Stem cells: disease models and therapeutics Jack Price Centre for the Cellular Basis of Behaviour...

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Stem cells: disease models and therapeutics Jack Price Centre for the Cellular Basis of Behaviour Institute of Psychiatry, KCL.

Transcript of Stem cells: disease models and therapeutics Jack Price Centre for the Cellular Basis of Behaviour...

Page 1: Stem cells: disease models and therapeutics Jack Price Centre for the Cellular Basis of Behaviour Institute of Psychiatry, KCL.

Stem cells:disease models and therapeutics

Jack PriceCentre for the Cellular Basis of Behaviour

Institute of Psychiatry, KCL.

Page 2: Stem cells: disease models and therapeutics Jack Price Centre for the Cellular Basis of Behaviour Institute of Psychiatry, KCL.

Jack PriceCentre for the Cellular Basis of Behaviour

Institute of Psychiatry, KCL.

Opportunities

TherapyMechanisms of Repair

Cellular ModelsDisease Mechanisms

Page 3: Stem cells: disease models and therapeutics Jack Price Centre for the Cellular Basis of Behaviour Institute of Psychiatry, KCL.

StrokeHuman

Neural stem cells

Page 4: Stem cells: disease models and therapeutics Jack Price Centre for the Cellular Basis of Behaviour Institute of Psychiatry, KCL.

iPS cells from human keratinocytes

SHANK3 domain structure

Deleted region: exons 4 - 23 Oct4

biopsy keratinocytes

piggybac iPS cells

Neural progenitorsNeurons

Cellular Assays

Page 5: Stem cells: disease models and therapeutics Jack Price Centre for the Cellular Basis of Behaviour Institute of Psychiatry, KCL.

ECThe CharlesWolfson Charitable Trust

Aaron JeffriesAaron JeffriesDafe UwanoghoDafe UwanoghoGraham CocksGraham CocksZahra HassaniZahra HassaniLeo PerfectLeo Perfect

Sandrine ThuretSandrine Thuret

Nick BrayNick Bray

Carmine ParianteCarmine Pariante

Jon MillJon Mill

Leo SchzlkwykLeo Schzlkwyk

Eva SykováEva SykováPavla JendelováPavla JendelováGovindan DayanithiGovindan Dayanithi

Mike ModoMike ModoEllen BibleEllen BibleNataliya GorenkovaNataliya Gorenkova