), their impact on current medical way of thinking (e.g. Prions) and diagnostic methods (e.g. recombinant DNA technology,

DNA sequencing), the description of their present and future medical applicability (e.g. in vitro fertilization), as well as to highlight their

potential relations to different diseases (e.g. cell cycle regulation, reprogram of differentiated cells, RNA interference, papillomaviruses,

HIV). Lectures are organized based on the topics related to the weekly schedule of the molecular cell biology course, not in chronological

order. Most of the presented discoveries and experiments are involved in the molecular cell biology course material, so hopefully their

discussion helps in the better understanding of those topics and lead to a more effective and shorter exam preparation.



Mid-term exams

2 written tests: on week 7 and on week 14.


Participation on Hungarian or German lectures is the only possibility to make-up missed lectures.

Reading material



- Notes


www.nobelprize.org

Lectures

1 Passive transport

Dr. Pap Marianna

2 Passive transport

Dr. Pap Marianna

3 Active transport

Dr. Pap Marianna

4 Action of hormones

Dr. Pap Marianna

5 G-proteins and their role in signal transduction

Dr. Pap Marianna

6 G-protein-coupled receptors

Dr. Pap Marianna

7 Growth factors

Dr. Pap Marianna

8 Growth factors

Dr. Pap Marianna

9 Reversible protein phosphorylation in signal transduction pathways

Dr. Pap Marianna

10 Reversible protein phosphorylation in signal transduction pathways

Dr. Pap Marianna

http://www.nobelprize.org/


67

11 Genetic control of early embryonic development

Dr. Pap Marianna

12 Genetic control of early embryonic development

Dr. Pap Marianna

13 Programmed cell death

Dr. Pap Marianna

14 Programmed cell death

Dr. Pap Marianna

15 DNA tumor viruses

Dr. Pap Marianna

16 DNA tumor viruses

Dr. Pap Marianna

17 RNA tumor viruses

Dr. Pap Marianna

18 RNA tumor viruses

Dr. Pap Marianna

19 Retroviral oncogenes

Dr. Pap Marianna

20 Retroviral oncogenes

Dr. Pap Marianna

21 Telomeres and telomerase activity in cancers

Dr. Pap Marianna

22 Telomeres and telomerase activity in cancers

Dr. Pap Marianna

23 Human cell- and tissue transplantation

Dr. Pap Marianna

24 Human cell- and tissue transplantation

Dr. Pap Marianna

25 In vitro fertilization

Dr. Pap Marianna

26 In vitro fertilization

Dr. Pap Marianna

27 The discovery of the green fluorescent protein and its significance in molecular biology

Dr. Pap Marianna

28 The discovery of the green fluorescent protein and its significance in molecular biology, Exam

Dr. Pap Marianna

Practices

Seminars



Participants


68

OPF-PLH-T THE PLACEBO EFFECT

Course director: TIBOR SZOLCSÁNYI, assistant professor

Department of Behavioural Sciences





Topic

The use of placebo effect has been an inherent part of medicine for thousands of years, and in the recent decades it has become an

inevitable element of medical research due to the introduction of placebo controlled clinical trials. In spite of this fact the research

methodology to measure the effectiveness of placebo effect has been clarified only in the last 10-15 years. At the same time researches

on the neurochemical mechanisms underlying the placebo effect have gained a new impetus. Currently, therefore, we have a much greater

understanding of placebo effect in the context of evidence-based medicine than before, which raises new types of ethical questions as

well. During the course we will examine the different aspects of the phenomenon of placebo effect, and the students will gain knowledge

of the current research results on the field. The main topics of the course: the history of the use of placebo therapies, the role of placebo

effect in medical research, the psycho-social factors that are able to induce placebo effect, neurochemical mechanisms underlying the

placebo effect, the ethical implications of the use of placebo effect in medical treatments.



Mid-term exams

Written test taking place in the last class. To improve the grade, the test can be repeated two times in the first two weeks of the exam

period.


According to the Code of Studies and Examinations.

Reading material


Franklin G. Miller; Luna Colloca; Ted J. Kaptchuk: The Placebo Effect: Illness and Interpersonal Healing, Perspect Biol Med. 2009

; 52(4)

Damien G. Finniss; Ted J. Kaptchuk; Franklin G. Miller; Fabrizio Benedetti: Biological, Clinical and Ethical Advances of Placebo

Effects, Lancet 2010; 375; 686-695

Franklin G. Miller; Donald L. Rosenstein: The Nature and Power of the Placebo Effect, Journal of Clinical Epidemiology 59, 2006;

331-335

Fabrizio Benedetti: Mechanisms of Placebo and Placebo-Related Effects across Diseases and Treatments, Annual Review of

Pharmacology and Toxicology, Vol. 48; 2008; 33-60.

Jozien M. Bensing; William Verheul: The Silent Healer: The Role of Communication in Placebo Effects, Patient Education and

Counseling 80, 2010; 293-299


Additional materials: Neptun MeetStreet

- Notes


Fabrizio Benedetti: Placebo Effect, Oxford University Press, Oxford, 2009

Lectures

Lectures

1 Introduction, definitions of placebo effect

Dr. Szolcsányi Tibor

2 The use of placebo effect in the history of medicine


3 The use of placebo effect in the context of medical research: the introduction of randomized placebo controlled clinical trials and

its consequences


4 The methodological and ethical challenges of placebo research



69

5 The main forms of placebo effect (expectancy based / classical conditioning / affective modulation) and their effectiveness in

different diseases


6 The neurochemistry of placebo effect: placebo analgesia


7 The neurochemistry of placebo effect: the cardiovascular and the respiratory system, immune response and hormone secretion,

Parkinson disease


8 The neurochemistry of placebo effect: further results


9 An overview of the psycho-social factors that are able to induce placebo effect


10 The anthropological and evolutionary background of placebo effect


11 Pain management through psychological interventions and placebo analgesia


12 Ethical implications: how to enhance the placebo effect through improving the physician-patient relationship


13 Ethical implications: the possible role of complementary medicine in the enhancement of placebo effect


14 Written test


Practices

Seminars


-


Participants


70

OPF-VVE-T VACCINATION, ANTI-VACCINATION MOVEMENTS: DO MORE HARM THAN GOOD

Course director: DR. KATALIN SZENDI, assistant professor






Topic

Vaccination belongs to one of the most successful modern health care programmes that decreased significantly the number of severe

infectious diseases. In today’s world experts are unable to compete with the media. Several delusions circulate infiltrating the public

opinion related to vaccines. The most susceptible target audience of these beliefs are the half-educated laymen who believe in the media

created pseudoscience. The activity of stubborn anti-vaccine minorities can be dangerous because that may open up new chances of the

spread of infectious diseases.

The objective of the course is to deepen the knowledge of vaccinations concerning the background, benefits, achievements and failures,

and the course also serves as a thought provoking initiation for practitioners relating to possible actions against the anti-vaccination

movements.


Participation in lectures and practicals is obligatory which is registered.

Absences should not exceed 15% (2x45 min). Otherwise signature of grade book is denied.

Mid-term exams

-


There are no make-up classes.

Reading material



Educational material uploaded on Neptun.

- Notes


Stanley A. Plotkin. History of Vaccine Development. Springer 2011.

Vaccine Fact Book 2013. http://www.phrma.org/sites/default/files/pdf/PhRMA_Vaccine_FactBook_2013.pdf

WHO, UNICEF, World Bank. State of the world’s vaccines and immunization, 3rd ed., Geneva, World Health Organization, 2009.

Lectures

1 History of vaccines and anti-vaccination movements

Dr. Szendi Katalin

2 Epidemiology of infectious diseases, morbidity and mortality rates before and after vaccine introduction. Is there any benefit of

vaccination?

Dr. Szendi Katalin

3 Epidemiological studies on vaccination, are there any at all?

Dr. Szendi Katalin

4 Morbidity, mortality, incidence, prevalence. Statistics, data availability, official sources. Are there enough and reliable data to

prove the effectiveness or safety of vaccines?

Dr. Szendi Katalin

5 Groups of vaccinations. Why are they compulsory?

Dr. Szendi Katalin

6 Types of vaccinations. Are there any unnecessary ones (e.g. BCG)? Is it possible that the only purpose of the pharmaceutical

industry is to increase their profits?

Dr. Szendi Katalin

7 The function of vaccination, types of immunity. Is artificial induction of immunity good for our immune system? Does it result

in more benefits if the diseases are fought off in a natural way?

Dr. Szendi Katalin

http://www.phrma.org/sites/default/files/pdf/PhRMA_Vaccine_FactBook_2013.pdf


71

8 The efficiency of vaccines. Do the European countries with better health indicators also have better epidemiological situation

than Hungary? Questions of herd immunity.

Dr. Szendi Katalin

9 Vaccine effectiveness. Are there any positive health effects, or just does the government want to make us believe in counterfeit

statistical data?

Dr. Szendi Katalin

10 Vaccination safety, components. Are the ingredients in vaccines dangerous? Do they cause any harm to health? Diversity of

conspiracy theories.

Dr. Szendi Katalin

11 Risks of vaccines, vaccination health hazards. Do the vaccines do more harm than good? MMR and autism. Mercury and autism.

Aluminium and autism.

Dr. Szendi Katalin

12 Legal background. The legal regulation of vaccines. The pros and cons of compulsory vaccination. What is the point of it? The

reason for the existence of free choice.

Dr. Szendi Katalin

Practices

1 Anti-vaccination activities in Hungary and abroad.

2 Do we have to deal with the anti-vaccination movements? Anti-vaccination movements, hazards, duties. Psychology of the anti-

vaccination attitudes.

Seminars


Neptun


Participants

Dr. Szendi Katalin (SZKFAPO.PTE)


72

OPE-BEE-T BASICS OF EPIDEMIOLOGY

Course director: DR. TÍMEA VARJAS, assistant professor




Course headcount limitations (min.-max.): 1 – 30 Prerequisites: OPA-B2E completed


Topic

During the semester students are acquainted with the basics of epidemiology and epidemiological studies frequently used in scientific

literature. With this knowledge one can easily elucidate and interpret scientific publications.

The course is recommended for pharmacists and dentists.


Absences should not exceed 15% of lectures and practicals (2x45 min). Otherwise signature of grade book is denied.

Mid-term exams

Examination: written test


Based on individual consideration

Reading material



PPT-presentations (Neptun)

- Notes


Lectures

1 Definition, history, goal and concept of epidemiology

Dr. Szabó István

2 Definition, history, goal and concept of epidemiology

Dr. Szabó István

3 Epidemiological indicators and their application (incidence, prevalence)

Dr. Szabó István

4 Epidemiological indicators and their application (RR, OR, statistical significance)

Dr. Szabó István

5 Epidemiological studies

Dr. Szabó István

6 Epidemiological studies

Dr. Szabó István

7 Epidemiology and Evidence Based Medicine

Dr. Szabó István

8 Epidemiology and Evidence Based Medicine

Dr. Szabó István

Practices

1 Basic epidemiological calculations

2 Basic epidemiological calculations

3 Analyzis of selected scientific publications

4 Analyzis of selected scientific publications

Seminars

1 Standardization, Screening

2 Bias, error


73


Neptun


Participants

Dr. Szabó István (SZIGABO.PTE)


74

OPE-EHS-T HUNGER, SATIETY AND DISTURBANCES OF BODY WEIGHT REGULATION

Course director: DR. LÁSZLÓ LÉNÁRD I, emeritus professor

Institute of Physiology



Course headcount limitations (min.-max.): 5 – 25 Prerequisites: OPA-FI2 completed + OPO-MB2 completed


Topic

Based on recent results, feeding related physiological and pathophysiological mechanisms will be discussed. Students will be trained to

understand these mechanisms. The knowledge based on this course will highly contribute to better understanding further clinical studies

on human diseases.

Peripheral and central mechanisms of hunger, satiety, salt appetite and body weight regulation will be discussed. Lectures will include

the following topics: Neural and humoral processes. Peripheral and central glucose-monitoring system. The role of neuropeptides in the

control of feeding and hydromineral balance. Pathological processes: obesity, bulimia, anorexia.


Absence from no more than 25% of the lectures.

Mid-term exams

Written exams.


-

Reading material



- Notes

Notes taken at the lectures.


Lectures

1 Basic parameters: caloric intake, energy expenditure, measurement of food and water intake, body weight and body mass index.

Body weight curves during development, adulthood and senescence.

Dr. Lénárd László I

2 Peripheral and central mechanisms of body weight regulation.


3 Endocrine mechanisms: the role of different hormones.


4 Body weight loss, obesity. Long run pathological consequences of obesity.


5 Hunger and satiety. Motivational mechanisms. Overeating, rejection.


6 Hypothalamic dual centers. The role of limbic system in hunger and satiety.


7 Peripheral glucose related signals. The central glucose monitoring system.


8 Food rewarded learning, the role of reinforcement. Aversive learning, the role of conditioned taste aversion in feeding habits.


9 The sight, odor, taste and texture of foods and their detection in the limbic system. Ingestive and rejective mimetic responses and

their genetic determination.


10 The role of monoamines in the regulation of feeding. Similarities of food rewarded learning and addictive behavior. The role of

dopamine and neuropeptides.


11 Orexigenic and anorexigenic neuropeptides.



75

12 The role of the central angiotensinergic system in drinking and hydromineral balance.


13 Childhood obesity and cognitive processes.


14 Anorexia nervosa, bulimia and binge eating. Clinical relevance of animal experiments


Practices

Seminars



Participants


76

OPE-HOS-T HORMONAL REGULATORY MECHANISMS IN HEALTH AND DISEASE

Course director: DR. MARIETTA VÉRTES M, professor emeritus




Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPO-MB2 completed


Topic

The aim of the program is to clarify the role of hormones and hormonal networks in the maintenance of homeostasis and regulation of

body processes including reproduction. The lectures attempts to provide an overview of function of hormonal networks and the integrity

of nervous and endocrine regulation in human body.



Mid-term exams

Written exam, multiple choice questions from lectures


Oral discussion of given chapter

Reading material



- Notes


Greenstein B.: Endocrinology at a Glance, Springer 1999

Williams Textbook of Endocrinology, 2004

Goodman M: Basic Medical Endocrinology, 2000

Greenspan FS, Baxter JD: Basic and Clinical Endocrinology, 2003

Lectures

1 Types of hormones. Hormone synthesis, transport

Dr. Vértes M Marietta

2 Mechanism of hormone action, hormone receptors


3 Signal transduction. Regulation of tissue responsiveness to hormones


4 Endocrine and nervous system relationships


5 Hypothalamo-hypophyseal tract


6 Anterior pituitary. Feedback regulation


7 Principles of hormonal integration.


8 Hormonal regulation of fuel metabolism. General concepts


9 Growth hormone and IGF


10 Hormones of pancreas


11 Metabolism in diabetes mellitus


12 Regulatory peptides in the gut



77

13 Cortisol


14 Stress and thyroid hormones


15 Regulation of salt and water balance. General concepts


16 Hypothalamo-neurophyseal system


17 Renin-angiotenzin-aldosteron system


18 Natriuretic hormones


19 Hormones in pregnancy and during fetal development

Dr. Kovács Kálmán András

20 Hormones in pregnancy and during fetal development


21 Menstrual cycle. Contraception


21 Menstrual cycle. Contraception


23 Breast development. Hormones during lactation


24 Ontogeny of endocrine system


25 Hormones and bones


26 Endocrine system and aging


27 Discussion


28 Exams


Practices

Seminars



Participants


78

OPE-TSA-T STATISTICAL ANALYSIS OF THESIS AND STUDENT RESEARCH PROJECTS

Course director: DR. KORNÉLIA FARKAS-BORBÁS, assistant professor






Topic

This course is for those students who are working on a student research plan or working on their thesis. They can process their own data

and learn the theory of the applied statistical methods as well.


Problem solving, oral report

Mid-term exams


Consultation

Reading material



Own database

- Notes


Andrew F. Siegel: Statistics and Data Analysis. An introduction, John Wiley & Sons, 1988

Douglas G. Altman: Practical Statistics for Medical Research, Chapman & Hall, 1994

P. Armitage and G. Berry: Statistical Methods in Medical Research, Blackwell Science, 1994

Robert R. Sokal / F. James Rohlf: Biometry, W. H. Freeman and Company, New York, 1981

Lectures

1 Set the data and complete the database for statistical processing


2 Select the right statistical methods


3 Learn the theory of the selected methods




5 Interpret the results




7 Conclusions


Practices

1 Set the data and complete the database for statistical processing

2 Select the right statistical methods





7 Conclusions


79

Seminars



Participants

Borbásné Dr. Farkas Kornélia (FAKAAA.T.JPTE)


80

OPE-TSS-T MEDICAL APPLICATIONS OF MASS SPECTROMETRY

Course director: DR. LÁSZLÓ MÁRK, associate professor






Topic

In medical sciences, emphasis is increasingly placed on instrumental techniques and accurate, quantitative measurements. This course is

give an overall review about the modern mass spectrometry and it shows the medical applications of the MS in the clinical and diagnostic

practice.

Topics:

Introduction to MS. Ionsources, analizators, detectors. Separation techniques. Sample handling. Biomedical sampling. Bioinformatics.

Proteomics, metabolomics and lipidomics. Biomarker discovery. Mass spectrometric imaging techniques.


Written exam. Max. absences: 20%.

Mid-term exams


Not possible.

Reading material



Lecture slides and notes.

- Notes


Vékey et al: Medical Applications of Mass Spectrometry, 2008.

Hoffman et al: Mass Spectrometry, 2007

Lectures

1 Introduction

Dr. Márk László

2 Basics of mass spectrometry

Dr. Márk László

3 Basics of mass spectrometry

Dr. Márk László

4 Ionization techniques

Dr. Márk László

5 Analizators

Dr. Márk László

6 Detectors, The mass spectrum

Dr. Márk László

7 Biomedical sampling

Dr. Márk László

8 Separation techniques, sample preparation

Dr. Márk László

9 Separation techniques, sample preparation

Dr. Márk László

10 Proteomics

Dr. Márk László

11 Proteomics

Dr. Márk László


81

12 Metabolomics

Dr. Márk László

13 Metabolomics

Dr. Márk László

14 Mass spectrometry of endocrine system

Dr. Márk László

15 Mass spectrometry of endocrine system

Dr. Márk László

16 Biomarker discovery

Dr. Márk László

17 Biomarker discovery

Dr. Márk László

18 Lipidomics

Dr. Márk László

19 Lipidomics

Dr. Márk László

20 Proteomics of viruses and bacteria

Dr. Márk László

21 Proteomics of viruses and bacteria

Dr. Márk László

22 Molecular imaging by MS

Dr. Márk László

23 Exam

Dr. Márk László

24 Exam

Dr. Márk László

Practices

Seminars


Ionsources.

Analizators.

Detectors.

Separation techniques.

Sample handling. Biomedical sampling.

Bioinformatics.

Proteomics.

Metabolomics

Lipidomics.

Biomarker discovery.

Mass spectrometric imaging techniques.

MS of endocrine system.


Participants


82

OPE-WMI-T WEAK MOLECULAR INTERACTIONS

Course director: DR. SÁNDOR KUNSÁGI MÁTÉ, associate professor




Course headcount limitations (min.-max.): 2 – 12 Prerequisites: általános és szervetlen k completed

Topic

Types of molecular interactions. Chemical equilibrium based on the weak molecular interactions. Determination of the chemical

equilibrium and the stoichiometry of the complexes. Correlation between the chemical equilibrium and the free enthalpy. Investigation

of the weak interaction by spectroscopical methods. Application of the Job’s method in the fluorescence measurements. Direct measuring

the interaction enthalpy by differential scanning calorimetry. Interactions of aromatic compounds. Interactions of antibiotics with

membrane elements. Interactions of bioactive molecules with DNA. Investigations of model-systems: interactions of calixarenes with

phenols and fullerenes. Packing of drug molecules by molecular containers. Interactions of bioactive molecules with elements of cell

membranes. Self-assembly of some hormones by weak interactions.



Mid-term exams

One written exam during the semester, the acceptance level is 60%.


There is no possibility to make up for a missed lecture and practice

Reading material


David Freifelder: Physical Biochemistry


Shyllabus and ppt presentation is available.

- Notes


Atkins: Physical Chemistry I-III.

David Freifelder: Physical Biochemistry

Lectures

1 Types of molecular interactions.

Dr. Kunsági Máté Sándor

2 Types of molecular interactions.


3 Chemical equilibrium based on the weak molecular interactions.


4 Chemical equilibrium based on the weak molecular interactions.


5 Determination of the chemical equilibrium and the stoichiometry of the complexes.


6 Determination of the chemical equilibrium and the stoichiometry of the complexes.


7 Correlation between the chemical equilibrium and the free enthalpy.


8 Correlation between the chemical equilibrium and the free enthalpy.


9 Investigation of the weak interaction by measuring the fluorescence.


10 Investigation of the weak interaction by measuring the fluorescence.



83

11 Application of the Job’s method in the fluorescence measurements.


12 Application of the Job’s method in the fluorescence measurements.


13 Direct measuring the interaction enthalpy by differential scanning calorimetry.


14 Direct measuring the interaction enthalpy by differential scanning calorimetry.


15 Interactions of aromatic compounds. Interactions of bioactive compounds with DNA.


16 Interactions of aromatic compounds. Interactions of bioactive compounds with DNA.


17 Investigations of model-systems: interactions of calixarenes with phenols and fullerenes.


18 Investigations of model-systems: interactions of calixarenes with phenols and fullerenes.


19 Investigations of the conformation changes of proteins by fluorescence and calorimetric methods.






22 Controlling of self-assembly of some hormones by weak interactions.






25 Modifications of structure of serum albumins by molecular capsules. Interactions of molecular capsules with aromatic amino

acids at terminated positions.


26 Effect of Molecular Environment on the Formation Kinetics of Complexes of Malvidin-3-O-glucoside with Caffeic Acid and

Catechin


27 Competitive hydrogen bonds associated with the effect of primycin antibiotic on oleic acid as a building block of plasma

membranes.Complex formation between primycin and ergosterol: entropy - driven initiation of modification of the fungal plasma

membrane structure


28 Role of the Conformational Freedom of the Skeleton in the Complex Formation Ability of Resorcinarene Derivatives toward a

Neutral Phenol Guest


Practices

Seminars


Types of molecular interactions.

Chemical equilibrium based on the weak molecular interactions.

Determination of the chemical equilibrium and the stoichiometry of the complexes.

Correlation between the chemical equilibrium and the Gibbs free energy.

Investigation of the weak interaction by spectroscopical methods.

Application of the Job’s method in the fluorescence measurements.

Direct measuring the interaction enthalpy by differential scanning calorimetry.

Interactions of aromatic compounds.

Interactions of bioactive compounds with DNA.

Investigations of model-systems: interactions of calixarenes with phenols and fullerenes.

Packing of drug molecules by molecular containers.

Interactions of bioactive molecules with elements of cell membranes.

Self-assembly of some hormones by weak interactions.


84


Participants

Dr. Kunsági Máté Sándor (KUSFAAP.PTE)


85

OPF-DRD-T DRUG DESIGN

Course director: DR. CSABA HETÉNYI, associate professor





Topic

The course offers an overview of the whole process of drug design between selection of the disease and marketing of the drug. The

introductory lectures are followed by detailed reviews of certain phases of drug design including prediction of both drug action and

pharmacokinetic properties. In this regard, theoretical and experimental methods of drug design will be also introduced. Case studies will

demonstrate successful examples and also difficulties arising during the design process. Students with a researcher attitude are primary

targets of this course. Besides them, the course provides useful knowledge for future medical doctors and pharmacists as it explains the

complex process of drug discovery in a comprehensible way. This hopefully helps the students navigating in the jungle of laws of

pharmacology also used in molecular design. Furthermore, the course deals with the problems of prediction of toxicity and side-effects,

and discusses certain questions of production and legalization process of new drugs, as well. In Journal Club sessions, recent research

articles will be featured with the students to deepen their knowledge in the areas discussed during the previous lectures. In this way, the

students can discover further connections themselves and make sure of the usefulness of their newly obtained knowledge in drug design.


