SMi Group's 8th annual Advances in Cell Based Assays
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Transcript of SMi Group's 8th annual Advances in Cell Based Assays
Workshop ALatest Generation Microscopes in HTS/HCS/HCA forlive cell imaging in Cells and Tissue Based AssaysWorkshop Leader: Aamir Ahmed, Head of Stem Cell and Prostate
Cancer Group, Kings College London
8.30am - 12.30pm
Workshop BApplying Tissue Engineering to Develop
3D Cell Based Assays Workshop Leader: Felicity Rose, Associate Professor
in Tissue Engineering, University of Nottingham
1.30pm - 5.30pm
Chair for 2015:Xavier Leroy, Associate Director,Actelion Pharmaceuticals Ltd
Reasons to Attend: • Discover pioneering 3D cell-based assays advancing reliable
and physiologically- relevant in vivo data with HCS technologies • New for 2015 - Next generation multidimensional fluorescence
imaging and computational quantification• New for 2015 - Learn high content, high throughput phenotypic
platforms for neglected tropical diseases
SMi present the 8th annual conference...
10 - 11
NOV2015
Holiday Inn Kensington Forum, London UK
Advances in Cell Based Assays
PLUS TWO INTERACTIVE POST-CONFERENCE WORKSHOPSThursday 12th November 2015, Holiday Inn Kensington Forum, London, UK
www.cellbasedassay.co.uk Register online or fax your registration to +44 (0) 870 9090 712 or call +44 (0) 870 9090 711
Developments in 3D functional assays and high-content analysis to propel drug development and improve translation to the patient
Keynote Speakers:• Aamir Ahmed, Head of Stem Cell and Prostate Cancer
Group, Kings College London• Nariman Ansari, Project Leader, Buchmann Institute for
Molecular Life Sciences - Goethe University Frankfurt • Neil Carragher, Principal Investigator Drug Discovery,
University of Edinburgh• Armin Wolf, Director, Novartis • Anna Collen, Project Director Pharmaceutical
Development, AstraZeneca• Martin Main, Director, AstraZeneca• Joanna Taylor, Senior Scientist, GSK• Clare Gardner, Senior Scientist, Pfizer• Roderick Beijersbergen, Group Leader, Division of Molecular
Carcinogenesis, Netherlands Cancer Institute• Farnaz-Fallah Arani, Senior Group Leader, UCB • Yolanda Chong, Principal Scientist, Johnson & Johnson
@SMIPHARM
Book by June 30th to save £300Book by September 30th to save £100
PLUS A FEATURED
INTERACTIVESESSION WITHNIKON, UK!
