Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) •...

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Structure of Plasma membrane

Transcript of Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) •...

Page 1: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Structure of Plasma membrane

Page 2: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together
Page 3: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Lipids in Plasma membrane

Page 4: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Lipid Functions in Plasma membrane

Page 5: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together
Page 6: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Movements of lipid molecules

Page 7: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Movements of lipid molecules

Page 8: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Cholesterol in plasma membranes

Page 9: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

• Increase firmness and integrity of cell membrane (50% of Cell membrane structure)

• cholesterol helps to separate phospholipids, so the fatty acid chains can't come together and crystallize

Helps preventing extremes and maintaining consistency of

membrane

Cholesterol in plasma membranes

Page 10: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Functional Phospholipids in plasma membranes

Page 11: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Proteins in plasma membranes

Page 12: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Proteins in plasma membranes

Page 13: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Protein functions in plasma membranes

Page 14: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Protein functions in plasma membranes

Page 15: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Channels Channels

Page 16: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Channels

Page 17: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Chemical gated Channels

Page 18: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Channels Carriers (Transporters)

Page 19: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

C Carriers (Transporters)

Page 20: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

ATP dependent Carriers

Page 21: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Receptors

Page 22: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Receptors & G proteins

Page 23: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Receptors & G proteins

Page 24: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Enzymes

Page 25: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Receptors & Enzymes

Page 26: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together
Page 27: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together
Page 28: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together
Page 29: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Receptors & Channels

Page 30: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Receptors & G proteins

Page 31: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Cell Identity Markers

Page 32: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together
Page 33: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Cell Identity Markers

Page 34: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Linkers

Page 35: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Tight Junction

Page 36: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Gap Junction

Page 37: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Desmosome

(Adhering Junction)

Page 38: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together
Page 39: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Transport across Plasma Membranes

Page 40: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

-Simple diffusion: transport through lipid bilayer, transport through channels, Ficks law of diffusion.-Facilitated diffusion: by carriersDifferences in diffusion Kinetics between the previous modalitiesEquivalent Concentration of particles.

Transport through plasma membranes

Passive transport modalities

Page 41: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

-Osmosis: concept of osmotic pressure (Van’t Hoff’s law), Oncotic (Colloid-osmotic) pressure. Osmolarity, OsmolalityHydrostatic pressure and filtration

Transport through plasma membranes

Passive transport modalities

Page 42: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

- Primary active transport (ATP-ase carriers or Pumps) (functions of pumps: Na+/K+ pump, Ca++ pump, H+ pump, H+/K+ pump). - Secondary active transport (Na+

dependent carriers) examples

Transport through plasma membranes

Active transport modalities

Page 43: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

- Vesicular transport: endocytosis, phagocytosis, transcytosis, pinocytosis and exocytosis and its control in secretory cells.-

Transport through plasma membranes

Active transport modalities

Page 44: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together
Page 45: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Active Transport Mechanisms

• Primary active transport• Secondary active transport• Vesicular transport

Page 46: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together
Page 47: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Types of Pumps

• Na+/K+ pump• H+ pump• H+/K+ pump• Ca++ pump

Page 48: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together
Page 49: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together
Page 50: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Phosphorylation & dephosphorylation

Page 51: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together
Page 52: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Types of Pumps

• Na+/K+ pump• H+ pump• H+/K+ pump• Ca++ pump

Page 53: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

The importance of pumps for cell functions

Page 54: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Secondary Active Transport

Page 55: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together
Page 56: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Secondary Active Transport-Co-transport-Counter transport

Page 57: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Vesicular Transport

Page 58: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together
Page 59: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Fig. 03.01

Page 60: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together
Page 61: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Formation of vesicles at ER

Page 62: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Endocytosis

Page 63: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Phagocytosis

Page 64: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Receptor mediated endocytosis

Page 65: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Exocytosis

Page 66: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together
Page 67: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Transcytosis

Page 68: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together
Page 69: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Control of Transport and activity of Enzymes

Page 70: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Receptors & Enzymes

Page 71: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Receptors & Channels

Page 72: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Receptors & G proteins

Page 73: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together
Page 74: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together
Page 75: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together
Page 76: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Control of Exocytosis

Page 77: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

Summary of Lectures

-Homeostasis-Control of body functions by feed-back mechanisms to keep homeostasis-Functions of Cell organells (ER, Golgi complex, Mitochondria, Lisosomes)-Cytoskeletal structures and Functions:

Page 78: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

- Membrane structure and function of lipids of plasma membrane including phospholipids, cholesterol and PIP2)-Functions of Protein structures of plasma membranes (Channels, Carriers, Receptors, Pumps, enzymes, cell markers, G proteins, adhesion molecules)-Activation of chemical gated channels

Plasma membrane

Page 79: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

-Simple diffusion: transport through lipid bilayer, transport through channels, Ficks law of diffusion.-Facilitated diffusion: by carriersDifferences in diffusion Kinetics between the previous modalitiesEquivalent Concentration of particles.

Transport through plasma membranes

Passive transport modalities

Page 80: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

-Osmosis: concept of osmotic pressure (Van’t Hoff’s law), Oncotic (Colloid-osmotic) pressure.Osmolarity, osmolalityHydrostatic pressure

Transport through plasma membranes

Passive transport modalities

Page 81: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

- Primary active transport (ATP-ase carriers or Pumps) (functions of pumps: Na+/K+ pump, Ca++ pump, H+ pump, H+/K+ pump). - Secondary active transport (Na+

dependent carriers) examples

Transport through plasma membranes

Active transport modalities

Page 82: Structure of Plasma membrane - JU Medicine · membrane (50% of Cell membrane structure) • cholesterol helps to separate phospholipids, so the fatty acid chains can't come together

- Vesicular transport: endocytosis, phagocytosis, transcytosis, pinocytosis and exocytosis and its control in secretory cells.-

Transport through plasma membranes

Active transport modalities


Lecture Outline Introduction/Chemistry/Cellsfalkowl/documents/IntroductionF20.pdfModule 3.2: Structure of the Plasma Membrane Phospholipids have two key properties: • A phosphate

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