Jelenleg a választható és elektív kurzusok esetén a szabályzat nem tartalmaz részvételi követelményt. Amennyiben szükséges itt valamit

megjelölnöm, akkor 25 %, de csak azért teszem, hogy kitölthető legyen az űrlap. Javasoltam a Tanulmányi Bizottság vezetőjének a

helyzet szabályzását és 50 % mértéket a hiányzásoknál.

Mid-term exams

There is a final test announced at the end of the semester. The test will include multiple choice questions and short essays. A mark is

offered according to the results of the written test and optionally by evaluation of the student’s presentation prepared for the Journal

Club. The student can improve the mark according to university regulations.


Replacement is possible according to personal consultation.

Reading material



The material of the course including pdfs of lectures and lists of questions will be made downloadable from the web site of the

Department of Pharmacology and Pharmacotherapy or a link will be provided during the lectures / in an e-mail.

- Notes


Patrick GL: An Introduction to Medicinal Chemistry, Oxford University Press

Lectures

1 Selection of the disease. Goals, terminology, trends.

Dr. Hetényi Csaba

2 Conditions. Strategies. Ligand-based design.

Dr. Hetényi Csaba

3 Traditional design.

Dr. Hetényi Csaba

4 Target-based drug design.

Dr. Hetényi Csaba

5 Target selection and validation.

Dr. Hetényi Csaba

6 Protein targets 1. General overview, structural proteins.

Dr. Hetényi Csaba

7 Protein targets 2. Enzymes and receptors.

Dr. Hetényi Csaba

8 Experimental structure determination methods.

Dr. Hetényi Csaba


86

9 Theoretical structure determination methods.

Dr. Hetényi Csaba

10 Lipids and nucleic acids as targets.

Dr. Hetényi Csaba

11 Journal club 1. Comparison of strategies

Dr. Hetényi Csaba

12 Journal club 2. Evaluation of targets

Dr. Hetényi Csaba

13 Journal club 3. X-ray crystallography and NMR

Dr. Hetényi Csaba

14 Journal club 4. Cryo-electronmicroscopy

Dr. Hetényi Csaba

15 Experimental methods of lead selection and design.

Dr. Hetényi Csaba

16 Molecular complexes of leads. Thermodynamic and kinetic stability.

Dr. Hetényi Csaba

17 Theoretical methods of lead selection and design.

Dr. Hetényi Csaba

18 Lead optimizations, transformations.

Dr. Hetényi Csaba

19 ADMETox optimization 1. Goals, general description.

Dr. Hetényi Csaba

20 ADMETox optimization 2. Methods.

Dr. Hetényi Csaba

21 Termination of design. Production and development.

Dr. Hetényi Csaba

22 Side-effects and postmarketing surveillance.

Dr. Hetényi Csaba

23 Case study 1. The design of antiviral drugs.

Dr. Hetényi Csaba

24 Case study 2. The design of anti-cancer drugs.

Dr. Hetényi Csaba

25 Journal club 5. Development of new methods

Dr. Hetényi Csaba

26 Journal club 6. Paradigm shifts of drug design

Dr. Hetényi Csaba

27 Journal club 7. Molecular dynamics

Dr. Hetényi Csaba

28 Journal club 8. Docking

Dr. Hetényi Csaba

Practices

Seminars


Lists of questions will be provided at the end of each lecture specifying the required knowledge.


Participants


87

OPF-EBK-T FOOD SAFETY AND CRISIS SITUATIONS







Topic

Although food legislation and legal background is strict in EU some food safety crises and emergencies occur we can hear just a few

word in the media about. This course „pulls the veil” of the background, causes and concealed information of food safety crises.

Topics are about the most interesting and important information of these situations.



Mid-term exams

Examination: written test


based on individual consideration

Reading material




- Notes


Lectures

1 Introduction, European and Hungarian food safety regulation I

Dr. Raposa László Bence

2 Introduction, European and Hungarian food safety regulation II


3 Cases and concealed facts I. (Historical overview)


4 Cases and concealed facts II. (Historical overview)


5 Crisis management and communication I


6 Crisis management and communication II


7 Cases and concealed facts III


8 Cases and concealed facts IV


9 Food industry „tricks”: Changes which the layman does not realize I


10 Food industry „tricks”: Changes which the layman does not realize II


11 Actual food safety crisis I


12 Actual food safety crisis II


13 Summary


14 Exam



88

Practices

Seminars


Neptun


Participants


89

OPF-GMS-T GENETICALLY MODIFIED ORGANISMS AND OUR HEALTH

Course director: DR. ZOLTÁN GYÖNGYI, senior research fellow






Topic

The application of genetically modified organisms (GMOs) gains more and more ground in food industry. Over the direct health effect,

they have an impact on human economy and health modifying natural environment. The topic provokes social debate, in which, in lack

of information, delusions also appear.

The goal of the education is that students receive impartial knowledge of the role of GMOs in our life and their beneficial or possible

harmful impact on our health.

During the education students receive a knowledge of molecular background of production of GMOs, their role in agriculture, the

appeared cases and possible health risks, their occurrence in foodstuffs, medical applications, tests, regulations, authorization, economical

and social impacts.



Mid-term exams

There is a final test only on the last lecture/practice. In case of absence there can be a personal consultation.


Consultation with good cause.

Reading material



Lecture slides on Coospace

- Notes


Morgan, Sally: Superfoods: Genetic Modification of Foods (Science at the Edge), Heinemann, 2003 ISBN 1-4034-4123-5.

Lectures

1 The appearance of genetically modified organisms (GMOs)

Dr. Gyöngyi Zoltán

2 Role of GMOs in agriculture


3 Basics of genetically modification I


4 Basics of genetically modification II


5 Possible harmful effect of GMOs to health


6 Background of deaths caused by GM food


7 Prevention of GMO induced health hazard


8 Genetically modification in medicine


9 GMOs in food I.


10 GMOs in food II.



90

11 Authorization of GMOs


12 Regulation of application


13 Impact of GMOs on nature environment and eco farms


14 Effect of GM business on economy, social debates and the flow of information


Practices

Seminars


1. Reasons, why GMOs are created

2. The role of GMOs in the agriculture

3. Impact of GMOs on natural environment and organic farms

4. Molecular basics of genetically modifications

5. Application of genetic modification in the medicine

6. The cause of deaths because of GM food

7. Possible harmful effect of GMOs to health

8. Prevention of harmful effect of GMOs

9. Occurrence of GMOs in foodstuffs, food tests

10. Authorization of GMOs, social debate, flow of information

11. Health impacts of glyphosate

12. Health impacts of Bt toxin


Participants


91

OPF-H3A-T MEDICAL HUNGARIAN 3A - BASICS OF MEDICAL COMMUNICATION FOR STUDENTS OF

PHARMACY





Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPE-H2A completed + OPF-H3B parallel

Topic

This course in devoted to the acquisition of language and communicative functions of the basic history taking process and the description

of medications.




Mid-term exams

-


Reading material



Mária Győrffy: English for Doctors, Idióma Bt. Pécs, 2001 - can be purchased in the Department

- Notes


Lectures

Practices

1 Family History, social history and previous diseases

2 Family History, social history and previous diseases

3 Complaint and Pain

4 Complaint and Pain

5 Headache, dizziness

6 Perspiration, nausea, vomiting

7 Vision, shortness of breath, cough-Listening comprehension and speaking skills-Listening comprehension and speaking skills

8 Stool, urine

9 Stool, urine

10 Heart complaints, appetite

11 Shivering, fever, oedema

12 Frequent diseases

13 Oesophagus, stomach, gallbladder

14 Bowel diseases, cardiovascular diseases

15 Forms of medications

16 Test 1

17 Types of medications

18 Types of medications

19 Instructions concerning the application of medications: oral medications

20 Instructions concerning the application of medications: oral medications

21 Instructions concerning the application of medications: drops

22 Instructions concerning the application of medications: creams and ointments

23 Instructions concerning the application of medications: creams and ointments

24 Prescriptions

25 Consolidation

26 Consolidation

27 Test 2

28 Consolidation


92

Seminars


-


Participants


Dr. Lepenye Katalin (EKLAXA.B.JPTE), Hild Gabriella (MAGAAD.B.JPTE), Lokodiné Szolcsányi Judit (LOSIAAB.PTE),

Mészégetőné Halmos Éva (MEHHABE.PTE), Móriczné Győrffy Mária (MOGPAAP.PTE), Ronczykné Berta Anikó

(BEAAAI.B.JPTE), Szántóné Dr. Csongor Alexandra (CSAAAA.B.JPTE), Váradi Katalin (VAKHAAE.PTE)


93

OPF-H3B-T MEDICAL HUNGARIAN 3B - MEDICAL COMMUNICATION IN PRACTICE FOR STUDENTS OF

PHARMACY





Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPE-H3A parallel + OPE-H2B completed

Topic

This course serves the skills development based on language and communicative functions acquired in course 3A.




Mid-term exams

-


Reading material



Mária Győrffy: English for Doctors, Idióma Bt. Pécs, 2001 - can be purchased in the Department

- Notes


Lectures

Practices

1 Family History, social history and previous diseases - Listening comprehension and speaking skills

2 Family History, social history and previous diseases - Listening comprehension and speaking skills

3 Complaint and Pain - Listening comprehension and speaking skills

4 Complaint and Pain - Listening comprehension and speaking skills

5 Headache, dizziness - Listening comprehension and speaking skills

6 Perspiration, nausea, vomiting - Listening comprehension and speaking skills

7 Vision, shortness of breath, cough - Listening comprehension and speaking skills

8 Stool, urine - Listening comprehension and speaking skills

9 Stool, urine - Listening comprehension and speaking skills

10 Heart complaints, appetite - Listening comprehension and speaking skills

11 Shivering, fever, oedema - Listening comprehension and speaking skills

12 Frequent diseases - Listening comprehension and speaking skills

13 Oesophagus, stomach, gallbladder - Listening comprehension and speaking skills

14 Bowel diseases, cardiovascular diseases - Listening comprehension and speaking skills

15 Forms of medications - Listening comprehension and speaking skills

16 Test 1

17 Types of medications - Listening comprehension and speaking skills

18 Types of medications - Listening comprehension and speaking skills

19 Instructions concerning the application of medications: oral medications - Listening comprehension and speaking skills

20 Instructions concerning the application of medications: oral medications - Listening comprehension and speaking skills

21 Instructions concerning the application of medications: drops - Listening comprehension and speaking skills

22 Instructions concerning the application of medications: creams and ointments - Listening comprehension and speaking skills

23 Instructions concerning the application of medications: creams and ointments - Listening comprehension and speaking skills

24 Prescriptions - Listening comprehension and speaking skills

25 Consolidation

26 Consolidation

27 Test 2

28 Consolidation


94

Seminars


-


Participants




Halmos Éva (MEHHABE.PTE), Móriczné Győrffy Mária (MOGPAAP.PTE), Nagy Gabriella (NAGMAAO.PTE), Ronczykné Berta

Anikó (BEAAAI.B.JPTE), Szántóné Dr. Csongor Alexandra (CSAAAA.B.JPTE), Váradi Katalin (VAKHAAE.PTE)


95

OPF-IPM-T INNOVATION AND PROJECT MANAGEMENT FROM A BUSINESS PERSPECTIVE (KÜLÖN

KURZUS!!!)

Course director: DR. RITA BOGNÁR, administrative officer






Topic

The main objective of the innovation and project management course is to develop the business orientation skills of the students, while

deepening their knowledge in project management theory, methods and practice. Participants will have the capability how to develop

innovative projects for business.



Mid-term exams

Written test will be on the week 13.


After consultation.

Reading material


Not relevant.


Lectures in pdf form will be available on Neptun Meet Street.

- Notes

Not relevant.


1. Joseph W. Weiss, Robert K. Wysocki (1992): 5-Phase Project Management: A Practical Planning & Implementation Guide,

Addison-Wesley

2. John Hauser, Gerard J. Tellis and Abbie Griffin: A Review and Agenda for „Marketing Science”, Marketing Science, Vol. 25, No.

6, 25th Anniversary Issue (Nov. - Dec., 2006), pp. 687-717

3. Barbara J. Gabrys, Jane A. Langdale (2012): How to succeed as a scientist, From Postdoc to Professor, Cambridge University

Press, New York, pp.45-57.

Lectures

1 Basic of project management (definition, objectives)

Dr. Bognár Rita

2 Global business overview

Dr. Bognár Rita

3 Project life cycle

Dr. Bognár Rita

4 Different type of business organisations

Dr. Bognár Rita

5 Project initialisation (structure, work packages)

Dr. Bognár Rita

6 Leadership of a project

Dr. Bognár Rita

7 Human resource management (team building, teamwork)

Dr. Bognár Rita

8 Project planning 1. (time, resources)

Dr. Bognár Rita


96

9 Project planning 2. (cost, risk, communication)

Dr. Bognár Rita

10 Project network

Dr. Bognár Rita

11 Project communication tools

Dr. Bognár Rita

12 Project protocol

Dr. Bognár Rita

13 Financial management 1.

Dr. Bognár Rita

14 Financial management 2.

Dr. Bognár Rita

15 Procurement management

Dr. Bognár Rita

16 Contracts

Dr. Bognár Rita

17 Risk management

Dr. Bognár Rita

18 Conflict management

Dr. Bognár Rita

19 Innovation management 1.(Intellectual properties)

Dr. Bognár Rita

20 Innovation management 2. (Patent)

Dr. Bognár Rita

21 Project controlling

Dr. Bognár Rita

22 Project monitoring

Dr. Bognár Rita

23 Project reporting 1.

Dr. Bognár Rita

24 Project reporting 2.

Dr. Bognár Rita

25 Written test

Dr. Bognár Rita

26 Written test

Dr. Bognár Rita

27 Project closing

Dr. Bognár Rita

28 Project maintenance

Dr. Bognár Rita

Practices

Seminars


Neptun Meet Street


Participants

Dr. Bognár Rita (BOREAA.K.JPTE)


97

OPF-MGE-T MOLECULAR GERONTOLOGY

Course director: DR. KRISZTIÁN KVELL, associate professor

Department of Pharmaceutical Biotechnology



Course headcount limitations (min.-max.): 5 – 200 Prerequisites: OPE-MS1 completed


Topic

The curriculum covers physiological aspects of ageing and the molecular background of the ageing process, at cell, intracellular signaling

and nucleic acid level. It highlights the potential molecular intervention possibilities to slow down the ageing process and decrease

development of age related diseases.



Mid-term exams

Writing test


None

Reading material



- Notes

www.medbiotech.com


Lectures

1 Basic Knowledge in Gerontology

Dr. Kvell Krisztián

2 Aging Theories


3 Mitochondrial Aging


4 Aging and Gene Expression


5 Genetic Background of Longevity


6 Alterations of the Genome due to Aging, Senescence and Cancer


7 Cellular Effects of Acute and Chronic Stress


8 Metabolism and Longevity I


9 Metabolism and Longevity II


10 Senescence-related Intracellular Pathologies


11 Senescence-related Intracellular Pathologies


12 Molecular Mechanisms of Interventions


13 Invited Lecturer I


14 Invited Lecturer II


http://www.medbiotech.com/


98

Practices

Seminars


MeetStreet

www.medbiotech.com


Participants



99

OPF-SSG-T HISTOLOGY SEMINAR FOR PHARMACY STUDENTS

Course director: DR. GABRIELLA HORVÁTH-OPPER, assistant professor

Department of Anatomy



Course headcount limitations (min.-max.): 5 – 25 Prerequisites: OPO-AF-2 parallel

Topic

The aim of the subject is to complete the knowledge about structure of organ systems. Besides gross anatomy and basic histological

knowledge presented in mandatory anatomy courses, the ‘Histology seminars for pharmacy students’ offers better understanding of

histological background of physiological and oathophysiological processes and conditions.


The semestar can not be accepted over 2 absences.

Mid-term exams

Multimedia test on last seminar.


Not possible.

Reading material



http://an-server.pote.hu

- Notes


Lectures

Practices

Seminars

1 Basic histotechnics

2 Skin of palm, skin of the armpit

3 Blood smear

4 Blood smear

5 Gastrointestinal tract I

6 Gastrointestinal tract II

7 Gastrointestinal tract III

8 Gastrointestinal tract IV

9 Gastrointestinal tract V

10 Gastrointestinal tract VI

11 Gastrointestinal tract VII

12 Respiratory system

13 Kidney

14 Female genital organs I

15 Female genital organs II

16 Female genital organs III

17 Male genitalia I

18 Male genitalia II

19 Endocrine glands I

20 Endocrine glands II

21 Endocrine glands III

22 Endocrine glands IV

23 Histology of the peripheral nervous system I

24 Histology of the peripheral nervous system II

http://an-server.pote.hu/


100

25 Eyebulb I

26 Eyebulb II

27 Test

28 Test


http://an-server.pote.hu


Participants

Füredi Nóra Judit (FUNQAAT.PTE)

http://an-server.pote.hu/


101

OPF-TG1-T STUDENT PROJECT RESEARCH FOR STUDENTS OF PHARMACEUTIST PROGRAMME 1

Course director: DR. GYÖRGYI HORVÁTH, associate professor





Topic

The course aims at promoting of students to make student research projects on the field of pharmaceutical sciences. Furthermore, we

wish to give individual possibilities of students to perform experiments in the different pharmaceutical institutes involved into Students’

Research Society.


The continuous student’s work is recommended. The continuous enrollment of consecutive courses can be stopped and continued in

further semesters.

The prerequisite of this course (TDK 1): registration of the student in the database of Students’ Research Society.

Mid-term exams

TG1

Topic plan of student’s research project with the confirmation of supervisor

- Introduction of scientific articles found by the student in databases

- The topic plan and articles must be sent for course supervisor at the end of 13th week of the semester.


There is no possibility.

Reading material



- Notes


ScienceDirect database

Lectures

Practices

1-24 Research.

Seminars


Not applicable.


Participants

Dr. Horváth Györgyi (HOGAAA.T.JPTE)


102

OPF-TMB-T MOLECULAR BIOLOGY OF TUMORS

Course director: DR. EDINA PANDUR, assistant professor




Course headcount limitations (min.-max.): 3 – 30 Prerequisites: OPO-GB1 completed + OPO-GB2 completed

Topic

During the course we will discuss the molecular mechanisms of tumor development. We will deal with characteristic features of tumor

cells, and cancers. The function of influencing factors, risk factors, causes, the underlying molecular mechanisms, e.g. mutations, the

role of oncogenes and tumor-suppressor genes, DNA repair, epigenetics and the role of immune system will be discussed in detail. We

will emphasize the function of cell signaling pathways and the failure of apoptosis in tumorigenesis. We will speak about the molecular

mechanisms of invasion and metastasis of tumors, the genes and proteins which have a crucial role in these processes. The participants

will get an insight into the molecular diagnosis, genetic aberrations, and molecular alterations of human cancers. We will discuss the

possibilities for cancer therapies, the new approaches such as gene therapy and immunotherapy.


Max. 3 absences

Mid-term exams

One assay, one midterm exam.


Personal consultation

Reading material



Educational materials will be uploaded to Neptune MeetStreet.

- Notes


Lauren Pecorino: Molecular Biology of Cancer

Wolfgang Arthur Schulz: Molecular Biology of Human Cancers

Lectures

1 Introduction to cancers: classification and characterization of cancers, causes of cancer, properties of cancer cells, principles of

therapies, targets of therapies

Dr. Pandur Edina

2 Introduction to cancers: classification and characterization of cancers, causes of cancer, properties of cancer cells, principles of

therapies, targets of therapies

Dr. Pandur Edina

3 Tumor genetics: mutations, carcinogenic agents, inheritance, tumor genes, defects in DNA repair and predispositions to cancer,

cell protection mechanisms

Dr. Pandur Edina

4 Tumor genetics: mutations, carcinogenic agents, inheritance, tumor genes, defects in DNA repair and predispositions to cancer,

cell protection mechanisms

Dr. Pandur Edina

5 Tumor epigenetics: mechanisms of epigenetic inheritance, imprinting, DNA methylation, epigenetics of cell differentiation and

tissue homeostasis

Poór Viktor Soma

6 Tumor epigenetics: mechanisms of epigenetic inheritance, imprinting, DNA methylation, epigenetics of cell differentiation and

tissue homeostasis

Poór Viktor Soma

7 Oncogenes and tumor-suppressor genes

Dr. Pandur Edina

8 Oncogenes and tumor-suppressor genes

Dr. Pandur Edina


103

9 The cell cycle, apoptosis and senescence: checkpoints, therapeutic targets and inhibitors, molecular mechanisms of apoptosis,

replicative senescence and its disturbances in human cancers

Pap Ramóna

10 The cell cycle, apoptosis and senescence: checkpoints, therapeutic targets and inhibitors, molecular mechanisms of apoptosis,

replicative senescence and its disturbances in human cancers

Pap Ramóna

11 Signaling pathways in tumors: MAPK, PI3K, TP53 network, NFkappaB, TGFbeta, STAT signaling

Dr. Pandur Edina

12 Signaling pathways in tumors: MAPK, PI3K, TP53 network, NFkappaB, TGFbeta, STAT signaling

Dr. Pandur Edina

13 Invasion and metastasis: genes and proteins involved in cell-to-cell, cell-matrix adhesion, in extracellular matrix remodeling

during tumor invasion; angiogenesis.

Dr. Pandur Edina

14 Invasion and metastasis: genes and proteins involved in cell-to-cell, cell-matrix adhesion, in extracellular matrix remodeling

during tumor invasion; angiogenesis.

Dr. Pandur Edina

15 The role of immune system in tumors: inflammation, infections, cancer vaccines, inhibition of the immune system

Pap Ramóna

16 The role of immune system in tumors: inflammation, infections, cancer vaccines, inhibition of the immune system

Pap Ramóna

17 Stem cells and cancer: Wnt signaling, Hh signaling, differentiation therapy

Dr. Pandur Edina

18 Stem cells and cancer: Wnt signaling, Hh signaling, differentiation therapy

Dr. Pandur Edina

19 Cancer prevention: nutrients, energy metabolism of tumors, hormones and gene interactions

Pap Ramóna

20 Cancer prevention: nutrients, energy metabolism of tumors, hormones and gene interactions

Pap Ramóna

21 Diagnosis of tumors: molecular diagnosis, molecular detection and classification

Jánosa Gergely

22 Diagnosis of tumors: molecular diagnosis, molecular detection and classification

Jánosa Gergely

23 Human cancers I: common properties, genetic aberrations, molecular alterations, histology and etiology of cancers

Dr. Tóth Dénes

24 Human cancers I: common properties, genetic aberrations, molecular alterations, histology and etiology of cancers

Dr. Tóth Dénes

25 Human cancers II: common properties, genetic aberrations, molecular alterations, histology and etiology of cancers

Dr. Tóth Dénes

26 Human cancers II: common properties, genetic aberrations, molecular alterations, histology and etiology of cancers

Dr. Tóth Dénes

27 Drugs in cancer therapy: molecular mechanisms of cancer chemotherapy, targeted drug therapy, immunotherapy, gene therapy

Dr. Poór Miklós

28 Drugs in cancer therapy: molecular mechanisms of cancer chemotherapy, targeted drug therapy, immunotherapy, gene therapy

Dr. Poór Miklós

Practices

Seminars


Simple choice test based on the lectures.