Advances in Cell Based Assays Day One | Tuesday 10th November 2015
8.30 Registration & Coffee
9.00 Chair's Opening Remarks
Xavier Leroy, Associate Director, Actelion Pharmaceuticals Ltd
A New Age of Modelling Disease through Cellular Assays
9.10 OPENING ADDRESS: Optimization of in-vitro and in-vivo
assays to visualise target activation
• Implementing robust models and assays
• Combination approaches to help identify novel targets
in drug discovery
Xavier Leroy, Associate Director, Actelion Pharmaceuticals Ltd
9.50 Pioneering cell-based models in drug discovery
• High content screening technologies to improve in
vivo-like data
• The importance of 3D Cell models in uncovering crucial
signal pathways and immune responses in drug
discovery
• Challenges to experimental design to achieve
physiologically relevant environments
Farnaz-Fallah Arani, Senior Group Leader, UCB
10.30 Morning Coffee
11.00 WNT Signalling: One cell based assay is just not enough!
A tale of low, medium and high through-put approaches
to identify new mechanisms and therapies
• Live calcium imaging
• Confocal and electron microscopy
• Medium and high-throughput tissue and cell based
assays
Aamir Ahmed, Head of Stem Cell and Prostate Cancer
Group, Kings College London
11.40 High-Content Assays for in vitro drug toxicity testing
• Development and characterisation of in vitro assays for
target organ toxicity
• Translational aspects of model development
• Evaluation of drug-induced mechanisms of toxicity
• Safety biomarker validation and profiling
Armin Wolf, Director, Novartis
12.20 Networking Lunch
Register online at: www.cellbasedassay.co.uk • Alternatively fax
Official media partners
SPONSORSHIP AND EXHIBITION OPPORTUNITIESSMi offer sponsorship, exhibition, advertising and branding packages, uniquely tailored to complement your company’s marketing strategy. Prime networking opportunities exist to entertain, enhance and expand your client base within the context of an independent discussion specific to your industry. Should you wish to join the increasing number of companies benefiting from sponsoring our conferences please call: Alia Malick on +44 (0) 20 7827 6168 or email: [email protected]
1.30 Cellular assays in the era of precision medicine• Application of cellular assays and reagents to advance
Oncology drug discovery projects• Improving translation from cellular models to patient
setting• Advances in cellular reagent generation and assay
development technologyMartin Main, Director, AstraZeneca
Combinatory Approaches and Live Imaging
2.10 Multidimensional fluorescence imaging for high contentanalysis• Fluorescence lifetime imaging• Fluorescence resonance energy transfer• Light sheet based fluorescence microscopyChristopher Dunsby, Senior Lecturer, Imperial CollegeLondon
2.50 Light Sheet-based Microscopy and three-dimensional cellcultures bridge the gap in tumour biology and drugdevelopment• Three-dimensional (3D) tumor spheroids bridge the gap
between cell cultures and real tissues in the pre-clinicaland clinical stage.
• 3D tumor spheroids are the system of choice fortherapeutically oriented biomedical and toxicity studiesand their potential market has rapidly expanded.
• Light sheet-based fluorescence microscopy (LSFM) isthe system of choice for live high-throughputphenotypic drug screening of 3D tumor spheroids.
Nariman Ansari, Project Leader, Buchmann Institute forMolecular Life Sciences (BMLS) - Goethe UniversityFrankfurt
3.30 Afternoon Tea
3D Models to Achieve Physiologically-Relevant and Predictable Results
4.00 Large scale functional genomic screens: Models matter!• Identifying key cellular pathways driving treatment
responses in 3D culture • Employing gene-editing and screening technologies to
advance mechanistic understanding • Development of relevant screening models for clinical
needRoderick L Beijersbergen, Associate Professor and HeadNKI Robotics and Screening Centre, Netherlands CancerInstitute
4.40 PANEL DISCUSSION: Innovation for the future • Challenges in building 3D human models and tracking
embryonic development • Seeing the full potential of iPSC-derived cell models• Which responses corresponds most like an in vivo
response? Panel leader: Xavier Leroy, Associate Director, ActelionPharmaceuticals LtdPanellists: Roderick L Beijersbergen, Associate Professor and HeadNKI Robotics and Screening Centre, Netherlands CancerInstituteAamir Ahmed, Head of Stem Cell and Prostate CancerGroup, Kings College London
5.20 Chairman's Closing Remarks and Close of Day One
SEPTEMBER
Cancer Vaccines16th – 17th September 2015Marriott Regents Park, London
OCTOBER