Participants


104

OPE-BKM-T BASIC METHODS OF SCIENTIFIC RESEARCH

Course director: DR. ÁGNES FARKAS, associate professor




Course headcount limitations (min.-max.): 3 – 15 Prerequisites: OPA-B2E completed + OPA-B2G completed

Topic

The course aims at introducing students to the basic steps of scientific research, guiding them through stages of becoming an independent

researcher. The course covers each step of the research process, from preparing a research plant to evaluating and reporting data. Students

will become familiar with various methods of literature search, data collection, data analysis, as well as the ethical questions of scientific

research. Students will be introduced to various types of scientific works, including rules and requirements of scientific communication.

A session will be dedicated to the special requirements of writing a thesis. Emphasis will be laid on practice: in the seminars students

should put into practice what they have learned in the lectures, based on their own research work.



Mid-term exams

The midsemester grade will be based on the successful completion of the above tasks.


A pótlásra az órákon kiadott segédanyagok biztosítanak lehetőséget.

Reading material



Az órák anyaga elérhető a Farmakognóziai Intézet honlapján.

- Notes


Turabian K. L. (2010): A Manual for Writers of Research Papers, Theses, and Dissertations. Chicago Style for Students &

Researchers. 8th edition. The University of Chicago Press. Chicago and London, pp. 448.

Lectures

1 Concept, process and strategies of scientific research. Organising research projects. Research plan.

Dr. Farkas Ágnes

2 Methods of data collection. Questionnaires.

Dr. Farkas Ágnes

3 Literature search.

Dr. Farkas Ágnes

4 Designing experiments.

Dr. Farkas Ágnes

5 Data processing, data analysis.

Dr. Farkas Ágnes

6 Evaluation of data.

Dr. Farkas Ágnes

7 The role of informatics in scientific research.

Dr. Farkas Ágnes

8 The role of informatics in scientific research.

Dr. Farkas Ágnes

9 Ethical questions of scientific research.

Dr. Farkas Ágnes

10 Animal studies. Clinical studies.

Dr. Farkas Ágnes

11 Scientific communication. Types of scientific works. Metrics of scientific achievement.

Dr. Farkas Ágnes


105

12 Rules and requirements in scientific communication.

Dr. Farkas Ágnes

13 Writing applications for scholarships and research grants.

Dr. Farkas Ágnes

14 Scientific co-operations. Scene and institutions of science in Hungary.

Dr. Farkas Ágnes

Practices

Seminars

1 Preparing a research plan based on the student’s own research objectives.

2 Preparing a questionnaire.

3 Literature search in the field of the student’s own research I.

4 Literature search in the field of the student’s own research II.

5 Evaluation of data from the student’s research project I.

6 Evaluation of data from the student’s research project II.

7 Practice of scientific communication I.

8 Practice of scientific communication II.

9 Practice of scientific communication III.

10 Practice of scientific communication IV.

11 Practice of scientific communication V.

12 Practice of scientific communication VI.

13 Practice of writing an application for a scholarship I.

14 Practice of writing an application for a research project II.


1. Research plan.

2. Methods of data collection.

3. Questionnaires.

4. Methods of literature search.

5. Methods of data analysis.

6. Critical evaluation of data.

7. Ethical questions of scientific research.

8. Animal studies. Clinical studies.

9. Scientific writing: types, rules and requirements.

10. References, bibliography.

11. Scene and institutions of science in Hungary.


Participants

Dr. Farkas Ágnes (FAADAB.T.JPTE)


106

OPE-EMM-T MOLECULAR BASIS OF ENDOCRINE DISEASES

Course director: DR. MARIETTA VÉRTES M, professor emeritus






Topic

Endocrinology is the study of hormones, their receptors and the intracellular signalling pathways they invoke. The aim of the program is

to understand the effects of hormones on cellular growth and function and their implications in development of endocrine dysfunction.

Explain the molecular and cellular abnormalities in common endocrine-based diseases.



Mid-term exams

Written exam, multiple choice questions from lectures


Oral discussion of given chapter

Reading material



- Notes


Greenstein B.: Endocrinology at a Glance, Springer 1999

Williams Textbook of Endocrinology, 2004

Goodman M: Basic Medical Endocrinology, 2000

Greenspan FS, Baxter JD: Basic and Clinical Endocrinology, 2003

Lectures

1 Disorders of endocrine system. Hypo- and hyperfunction


2 Disorders of endocrine system. Hypo- and hyperfunction


3 Defect in sensitivity to hormones. Approach to the patient with endocrine disease


4 Defect in sensitivity to hormones. Approach to the patient with endocrine disease


5 Laboratory and imaging studies. Endocrinologic evaluation of the hypothalamo-pituitary axis


6 Laboratory and imaging studies. Endocrinologic evaluation of the hypothalamo-pituitary axis


7 Pituitary disorders: adenomas, Hypopitutarism, hypothalamic dysfunction.


8 Pituitary disorders: adenomas, Hypopitutarism, hypothalamic dysfunction.


9 Hormonal disorders of growth.


10 Hormonal disorders of growth.


11 Disorders of the thyroid


12 Disorders of the thyroid



107

13 Goiter. Hypothyroidism.


14 Goiter. Hypothyroidism.


15 Hyperthyroidism. Autoimmune disorders


16 Hyperthyroidism. Autoimmune disorders


17 Hormonal dysfunction of carbohydrate, protein and fat metabolism


18 Hormonal dysfunction of carbohydrate, protein and fat metabolism


19 Disorders of pancreas


20 Disorders of pancreas


21 Glucocorticoids, Adrenal medulla


22 Glucocorticoids, Adrenal medulla


23 Neural and hormonal integration in control of fluid homeostasis


24 Neural and hormonal integration in control of fluid homeostasis


25 Antidiuretic hormones, Mineral corticoids, Atrial Natriuretic Hormones


26 Antidiuretic hormones, Mineral corticoids, Atrial Natriuretic Hormones


27 Exam


28 Exam


Practices

Seminars



Participants


108

OPE-GMO-T MODELLING THE STRUCTURE AND INTERACTIONS OF BIOACTIVE MOLECULES

Course director: DR. SÁNDOR KUNSÁGI MÁTÉ, associate professor





Topic

In this course the basic examination methods of theoretical chemistry will be discussed by the practical point of view in the frame of

following subtopics: Methods of molecular modelling. Description of the forcefield, semiempirical, ab initio and density functional

methods, advantages and disadvantages. Discovering the balance between the model ant the calculation methods. The algorithm of the

choice of appropriate model and calculation method. Short description of the basic rules and mathematical background of theoretical

chemistry. calculation of the electronic structure of atoms and molecules. Calculation the equilibrium conformations of molecules, the

role of the entropy in the interactions of bioactive molecules and its calculation. Description of the correlation between the reactivity and

the temperature. Examples at molecular level. Considering the molecular environment: explicit and implicit methods. Interesting

examples and applications in pharmacy.


Mid-term exams

Two tests, each above 60 % is required for acceptance


Upto 15% is allowed, electronical material is available

Reading material


P.W. Atkins: Physical Chemistry


- Notes

Slides and Summaries of lectures are available electronically


Jensen_F.-Introduction_to_Computational_Chemistry_(2007)

Scientific papers, list will be given during the lectures

Lectures

1 1 lecture Experimental results raise the necessity of quantum-chemical description of the structure of materials. Quantitization

and related quantities (energy, momentum, spin). Simple mathematical descriptions.


2 1 lecture Experimental results raise the necessity of quantum-chemical description of the structure of materials. Quantitization

and related quantities (energy, momentum, spin). Simple mathematical descriptions.


3 2 lecture Axiomatic description of the quantum theory. Atomic unit system. Overview on the exact and approximative solutions

of the time - independent Schrödinger equation.


4 2 lecture Axiomatic description of the quantum theory. Atomic unit system. Overview on the exact and approximative solutions

of the time - independent Schrödinger equation.


5 3 lecture Approximative solutions: the molecular mechanics methods.


6 3 lecture Approximative solutions: the molecular mechanics methods.


7 4 lecture Semi - empirical methods, advantages and disadvantages.


9 5 lecture Conformation analysis, energy minimization algorithms.


11 6 lecture Electronic structure of molecules. The chemical bonds, tipes of bonds. The structure of molecules, stereochemistry.



109

13 7 lecture Modelling in comparison with the experiments, calculation of the enthalpy, entropy and their appropriate experimental

values.


15 8 lecture Molecular symmetry, point groups and the symmetry of molecular vibrations.


17 9 lecture Interactions of the primycin, ergosterol and oleic acid as plasma membrane unit.


19 10 lecture Modelling the interactions of bioactive molecules with molecular containers in accordance with molecular packing of

drugs.


21 11 lecture Quantum - chemical background of the rules in atomic and molecular spectroscopy. Rules of Raman and Infrared

transitions and their relationship with the molecular symmetry.


23 12 lecture Effective calculation methods to consider the molecular environment: Onsager-model, Polarizable Continuum Model


25 13 lecture Examples: simple chemical reactions, calculation of the stability weak molecular complexes, conformation analysis.


27 14 lecture Examples: modelling the systems possessing high symmetry and infinite volume. Crystals and polymers.


Practices

4 4 practice : Geometry optimization and conformation analysis. Energy minimization algorythm mostly used in geometry

optimization practice.

5 5 practice: Calculation of the static potential energy surfaces of chemical reactions. Methods to determine the transition states

associated to the chemical reactions. Activation energy and activation free enthalpy.

6 6 practice Molecular dynamics methods, Monte-Carlo method and the Langevin model. The implicite consideration of the

molecular environment.

7 7 practice Modelling the elementary chemical reactions. Calculation of molecular dynamics. Determination of the rection rate

using direct trajectory method.

8 8 practice Methods for consideration of the solvents: the Onsager-model, and the Polarizable Continuum Model, PCM. Explicit

consideration of the solvent molecules. The TIP3P model.

9 9 practice Calculation of molecular parameters have significant importance in the practice. The QSAR and the molecular

similarity - analysis.

10 10 practice Examples: conformation analysis, bong length, bond angle and dihedral angles. The bipyridile and thionine molecules.

Calixarenes and stereoisomers. Importance of hydrogen bonds in the stability of molecular geometries.

11 11 practice Examples: interactions of molecules. Calculation of the host - guest interactions, calculations of interactions of

calixarenes with neutral molecules based on pi-pi interactions.

12 12 practice Examples : elementary dissociation reactions: dissociation of asymmetric olefines. Effect of melecular environment

on the reaction rate.

13 13 practice Examples: Interaction of Primycin and oleic acid. Calculation of the interaction energy in system possessing large

numbers of electrons.

14 14 practice E+xamples: dynamic processes: modelling the crystal growth.

Seminars


Methods of molecular modelling. Description of the forcefield, semiempirical, ab initio and density functional methods, avantages and

disadvantages. The balance between the model ant the calculation methods. The algorithm of the choice of appropriate model and

calculation method.Short description of the basic rules and mathematical background of theoretical chemistry. calculation of the

electronic structure of atoms and molecules. Calculation the equilibrium conformations of molecules, the role of the entropy in the

interactions of bioactive molecules and its calculation. Description of the correlation between the reactivity and the temperature.

Examples at moecular level. Considering the molecular environment: explicit and implicit methods. Interesting examples and

applications in pharmacy.


Participants

Dr. Kunsági Máté Sándor (KUSFAAP.PTE)


110

OPE-PPP-T PROTEINS AND PEPTIDES IN PHARMACOLOGY

Course director: DR. CSABA HETÉNYI, associate professor





Topic

The course describes the pharmacological role of proteins and peptides. The character and various functions of these biopolymers are

featured on the basis of structural considerations. Besides the usual discussion according to biochemical and physiological classifications,

an emphasis is placed on the introduction of the corresponding methodologies, as well. In Journal Club sessions, recent research articles

will be featured with the students to deepen their knowledge in the areas discussed during the previous lectures. In this way, the students

can discover further connections themselves and make sure of the usefulness of their newly obtained knowledge on proteins and peptides.


Jelenleg a választható és elektív kurzusok esetén a szabályzat nem tartalmaz részvételi követelményt. Amennyiben szükséges itt valamit

megjelölnöm, akkor 25 %, de csak azért teszem, hogy kitölthető legyen az űrlap. Javasoltam a Tanulmányi Bizottság vezetőjének a

helyzet szabályzását és 50 % mértéket a hiányzásoknál.

Mid-term exams

There is a final test announced at the end of the semester. The test will include multiple choice questions and short essays. A mark is

offered according to the results of the written test and optionally by evaluation of the student’s presentation prepared for the Journal

Club. The student can improve the mark according to university regulations.


Replacement is possible according to personal consultation.

Reading material



The material of the course including pdfs of lectures and lists of questions will be made downloadable from the web site of the

Department of Pharmacology and Pharmacotherapy or a link will be provided during the lectures / in an e-mail.

- Notes


Lectures

1 General properties, building blocks, classification

Dr. Hetényi Csaba

2 Synthesis, purification, analysis

Dr. Hetényi Csaba

3 Structural properties

Dr. Hetényi Csaba

4 Structure determination methods

Dr. Hetényi Csaba

5 Structure and function 1. Peptides

Dr. Hetényi Csaba

6 Structure and function 2. Proteins

Dr. Hetényi Csaba

7 Stability, folding, flexibility

Dr. Hetényi Csaba

8 Molecular interactions

Dr. Hetényi Csaba

9 Endogenous peptides

Dr. Hetényi Csaba

10 Exogenous peptides, peptidomimetics

Dr. Hetényi Csaba


111

11 Journal club 1. Experimental and computational structure determination

Dr. Hetényi Csaba

12 Journal club 2. Disordered proteins and pathological folds

Dr. Hetényi Csaba

13 Journal club 3. X-ray crystallography and NMR

Bálint Mónika Enikő

14 Journal club 4. Cryo-electronmicroscopy


15 General properties of enzymes


16 Inhibition


17 Experimental methods of enzymology


18 Computational methods of enzymology


19 Membrane proteins, transporters


20 Specialty drugs (biologics)


21 Anti-cancer targets 1: proteins of signaling pathways


22 Anti-cancer targets 2: structural and motor proteins


23 Antiviral targets 1: enzymes


24 Antiviral targets 2: structural proteins


25 Journal club 5. Enzyme targets


26 Journal club 6. Receptors, structural and motor protein targets


27 Journal club 7. Molecular dynamics


28 Journal club 8. Docking


Practices

Seminars


Lists of questions will be provided at the end of each lecture specifying the required knowledge.


Participants


112

OPE-SME-T SPECTROMETRIC IDENTIFICATION OF ORGANIC COMPOUNDS

Course director: DR. CECÍLIA PÁPAY- SÁR, associate professor




Course headcount limitations (min.-max.): 2 – 10 Prerequisites: OPA-SV1 completed

Topic

The aim of this course is to introduce the students how to identify organic compounds from the complementary information afforded by

three types of spectra: infrared, mass and NMR.



Mid-term exams

The student who has been absent from more than 25 % of the classes cannot be granted to entry of exam.


Students can personally consult with the lecturer.

Reading material


Silverstein, R.M., Webster, F.X., Kiemle, D.: Spectrometric Identification of Organic Compounds, John Wiley and Sons, 2005.


- Notes


Lectures

1 Infrared Spectroscopy: Introduction, theory, instrumentation, interpretation of spectra.

Dr. Pápayné Dr. Sár Cecília

2 Infrared Spectroscopy: Introduction, theory, instrumentation, interpretation of spectra


3 Infrared Spectroscopy: Characteristic group absorptions of organic molecules


4 Infrared Spectroscopy: Characteristic group absorptions of organic molecules


5 Infrared Spectroscopy: Solving problems


6 Infrared Spectroscopy: Solving problems


7 Proton Magnetic Resonance Spectrometry (1H NMR): Introduction, theory, instrumentation.


8 Proton Magnetic Resonance Spectrometry (1H NMR): Introduction, theory, instrumentation


9 1H NMR: Chemical shift, simple spin coupling


10 1H NMR: Chemical shift, simple spin coupling


11 1H NMR: Protons on heteroatoms, chemical shift equivalence and magnetic equivalence, effects of a chiral center.


12 1H NMR: Protons on heteroatoms, chemical shift equivalence and magnetic equivalence, effects of a chiral center.


13 13 C NMR Spectroscopy: Interpretation of 13 C spectra. The principles of MRI.


14 13 C NMR Spectroscopy: Interpretation of 13 C spectra. The principles of MRI



113

15 1H NMR and 13 C NMR: Solving problems


16 1H NMR and 13 C NMR: Solving problems


17 Mass Spectrometry: Mass spectrometer parts, ionization processes

Dr. Kálai Tamás

18 Mass Spectrometry: Mass spectrometer parts, ionization processes

Dr. Kálai Tamás

19 Mass Spectrometry: Appearance of the mass spectrum, mass spectra of classes of organic compounds.

Dr. Kálai Tamás

20 Mass Spectrometry: Appearance of the mass spectrum, mass spectra of classes of organic compounds

Dr. Kálai Tamás

21 Mass Spectrometry: Interpretation of the mass spectrum through examples.

Dr. Kálai Tamás

22 Mass Spectrometry: Interpretation of the mass spectrum through examples.

Dr. Kálai Tamás

23 Summary of spectroscopic methods: identification of organic molecules from IR, NMR and mass spectra.








27 Evaluation, written exam


28 Evaluation, written exam


Practices

Seminars


Infrared Spectroscopy: theory, instrumentation, interpretation of spectra, chacteristic group absorptions of organic molecules.

Proton Magnetic Resonance Spectrometry (1H NMR): theory, instrumentation, chemical shift, simple spin coupling, protons on

heteroatoms, chemical shift equivalence and magnetic equivalence, effects of a chiral center.

Mass Spectrometry: mass spectrometer parts, ionization processes, appearance of the mass spectrum, mass spectra of classes of organic

compounds.

Identification of simple organic molecules from IR, NMR and mass spectra.


Participants


114

OPE-TIZ-T CENTRAL REGULATION OF FEEDING AND METABOLISM. NEW APPROACHES

Course director: DR. ZOLTÁN KARÁDI, professor




Course headcount limitations (min.-max.): 2 – 25

Prerequisites: OPO-A2S completed + OPO-EN1 completed + OPA-G1B parallel


Topic

The high incidence and costs of eating and metabolic disorders make it indispensable to experimentally test new theoretical

considerations, and to employ their conclusive results in basically new clinical protocols. Students at early stage of their studies are, thus,

encouraged to familiarize with new theoretical aspects and experimental findings.

Neural and humoral mechanisms in the central feeding control and metabolic regulation. Body weight control in health and disease.

Peripheral and central taste information processing; gustation in the central regulation of food and fluid intake. Obesity, diabetes mellitus

and the metabolic syndrome: New interpretations.


According to general regulations

Mid-term exams


Individually discussed

Reading material


Guyton & Hall: Textbook of Medical Physiology, Saunders


- Notes


Williams and Pickup: Handbook of Diabetes, Blackwell

Doty: Handbook of Olfaction and Gustation, Marcel Dekker

Lectures

1 Physiological significance of food and fluid intake, and metabolism.

Dr. Karádi Zoltán

2 Homeostasis, motivation.

Dr. Karádi Zoltán

3 Neuronal and humoral factors in the central regulation of homeostatic functions: brain centers, neurotransmitter pathways,

neuropeptides. I

Dr. Karádi Zoltán


neuropeptides. II

Dr. Karádi Zoltán


neuropeptides. III

Dr. Karádi Zoltán

6 Exogenous chemosensory modalities. Physiologic roles of gustation.

Dr. Karádi Zoltán

7 Central taste pathways, „labeled lines”, neurons.

Dr. Karádi Zoltán

8 Taste preference, taste aversion, palatability, flavour.

Dr. Karádi Zoltán

9 The glucose-monitoring (GM) neural network. I

Dr. Karádi Zoltán

10 The glucose-monitoring (GM) neural network. II

Dr. Karádi Zoltán


115

11 The glucose-monitoring (GM) neural network. III

Dr. Karádi Zoltán

12 Eating and metabolic disorders: obesity, anorexia nervosa, diabetes mellitus, metabolic syndrome. I

Dr. Karádi Zoltán

13 Eating and metabolic disorders: obesity, anorexia nervosa, diabetes mellitus, metabolic syndrome. II

Dr. Karádi Zoltán

14 Feeding and metabolic disorders: disturbance of the GM system?

Dr. Karádi Zoltán

Practices

Seminars


According to topics of the lectures


Participants


116

OPF-CSU-T MIRACLES OF LIVING MATERIALS ("REALISTIC" BIOCHEMISTRY)

Course director: DR. BALÁZS VERES, associate professor






Topic

The aim of the course is to enlighten and uncover the biochemical background of those topics which are selected as recent „mainstream”

natural science issues. The topic spectrum is wide enough to cover problems from synthetic biology through dopes in sport until toxins

and poisons of plants, fungi and animals. There is a special session about the physical, chemical and medical Nobel prizes from the last

decade to get insight to the hottest fields of natural sciences.



Mid-term exams

-


There is no possibility to make up.

Reading material



Lecture slides (in pdf format) will be available for the students. WEB links and additional on line materials will be included as well.

- Notes




Lectures

1 Human genome project, gene therapy, epigenetics

Dr. Veres Balázs

2 DNA sequencing, PCR, CSI

Dr. Veres Balázs

3 Playing God: synthetic biology

Dr. Veres Balázs

4 You are what you eat: GMO

Dr. Veres Balázs

5 Superman: doping in sport and brain doping

Dr. Veres Balázs

6 Dependence: biochemistry of alcohol and drugs

Dr. Veres Balázs

7 Falling down: apoptosis, necrosis, autophagy

Dr. Veres Balázs

8 Cancer, AIDS: beyond therapy

Dr. Veres Balázs

9 Biochemistry of neurodegenerative disorders

Dr. Veres Balázs

10 Antibiotics: past, present, future

Dr. Veres Balázs

11 Home delivery: nanoparticles, liposomes

Dr. Veres Balázs


117

12 Nature strikes back: toxins of plants, fungi and animals

Dr. Veres Balázs

13 Ideas behind Nobel prizes I

Dr. Veres Balázs

14 Ideas behind Nobel prizes II

Dr. Veres Balázs

Practices

Seminars


Exam topics are the topics of the lectures during the course.


Participants


118

OPF-GMI-T GYÓGYSZERÉSZEK A MINDENNAPOKBAN - ANGOL VÁLTOZAT






Topic

This course intends to provide insight into various career opportunities for graduates with a degree in pharmacy. Invited speakers working

in various fields of the pharmaceutical professsion talk about characteristic features of their job, including daily routine, challenging

situations and peculiarities they have come accross. Speakers represent pharmacists working in community pharmacies, clinical

pharmacies, in the pharmaceutical industry, as well as at health authorities and at universities or research institutes.



Mid-term exams

Active participation is expected from students. They should be prepared to ask questions from each speaker and they are requested to

take notes on each occasion. These notes should be handed in to the course instructor at the end of each class.

The final grade is based on students’ activity in class and the written notes they have taken on each occassion.


There is no opportunity to make up for absences, since different speakers are invited to each class.

Reading material


None


- Notes


Lectures

1 Invited speaker. Pharmacist at a community pharmacy.

2 Invited speaker. Pharmacist at a community pharmacy.

3 Invited speaker. Pharmacist at a clinical pharmacy.

4 Invited speaker. Pharmacist at a clinical pharmacy.

5 Invited speaker. Pharmacist working in the pharmaceutical industry.

6 Invited speaker. Pharmacist working in the pharmaceutical industry.

7 Invited speaker. Pharmacist working at a university.

8 Invited speaker. Pharmacist working at a university.

9 Invited speaker. Pharmacist working in a research institute.

10 Invited speaker. Pharmacist working in a research institute.

11 Invited speaker. Pharmacist working at the health authorities.

12 Invited speaker. Pharmacist working at the health authorities.

13 Invited speaker. Daily routine of a specialty pharmacist.

14 Invited speaker. Daily routine of a specialty pharmacist.

Practices

Seminars


No exam questions.


Participants


119

OPF-H4A-T MEDICAL HUNGARIAN 4A - BASICS OF MEDICAL COMMUNICATION FOR STUDENTS OF

PHARMACY





Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPF-H3A completed + OPF-H4B parallel

Topic

This course provides language and communicative functions in the areas of medications, the application of medications and prescribing

medications and is also meant to give opportunities for putting skills and knowledge into practice in preparation for the final exam.




Mid-term exams

-


Reading material



Hand-outs

- Notes


Lectures

Practices

1 Types and forms of medications - Review

2 Application of medications - Review

3 Instructions concerning the use of medications: painkillers

4 Instructions concerning the use of medications: painkillers

5 Instructions concerning the use of medications: antipyretics

6 Instructions concerning the use of medications: cough medications

7 Instructions concerning the use of medications: antidiabetics

8 Instructions concerning the use of medications: spasmolytics

9 Instructions concerning the use of medications: sleeping pills

10 Instructions concerning the use of medications: steroids

11 Instructions concerning the use of medications: antibiotics

12 Instructions concerning the use of medications: antiinlammatory medications

13 Instructions concerning the use of medications: emetics and aniemetics

14 Instructions concerning the use of medications: eye, ear and nasal drops

15 Instructions concerning the use of medications: medications applied to the skin

16 Test 1

17 Instructions concerning the use of medications: suppository

18 First aid instruments

19 Preparation for the Final Exam in Medical Hungarian








27 Test 2



120

Seminars


-


Participants







121

OPF-H4B-T MEDICAL HUNGARIAN 4B - MEDICAL COMMUNICATION IN PRACTICE FOR STUDENTS OF

PHARMACY





Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPF-H3B completed + OPF-H4A parallel

Topic

This course provides language and communicative functions in the areas of medications, the application of medications and prescribing

medications and is also meant to give opportunities for putting skills and knowledge into practice in preparation for the final exam.



the case of absences up to 25% of total class time, oral examination will have to be taken.

Mid-term exams


Reading material



Hand-outs

- Notes


Lectures

Practices

1 Types and forms of medications - Review

2 Application of medications - Review

3 Instructions concerning the use of medications: painkillers - Pharmacist-patient dialogue

4 Instructions concerning the use of medications: painkillers - Pharmacist-patient dialogue

5 Instructions concerning the use of medications: antipyretics - Pharmacist-patient dialogue

6 Instructions concerning the use of medications: cough medications - Pharmacist-patient dialogue

7 Instructions concerning the use of medications: antidiabetics - Pharmacist-patient dialogue

8 Instructions concerning the use of medications: spasmolytics - Pharmacist-patient dialogue

9 Instructions concerning the use of medications: sleeping pills - Pharmacist-patient dialogue

10 Instructions concerning the use of medications: steroids - Pharmacist-patient dialogue

11 Instructions concerning the use of medications: antibiotics - Pharmacist-patient dialogue

12 Instructions concerning the use of medications: antiinlammatory medications - Pharmacist-patient dialogue

13 Instructions concerning the use of medications: emetics and antiemetics - Pharmacist-patient dialogue

14 Instructions concerning the use of medications: eye, ear and nasal drops - Pharmacist-patient dialogue

15 Instructions concerning the use of medications: medications applied to the skin - Pharmacist-patient dialogue

16 Test 1

17 Instructions concerning the use of medications: suppository - Pharmacist-patient dialogue

18 First aid instruments -Listening comprehension and speaking skills









27 Test 2



122

Seminars


-


Participants







123

OPF-MAS-T INSTRUMENTAL ANALYSIS - SEMINAR

Course director: DR. TÍMEA DERGEZ, assistant professor





Topic

The seminars will be available for helping the students in their studies in Instrumental analysis - both theory and practice.


According to the Faculty rules.

Mid-term exams

-


-

Reading material



Material can be downloaded from the website of the Institute of Bioanalysis under the

Educational materials link: http://aok.pte.hu/en/egyseg/oktatas/160 (the username and password

are provided in the lectures).

Instrumental Analysis. Laboratory Practice. DOI: 10.15170/TTK.2014.00001 (dowloadable by the DOI number).

- Notes


D.A. Skoog, F.J. Holler, S.R. Crouch: Principles of Instrumental Analysis

D.G. Watson: Pharmaceutical Analysis, Elsevier

Lectures

Practices

Seminars

1 Potentiometry

2 Conductometry

3 Atomspectroscopy

4 Molecular spectroscopy

5 Infrared spectroscopy

6 Nuclear magnetic resonance spectroscopy

7 Separation techniques in general

8 Gas-chromatography

9 Liquid chromatography

10 Electrophoretic techniques

11 Capillary electrophoresis

12 Mass spectrometry

13 Coupled separation techniques

14 Data evaluation and error calculation



Participants

Dr. Dergez Tímea (DETCAA.T.JPTE), Dr. Kilár Ferenc (KIFGAAO.PTE), Dr. Poór Viktória (POVAAA.T.JPTE), Páger Csilla

(PACMAAO.PTE)

http://aok.pte.hu/en/egyseg/oktatas/160


124

OPF-MMR-T NUCLEAR MAGNETIC RESONANCE FOR DUMMIES

Course director: DR. ZOLTÁN BERENTE, associate professor




Course headcount limitations (min.-max.): 1 – 20 Prerequisites: OPA-AN2 completed + OPA-BA1 completed


Topic

Nuclear magnetic resonance offers an exceptionally versatile, non-invasive and non-destructive way for studying intact living organisms.

However, magnetic resonance imaging (MRI), and especially NMR spectroscopy, are strikingly underrepresented among diagnostic

methods. It may be due to regarding the method a strange, obscure if not suspicious „black box”; this way of thinking is far more

widespread among graduated medical doctors than it should be.

Take the courage, the time and the effort to take a closer look at nuclear magnetic resonance. Let’s start from scratch and let’s understand

what your fellow students do not bother to understand: what happens with the sample in the magnet during an NMR or MRI experiment,

how does it happen and why.

The course covers the theoretical background of the medical diagnostic (imaging and biomarkers) and drug industrial (drug development,

drug analysis) applications of nuclear magnetic resonance with a problem-based attitude and case studies.



Mid-term exams

The student is expected to present a project.


On the judgement of the instructor.

Reading material


http://cis.rit.edu/htbooks/nmr

http://cis.rit.edu/htbooks/mri


- Notes


R. A. de Graaf: In vivo NMR Spectroscopy, Wiley, 1998

http://www.imaios.com/en/e-Courses/e-MRI

http://www.magnetic-resonance.org/

http://eprints.drcmr.dk/37/1/MRI_English_a4.pdf

Lectures

1 The NMR phenomenon. Excitation, relaxation and signal formation

Dr. Berente Zoltán

2 Fourier-transform pulse NMR: Theory and practice

Dr. Berente Zoltán

3 Structure elucidation of small molecules 1. One-dimensional techniques based on coupling through chemical bonds or through

the space.

Dr. Berente Zoltán

4 Structure elucidation of small molecules 2. NMR in more dimensions, strategy of structure analysis

Dr. Berente Zoltán

5 Structure elucidation of small molecules 3. NMR in drug development and in drug analysis

Dr. Berente Zoltán

6 Structure elucidation of macromolecules. Intramolecular and intermolecular interactions, structure-activity relationship

Dr. Berente Zoltán

7 Study of energy metabolism using 31P NMR spectroscopy

Dr. Berente Zoltán







125

8 Study of fuel metabolism using 13C NMR spectroscopy

Dr. Berente Zoltán

9 Applications of NMR spectroscopy of other nuclei (19F, 23Na, 87Rb) in life sciences

Dr. Berente Zoltán

10 Statistical NMR spectroscopy: searching for biomarkers

Dr. Berente Zoltán

11 Basics of MR imaging

Dr. Berente Zoltán

12 Current MR imaging techniques

Dr. Berente Zoltán

13 Localised (volume selective) NMR spectroscopy

Dr. Berente Zoltán

14 NMR in solid phase: study of biological membranes

Dr. Berente Zoltán

Practices

Seminars



Participants


126

OPF-QBI-T QUANTUM BIOLOGY: QUANTUM PHENOMENA IN BIOLOGICAL PROCESSES





Course headcount limitations (min.-max.): 3 – 50 Prerequisites: OPO-GB2-T completed

Topic

Course description:

Based on common scientific approach quantum phenomena are not relevant in biological processes. The living cell has relatively large

dimensions, is filled with hydrated vibrating macromolecules, and follows the rules thermodynamics rather than quantum mechanics.

Yet, besides attractive theories, experimental data also accumulate suggesting that living cells readily exploit quantum phenomena.

Several biological processes require quantum biology approach for full understanding. These include photosynthesis, various enzyme

activities, DNA mutation accumulation, avian magnetoreception, mammalian olfaction etc. During the course students get familiar with

the quantum biology explanation of these biological processes.



Mid-term exams

There will be several occasions for the students to rewrite midterm tests.


Students will get e-learning material to cope to follow the course at home.

Reading material


Life on the edge: The coming of age of quantum biology

Johnjoe McFadden, Jim Al-Khalili

Broadway Books (2016) 368 pages

ISBN-13: 978-0307986825


Topics:

- Quantum phenomena and basics terms

- Thermodynamics vs quantum mechanics

- Structural characteristics of biological macromolecules

- Quantum biology approach of the living cell

- Quantum biology approach of cell death

- Quantum biology approach of molecular energy transport

- Quantum biology approach of genetic mutation accumulation

- Quantum biology approach of photosynthesis

- Quantum biology approach of enzyme activity

- Quantum biology approach of avian magnetoreception

- Quantum biology approach of mammalian olfaction

- Quantum biology approach of the conscious mind

- Basic principles of quantum computers and quantum biology analogies

- Written exam

- Notes




ISBN-13: 978-0307986825





ISBN-13: 978-0307986825


127

Lectures

1 Quantum phenomena and basics terms I.

Dr. Lukács András Szilárd

2 Quantum phenomena and basics terms II.


3 Thermodynamics vs quantum mechanics I.


4 Thermodynamics vs quantum mechanics II.


5 Structural characteristics of biological macromolecules I.


6 Structural characteristics of biological macromolecules II.


7 Quantum biology approach of the living cell I.

Dr. Ábrahám István Miklós

8 Quantum biology approach of the living cell II.


9 Quantum biology approach of cell death I.


10 Quantum biology approach of cell death II.


11 Quantum biology approach of molecular energy transport I.

Dr. Pál Szilárd

12 Quantum biology approach of molecular energy transport II.

Dr. Pál Szilárd

13 Quantum biology approach of genetic mutation accumulation I.


14 Quantum biology approach of genetic mutation accumulation II.


15 Written exam


16 Quantum biology approach of photosynthesis I.

Dr. Hoffmann Gyula

17 Quantum biology approach of photosynthesis II.

Dr. Hoffmann Gyula

18 Quantum biology approach of enzyme activity I.

Dr. Pál Szilárd

19 Quantum biology approach of enzyme activity II.

Dr. Pál Szilárd

20 Quantum biology approach of avian magnetoreception I.

Dr. Hoffmann Gyula

21 Quantum biology approach of avian magnetoreception II.

Dr. Hoffmann Gyula

22 Quantum biology approach of mammalian olfaction I.

Dr. Hoffmann Gyula

23 Quantum biology approach of mammalian olfaction II.

Dr. Hoffmann Gyula

24 Quantum biology approach of the conscious mind I.

Dr. Sik Attila Gábor

25 Quantum biology approach of the conscious mind II.

Dr. Sik Attila Gábor

26 Basic principles of quantum computers and quantum biology analogies I.


27 Basic principles of quantum computers and quantum biology analogies II.


28 Written exam



128

Practices

Seminars


https://www.dropbox.com/home/munka/Kvantumbiológia?preview=LifeOnTheEdge2014.pdf


Participants

Dr. Ábrahám István Miklós (ABIUAAP.PTE), Dr. Hoffmann Gyula (HOGFABP.PTE), Dr. Kvell Krisztián (KVKFAAO.PTE), Dr.

Lukács András Szilárd (LUATAA0.PTE), Dr. Miskei György Zsolt (MIGUAA0.PTE), Dr. Pál Szilárd (PASMAAO.PTE), Dr. Sik Attila

Gábor (A12OXW)

https://www.dropbox.com/home/munka/Kvantumbiológia?preview=LifeOnTheEdge2014.pdf


129

OPF-SKI-T BASICS OF CHEMICAL INFORMATICS

Course director: DR. GYŐZŐ KORNÉL KULCSÁR, assistant professor




Course headcount limitations (min.-max.): 3 – 15 Prerequisites: OPA-SV1-T completed

Topic

The aim of the course is to give the students a basic knowledge of chemical informatics. An overview of how computers have become

the indispensable tools for chemical experiments, measurements, regulatory and performance evaluation tasks, and theoretical chemistry

tests.

We cover the chemical sciences from used software, web resources, which we believe are most useful during academic years in chemical

science student work and in preparing theses. Students can learn the basics of molecular modeling, the use of databases available in the

University (ScienceDirect, PubMed, SciFinder ...), the general steps of the search.



Mid-term exams


Maximum three absences can be accepted.



Reading material



The worksheets will be handed on the seminars.

- Notes


https://docs.chemaxon.com/display/docs/MarvinSketch+User%27s+Guide

http://www.cambridgesoft.com/support/DesktopSupport/Documentation/Manuals/files/chemdraw_9_english.pdf

Lectures

1 Introduction, simple database managers (literature, citations, etc.) in chemistry.

Dr. Kulcsár Győző Kornél

2 Introduction into the Molecular Modeling Software’s


3 Molecular modeling - structural fundamentals


4 Molecular modeling - structure optimization


5 Molecular modeling - molecules and interaction with the surroundings


6 Molecular modeling - molecular Interactions


7 Molecular modeling - applied modeling in drug research


8 Chemical databases I.


9 Chemical databases II.


10 Using a text editor application in chemistry


11 Handling bibliography


https://docs.chemaxon.com/display/docs/MarvinSketch+User%27s+Guide

http://www.cambridgesoft.com/support/DesktopSupport/Documentation/Manuals/files/chemdraw_9_english.pdf


130

12 Apply a spreadsheet program in chemistry


13 Apply a vector drawing program. Creating a flowchart of science, chemical content and flow charts. Photos and videos in

chemistry, the basics of image processing.


14 Presentation of student results, evaluation of the semester


Practices

Seminars


Written test covering the topics of the lectures.


Participants


131

OPF-TG2-T STUDENT PROJECT RESEARCH FOR STUDENTS OF PHARMACEUTIST PROGRAMME 2



2 credit ▪ midsemester grade ▪ Optional subject for the G module ▪ spring semester ▪ recommended semester: 4


Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPF-TG1 completed

Topic



Research Society.



further semesters.

The prerequisite of this course (TDK 2): registration of the student in the database of Students’ Research Society and the fulfillment of

the Student Project Research for Students of Pharmaceutist Programme 1 course.

Mid-term exams

TG2

- Introduction of conference abstract or conference manuscript (student is co-author) for the course supervisor at the end of 13th week of

the semester.

- Written report on the work performed by the student. It must be sent to the course supervisor at the end of 13th week of the semester.

- Among the two conditions, one of them should be made at least.



Reading material



- Notes



Lectures

Practices

1-24 Research.

Seminars


Not applicable.


Participants



132

OPF-VAA-T IRON METABOLISM: FROM MOLECULAR MECHANISMS TO CLINICAL CONSEQUENCES

Course director: DR. EDINA PANDUR, assistant professor





Topic

During the course we will discuss the role of iron in the metabolism. We will deal with the iron demand of microorganisms and with the

role of iron in the protective mechanisms against bacterial infections. The function of influencing factors of iron metabolism, their effects

and crosstalk between them will be discussed in detail. The roles of iron containing proteins and their functions will be talked over.

During the course we will emphasize the disorders of iron metabolism (iron deficiency, iron overload), their genetic backgrounds and

their therapies. Based on the most actual findings the role of iron in the development of neurodegenerative diseases (Parkinson’s disease,

Alzheimer’s disease and Huntington’s disease) will be also discussed.


Max. 3 absences

Mid-term exams

One assay and one midterm exam.


Personal consultation

Reading material



The educational materials will be uploaded to Neptune MeetStreet

- Notes


Robert Crichton: Iron Metabolism - From Molecular Mechanisms to Clinical Consequences

Lectures

Practices

Seminars

1 Solution chemistry of iron, interactions with other metal ions.

2 The Importance of Iron for Biological Systems: haemoproteins, iron-sulfur proteins, other iron containing proteins

3 Microbial Iron Transport and Metabolism

4 Iron uptake by yeasts

5 Cellular Iron Uptake and Export in Mammals: iron transporters

6 Intracellular Iron Storage and Biomineralisation: ferritin, haemosiderin

7 Intracellular Iron Metabolism and Cellular Iron Homeostasis I: Labile iron pool, mitochondrial iron uptake and metabolism haem

biosynthesis

8 Intracellular Iron Metabolism and Cellular Iron Homeostasis II: synthesis of iron-sulfur clasters, functions of iron responsive

elements and iron regulatory proteins

9 Iron Absorption in Man: functions of luminal factors, regulation of Systemic Iron Balance

10 Pathophysiology of Iron Deficiency and Iron Overload: Acquired and Genetic Disorders of Iron Metabolism, haemochromatosis,

thalassemias, secondary iron overload, anemias

11 Iron disorders and Laboratory parameters

12 Iron and oxidative stress: cytoprotective enzymes, antioxidants, aging, role of the immune system

13 Brain iron metabolism, the role of iron in neurodegenerative diseases

14 Assay, exam


Simple choice test based on the seminars.


133


Participants

Dr. Nagy Tamás II (NATFABO.PTE), Dr. Pandur Edina (PAEFAA.T.JPTE), Jánosa Gergely (JAGTAAT.PTE), Pap Ramóna

(PARTAAT.PTE), Poór Viktor Soma (POVFAB.T.JPTE)


134

OPE-EFA-T ETHNOPHARMACOBOTANY

Course director: DR. NÓRA PAPP, associate professor




Course headcount limitations (min.-max.): 4 – 20 Prerequisites: OPO-GN1 completed + OPO-GN2 completed


Topic

Several written sources are available on the ethnobotanical usage and pharmaceutical history of medicinal plants from the Ancient Times.

The course presents a summary about ethnobotanical data focusing on folk therapeutical methods and values of the Mediterranean area,

Transylvania, countries of Europe, Asia, America and Africa completed by the scientific activity and curriculum vitae of ethnobotanists

and researchers in this topic. Students receive a general approach about the rules and regularity of the special folk terminology, practice,

folk customs and symbols in consideration of medicinal plants. In addition to ethnobotanical methods, the actual state, position and

necessity of surveys are discussed during the course.


Satisfactory fulfilment of 2 written tests based on the lectures.

Absences: according to the Code of Studies and Examinations of the Medical School.

Mid-term exams

The required 2 tests can be retaken or corrected in the course.


Downloading lectures.

Reading material





- Notes


Cunninham A. B.: Applied Ethnobotany. People, Wild Plant Use and Conservation, Earthscan, London, 2002

Ellen, Davi E., Hatfield, G.: Medicinal Plants in Folk Tradition an Ethnobotany of Britain and Ireland, Timber Press, Portland,

Cambridge, 2004

Lise Manniche: The Ancient Egyptian Herbal, The British Museum Press, London, 1989

Martin G. J.: Ethnobotany. A Methods Manual, Earthscan, London, 2007

Minnis P. E.: Ethnobotany. A Reader, University of Oklahoma Press, U.S.A., 2000

Moerman, Daniel E.: Native American Ethnobotany, Timber Press, Portland, London, 2010

Paye, Gabriell DeBear: Cultural Uses of Plants, The New York Botanical Garden Press, Bronx, New York, 2000

Lectures

1 Ethnopharmacological data of the Ancient Times (Egypt, Mesopotamia).

Dr. Papp Nóra

2 Ethnopharmacological data of the Ancient Times (Egypt, Mesopotamia).

Dr. Papp Nóra

3 Ethnobotanical studies of the Native Indian populations of North, South and Central America (Cuba, Mexico).

Dr. Papp Nóra

4 Ethnobotanical studies of the Native Indian populations of North, South and Central America (Cuba, Mexico).

Dr. Papp Nóra

5 Ethnopharmacology of the ancient cultures of Iran, China, India, Tibet, Japan.

Dr. Papp Nóra

6 Ethnopharmacology of the ancient cultures of Iran, China, India, Tibet, Japan.

Dr. Papp Nóra




135

7 Ethnopharmacology of African and Mediterranean countries (Greece, Spain, Portugal, Italy).

Dr. Papp Nóra

8 Ethnopharmacology of African and Mediterranean countries (Greece, Spain, Portugal, Italy).

Dr. Papp Nóra

9 Ethnopharmacological data from the Middle Ages: therapy and medicinal plants in monastery gardens.

Dr. Papp Nóra

10 Ethnopharmacological data from the Middle Ages: therapy and medicinal plants in monastery gardens.

Dr. Papp Nóra

11 Transylvanian ethnobotanical values.

Dr. Papp Nóra

12 Transylvanian ethnobotanical values.

Dr. Papp Nóra

13 Written test I.

Dr. Papp Nóra

14 Written test I.

Dr. Papp Nóra

15 Ancient medico-botanical and herbal books and written sources with the morphological and therapeutical description of medicinal

plants.

Dr. Papp Nóra

16 Ancient medico-botanical and herbal books and written sources with the morphological and therapeutical description of medicinal

plants.

Dr. Papp Nóra

17 Scientific activity and curriculum vitae of ethnobotanists.

Dr. Papp Nóra

18 Scientific activity and curriculum vitae of ethnobotanists.

Dr. Papp Nóra

19 Methodologies in ethnobotanical collection.

Dr. Papp Nóra

20 Methodologies in ethnobotanical collection.

Dr. Papp Nóra

21 Interactive lecture: analysis and elaboration of scientific articles published in international journals and books based on the

knowledge and view of the previous lectures.

Dr. Papp Nóra

22 Interactive lecture: analysis and elaboration of scientific articles published in international journals and books based on the

knowledge and view of the previous lectures.

Dr. Papp Nóra

23 Traditional and folk terminology in plant names.

Dr. Papp Nóra

24 Traditional and folk terminology in plant names.

Dr. Papp Nóra

25 Medicinal plants in folk custom and tradition as symbols.

Dr. Papp Nóra

26 Medicinal plants in folk custom and tradition as symbols.

Dr. Papp Nóra

27 Written test II.

Dr. Papp Nóra

28 Written test II.

Dr. Papp Nóra

Practices

Seminars


According to the topics of the course.


Participants


136

OPE-GMK-T QUALITATIVE AND QUANTITATIVE ANALYSIS OF DRUGS FROM HUMAN TISSUE






Topic

The course provides knowledge about the traceability of active pharmaceutical ingredients in various biological matrices. It discusses

sampling of biological matrices, sample preparation (extraction) methods [LLE, SPE, SPEC, SPME, MEPS], and various

chromatographic techniques [TLC, GC, LC] as well.

The course intends to present the CNS effects of active pharmaceutical ingredients, as well as drugs in the official investigation. The

sampling procedures and techniques are presented, as well as their official confidence circumstances.

The appearance of drug compounds and drugs in biological matrices, and their pharmacokinetic properties are discussed, as well as

traceability of live and corpse biological matrices (blood, urine, hair, nails, saliva, or liver, kidney, brain, or cerebrospinal fluid).

After proper selection of analytical tests, the requirements set for a variety of measuring instruments will be discussed. Standard

evaluation and communication, as well as the laws and regulations in force in the analytical results complete the course topics.



Mid-term exams

Students have to prove their knowledge of the course material by presenting a selected topic in a short (10 min) talk. The topic should be

related to one of the topics of the course, and students should rely on their knowledge acquired in previous classes.



Reading material


R.C. Baselt: Disposition of Toxic Drugs and Chemicals in Man, 6th ed., Biomedical Publications, Foster City, CA, 2002

A.C. Moffat, M.D. Osselton, B. Widdop: Clarke’s Analysis of Drugs and Poisons, Pharmaceutical Press, London, 2004.


The Lecturer’s presentations (ppt files) will be available from the website of the Department of Pharmacognosy.

- Notes


R.J. Flanagan, A. Taylor, I.D. Watson, R. Whelpton: Fundamentals of Analytical Toxicology, John Wiley & Sons, Hoboken, NJ,

2007.

Lectures

1 Introduction to Toxicology. Categorization of Toxins I

Dr. Benkő András Antal

2 Introduction to Toxicology. Categorization of Toxins II


3 Effect of Poisons on the Living Body I


4 Effect of Poisons on the Living Body II


5 Investigation in Forensic Laboratories. Sampling rules. I


6 Investigation in Forensic Laboratories. Sampling rules. II


7 Investigation of Non-standard Human Tissues I


8 Investigation of Non-standard Human Tissues II



137

9 Biological Materials Preparation. Extraction Procedures I


10 Biological Materials Preparation. Extraction Procedures II


11 Forensic Toxicological Investigation of Human Samples by Chromatography I


12 Forensic Toxicological Investigation of Human Samples by Chromatography II


13 Criteria and Evaluation. Expert Opinion in Forensic Toxicology I


14 Criteria and Evaluation. Expert Opinion in Forensic Toxicology II


15 Natural Cannabinoids (marihuana, hashish, and hashish oil) I


16 Natural Cannabinoids (marihuana, hashish, and hashish oil) II


17 Synthetic Cannabino-mimetics (spice, pot-puri, herbal, bio-grass, K2) I


18 Synthetic Cannabino-mimetics (spice, pot-puri, herbal, bio-grass, K2) II


19 First Generation of Amphetamines (ecstasy, speed)


20 Second generation of disco drugs (catinon and derivatives)


21 Opiates (morphine, codeine, heroine) I


22 Opiates (morphine, codeine, heroine) II


23 Cocaine


24 Body-pack Syndrome.


25 Final Student ppt Presentation I


26 Final Student ppt Presentation II


27 Final Student ppt Presentation III


28 Final Student ppt Presentation IV


Practices

Seminars


10 min ppt presentation based on an international forensic science article


Participants

Dr. Benkő András Antal (BEAQAAP.PTE)


138

OPE-KMS-T SEMINARS IN PHARMACEUTICAL SCIENCES - RESEARCH PERSPECTIVES






Topic

Seminars in Pharmaceutical Sciences - Research Perspectives



Mid-term exams

Written test


None

Reading material



- Notes


www.medbiotech.com

Lectures

1 Seminars in Pharmaceutical Sciences - Research Perspectives I.


2 Seminars in Pharmaceutical Sciences - Research Perspectives II.


3 Seminars in Pharmaceutical Sciences - Research Perspectives III.


4 Seminars in Pharmaceutical Sciences - Research Perspectives IV.


5 Seminars in Pharmaceutical Sciences - Research Perspectives V.


6 Seminars in Pharmaceutical Sciences - Research Perspectives VI.


7 Seminars in Pharmaceutical Sciences - Research Perspectives VII.


8 Seminars in Pharmaceutical Sciences - Research Perspectives VIII.kve


9 Seminars in Pharmaceutical Sciences - Research Perspectives IX.


10 Seminars in Pharmaceutical Sciences - Research Perspectives X.


11 Seminars in Pharmaceutical Sciences - Research Perspectives XI.


12 Seminars in Pharmaceutical Sciences - Research Perspectives XII.


13 Seminars in Pharmaceutical Sciences - Research Perspectives XIII:


14 Seminars in Pharmaceutical Sciences - Research Perspectives XIV.




139

Practices

Seminars


www.medbiotech.com


Participants



140

OPE-TG3-T STUDENT PROJECT RESEARCH FOR STUDENTS OF PHARMACEUTIST PROGRAMME 3





Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPF-TG2 completed

Topic



Research Society.



further semesters.



Mid-term exams

TG3


the semester.

- Introduction of original article published in national and/or international journals (student is co-author) at the end of 13th week of the

semester.

- Participation on Students’ Research Conference.

- Among the three conditions, one of them should be made at least.



Reading material



- Notes



Lectures

Practices

1-24 Research.

Seminars


Not applicable.


Participants



141

ATT5-T PHYSICAL EDUCATION 5

Course director: TAMÁS TÉCZELY, physical education teacher

UP MS Sports Facilities

0 credit ▪ signature ▪ Optional subject ▪ both semesters ▪ recommended semester: 5


Course headcount limitations (min.-max.): 2 – 50 Prerequisites: ATT4-T completed


Topic

This subject provides theoretical and practical information for the students to maintain and improve their physical condition and helps to

deepen the knowledge in the field of healthy lifestyle.

Theoretical and practical knowledge during different types of exercises e.g. how to improve endurance, muscle force, motor skills and

how to prevent the body from injuries.


Active participation at least 20 practical lessons provided by the Institute of Human Movement Sciences or regular participation of the

trainings of the Medikus Sport Club or PEAC.

Mid-term exams

-


We provide opportunities to attend extra lessons in the first week of the exam period in that case the requirements are not fulfilled till the

end of the teaching weeks with agreement of the PE Teacher.

Reading material



Not available.

- Notes


Lectures

Practices

1-28 For the list of actual courses please turn to the end of the Basic Module document

Seminars



Participants

Farkas György (FAGMAAO.PTE), Lipcsik Zoltán (LIZIAAT.PTE), Németh Attila Miklós (NEAGAET.PTE), Téczely Tamás

(PETLAAT.PTE)


142

OPF-EGZ-T EGZOTIC MEDICINAL PLANTS





Course headcount limitations (min.-max.): 5 – 25 Prerequisites: OPA-GN2 completed

Topic

The course includes 28 lectures. The aim of the course is to present the most frequently used exotic plants in the medical therapy. The

course gives a general overview about the botanical character, active ingredients, and drug part of the plants. Application forms and

safety instructions are also highlighted during the lectures. Herbs and drugs will presented according to their areas of application.



Mid-term exams

Oral presentation about a medicinal value of a selected plant. Fulfillment of the final test (minimum 60%).


Downloading of lectures in Neptun.

Reading material



- Notes


Bremness L. (1988): The Complete Book of Herbs: A Practical Guide to Growing and Using Herbs.

Ratsch C., Hofmann A.(2007): The Encyclopedia of Psychoactive Plants: Ethnopharmacology and Its Applications.

Kane C.W. (2007): Medicinal Plants of the Western Mountain States

Bett J. (2015): Chinese Medicinal Plants: How To Grow Them, How To Use Them: Growing and Using Herbs And Plants For

Natural Remedies And Healing.

Lectures

1 Herbs of the gastrointestinal tract I.

Dr. Ács Kamilla

2 Herbs of the gastrointestinal tract II.

Dr. Ács Kamilla

3 Herbs of the gastrointestinal tract III.

Dr. Ács Kamilla

4 Herbs of the gastrointestinal tract IV.

Dr. Ács Kamilla

5 Aromatic plants and products containing essential oils I.

Dr. Ács Kamilla

6 Aromatic plants and products containing essential oils II.

Dr. Ács Kamilla

7 Aromatic plants and products containing essential oils III.

Dr. Ács Kamilla

8 Aromatic plants and products containing essential oils IV.

Dr. Ács Kamilla

9 Herbs and products containing fatty oils I.

Dr. Ács Kamilla

10 Herbs and products containing fatty oils II.

Dr. Ács Kamilla

11 Plants for external use, dermatology and cosmetics I.

Dr. Ács Kamilla

12 Plants for external use, dermatology and cosmetics II.

Dr. Ács Kamilla


143

13 Plants which affect the central nervous system I.

Dr. Ács Kamilla

14 Plants which affect the central nervous system II.

Dr. Ács Kamilla

15 Plants for cardiovascular disorders I.

Dr. Ács Kamilla

16 Plants for cardiovascular disorders II.

Dr. Ács Kamilla

17 Plants for well-being I.

Dr. Ács Kamilla

18 Plants for well-being II.

Dr. Ács Kamilla

19 Psychoactive and hallucinogenic plants I.

Dr. Ács Kamilla

20 Psychoactive and hallucinogenic plants II.

Dr. Ács Kamilla

21 Plants with immunostimulant effect I.

Dr. Ács Kamilla

22 Plants with immunostimulant effect II.

Dr. Ács Kamilla

23 Plants for tropical, and contagious diseases I.

Dr. Ács Kamilla

24 Plants for tropical, and contagious diseases II.

Dr. Ács Kamilla

25 Presentations of students I.

Dr. Ács Kamilla

26 Presentations of students II.

Dr. Ács Kamilla

27 Exam

Dr. Ács Kamilla

28 Exam

Dr. Ács Kamilla

Practices

Seminars


It is similar to the topics of lectures.


Participants


144

OPF-GKG-T GAS CHROMATOGRAPHY

Course director: DR. VIKTÓRIA POÓR, assistant professor




Course headcount limitations (min.-max.): 4 – 10 Prerequisites: OPA-MAN completed

Topic

Key

Topics

-practical theory about Gas Chromatography

-how to select and use the carrier gas

-various injection techniques and when to use each

-how to select a GC column

-the operation and selection of an appropriate GC detector

-how to write measuring methods

-how to undertake data analysis

-sampling techniques for GC

-strategies for method development

-introduction to GC & MS advanced techniques

-applications (pharmaceutical application)



Mid-term exams

1 test during the semester

1 oral presentation (based on research articles on the field of pharmaceutical apllication)


There is no possibility for retake

Reading material


Modern Analytical Cheymistry,David Harvey


www.aok.pte.hu/bioanalitika

- Notes


Lectures

1 Introduction

Dr. Poór Viktória

2 Parts of gas chromatograph

Gases, injection techniques

Dr. Poór Viktória

3 Columns

Dr. Poór Viktória

4 Detectors

Dr. Poór Viktória

5 Gas chromatography-mass spectrometry

Dr. Poór Viktória

6 Data analysis

Dr. Poór Viktória

7 Applications, pharmaceutical applications

Dr. Poór Viktória

http://www.aok.pte.hu/bioanalitika


145

Practices

1 Introduction

2 How to write a measuring methods

3 How to write a measuring methods

4 Measurements with flame ionization detector

5 Measurements with mass spectrometer detector

6 Data analysis

7 Sample preperation techiques

Seminars


1 test during the semester

1 oral presentation (based on research articles on the field of pharmaceutical apllication)


Participants

Dr. Poór Viktória (POVAAA.T.JPTE)


146

OPF-GLK-T BIOINORGANIC CHEMISTRY FOR PHARMACY STUDENTS

Course director: DR. IMRE HUBER, associate professor





Prerequisites: OPA-AS2 completed + OPA-SK2 completed + OPA-BA2 completed

Topic

We will provide an overview in this block about bioinorganic topics of chemistry, regarding the role of the different elements in medicinal

and pharmaceutical chemistry. Our aim is to offer a concise knowledge also about bioinorganic relations on medical contrast agents like

X-ray, tomographic, MR and ultrasound contrast agents. The use of radionuclids in diagnostical methods will be discussed too.



Mid-term exams

Students will have to write a written test at the end of the semester.


In case of absences the students must follow up with self-education!

Reading material



Lecture notes provided by the lecturer.

- Notes


Lectures

1 Introduction, The biological importance of non-metals and metals.

Dr. Huber Imre

2 An overview of the elements.

Dr. Huber Imre

3 Rtg-contrast agents.

Dr. Huber Imre

4 Watersoluble nephrothrop Rtg-contrast agents with high osmolality.

Dr. Huber Imre

5 Watersoluble nephrothrop Rtg-contrast agents with low osmolality.

Dr. Huber Imre

6 Watersoluble hepatothrop Rtg-contrast agents.

Dr. Huber Imre

7 Water-insoluble Rtg-contrast agents.

Dr. Huber Imre

8 Contrast agents for MRI.

Dr. Huber Imre

9 Contrast agents for CT.

Dr. Huber Imre

10 Contrast agents for ultrasound.

Dr. Huber Imre

11 Radioactive diagnostics (radionuclids).

Dr. Huber Imre

12 Platinum comlexes in medicin. Chelation therapy.

Dr. Huber Imre

13 Bisphosphonates in medicin.

Dr. Huber Imre

14 Geometry of complexes. Closing written test.

Dr. Huber Imre


147

Practices

Seminars


These are listed in the lecture notebook written by the lecturer. These notes are about the different questions of this field with the

corresponding answers, parallely.


Participants


148

OPF-GMT-T DRUG METABOLISM AND DRUG TOXICITY

Course director: DR. ATTILA ALMÁSI, assistant professor




Course headcount limitations (min.-max.): 3 – 50 Prerequisites: OPA-G1B completed

Topic

On the seminaries of this facultative course the molecular background and the influenceability of the side and toxic effects of different

drugs are aimed, during the drug absorption, drug transformation and drug elimination.

During the course, the metabolic activation and transformation of the environmental carcinogens are to be discussed.



Mid-term exams

In the end of the semester the students write an end-semester test. The test is evaluated in percentage and the final grade is to be established

based on this result. The result of the test should be above 60%.


The replacement of the missed test is required.

Reading material



Slides of the lectures.

- Notes


Lectures

1 Introduction. The toxicological aspects of drug metabolism.

Dr. Almási Attila

2 Characteristics of xenobiotics in the body

Dr. Almási Attila

3 Metabolic transformation I. Phase I. or functionalisation reactions 1 (CYP enzymes).

Dr. Almási Attila

4 Metabolic transformations II. Phase I. or functionalisation reactions 2 (FAD enzymes and non microsomal transformations).

Dr. Almási Attila

5 Metabolic transformations III. Phase II. or conjugation reactions 1 ( glucuronic acid conjugation, sulphate conjugation).

Dr. Almási Attila

6 Metabolic transformations IV. Phase II. or conjugation reactions 2 ( amino acid conjugation, acetylation, methylation, gluthatione

conjugation).

Dr. Almási Attila

7 Phase III. transformations (transporters), general molecular mechanism of drug toxicity.

Dr. Almási Attila

8 Biotransformation and the toxic effects of the paracetamol. Factors influence the toxicity of the paracetamol.

Dr. Almási Attila

9 Toxicity of the non-steroid antiinflammatory drugs (NSAIDs). Hepatotoxic effect of the diclofenac.

Dr. Almási Attila

10 Toxicity of the troglitazone. Sulfonamide hypersensitivity.

Dr. Almási Attila

11 Chemical carcinogenesis I., Definition, cell division, environmental carcinogens, chemical carcinogenesis.

Dr. Almási Attila

12 Chemical carcinogenesis II., Structure and metabolic activation of environmental carcinogens.

Dr. Almási Attila

13 Metabolic differences between species, genetic polymorphism.

Dr. Almási Attila


149

14 Changes in drug metabolism during pregnancy and at aged people.

Dr. Almási Attila

Practices

Seminars


Based on the announced thesis list.


Participants


150

OPF-HVS-T SYNTHESIS OF HETEROCYCLIC COMPOUNDS AND THEIR APPLICATION IN THERAPY

Course director: DR. TAMÁS KÁLAI, professor




Course headcount limitations (min.-max.): 1 – 12 Prerequisites: OPA-SV1 completed

Topic

Heterocyclic chemistry is an important subdivision of organic chemistry, as 70% of all medicines are heterocyclic compound or contains

a heterocyclic moiety. This course will give an introduction to, and the summary of, the most important principles and ideas of

heterocyclic chemistry. This course partially re-calls the knowledge of Organic chemisty 1 and Organic chemistry 2 course, discusses

those details which were not reflected on, because of time shortage and supports to evaluate the pharmacological chemistry subject.

Electronic structure of heterocycles

-Nomenclature of heterocyclic compounds

-Main synthetic routes to heterocyclic compounds

-Saturated heterocycles

-Three and four membered heterocycles (synthesis, reactions, occurence)

-The pyrrole and indole (synthesis, reactions, occurence)

-Furan, thiophene and their benzo derivatives.

-Five membered heterocycles with two or more heteroatoms

-Six-membered heterocycles with one oxygen heteroatom (piranes, chromones, flavones and coumarins)

-Six membered heterocycles with one nitrogen atom (pyridine, quinoline, isoquinoline)

-Six membered heterocycles with two or more heteroatoms (purine, diazines etc.)

-Seven membered heterocyclic chemistry

- Heterocycles in supramolecular chemitry

-Heterocyclic compounds in organic snthesis



Mid-term exams

The students write two tests, at the middle of the semester and at the end of the semester. Every student have a chance to make a

presentation based on a heterocyclic chemistry paper for an extra grade.


Personal communication. The english program student might visit the paralell hungarian course to catch up the main reaction equations.

Reading material


Li, J. J. Hetrocyclic chemistry in Drug Discovery, Wiley


Slides will be given to students as a ppt or pdf files.

- Notes

Joule, J. J.; Mills, K. Heterocyclic chemistry at a Glance. (Wiley)


Li, J. J. Top 10 drugs Oxfors University Press

Lectures

Practices

Seminars

1 Electronic structure of heterocycles

2 Nomenclature of heterocyclic compounds

3 Heterocycles in natural products

4 Common reaction types in heterocyclic chemistry

5 The main syntetic methods of heterocycles

6 Palladium in heterocyclic chemistry


151

7 Three and four membered heterocycles, beta lactams

8 Three and four-membered heterocycles and beta lactams

9 Synthesis of pyrroles and porfirine ring containing compounds

10 Synthesis of indoles, main reactions of indoles.

11 Furans and benzofurans

12 Thiophenes and benzothiophenes

13 1,2-azoles, their synthesis, reactions and their occurence in drugs

14 1,3-azoles, their synthesis, reactions, occurence in drugs

15 1st test (generral feature of heterocyclic compounds (3-, 4-, 5-membered heterocycles)

16 Six membered heterocycles containing oxygen heteroatom

17 Pyridines (synthesis, reactions, occurence in drugs and biomolecules)

18 Quinolines, isoquinolines (synthesis, reactions, occurence in drugs)

19 Synthesis of pyrimidines and their occurence in medicines

20 Synthesis and reactions of 1,2- and 1,4-diazines

21 Quinoxalines, quinazolines and quinazolinones

22 Synthesis and reaction of purines

23 Nucleic acid based drugs

24 Seven-membered heterocyclic compounds, their role in medicines

25 Heterocycles in supramolecular chemistry

26 Heterocycles in organic synthesis

27 2nd test (6- and 7-membered heterocycles)

28 Short presentations, evaluations


-Electronic structure of heterocycles

-Nomenclature of heterocyclic compounds

-Main synthetic routes to heterocyclic compounds

-Saturated heterocycles

-Three and four membered heterocycles (synthesis, reactions, occurence)

-The pyrrole and indole (synthesis, reactions, occurence)

-Furan, thiophene and their benzo derivatives.

-Five membered heterocycles with two or more heteroatoms

-Six-membered heterocycles with one oxygen heteroatom (piranes, chromones, flavones and coumarins)

-Six membered heterocycles with one nitrogen atom (pyridine, quinoline, isoquinoline)

-Six membered heterocycles with two or more heteroatoms (purine, diazines etc.)

-Seven membered heterocyclic chemistry

- Heterocycles in supramolecular chemitry

-Heterocyclic compounds in organic snthesis


Participants

Dr. Kálai Tamás (KATFABP.PTE)


152

OPF-MME-T MOLECULAR MEDICINE

Course director: DR. JUDIT PONGRÁCZ, professor






Topic

Introduction into molecular medicine



Mid-term exams

Writing test


None

Reading material



- Notes

www.medbiotech.com


Lectures

1 Introduction into molecular medicine

Dr. Pongrácz Judit

2 The genome

Dr. Pongrácz Judit

3 Sequencing of the genome

Dr. Pongrácz Judit

4 Investigation of the human genome with microarrays

Dr. Pongrácz Judit

5 Genes and diseases

Dr. Pongrácz Judit

6 Nuclear receptors

Dr. Pongrácz Judit

7 Personalized genetics

Dr. Pongrácz Judit

8 Immunodeficiencies

Dr. Pongrácz Judit

9 Cancers (introduction)

Dr. Pongrácz Judit

10 Molecular mechanisms of cancer development

Dr. Pongrácz Judit

11 Obesity: introduction

Dr. Pongrácz Judit

12 Genomics of obesity

Dr. Pongrácz Judit

13 Genes involved in development of obesity

Dr. Pongrácz Judit

14 Therapeutic approaches to obesity. Interconnected mechanisms in lipid metabolism

Dr. Pongrácz Judit



153

Practices

Seminars


www.medbiotech.com


Participants



154

OPF-MOD-T MOLECULAR DIAGNOSTICS







Topic

Structure of a molecular genetic laboratory, working areas, special devices and instrumentation. Biological information.



Mid-term exams

Writing test



Reading material



- Notes

www.medbiotech.com


Lectures

1 Structure of a molecular genetic laboratory, working areas, special devices and instrumentation. Biological information.

Dr. Pongrácz Judit

2 Mutations, polymorphisms. The genetic code.

Dr. Pongrácz Judit

3 Mutations, polymorphisms. The genetic code.

Dr. Pongrácz Judit

4 Special mutation consequences.

Dr. Pongrácz Judit

5 Dynamic mutations.

Dr. Pongrácz Judit

6 Mendelian inheritance.

Dr. Pongrácz Judit

7 Multifactorial diseases.

Dr. Pongrácz Judit

8 Examples for monogenic diseases.

Dr. Pongrácz Judit


Dr. Pongrácz Judit


Dr. Pongrácz Judit

11 Pharmacogenetics.

Dr. Pongrácz Judit

12 Molecular testing in oncology.

Dr. Pongrácz Judit

13 Methodology of the molecular diagnostic procedures.

Dr. Pongrácz Judit

14 Methodology of the molecular diagnostic procedures.

Dr. Pongrácz Judit



155

Practices

Seminars


www.medbiotech.com


Participants



156

OPF-MOT-T MOLECULAR THERAPIES







Topic

Gene therapy, in vivo gene therapy



Mid-term exams

Writing test


None

Reading material



- Notes

www.medbiotech.com


Lectures

1 Functional genomics I

Dr. Pongrácz Judit

2 Functional genomics II

Dr. Pongrácz Judit

3 Recombinant protein expression

Dr. Pongrácz Judit

4 Gene therapy, in vivo gene therapy

Dr. Pongrácz Judit

5 Ex vivo gene therapy, Therapies based on protein replacement I

Dr. Pongrácz Judit

6 Therapies based on protein replacement II

Dr. Pongrácz Judit

7 Recombinant antibodies and phage phage display technique

Dr. Pongrácz Judit

8 Anti-cytokine therapy (Sepsis)

Dr. Pongrácz Judit

9 Transgene technology and mouse models in modern biological research

Dr. Pongrácz Judit

10 Embryonic and adult stem cells for regenerative medicine I

Dr. Pongrácz Judit

11 Embryonic and adult stem cells for regenerative medicine II

Dr. Pongrácz Judit

12 Cell cycle and cancer therapy, p53 I

Dr. Pongrácz Judit

13 Cell cycle and cancer therapy, p53 II

Dr. Pongrácz Judit

14 Gene silencing technologies

Dr. Pongrácz Judit



157

Practices

Seminars


www.medbiotech.com


Participants



158

OPE-ASZ-T THE ANTIMICROBIAL DRUGS AND THEIR CLINICAL USE

Course director: DR. BÉLA KOCSIS, associate professor

Department of Medical Microbiology and Immunology





Topic

The aim of these lectures is to give a reliable and detailed knowledge about the antimicrobial drugs and their clinical use; to give ideas

how to choose the proper drug for the prophylaxis and therapy of infectious diseases



Mid-term exams

In the first 2 weeks of the exam period we give three times possibilities to write tests


None

Reading material


Jawetz et al.: Medical Microbiology


- Notes


Lectures

1 Introduction, historical data, basic definitions

Dr. Kocsis Béla

2 Characterisation of antimicrobial drugs, chemical structure, their targets

Dr. Kocsis Béla

3 Characterisation of antimicrobial drugs, sensitivity and resistance

Dr. Kocsis Béla

4 Characterisation of antimicrobial drugs, sensitivity and resistance

Dr. Kocsis Béla

5 Pharmacokinetics and pharmacodynamics of anti-infective drugs

Dr. Kocsis Béla

6 The antibiotic prophylaxis.

Dr. Kocsis Béla

7 The empiric antimicrobial therapy

Dr. Kocsis Béla

8 The antimicrobial therapy based on microbiologic result

Dr. Kocsis Béla

9 The choice of best antimicrobial drug

Dr. Kocsis Béla

10 The reasons of an unsuccessful antimicrobial therapy

Dr. Kocsis Béla

11 The antimicrobial drugs in details. The inhibitors of the cell wall biosynthesis Beta-lactams Penicillins

Dr. Kocsis Béla

12 Cephalosporins

Dr. Kocsis Béla

13 Carbapenems, monobactams, glicopeptides

Dr. Kocsis Béla

14 The inhibitors of the protein biosynthesis Aminoglicosides

Dr. Kocsis Béla


159

15 Tetracyclines Chloramphenicol Macrolides

Dr. Kocsis Béla

16 The inhibitors of the nucleic acid biosynthesis Rifampins Sulfonamides

Dr. Kocsis Béla

17 Kinolons Fluorokinolons

Dr. Kocsis Béla

18 The antimycotic drugs

Dr. Kocsis Béla

19 The antimycotic drugs

Dr. Kocsis Béla

20 The antiviral drugs

Dr. Kocsis Béla

21 The antiviral drugs HIV - AIDS

Dr. Kocsis Béla

22 The antiparasitic therapy. The chemoprophylaxis of malaria

Dr. Kocsis Béla

23 The antimicrobial therapy of respiratory and urinary tract infections

Dr. Kocsis Béla

24 Cardiovascular and wound infections, sepsis

Dr. Kocsis Béla

25 Central nervous system, abdominal and enteric infections

Dr. Kocsis Béla

26 Antimicrobial therapy of patients under immunosuppression, pregnancy....

Dr. Kocsis Béla

27 The pharmacological aspects of antimicrobial therapy

Dr. Kocsis Béla

28 The future of antimicrobial therapy

Dr. Kocsis Béla

Practices

Seminars


None


Participants


160

OPE-GFK-T PHYSICO-CHEMICAL BASES OF DRUG ACTION






Topic

The main objective of this course is to expand the knowledge in phyisico-chemical characterization of drug molecules and drug targets

for better understanding the drug action.



Mid-term exams

Written exam


None

Reading material



Lecture notes

- Notes


Vogel HG: Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays, Springer, 2006

Lectures

1 Molecular bases of biological actions. Structural characteristics of drug targets.

Dr. Rozmer Zsuzsanna

2 Molecular bases of biological actions. Structural characteristics of drug targets.


3 Receptors as drug targets.


4 Receptors as drug targets.


5 Enzymes as drug targets.


6 Enzymes as drug targets.


7 Transporters and ion channels as drug targets.


8 Transporters and ion channels as drug targets.


9 Nucleic acids as drug targets.


10 Nucleic acids as drug targets.


11 Physicochemical properties of drug-drug target interactions. Intermolecular bonding.


12 Physicochemical properties of drug-drug target interactions. Intermolecular bonding.


13 Physicochemical properties of drug-drug target interactions. Affinity. Efficiency and selectivity.


14 Physicochemical properties of drug-drug target interactions. Affinity. Efficiency and selectivity.



161

15 Physicochemical properties of drug-drug target interactions. Stucture, stereochemistry.


16 Physicochemical properties of drug-drug target interactions. Stucture, stereochemistry.


17 Physicochemical characteristics of drugs. Solubility.


18 Physicochemical characteristics of drugs. Solubility.


19 Physicochemical characteristics of drugs. Acid-base properties. Relevance and determination of the pKa value.


20 Physicochemical characteristics of drugs. Acid-base properties. Relevance and determination of the pKa value.


21 Physicochemical characteristics of drugs. Lipophilicity and partition coefficient. Determination of partition coefficients.


22 Physicochemical characteristics of drugs. Lipophilicity and partition coefficient. Determination of partition coefficients.


23 Physicochemical characteristics of drugs. Permeability. Experimental methods to determine permeability.


24 Physicochemical characteristics of drugs. Permeability. Experimental methods to determine permeability.


25 In silico ADME modelling. In vitro and in vivo tests.


26 In silico ADME modelling. In vitro and in vivo tests.


27 Physicochemical characteristics of drugs. Metabolic stability.


28 Physicochemical characteristics of drugs. Metabolic stability.


Practices

Seminars


Written test, questions avalaible from the teacher


Participants


162

OPE-KPR-T CHEMOPREVENTION







Topic

Chemoprevention is the administration of natural or (semi)synthetic agents to prevent, inhibit, or delay the progression of chronic

diseases. The focus is on cancer chemoprevention.

The way from a potent agent to a chemopreventive strategy will also be discussed.

Involving (chemo)preventive interventions in every-day practice could spare valuable life years.



Examination: test

Mid-term exams

Examination: test


based on individual consideration

Reading material




- Notes


Lectures

1 Introduction; Chemoprevention as a preventive strategy

Dr. Szabó István

2 Introduction; Chemoprevention as a preventive strategy

Dr. Szabó István

3 Finding evidence

Dr. Szabó István

4 Finding evidence

Dr. Szabó István

5 Interventing chronic diseases I

Dr. Szabó István

6 Interventing chronic diseases I

Dr. Szabó István

7 Interventing chronic diseases II

Dr. Szabó István

8 Interventing chronic diseases II

Dr. Szabó István

9 Chemopreventive strategies - antioxidants

Dr. Szabó István

10 Actualities of antioxidants

Dr. Szabó István

11 Natural chemopreventive agents

Dr. Szabó István

12 Natural chemopreventive agents

Dr. Szabó István


163

13 Chemopreventive dietary factors

Dr. Szabó István

14 Chemopreventive dietary factors

Dr. Szabó István

Practices

Seminars


Neptun


Participants


164

OPE-STK-T BASICS OF STEREOCHEMISTRY

Course director: DR. IMRE HUBER, associate professor





Prerequisites: OPA-SK2 completed + OPG-GK1 completed + OPA-BA2 completed

Topic

In the frame of this topic we will provide an overview about fundamentals of stereochemical definitions and processes. The students will

receive the most important knowledge about stereochemistry, with what they can understand the different binding types of drugs to their

place of biological action.



Mid-term exams

Students will have to write a written test at the end of the semester.


In case of absences the students must follow up with self-education!

Reading material




- Notes



K.-H. Hellwich, C. D. Siebert: Stereochemistry workbook, 191 problems and solutions, Springer, 2006.

Lectures

1 Introduction, confoguration, conformation definitions.

Dr. Huber Imre

2 Chirality, asymmetry.

Dr. Huber Imre

3 Asymmetric syntheses

Dr. Huber Imre

4 Fischer projection, CIP system.

Dr. Huber Imre

5 Diastereomers, enantiomers.

Dr. Huber Imre

6 Epimers, eutomers, distomers.

Dr. Huber Imre

7 Homochirality, inversion, meso-isomers.

Dr. Huber Imre

8 Newman projection.

Dr. Huber Imre

9 Optical purity.

Dr. Huber Imre

10 Prochirality, prostereoisomerism.

Dr. Huber Imre

11 Racemate, racemisation.

Dr. Huber Imre

12 Retention in stereochemistry.

Dr. Huber Imre


165

13 Stereoselectivity, stereospecificity.

Dr. Huber Imre

14 Summary, written test.

Dr. Huber Imre

Practices

Seminars


These are listed in the lecture notebook written by the lecturer. These notes are about the different questions of this field with the

corresponding answers, parallely.


Participants


166

OPE-TG4-T STUDENT PROJECT RESEARCH FOR STUDENTS OF PHARMACEUTIST PROGRAMME 4





Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPE-TG3 completed

Topic



Research Society.



further semesters.



Mid-term exams

TG4


the semester.

- Introduction of an article published in a national and/or international journal (student is co-author). It must be sent to the course

supervisor at the end of 13th week of the semester.

- Oral presentation at the Students’ Research Conference.

- Dean’s thesis

- Among the four conditions, one of them should be made at least.



Reading material



- Notes



Lectures

Practices

1-24 Research.

Seminars


Not applicable.


Participants



167

OPE-VFM-T BUSINESS DEVELOPMENT AND MANAGEMENT (KÜLÖN KURZUS!!!)

Course director: DR. BOGNÁR RITA, ügyvivő szakértő





Topic

The main objective of the course is to develop the business orientation skills of the students, while deepening their knowledge in business

models, business plans, innovative business strategies, time-, product-, process- and human resource management. Participants will have

the capability how to develop healthcare businesses in international environment and how to plan better their time.



Mid-term exams

TVSZ szerint


Következő félévben, TVSZ szerint.

Reading material



Neptun

- Notes


1. Baum Neil, Thomas Raju : The Basics of Business of Medicine, 2015

2. Helen Ewing: Healthcare Finance: An Introduction to Accounting and Financial Management, 5th edition, 2013

Lectures

1 Global healthcare

Dr. Bognár Rita

2 Different healthcare systems

Dr. Bognár Rita

3 Regional healthcare

Dr. Bognár Rita

4 Different types of business organisations

Dr. Bognár Rita

5 Innovation, Innovative businesses

Dr. Bognár Rita

6 Business Model Generation

Dr. Bognár Rita

7 Business plan

Dr. Bognár Rita

8 Business plan development

Dr. Bognár Rita

9 Intercultural business communication

Dr. Bognár Rita

10 Basics of Marketing in healthcare business

Dr. Bognár Rita

11 Production

Dr. Bognár Rita

12 Product and process management

Dr. Bognár Rita

13 Quality management

Dr. Bognár Rita


168

14 Time planning

Dr. Bognár Rita

15 Time management

Dr. Bognár Rita

16 Human resource management

Dr. Bognár Rita

17 Team building

Dr. Bognár Rita

18 Team work

Dr. Bognár Rita

19 Strategic management

Dr. Bognár Rita

20 Risk management

Dr. Bognár Rita

21 Healthcare finance

Dr. Bognár Rita

22 Introduction to accounting and financial management

Dr. Bognár Rita

23 Sustainable healthcare

Dr. Bognár Rita

24 Presenation methods

Dr. Bognár Rita

25 Presentation techniques

Dr. Bognár Rita

26 Administration

Dr. Bognár Rita

27 Documentation, Reports

Dr. Bognár Rita

28 Summary for written test

Dr. Bognár Rita

Practices

Seminars


Neptun


Participants


169

OPF-DTS-T THE ROLE OF DRUG TRANSPORTERS

Course director: DR. LUCA JÁROMI, assistant professor




Course headcount limitations (min.-max.): 5 – 15 Prerequisites: OPG-GK1-T completed

Topic

Understanding the clinical importance, role and molecular procedures of interindividual variability in drug response is a critical area of

drug development and clinical pharmacotherapy.The genetic polymorphisms in drug-metabolizing enzymes, receptors, transporters and

other drug targets may have a crucial role in the background of this phenomenon, that can lead to the interindividual differences in

molecular ways, efficacy, as well as toxicity as a response to numerous clinical treatment. Cancer is the leading cause of mortality and

morbidity worldwide. The greatest obstacle of the successful treatment is the development of multidrug resistance (MDR) against

chemotherapy. During the past two decades, the act of carrier-mediated transport in defining the pharamcokinetics of drugs has become

progressively evident with the discovery of genetic polymorphisms that influence expression, localization, and/or function of a given

drug transporter. The aim of the course is to present the drug transporters and their genetic and pharmacogenetic background, to explain

their role in drug metabolism, especially focusing on different drug transporter families and on interactions of protein - drug - transporters.



Mid-term exams

Félév végén vizsga, vizsgaidőszakban pótvizsga lehetőségek


Nincs, mert csak előadásokból áll a kurzus.

Reading material



PPT-bemutatók az előadások során.

- Notes


1.) Yuichi Sugiyama - Bente Steffansen

Transporters in Drug Development Discovery, Optimization,

Clinical Study and Regulation

ISSN 2210-7371 ISSN 2210-738X (electronic)

ISBN 978-1-4614-8228-4 ISBN 978-1-4614-8229-1 (eBook)

DOI 10.1007/978-1-4614-8229-1

Springer New York Heidelberg Dordrecht London

Library of Congress Control Number: 2013947789

2.) Toshihisa Ishikawa, Richard B. Kim

Pharmacogenomics of Human Drug Transporters

ISBN 978-0-470-92794-6

3.) Russ. B. Altman, David Flockhart, David B. Goldstein

Pharmacogenetics and Pharmacogenomics

ISBN 978-0-521-88537-9

Lectures

1 Introduction to world of drug transporters

Dr. Járomi Luca

2 General characteristics of drug transporters

Dr. Járomi Luca

3 Terms definition of drug transporters

Dr. Járomi Luca

4 Genetic role of drug transporters

Dr. Járomi Luca


170

5 Pharmacogenetic characteristics of drug transporters

Dr. Járomi Luca

6 Basics in phamacokinetics: definition of absorption, distribution, metabolism, and excretion (ADME)

Dr. Járomi Luca

7 Explanation of absorption, distribution, metabolism, and excretion (ADME)

Dr. Járomi Luca

8 Membrane transporters in ADME I.

Dr. Járomi Luca

9 Membrane transporters in ADME II.

Dr. Járomi Luca

10 ADME pharmacogenomics in drug development I.

Dr. Járomi Luca

11 ADME pharmacogenomics in drug development II.

Dr. Járomi Luca

12 The role of transporters in drug development: regulatory science perspectives from the FDA

Dr. Járomi Luca

13 Industrial evaluation of drug transporters in ADME

Dr. Járomi Luca

14 The pharmacogenomics of membrane transporters I.

Dr. Járomi Luca

15 The pharmacogenomics of membrane transporters II.

Dr. Járomi Luca

16 Nucleoside transporters family

Dr. Járomi Luca

17 General characteristics of ABC-transporter family

Dr. Járomi Luca

18 Most relevant ones: ABC-transporters

Dr. Járomi Luca

19 P-glycoprotein (MDR1/ABCB1)

Dr. Járomi Luca

20 ABCG2

Dr. Járomi Luca

21 Cancer: exsorptive transporters (ABC) expressed on transformed cells

Dr. Járomi Luca

22 Proton-coupled nutrient transporters affect ADME properties

Dr. Járomi Luca

23 In vitro characterization of interactions with drug transporting proteins

Dr. Járomi Luca

24 In vivo characterization of interactions on transporters

Dr. Járomi Luca

25 Indication specific transporter studies

Dr. Járomi Luca

26 Future perspectives

Dr. Járomi Luca

27 Conclusions and outlook, summary

Dr. Járomi Luca

28 Exam

Dr. Járomi Luca

Practices

Seminars


Introduction to world of drug transporters

General characteristics of drug transporters

Terms definition of drug transporters

Genetic role of drug transporters

Pharmacogenetic characteristics of drug transporters

Basics in phamacokinetics: definition of absorption, distribution, metabolism, and excretion (ADME)


171

Explanation of absorption, distribution, metabolism, and excretion (ADME)

Membrane transporters in ADME I.

Membrane transporters in ADME II.

ADME pharmacogenomics in drug development I.

ADME pharmacogenomics in drug development II.

The role of transporters in drug development: regulatory science perspectives from the FDA

Industrial evaluation of drug transporters in ADME

The pharmacogenomics of membrane transporters I.

The pharmacogenomics of membrane transporters II.

Nucleoside transporters family

General characteristics of ABC-transporter family

Most relevant ones: ABC-transporters

P-glycoprotein (MDR1/ABCB1)

ABCG2

Cancer: exsorptive transporters (ABC) expressed on transformed cells

Proton-coupled nutrient transporters affect ADME properties

In vitro characterization of interactions with drug transporting proteins

In vivo characterization of interactions on transporters

Indication specific transporter studies

Future perspectives


Participants


172

OPF-EXT-T EXTRACTION AND CHROMATOGRAPHIC TECHNIQUES IN MEDICINAL PLANT ANALYSIS

Course director: DR. TÍMEA BENCSIK, assistant professor




Course headcount limitations (min.-max.): 5 – 20 Prerequisites: OPA-MAN completed


Topic

With the increasing demand for herbal medicinal products, nutraceuticals, and natural products for health care all over the world,

medicinal plant extract manufacturers and essential oil producers have started using the most appropriate extraction and chromatographic

technologies in order to produce and standardize extracts and essential oils of defined quality. The aim of this course is to introduce the

most important extraction methods and chromatographic techniques used in the research of medicinal plants. Students should be able to

apply the acquired knowledge in their medical or pharmaceutical practice.

Task: To introduce state-of-the-art extraction techniques (maceration, infusion, digestion, decoction, percolation, Soxhlet, ultrasound

extraction, supercritical fluid extraction, water and steam distillation, enfleurage, expression) and chromatographic analyses (column

chromatography, thin layer chromatography, high pressure liquid chromatography) of medicinal plants and their role in the production

of herbal medicines. Some applications, relating to different classes of substances, are presented to demonstrate the versatility of various

chromatographic techniques.

Requirements: students have to know the most frequent extraction and analytical techniques used in medicinal and aromatic plant

research.



Mid-term exams

One written exam during the semester, the acceptance level is 60%. One oral presentation by students.


There is no possibility to make up for a missed lecture and practice.

Reading material



PowerPoint presentations prepared by lecturers.

- Notes


1. Handa S.S., Khanuja S.P.S., Longo G., Rakesh D.D.: Extraction Technologies for Medicinal and Aromatic Plants, International

Centre for Science and High Technology, Trieste, 2008

2. Reich E., Schibli A.: High-Performance Thin-Layer Chromatography for the Analysis of Medicinal Plants, Thieme, UK, 2007

3. Colegate S.M.: Bioactive Natural Products Detection Isolation and Structural Determination, CRC Press, 2008

4. Niessen W.M.A.: Liquid Chromatography - Mass Spectrometry, CRC Press, 2006

5. Nyiredy, Sz.: Planar Chromatography, Springer, Budapest, 2001.

6. Harris, DC.: Quantitative Chemical Analysis, WH. Freeman and Co., 7th edition, New York, 2007,

7. Schiedt K., Liaaen-Jensen S.: Isolation and Analysis, in Carotenoids Vol. 1A: Isolation and Analysis, Eds.: Britton G., Liaaen-

Jensen S., Pfander H., Birkhäuser Verlag, Basel, 1995.

Lectures

1 Introduction of the course requirements. An Overview of Extraction Techniques for Medicinal and Aromatic Plants.

Dr. Horváth Györgyi

2 Introduction of state-of-the-art extraction techniques: maceration, infusion, digestion, decoction, percolation, Soxhlet, ultrasound

extraction, supercritical fluid extraction, water and steam distillation, enfleurage, expression.


3 Introduction to Analytical Separations.


4 Techniques for the Purposes of Botanical Research.



173

5 Planar Chromatography: TLC.


6 Role of Different Procedures and Test Systems in the Knowledge of Herbal Substances.


7 Column Chromatography Systems: GC.


8 Column Chromatography Systems: HPLC.


9 Detectors Used in Different Separation Techniques and their Role in Qualitative and Quantitative Analysis.


10 Classification of Detectors Based on their Sensitivity and Selectivity.


11 Role of thin layer chromatography (TLC) in detecting microbiological processes: TLC-Bioautography.


12 Antimicrobial activity of essential oils using TLC-Bioautography.


13 Isolation and identification of carotenoids from medicinal plants.

Dr. Molnár Péter

14 Role of column liquid chromatography (CLC) in carotenoid research.

Dr. Molnár Péter

15 Examination of honeys, sugars, polyphenols.

Dr. Farkas Ágnes

16 Examination of honeys, sugars, polyphenols.

Dr. Farkas Ágnes

17 Identification of specific metabolites in herbal products. Adulterated dietary supplements.

Dr. Bencsik Tímea

18 Identification of specific metabolites in herbal products with TLC.

Dr. Bencsik Tímea

19 Isolation and Identification of flavonoids in medicinal plants.

Dr. Papp Nóra

20 Isolation and Identification of flavonoids in medicinal plants.

Dr. Papp Nóra

21 Quality of herbal products; our experiences in the Department of Pharmacognosy.

Dr. Bencsik Tímea

22 Quality of herbal products; our experiences in the Department of Pharmacognosy.

Dr. Bencsik Tímea

23 Student’s lecture.

Dr. Bencsik Tímea


Dr. Bencsik Tímea

25 Written test.


26 Written test.


Practices

Seminars

1 Chromatographic seminar: TLC.

2 Chromatographic seminar: HPLC.


The topics of the 1 written test are similar to the topics of the lectures.


Participants

Dr. Bencsik Tímea (BETMACO.PTE), Dr. Benkő András Antal (BEAQAAP.PTE)


174

OPF-KNH-T DRUG PLANTS AND HALLUCINOGENES





Course headcount limitations (min.-max.): 5 – 25 Prerequisites: OPA-GN2 completed

Topic

The course includes 28 lectures. The aim of the course is to present the most commonly used psychoactive plants and hallucionogens

around the world. The course gives a general overview about the botanical character and medicinal value of the most frequent plants and

fungi. In addition legal regulation, international guidelines for their control and the problem of addiction are also discussed.



Mid-term exams

Fulfillment of the final test (minimum 60%).


Downloading of lectures in Neptun.

Reading material



- Notes


Ratsch C., Hofmann A.(2007): The Encyclopedia of Psychoactive Plants: Ethnopharmacology and Its Applications.

McKenna D. (2018): Ethnopharmacologic Search for Psychoactive Drugs (Vol. 1 & 2): 50 Years of Research.

Schultes R.E. (2001): Plants of the Gods: Their Sacred, Healing, and Hallucinogenic Powers.

Willis C.(2015): Hallucinogens: The Truth About Hallucinogenic Plants.

Meuninck J. (2014): Basic Illustrated Poisonous and Psychoactive Plants.

Lectures

1 Attitude of psychoactive drugs in Hungary and Europe.

Dr. Ács Kamilla

2 Classification of psychoactive drugs: psychedelics, dissociatives and deliriants. Drug or medication?

Dr. Ács Kamilla

3 Opium and opiates around the world I.: Middle East, Western-, Middle- and South Asia

Dr. Ács Kamilla

4 Opium and opiates around the world II.: Southeast Asia, Europe, America

Dr. Ács Kamilla

5 Poppy seed (Papaver somniferum): legal use

Dr. Ács Kamilla

6 Poppy seed (Papaver somniferum): illegal use

Dr. Ács Kamilla

7 History of international audit of psychoactive drugs

Dr. Ács Kamilla

8 International guidelines for the control of psychoactive substances

Dr. Ács Kamilla

9 Synthetic opioids

Dr. Ács Kamilla

10 Detection of synthetic and plant originated hallucinogens. Analytics of psychoactive agents.

Dr. Ács Kamilla

11 Hallucinogenic plants I.: Solanaceae species

Dr. Ács Kamilla

12 Hallucinogenic plants II.: Ergot

Dr. Ács Kamilla


175

13 Hallucinogenic plants III.: Plants from Asia

Dr. Ács Kamilla

14 Hallucinogenic plants IV.: Plants from South-America

Dr. Ács Kamilla

15 Hallucinogenic fungi

Dr. Ács Kamilla

16 Medicinal use of psychoactive plants I.: Erythroxylum coca

Dr. Ács Kamilla

17 Medicinal use of psychoactive plants II.: Catha edulis I.

Dr. Ács Kamilla

18 Medicinal use of psychoactive plants II.: Catha edulis II.

Dr. Ács Kamilla

19 Medicinal use of psychoactive plants III.: Ephedraceae I.

Dr. Ács Kamilla

20 Medicinal use of psychoactive plants III.: Ephedraceae II.

Dr. Ács Kamilla

21 Medicinal use of psychoactive plants IV: Cannabis sativa indica I.

Dr. Ács Kamilla

22 Medicinal use of psychoactive plants IV: Cannabis sativa indica II.

Dr. Ács Kamilla

23 Legalization of psychoactive agents I.

Dr. Ács Kamilla

24 Illegal drugs in criminal investigations.

Dr. Ács Kamilla

25 Drug abuse and addiction I.

Dr. Ács Kamilla

26 Drug abuse and addiction II.

Dr. Ács Kamilla

27 Exam

Dr. Ács Kamilla

28 Exam

Dr. Ács Kamilla

Practices

Seminars


Topics include the lectures of the semester.


Participants


176

OPF-MMG-T NUCLEAR MAGNETIC RESONANCE IN DRUG DEVELOPMENT

Course director: DR. ZOLTÁN BERENTE, associate professor




Course headcount limitations (min.-max.): 3 – 20 Prerequisites: OPA-BA2 parallel + OPA-MAN parallel

Topic

The course provides an insight into the process of drug development through examples that involve nuclear magnetic resonance as an

analytical tool. The method is extensively applied at numerous different points of the process, due to its versatility.

The course will discuss, after a brief theoretical introduction, the study of structure determination and structure-activity relationship of

drug candidate molecules. In the second phase the course will discuss some (mostly in vivo) applications used for the investigation of

the efficacy of drug candidates in various animal models.



Mid-term exams

Presentation of a home project is required.


On the judgement of the course director.

Reading material


None


See Neptun Meet Street

- Notes

See Neptun Meet Street


R. A. de Graaf: In vivo NMR Spectroscopy, Wiley, 1998

N. Beckman: In vivo MR Techniques in Drug Discovery and Development, Taylor and Francis, 2006






Lectures

1 The NMR phenomenon, excitation and signal formation, relaxation

Dr. Berente Zoltán

2 Theory and practice of the Fourier-transform pulse NMR

Dr. Berente Zoltán

3 Basics of MR imaging

Dr. Berente Zoltán

4 MR methods in the drug development process

Dr. Berente Zoltán

5 Role of MR-based biomarkers in decision making during drug development

Dr. Berente Zoltán

6 Structure determination of small molecules using NMR

Dr. Berente Zoltán

7 Structure determination of biomolecules using NMR

Dr. Berente Zoltán

8 Structure-activity-relationships using NMR

Dr. Berente Zoltán







177

9 MR contrast agents

Dr. Berente Zoltán

10 MR studies of diabetes, obesity and inflammation models

Dr. Berente Zoltán

11 MR studies of stroke, MS and neurodegenerative disease models

Dr. Berente Zoltán

12 MR studies of preclinical tumor models

Dr. Berente Zoltán

13 MR studies of CV and lung disease models

Dr. Berente Zoltán

14 Project presentations

Dr. Berente Zoltán

Practices

Seminars


-


Participants


178

OPF-PNT-T PHARMACEUTICAL NANOTECHNOLOGY

Course director: Dr. Aleksandar SECENJI, senior research fellow




Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPG-GT1-T completed

Topic

Nanotechnology is a multidisciplinary discipline, which is the approach of the production of materials, structures, and systems, in which

the material is handled and produced in nanometers i.e. in a billionth of a meter. Pharmaceutical nanotechnology is the application of

nanotechnology in the pharmaceutical industry in life and health sciences and is base for the development of nanostructured modern drug

delivery systems for therapeutic purposes as well as advanced diagnostic biosensors dealing with early detection of diseases

The aim of the course is to provide a comprehensive picture of the application of nanotechnology in drug development and

pharmaceuticals. A brief introduction to the history, role, and impact of nanotechnology on state-of-the-art technologies. The properties

of specific physicochemical properties of nanomaterials can be explained by the well-known thermodynamic principles. Because of the

small size, the surface and the quantum effects play a prominent role, the theoretical basis of which is presented. Hereinafter, the

classification of nanoscale medicines and their detailed presentation will be presented.



Mid-term exams

1 written test


not needed

Reading material



- Notes


1. Nanotechnology in Drug Delivery, Melgardt M. de Villiers, Pornanong Aramwit, Glen S. Kwon, Springer, DOI: 10.1007/978-

0-387-77667-5

2. Pharmaceutical Nanotechnology: Fundamentals and Practical Applications, Costas Demetzos, ADIS, DOI 10.1007/978-981-

10-0791-0

3. Pharmaceutical Nanotechnology: Innovation and Production, Jean Cornier, Andrew Owen, Arno Kwade, and Marcel Van de

Voorde, WILEY-VCH, Print ISBN: 978-3-527-34054-5, ePDF ISBN: 978-3-527-80067-4

Lectures

1 Introduction to Nanotechnology

Dr. Secenji Aleksandar

2 Introduction to Nanotechnology


3 Theoretical basics of nanotechnology


4 Theoretical basics of nanotechnology


5 Drug nanocarriers classification


6 Drug nanocarriers classification


7 Inorganic nanostructures


8 Inorganic nanostructures



179

9 Organic nanostructures


10 Organic nanostructures


11 Pharmaceutical nanocrystals


12 Pharmaceutical nanocrystals


13 Matrix Systems


14 Matrix Systems


15 Porous systems


16 Porous systems


17 Binding, filling, trapping and releasing the drug from nanostructures


18 Binding, filling, trapping and releasing the drug from nanostructures


19 Hydrophobic drugs


20 Hydrophobic drug


21 Hydrophilic drugs


22 Hydrophilic drugs


23 Makromolecular drug carriers


24 Makromolecular drug carriers


25 Vesicular drug delivery systems


26 Vesicular drug delivery systems


27 Nano Emulsions, Pickering Emulsions


28 Nano Emulsions Pickering Emulsions


Practices

Seminars


1. Introduction to Nanotechnology

2. Theoretical basics of nanotechnology

3. Drug nanocarriers classification

4. Inorganic nanostructures

5. Organic nanostructures

6. Pharmaceutical nanocrystals

7. Matrix Systems

8. Porous systems

9. Binding, filling, trapping and releasing the drug from nanostructures

10. Hydrophobic drug

11. Hydrophilic drugs

12. Makromolecular drug carriers

13. Vesicular drug delivery systems

14. Nano Emulsions Pickering Emulsions


180


Participants


181

OPF-SNA-T CARBON NANOSTRUCTURES

Course director: DR. BEÁTA LEMLI, assistant professor




Course headcount limitations (min.-max.): 5 – 20 Prerequisites: OPG-GK1-T completed + OPG-R1E-T completed

Topic

Carbon is an indispensable element of life, thanks to the ability to form different chemical bonds with most elements of the periodic

table, enabling the creation of different and complex life forms. The discovery of the organic carbon compounds has been started in the

19th century, and now they are the part of our lives. Nowadays the previously discovered allotropes of carbon - fullerenes, carbon

nanotubes, graphenes, graphene nanoribbons - are in the focus, however, their real wide application still seems to be a big challenge and

needs further investigations. During this curse, students will be introduced to the promising pharmaceutical chemistry, medical and

biological applications of these materials and to the latest results of related research.



Mid-term exams

One written exam during the semester, the acceptance level is 60%. One oral presentation by students.


There is no possibility to make up for a missed lecture and practice

Reading material


Physical Biochemistry: Applications to Biochemistry and Molecular Biology (Life Sciences/Biochemistry) by David M. Freifelder,

2nd Edition, ISBN-13: 978-0716714446, ISBN-10: 0716714442


The slides of the lectures are electronically available.

- Notes


Physical Biochemistry: Applications to Biochemistry and Molecular Biology (Life Sciences/Biochemistry) by David M. Freifelder,

2nd Edition, ISBN-13: 978-0716714446, ISBN-10: 0716714442

Lectures

1 Introduction of the course requirements. Fullerenes, carbon nanostructure, graphene: their discovery, historical review

Dr. Lemli Beáta

2 Introduction of the course requirements. Fullerenes, carbon nanostructure, graphene: their discovery, historical review

Dr. Lemli Beáta

3 Preparation, synthesis, cleaning, general properties

Dr. Lemli Beáta

4 Preparation, synthesis, cleaning, general properties

Dr. Lemli Beáta

5 Covalent and non-covalent functionalization of carbon nanomaterials

Dr. Lemli Beáta

6 Covalent and non-covalent functionalization of carbon nanomaterials

Dr. Lemli Beáta

7 Cellular uptake mechanism of carbon nanotubes

Dr. Lemli Beáta

8 Cellular uptake mechanism of carbon nanotubes

Dr. Lemli Beáta

9 Carbon nanotube biodistribution

Dr. Lemli Beáta

10 Carbon nanotube biodistribution

Dr. Lemli Beáta


182

11 Application of carbon nanocapsules in drug delivery

Dr. Lemli Beáta

12 Application of carbon nanocapsules in drug delivery

Dr. Lemli Beáta

13 Carbon nanotubes applied for in vitro, in vivo and in silico drug delivery

Dr. Lemli Beáta

14 Carbon nanotubes applied for in vitro, in vivo and in silico drug delivery

Dr. Lemli Beáta

15 Carbon nanostructures and DNA

Dr. Lemli Beáta

16 Carbon nanostructures and DNA

Dr. Lemli Beáta

17 Novel strategies for cancer diagnosis and treatment

Dr. Lemli Beáta

18 Novel strategies for cancer diagnosis and treatment

Dr. Lemli Beáta

19 The toxicity of carbon nanomaterials

Dr. Lemli Beáta

20 The toxicity of carbon nanomaterials

Dr. Lemli Beáta

21 Outlook: about the nanomedicines and drug delivery nanosystems

Dr. Lemli Beáta

22 Outlook: about the nanomedicines and drug delivery nanosystems

Dr. Lemli Beáta


Dr. Lemli Beáta


Dr. Lemli Beáta

25 Written test.

Dr. Lemli Beáta

26 Written test.

Dr. Lemli Beáta

27 Summary and conclusions

Dr. Lemli Beáta

28 Summary and conclusions

Dr. Lemli Beáta

Practices

Seminars


The topics of the written test are similar to the topics of the lectures.


Participants


183

OPE-FM2-T DATA ANALYSIS 2



1 credit ▪ midsemester grade ▪ Elective subject ▪ autumn semester ▪ recommended semester: 7


Course headcount limitations (min.-max.): 1 – 12 Prerequisites: OPE-FMA parallel


Topic

The goal of this course is to help students to prepare for thesis writing or making their own student research project. It covers two fields

of that job: the practice of data collection and prepare data for the analysis as well as the performing the analysis based on the preliminary

analysis plan. Shortly to say: How to perform the data collection and analysis of your own study project. (This course can be the

continuation of the ‘Data analysis 1’ course however someone can complete these two courses on a reversed order as well. The main

reason of this flexibility is, that many students are asking for help when they have already had their data at hands (at least partially), and

this course is processing the steps from this point of the job. Even though, it is beneficial for the students doing this course first to

complete the Data analysis 1 course later. They can do it next year for example - so to understand the preliminary steps of a research

work: How to make a research plan?)

This course is also based on the medical papers. Students may pick the appropriate data collection methods and recognize the critical

points of this process based on the most fundamental papers of their own research field. They can learn from the most rewarded experts

on this way. From a paper you may extract the principles as well as you can follow immediately the realization. It is an excellent way to

learn the methodology. You may even learn from the errors.

The same way is followed for the data analysis and making conclusions. Every student will do his/her own data analysis based on their

own plan.

Students will have all help to the practical evaluation of their own data and making the right conclusion. The steps and results will be

discussed and improved by a class discussion.


Maximum 1 lesson absence.

Mid-term exams

Evaluate your data step by step and present it to the group weekly.


One extra class

Reading material


1-3 medical papers brought by each student (from library, from your department or from the tutor of your thesis).


Supporting materials (papers, posters, research reports, ...) supplied by the tutor of the classes.

- Notes


Any statistical books.

Lectures

1 Introduction. Find a paper to process. Prepare or present your own data collection plan.

Dr. Pótó László

2 The realization of the data collection - examples are based on papers

Dr. Pótó László

3 The preliminary data preparations for the following statistical analysis.

Dr. Pótó László

4 Do your own statistical analysis 1 - select the right methods

Dr. Pótó László

5 Do your own statistical analysis 2 - interpret the results.

Dr. Pótó László

6 Make your conclusion and share the results with the others.

Dr. Pótó László

7 Summary. Consolidation and evaluation of the results.

Dr. Pótó László


184

Practices

1 Find a paper to process. Work on your own data collection plan.

2 Present the realization of the data collection - based on selected papers

3 Share your experiences on your preliminary data preparations - make corrections if needed.

4 Present your own statistical analysis 1 - methods and results 1

5 Continue - methods and results 2

6 Make your conclusion and share the results with the others.

7 Overview and summarize the results of the class.

Seminars


Evaluate your data and submit your own results based on your active participation.


Participants



185

OPE-FMA-T DATA ANALYSIS 1



1 credit ▪ midsemester grade ▪ Elective subject ▪ autumn semester ▪ recommended semester: 7




Topic

The goal of this course is to help students to prepare for thesis writing or making their own student research project. It covers mainly two

fields of that: read and interpret scientific papers and prepare an own study plan. Shortly to say: How to prepare for your own study

project.

Block One: The medical papers are likely the most important source to improve your present knowledge as a student and as an

MD. Most of these ‘original papers’ are based on carefully planned data collection and evaluation applying a wide array of statistical

methods. It is essential to be familiar with this methodology so to understand these papers. But you may learn these steps and methods

from the papers since all are based on the rules of designing scientific research projects. From a paper you may extract the principles as

well as you can follow immediately the realization. It is an excellent way to learn the methodology. You may even learn from the errors.

Block Two: Apply all these for your own research: make a study plan. It should include your study goal the extent and way of

your data collection the preliminary data processing the way of data analysis and the way of conclusion making.

Based on this outline you will prepare your own study design on your own student’s research work or on your thesis job. If you have no

such project at the moment you may construct an own „sample study plan” that can be a working model for your future thesis work. You

will have all help to find your own project and complete the plan in the practice if you need. All of your personal design elements will

be discussed and improved by a class discussion.

The practical realization of your study will be supported by the Data analysis 2 course.


Maximum 1 lesson absence.

Mid-term exams

Prepare and submit your own study plan step-by-step and present sortly weekly to the group - based on your active participation.


One extra class

Reading material


1-3 medical papers brought by each student (from library, from your department or from the tutor of your thesis).


Other supporting materials supplied by the tutor of the classes.

- Notes


Any statistical books on study design and data analysis.

Lectures

1 Introduction. Find a paper to process. Find your own study.

Dr. Pótó László

2 The goal of your study - based on a demo paper

Dr. Pótó László

3 The main- and ‘sub-’hypotheses of the study.

Dr. Pótó László

4 Finding your sample frame - based on your hypotheses.

Dr. Pótó László

5 The research design and the methods of the data collection. How many data should be collected?

Dr. Pótó László

6 Creating the plan of the data analysis.

Dr. Pótó László

7 The complete study plan.

Dr. Pótó László


186

Practices

1 Introduction. Overview of some sample papers.

2 The goal of your study - processing a few papers brought and presented by students.

3 Setting the study hypotheses. Further analysis of the papers.

4 Which data should you collect and how to do that.

5 Finalize the plan of your data collection.

6 Make a plan of the data processing.

7 Create, present and discuss of your study plan.

Seminars


Preparation of the study plan


Participants



187

OPE-SHK-T DESIGN AND INDUSTRIAL MANUFACTURE OF MEDICINES





Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPG-BFM completed + OPG-GT2 completed

Topic

During the course, the process of the design of modified drug delivery systems is acquired by the students based on the theory and

practice of biopharmaceutical including examinations of dosage forms. The course consists of theoretical lectures and seminars.


- participation on the lectures

- accepted work reports

- accepted written assessments

Mid-term exams

Students have to write an end-semester assessment from the lectures at acceptance level of 60%.


Students must fulfil requirements determined by the Code of Studies and Examinations. Student has make up for the missed lectures and

work reports.

Reading material



- Notes


Leon Shargel, A. B.C. Yu, Stamford: Applied Biopharmaceutics and Pharmacokinetics

Susanna Wu-Pong, Yon Rojanasakul: Biopharmaceutical Drug Design and Development, Humana Press

Gilbert S. Banker, Christopher T. Rhodes: Modern Pharmaceutics, Marcel Dekker Inc., New York- Basel

Michael J. Rathbone, Michael S. Roberts: Modified-Release Drug Delivery Technology, Informa Healthcare

Michael E. Aulton: The Design and Manufacture of Medicines, Churchill Livingstone

Lectures

1 Floating drug delivery, Targeted Drug Delivery Systems

Dr. Pál Szilárd


Dr. Pál Szilárd


Dr. Pál Szilárd


Dr. Pál Szilárd

5 Introduction of modified drug delivery

Dr. Kása Péter


Dr. Kása Péter


Dr. Kása Péter


Dr. Kása Péter

9 Targeted Drug Delivery Systems



188




Dr. Pál Szilárd


Dr. Pál Szilárd

13 Pulsative Drug Delivery Systems

Dr. Pál Szilárd


Dr. Pál Szilárd


Dr. Pál Szilárd


Dr. Pál Szilárd

17 Dissolution, lecture and practice

Ámanné Dr. Takácsi-Nagy Anna


Ámanné Dr. Takácsi-Nagy Anna


Dr. Pál Szilárd


Dr. Pál Szilárd

21 From molecule to the preparition

Dr. Kása Péter


Dr. Kása Péter


Dr. Pál Szilárd


Dr. Pál Szilárd

25 Test

Dr. Pál Szilárd

26 Test

Dr. Pál Szilárd

27 Assessment

Dr. Pál Szilárd

28 Assessment

Dr. Pál Szilárd

Practices

Seminars


Students can get the test topics in the institute or download the from website of the institute.


Participants

Dr. Dévay Attila (DEAHABO.PTE), Dr. Pál Szilárd (PASMAAO.PTE)


189

OPE-T2F-T PHARMACEUTICAL BIOTECHNOLOGY AND ITS LINKS TO BIOPHARMACEUTICALS






Topic

The aim of this course is to introduce students to the science of pharmaceutical biotechnology and its links to biopharmaceuticals.



Mid-term exams

Writing test



Reading material



- Notes

Lecture notes, lecture materials available on MeetStreet


Lectures

1 Pharmaceuticals, biologics and biopharmaceuticals - link to Biotechnology. An introduction.


2 Protein structure and its importance of engineering biopharmaceuticals


3 Gene manipulation and recombinant DNA technology 1: Nucleic acid manipulation


4 Gene manipulation and recombinant DNA technology 2: Recombinant production of therapeutic proteins.


5 Gene manipulation and recombinant DNA technology 3: Nucleic acid manipulation.


6 Biotechnological methodology in drug development 1

Dr. Pongrácz Judit


Dr. Pongrácz Judit


Dr. Pongrácz Judit

9 Sources and upstream processing 1

Dr. Pongrácz Judit

10 Sources and upstream processing 2

Dr. Pongrácz Judit

11 Downstream processing 1

Dr. Járomi Luca

12 Downstream processing 2

Dr. Járomi Luca

13 Product analysis

Dr. Járomi Luca

14 The cytokines: the interferon family

Dr. Járomi Luca

15 Cytokines: Interleukin and tumor necrosis factor

Dr. Járomi Luca


190

16 Growth factors

Dr. Pongrácz Judit

17 Therapeutic hormones

Dr. Pongrácz Judit

18 Recombinant blood proteins and therapeutic enzymes

Dr. Pongrácz Judit

19 Antibodies in diagnostics and therapy

Dr. Pongrácz Judit

20 Vaccines and adjuvants

Dr. Pongrácz Judit

21 Vaccine production

Dr. Pongrácz Judit

22 Nucleic acid-based therapeutics. Gene therapy.


23 Nucleic acid-based therapeutics. Recombinant viruses in cancer therapy.

Dr. Pongrácz Judit

24 Cell-based therapeutics


25 Test systems for toxicology

Dr. Járomi Luca

26 Test systems for efficacy

Dr. Járomi Luca

27 Nanotechnology

Dr. Pongrácz Judit

28 Legal aspects of healthcare-related Biotechnology

Dr. Pongrácz Judit

Practices

1 Principals of gene cloning - using the NCBI database

2 Cloning a specific gene - a practical approach 1



5 Culturing organisms for protein production

6 Culturing organisms for protein production

7 Selection and application of organisms for protein production

8 Protein purification for therapeutic application 1

9 Protein purification for therapeutic application 2

10 Technical approach for monoclonal antibody production 1

11 Technical approach for monoclonal antibody production 2

12 Testing toxicity using methodology of biotechnology

13 Efficacy testing using methodology of biotechnology

14 Nanotechnological methods

Seminars


MeetStreet


Participants

Dr. Járomi Luca (JALGAAT.PTE), Dr. Kvell Krisztián (KVKFAAO.PTE)


191

OPF-KIA-T ESSENTIAL OILS AND CLINICAL AROMATHERAPY





Course headcount limitations (min.-max.): 3 – 50 Prerequisites: OPG-FG1 completed + OPG-FG2 completed

Topic

Essential oils (EOs) are very interesting natural products and among other qualities they possess various biological properties. The term

biological comprises to all activities that these mixtures of volatile compounds (mainly mono- and sesquiterpenoids, phenylpropanoids,

etc.) exert on humans. EOs are used for their therapeutic action, for flavouring, in perfumery, or as starting materials for the synthesis of

other compounds. For therapeutic purposes they are administered as inhalations (e.g. eucalyptus oil), orally (e.g. peppermint oil) and

transdermally (e.g. rosmary oil). Oils with a high phenol content, for instance thyme and clove, have antiseptic properties, whereas others

are used as carrminatives. Oils showing antispasmodic activity, and much used in popular medicine, are those of melissa, peppermint,

chamomile, fennel, caraway and orange. Furthermore, in traditional medicine, EOs are also well-known for their analeptic, antimicrobial,

antinociceptive, antiphlogistic, antioxidative and sedative activities. All terpenoids easily enter the human body by oral absorption,

penetration through the skin, or inhalation very often leading to measurable blood concentrations. The aim of this course is to introduce

the most important medicinal plants containing essential oils and their medicinal role in the therapy and the clinical aromatherapy. We

would like to highlight their appropriate use, their profiles, but to call students’ attention to the cautions and contraindications of EOs, as

well.



Mid-term exams

Two written exams during the semester, acceptance of them from 60%.



Reading material



PowerPoint presentations prepared by lecturers.

- Notes


1. Evans W.C.: Trease and Evans Pharmacognosy, Saunders, London, New York, 2000

2. Tisserand R., Balacs T.: Essential Oil Safety: A Guide for Health Care Professionals, Churchill Livingstone, 1995

3. Tisserand R., Young R: Essential Oil Safety: A Guide for Health Care Professionals, Second edition, Churchill Livingstone, 2013

Baser C.H, Buchbauer G.: Handbook of Essential Oils. Science, Technology and Application. CRC Press, Boca Raton, 2010

Lectures

1 Introduction of the course requirements. Definition of aromatherapy and clinical aromatherapy.


2 Advantages and disadvantages of the application of essential oils.


3 History of the use of essential oils.


4 Biological activities of essential oils.


5 Sources of essential oils.


6 Chemistry of essential oils. Chemical composition of essential oils.



192

7 Extraction techniques of essential oils: water-steam distillation, enfleurage, expression, supercritical fluid extraction. Gas

chromatographic analysis of essential oils.


8 Extraction techniques of essential oils: water-steam distillation, enfleurage, expression, supercritical fluid extraction. Gas

chromatographic analysis of essential oils.


9 Drugs containing essential oils in the European Pharmacopoeia and in the ESCOP Monograph.


10 Quality of essential oils according to the official Pharmacopoeias.


11 External application of essential oils.


12 The most important base oils.


13 Physiological effects of essential oils. Metabolism of essential oil components in animal models and humans.


14 Contraindications.


15 Written test I


16 Written test I


17 Antimicrobial activity of essential oils. In vitro methods.


18 Antimicrobial activity of essential oils. In vivo methods.


19 Description of essential oils I: their main components and medicinal use. Peppermint oil, lemon oil, citronella oil, pine oil,

lavender oil.


20 Description of essential oils I: their main components and medicinal use. Peppermint oil, lemon oil, citronella oil, pine oil,

lavender oil.


21 Description of essential oils II: their main components and medicinal use. Clary sage oil, rosemary oil, tea tree oil, clove oil,

thyme oil, chamomile oil.


22 Description of essential oils II: their main components and medicinal use. Clary sage oil, rosemary oil, tea tree oil, clove oil,

thyme oil, chamomile oil.


23 Description of essential oils II.: their main components and medicinal use. Cinnamon oil, bitter and sweet orange oil, anise oil,

carraway oil, eucalyptus oil, sweet fennel oil, spearmint oil.


24 Description of essential oils II.: their main components and medicinal use. Cinnamon oil, bitter and sweet orange oil, anise oil,

carraway oil, eucalyptus oil, sweet fennel oil, spearmint oil.


25 Safety guidelines of essential oils.


26 Safety guidelines of essential oils.


27 Written test II


28 Written test II


Practices

Seminars


There is no list. The questions of the written test is similar to the lecture topics.


193


Participants


194

OPF-XES-T THE FATE OF DRUG

Course director: Dr. Orsolya RIDEG, research associate professor




Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPG-GK1-T completed

Topic

By the end of the course, the students get an outlook on the history and basics of genetics and pharmacogenetics.They get an outlook on

the newest methodical aspects of genetic variants and enzyme function. By discussing certain clinical cases (mostly clinical cases from

the central nervous system, pulmonology, and hepatology) students get an outlook on the importance and complexity of the area.



Mid-term exams

One test at the end of the course.


No option for supplement.

Reading material



Educational material in PDF

- Notes


Genetic Variation: Methods and Protocols; Barnes Michael R.; Springer

Concepts and tools in Pharmacogenomics - FDA

Principles of Pharmacogenetics and Pharmacogenomics; Rus B. Altman;Cambridge

Lectures

1 Basics on Genetics and Pharmacology, History of Pharmacogenetics

Dr. Rideg Orsolya

2 Basics on Genetics and Pharmacology, History of Pharmacogenetics

Dr. Rideg Orsolya

3 Biotransformation; Phase I enzymes: focusing on the liver (function, genetic, case studies)

Dr. Rideg Orsolya

4 Biotransformation; Phase I enzymes: focusing on the liver (function, genetic, case studies)

Dr. Rideg Orsolya

5 Biotransformation; Phase II enzymes: focusing on the liver (function, genetic, case studies)

Dr. Rideg Orsolya

6 Biotransformation; Phase II enzymes: focusing on the liver (function, genetic, case studies)

Dr. Rideg Orsolya

7 Expression and regulation of xenobiotic Metabolizing Cytochrome P450 Enzymes in the Central Nervus System

Dr. Rideg Orsolya

8 Expression and regulation of xenobiotic Metabolizing Cytochrome P450 Enzymes in the Central Nervus System (case study)

Dr. Rideg Orsolya

9 Expression and regulation of xenobiotic Metabolizing Cytochrome P450 Enzymes in the Lung

Dr. Rideg Orsolya

10 Expression and regulation of xenobiotic Metabolizing Cytochrome P450 Enzymes in the Lung (case study)

Dr. Rideg Orsolya

11 Role of CYP genepolymorphisms’ in neurological and cardiological diseases.

Dr. Rideg Orsolya


195

12 Methodical aspects of genetic variants

Dr. Rideg Orsolya

13 Methodical aspects of enzyme function.

Dr. Rideg Orsolya

14 Test

Dr. Rideg Orsolya

Practices

Seminars


-


Participants


196

OPE-FAJ-T PAIN AND ANALGESICS

Course director: DR. GÁBOR PETHŐ, professor




Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPG-GH1 completed


Topic

The aim of the course is to give an integrative overview on the physiological, pathophysiological and pharmacological aspects of pain.

Major tasks are to (i) provide information on peripheral and central mechanisms of pain and hyperalgesia; (ii) describe the major features

of existing analgesics including opioids, non-steroidal antiinflammatory agents and adjuvant analgesics; (iii) outline novel targets for

development of analgesic drugs. The course will also help students prepare for the exams in Pharmacology 2 and 3.



Mid-term exams

After the last lecture of the course, a written test is taken in the instruction period to obtain a mid-semester grade. Those who fail or do

not write this test have a second chance in the instruction period to improve in form of an oral conversation. Upon failing or missing

there is one more oral chance to obtain a mid-semester grade during the first two weeks of the exam period.


There is no way to make up for missed lectures.

Reading material


None.


The material of the lectures is available in PDF format in the Neptun.

- Notes

None.


None.

Lectures

1 Basic terms related to pain and nociceptors

Dr. Pethő Gábor

2 Features of capsaicin-sensitive nociceptors

Dr. Pethő Gábor

3 Peripheral mechanisms of hyperalgesia

Dr. Pethő Gábor

4 Central mechanisms of hyperalgesia and allodynia

Dr. Pethő Gábor

5 Features of neuropathic pain

Dr. Pethő Gábor

6 Pharmacology of opioid analgesics I

Dr. Pethő Gábor

7 Pharmacology of opioid analgesics II

Dr. Pethő Gábor

8 Pharmacology of non-steroidal antiinflammatory analgesic drugs II

Dr. Pethő Gábor

9 Pharmacology of non-steroidal antiinflammatory analgesic drugs II

Dr. Pethő Gábor

10 Adjuvant analgesics

Dr. Pethő Gábor


197

11 New targets for development of analgesics I

Dr. Pethő Gábor

12 New targets for development of analgesics II

Dr. Pethő Gábor

Practices

Seminars


No exam questions are given. The essay questions of the written exam are based on the material presented.


Participants


198

OPE-MGT-T PHARMACEUTICAL TECHNOLOGY OF MODIFIED DRUG RELEASE





Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPG-GT4 parallel

Topic

Students can get acquainted in details with modified drug delivery technologies and special industrial drug manufacture (3D printing,

manufacture of multi-layer tablets and osmotic preparations) and the importance of pharmaceutical excipients. Student will learn special

manufacturing technologies through the demonstration of dosage forms already available in the pharmaceutical therapy.



Mid-term exams

During the end semester test 60 % should be reached.



Reading material



- Notes


James Swarbrick: Encyclopedia of Pharmaceutical Technology, Informa Healthcare, 2011

Lectures

1 Theory of modified drug release

Dr. Pál Szilárd

2 Importance of excipients, patents of excipient-compositions

Dr. Kása Péter

3 Immediate drug-release (OraSolv, DuraSolv, Zydis technology)

Dr. Pál Szilárd

4 Sustained drug-release: Multiparticulate dosage forms I. (sustained release pellets in practice)

Dr. Pál Szilárd

5 Multiparticulate dosage forms II. (MUPS technology)

Dr. Pál Szilárd

6 Matrix systems I. (hydrophilic matrices)

Dr. Pál Szilárd

7 Matrix systems II. (hydrophobic matrices)

Dr. Pál Szilárd

8 Osmotic technology (EOP, OROS, L-OROS, GITS)

Dr. Pál Szilárd

9 Geometry based drug-release (Geomatrix, Procise, Smartrix technology)

Dr. Kása Péter

10 Chronotherapeutic systems (Geoclock technology)

Dr. Pál Szilárd

11 Parenterally administered modified drug delivery

Dr. Pál Szilárd

12 Site specific drug release (gastroretentive systems, colon-specific drug delivery)

Dr. Pál Szilárd

13 Halving of tablets, technology of halving-friendly tablets, concept of ,,ghost” tablets

Dr. Kása Péter

14 End-year test

Dr. Pál Szilárd


199

Practices

Seminars


http://gytk.pte.hu


Participants

Dr. Kása Péter (ISWPRM), Dr. Pál Szilárd (PASMAAO.PTE)

http://gytk.pte.hu/


200

OPF-GTH-T GENE THERAPY

Course director: DR. GÉZA SÁFRÁNY, visiting professor

Institute of Laboratory Medicine




Topic

We wish to give a short overview about the present state of gene therapy, the current ongoing clinical trials and the potential side effects

of gene therapy and about the ethical considerations. The various viral and non-viral gene delivery protocols suitable for high efficiency

gene delivery both under in vitro and in vivo conditions will be discussed in details. Gene therapy protocols applied in the treatment of

malignant diseases will be presented together with the results of ongoing clinical trials. We will talk about the results and the potentials

of the treatments of inherited genetic disorders. One of the most promising field of the current clinical trials is the treatment of ischemic

diseases, the results will be presented. The potential applications of stem cells during gene therapy will be described, as well. Finally, we

will discuss the side effects occurring during gene therapy and the ethical considerations will also be mentioned.



Mid-term exams

Test


Joining later lectures, individual consultations.

Reading material


1. Kelly K. Hunt, Stephan A. Vorburger and Stephen G. Swisher (ed.): Gene Therapy for Cancer, 2007 Humana Press Inc. 999

Riverview Drive, Suite 208 Totowa, New Jersey 07512

2. Thomas F. Kresina (ed.): Introduction to Molecular Medicine and Gene Therapy, 2001 by Wiley-Liss, Inc. ISBNs: 0-471-39188-

3 (Hardback); 0-471-22387-5 (Electronic)


1. Sáfrány G.: A génterápia génsebészeti alapjai és jelenlegi helyzete, A Genom (ed.: Hídvégi EJ), Budapest, Széphalom

Könyvműhely 2003, pp 187-204

2. Sáfrány G.: A vasculáris génterápia és a csontvelőőssejt-terápia, Atherosclerosis (ed.: Császár A.), Budapest, Synergo Kiadó,

2004 pp 336-344

- Notes


http://www.genetherapynet.com/clinicaltrialsgov.html

http://www.bioportfolio.com/cgi-bin/acatalog/Human_Gene_Therapy_Course.html

http://openlearn.open.ac.uk/course/view.php?id=2430

Lectures

1 Introduction to gene therapy, ongoing clinical trials

Dr. Sáfrány Géza

2 Gene delivery protocols, viral vectors applied in gene therapy

Dr. Sáfrány Géza

3 Targeted gene delivery and targeted gene expression

Dr. Miseta Attila

4 Gene therapy of HIV

Dr. Sáfrány Géza

5 Application of dendritic cells in gene therapy

Dr. Sáfrány Géza

6 Gene directed enzyme pro-drug therapy of malignant diseases

Dr. Sáfrány Géza

7 Immune therapy of malignant diseases

Dr. Sáfrány Géza

http://www.genetherapynet.com/clinicaltrialsgov.html

http://www.bioportfolio.com/cgi-bin/acatalog/Human_Gene_Therapy_Course.html

http://openlearn.open.ac.uk/course/view.php?id=2430


201

8 Radiation-driven gene therapy of malignant disease

Dr. Sáfrány Géza

9 Stem cells in gene therapy

Dr. Sáfrány Géza

10 Treatment of immune-deficiencies with gene therapy

Dr. Sáfrány Géza

11 Gene therapy of ischemic diseases

Dr. Sáfrány Géza

12 Gene therapy of cystic fibrosis

Dr. Miseta Attila

13 Gene therapy of thalassemia

Dr. Sáfrány Géza

14 Oncolytic viruses in tumor therapy

Dr. Sáfrány Géza

Practices

Seminars


Multiple choice tests for checking the acquisition of course material is given at the end of semester. Questions include material discussed

in lectures and seminars.


Participants


202

OPF-IVF-T INFECTIONS AND IMMUNITY

Course director: DR. JÚLIA BARTHÓ-SZEKERES, professor




Course headcount limitations (min.-max.): 2 – 25 Prerequisites: OPO-IMM completed + OPO-MI1 completed


Topic

The importance of anti-infectious immunity is not restricted to elimination of pathogens, but is also responsible for long lasting protection,

as well as -in some cases- immunopathological disorders



Mid-term exams

Continuous


Consultation

Reading material



Lecture slides

- Notes


1. H. Chapel, M. Haeney, N. Misbah, Snowden: Clinical Immunology, Blackwell, 2008

2. S. Kartikeyan, R.N. Bharmal, R.P. Tiwari, and P.S. Bisen: HIV and AIDS: Basic Elements and Priorities, 2007

3. T. Platts-Mills and Johannes Ring: Allergy in Practice, 2003

Lectures

1 Non-specific defence. Surface barriers, normal colonizing flora, phagocytosis, complement system.

Dr. Barthóné Dr. Szekeres Júlia

2 Non-specific defence. Surface barriers, normal colonizing flora, phagocytosis, complement system.


3 Antigen presentation and recognition. Dendritic cells, pattern recognition receptors.


4 Antigen presentation and recognition. Dendritic cells, pattern recognition receptors.


5 Defence against extracellular microorganisms. The role of immunoglobulin classes. Mucosal immunity.


6 Defence against extracellular microorganisms. The role of immunoglobulin classes. Mucosal immunity.


7 Defence against intracellular microorganisms. Defence against viral infections. Viruses and immunosuppression.


8 Defence against intracellular microorganisms. Defence against viral infections. Viruses and immunosuppression.


9 Defence against parasitic infections. Micro-and macroparasite infections that polarize the immune response.


10 Defence against parasitic infections. Micro-and macroparasite infections that polarize the immune response.


11 Evasion and use of the innate and adaptive immune responses by microorganisms.


12 Evasion and use of the innate and adaptive immune responses by microorganisms.



203

13 Healing of infectious diseases. The pathogenic role of anti-infectious immunity; local inflammation, systemic inflammation,

sepsis, endotoxin shock, toxic shock syndrome.


14 Healing of infectious diseases. The pathogenic role of anti-infectious immunity; local inflammation, systemic inflammation,

sepsis, endotoxin shock, toxic shock syndrome.


15 The pathogenic role of anti-infectious immunity; hypersensitivity reactions in bacterial-parasitic and fungal infections.


16 The pathogenic role of anti-infectious immunity; hypersensitivity reactions in bacterial-parasitic and fungal infections.


17 Induction of autoimmunity; molecular mimicri, epitope spreading, polyclonal T or B cell activation.


18 Induction of autoimmunity; molecular mimicri, epitope spreading, polyclonal T or B cell activation.


19 Immunopathological alterations following viral infections. The involvement of CD8+ T cells.








23 Immunopathological alterations following viral infections. The involvement of antibodies.


24 Immunopathological alterations following viral infections. The involvement of antibodies


25 Vaccination; Type of vaccines, requirements for vaccines.


26 Vaccination; Type of vaccines, requirements for vaccines.


27 Vaccination; rational vaccine development, mandatory vaccines.


28 Vaccination; rational vaccine development, mandatory vaccines.


Practices

Seminars


The same as lecture topics


Participants


204

OPE-GSI-T PHARMACEUTICAL INFORMATICS

Course director: DR. LAJOS BOTZ, professor

Department of Pharmaceutics and University Pharmacy



Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPG-GI3-T completed

Topic

Students will become familiar with pharmaceutical databases, IT communication systems and drug management software applications.

Pharmaceutical IT methods such as telemedicine, or Internet pharmacies will be also covered in lectures. Lectures will give students

insight into ethical and legal aspects of information sources, and their critical evaluation. The aim of the lectures is to consolidate the

pharmaceutical IT skills of students. Students will be equipped with up-to-date pharmaceutical IT skills: use of databases and Internet

information sources.

During the semester the students will become familiar with the basics of personal computer and network systems is general and with the

specifications of pharmaceutical informatics, such as the development and stages of pharmacy informatics, principles of pharmacy

softwares. Also the different software types and drug dispensing rules used in pharmacies are introduced in this semester. The basic

knowledge of drug interactions and the available techniques and databases for screening interactions in everyday practice is also an

emphasized topic. After acquiring the principles of informatics and pharmaceutical informatics the students will be able to synthesize the

elements and understand the functions of pharmacy information management systems. Even the possibilities and threats of online drug

marketing and the capability of finding relevant and authentic pharmaceutical information on the web is the objective of this course.


Acceptance of term/semester (requirements of registration for the exam):

- Regular attendance of classes/lectures (maximum 25 % of absence is accepted),

- Assignments given in class should be carried out during term-time and,

- The mid-term and end-of-the-term test(s) should be passed (60,1%, minimum grade 2).

End-of-semester grade is given by end-of-the-term test’s result, any tests written throughout the semester and student performance during

the semester.

Examination and granting of grades: for Pharmaceutical Informatics grade (midterm grade) is given based on mid-term and end-of-the-

term test results.

Mid-term exams

Retake opportunity is possible following personal discussion.


Retake opportunity is possible following personal discussion.

Reading material



List of study aids to acquire curriculum (books, notes, other) and all presentations can be downloaded from Neptun Meet Street.

- Notes


Ed. R. Fisher: Information Technology for Pharmacists, Pharmaceutical Press

Brent I. Fox, Margaret R. Thrower, Bill G. Felkey: Building Core Competencies in Pharmacy Informatics, American Pharmacists

Association, 2010

Lectures

1 Personal computer and network system fundamentals 1.

Dr. Vida Róbert György

2 Personal computer and network system fundamentals 2.


3 Database systems, IT and search engines 1.


4 Database systems, IT and search engines 2.



205

5 Drug interactions, Drug interaction databases 1.

Dr. Végh Anna


Dr. Végh Anna


Dr. Végh Anna


Dr. Végh Anna

9 Pharmaceutical Information Management Systems 1.

Dr. Fittler András Tamás







Practices

1 Evidence Based Medicine - Critical Appraisal.

2 Evidence Based Medicine: Outcome Measures.

3 Evidence Based Medicine: Calculations.

4 Evidence Based Medicine: Interpretation of results. Practice

5 Kaposi Mór Oktató Kórház visit




9 Retail Pharmacy software: features and structure of professional pharmaceutical systems.

10 Pharmaceutical software for the follow-up of work procedures (compounding, drug manufacturing).

11 Application of professional pharmaceutical software interfaces for the improvement of medication of patients (filtering of

endangered patient groups and drug interactions).

12 Pharmacy software for the follow-up of work procedures: (management, accounting of prescriptions).

Seminars


Based on the topics of the lectures and seminars.


Participants

Dr. Botz Lajos (BOLFAAP.PTE), Dr. Fittler András Tamás (FIAQAAK.PTE), Dr. Végh Anna (VEAOABO.PTE), Dr. Vida Róbert

György (VIRNAAO.PTE)


206

OPE-GST-T SPECIAL FIELDS OF PHARMACOLOGY

Course director: DR. GÁBOR PETHŐ, professor




Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPG-GH1 completed


Topic

The aim of the course is to present those fields of pharmacology that are not covered at all or only partially discussed in the compulsory

courses Pharmacology 1-2-3 because of time limits. These are the following: use of drugs during pregnancy and lactation; significance

of pharmacogenomics in therapy and drug development, pharmacology of retinoids; other drugs used in dermatology; special aspects of

drugs used in urology; use of meta-analysis in evaluation of drugs, clinical significance of basic pharmacodynamic and pharmacokinetic

parameters; special aspects of drugs used by inhalation, basics of chronopharmacology; pharmacology of contrast media, drugs and

chirality. The course wishes to contribute to a better understanding of the use of drugs in the clinical practice and may help students

prepare for the pharmacology exams.



Mid-term exams

After the last lecture of the course, a written test is taken in the instruction period to obtain a mid-semester grade. Those who fail or do

not write this test have a second chance in the instruction period to improve in form of an oral conversation. Upon failing or missing

there is one more oral chance to obtain a mid-semester grade during the first two weeks of the exam period.


There is no way to make up for missed lectures.

Reading material


None.


The material of the lectures is available in PDF format in the Neptun.

- Notes

None.


None.

Lectures

1 Special aspects of use of drugs during pregnancy and lactation

Dr. Pethő Gábor

2 Significance of pharmacogenomics in therapy and drug development

Dr. Pethő Gábor

3 Use of meta-analysis in evaluation of drugs

Dr. Pethő Gábor

4 Drugs and chirality

Dr. Pethő Gábor

5 Clinical significance of pharmacodynamic and pharmacokinetic parameters on the example of drugs used in respiratory diseases I

Dr. Pethő Gábor

6 Clinical significance of pharmacodynamic and pharmacokinetic parameters on the example of drugs used in respiratory diseases II

Dr. Pethő Gábor

7 Pharmacology of retinoids

Dr. Pethő Gábor

8 Drugs (other than retinoids) used in dermatology

Dr. Pethő Gábor


207

9 Urological pharmacology I

Dr. Pethő Gábor

10 Urological pharmacology II

Dr. Pethő Gábor

11 Pharmacology of contrast media

Dr. Pethő Gábor

12 Basics of chronopharmacology

Dr. Pethő Gábor

Practices

Seminars


No exam questions are given. The essay questions of the written exam are based on the material presented.


Participants


208

OPF-SUO-T EMERGENCY MEDICINE

Course director: DR. ZSÓFIA VERZÁR, associate professor

Department of Emergency Medicine



Course headcount limitations (min.-max.): 5 – 150 Prerequisites: OPO-KL1 completed


Topic

It is a basic requirement to initialize the aspect of proper emergency care for those who do not take part in emergency medicine. The aim

is getting closer to the purpose of care, decrease of avoidable death rates, prevention of organ failure, avoidance of disability, relief of

suffering and pain.


Test exam.

Mid-term exams

-


Personal communication with the tutors.

Reading material


R. Aghababian: Essentials of Emergency Medicine, 2nd edition


- Notes


Lectures

1 Patient examination according to ABCDE

Dr. Gaál Ildikó

2 Resuscitacion

BLS, ALS, EPLS

Dr. Gaál Ildikó

3 Cardiovascular diseases

Dr. Verzár Zsófia

4 Cardiovascular diseases

Dr. Verzár Zsófia

5 Differential diagnosis of limb pain

Dr. Bóna Ernő

6 Pediatric emergency care

Dr. Bóna Ernő

7 Toxicology

Environmental diseases

Dr. Varga Szilárd

8 Toxicology

Environmental diseases

Dr. Varga Szilárd

9 Emergency care in neurology

Dr. Bóna Ernő

10 Acut psychiatric disorders

Dr. Bóna Ernő

11 Trauma care (ETC), Burns

Dr. Gaál Ildikó

12 Trauma care (ETC), Burns

Dr. Gaál Ildikó


209

13 Acute abdomen, Abdominal pain

Dr. Verzár Zsófia

14 Acute abdomen, Abdominal pain

Dr. Verzár Zsófia

Practices

Seminars


Website of Emergency Medicine, University of Pécs.


Participants

STUDY PROGRAM 2018/2019 Elective and Optional...

Documents

Transcript of STUDY PROGRAM 2018/2019 Elective and Optional...