Biosimilars and Biobetters30th September – 1st October 2015Holiday Inn Kensington Forum, London
European Pharmaceutical Pricing& Reimbursement5th – 6th October 2015Holiday Inn Regents Park, London
Orphan Drugs19th – 20th October 2015Holiday Inn Regents Park, London
COPD: Novel Therapeutics andManagement Strategies19th – 20th October 2015Holiday Inn Regents Park, London
NOVEMBER
Cell Based Assays10th – 11th November 2015Holiday Inn Kensington Forum,London
Biosimilars & Biobetters USA16th November to 17th November2015, Iselin, New Jersey, USA
DECEMBER
Cold Chain Distribution3rd – 4th December 2015Park Plaza Victoria, London
SMi Pharmaceutical Autumn 2015 Planner
Advances in Cell Based AssaysDay Two | Wednesday 11th November 2015
8.30 Registration & Coffee
9.00 Chair's Opening Remarks
Xavier Leroy, Associate Director, Actelion Pharmaceuticals Ltd
Advances in Phenotype Screening
9.10 OPENING ADDRESS: Development of Phenotypic Assays
applicable to Pain & Neurosensory disorders
• Challenges of screening in the Pain field
• Development of Electrical Field Stimulation assays as a
medium throughput plate-based screening solution
• Understanding mechanism – the power of combining
high-content image analysis with functional live-cell
assays
Clare Gardner, Senior Scientist, Pfizer
9.50 Phenotypic Targeting in Drug Discovery: High-throughput
imaging analyses and computational quantification to
identify underlying mechanisms and phenotype changes
• Latest developments of computational and High-
throughput imaging platforms
• Detection of phenotypic changes and genetic analysis
• Targeted validation and imaging analysis
Yolanda Chong, Principal Scientist, Johnson &Johnson
10.30 Morning Coffee
11.00 High content, high throughput phenotypic platforms for
neglected tropical diseases
• Latest developments of technology platforms for
increased understanding
• Underpinning novel drug targets
• Targeted validation and imaging analysis
David Gray, Head of Biology, Drug Discovery Unit,
University of Dundee
11.40 Phenotypic high-throughput screening (HTS)
• Case study: New collaboration developments in cancer
drug treatments
• Applications of phenotype assays in uncovering new
cancer signalling pathways and how this can be
translated for new and effective medicines
Neil Carragher, Principal Investigator Drug Discovery,
University of Edinburgh
12.20 Networking Lunch
1.30 Scar in a jar: Enabling phenotypic screening forextracellular matrix modulators• Excessive scarring is characterised by the accumulation
of extracellular matrix proteins, which can lead to loss oftissue function and ultimately organ failure.
• Characteristically, cultured fibroblasts producecollagen but do not assemble this into extracellularfibrils. Chen et al disclosed a potentially useful methodto induce fibrillar collagen production by fibroblasts.
• We have developed this technique into a high content,high throughput format to identify novel modulators ofthe extracellular matrix and potentially new targets.
Joanna Taylor, Senior Scientist, GSK
Formulation in Assay Development
2.10 KEY NOTE ADDRESS: Formulation and the importance ofdrug delivery systems • Implementing robust models and assays to improve
formulation strategies • Important considerations for drug delivery systems:
Progress and limitations • Future aspects of drug delivery and the importance of
suitable cellular assay systemsAnna Collen, Project Director, Project and PortfolioManagement, Pharmaceutical DevelopmentAstraZeneca
2.50 High Throughput Image-based Systems for thecharacterisation of novel cellular processes • Quantifying drug efficacy and phenotypic effects Ross Pavely, Senior Scientist, UCB
3.30 Afternoon Tea
Key Considerations and Future Innovations
4.00 High Throughput, High Content, Multiplex Assays forAssessing Cellular Toxicity • The merit of multiplex assays for assessing cellular
toxicity • Population profiling and variability assessment through
HTS methods Alison Howarth, Research Assistant, University of Oxford
4.40 Flow Cytometry: There is no business like Flow Business• Importance of Flow Cytometry• Applications of Flow CytometryRachael Walker, Head of Flow Cytometry, BabrahamInstitute
5.20 PANEL DISCUSSION: Merits and Future prospects • The merits of High Throughput and Phenotype
Screening• Discovering new insights of the root causes of diseases• Understanding heterogeneity and ways to approach
unexpected phenotype changes Panel leader: Xavier Leroy, Associate Director, ProjectLeader, Actelion Pharmaceuticals Ltd
6.00 Chair’s Closing Remarks and Close of Day Two
Want to know how you can get involved? Interested in promoting your services to this market?Contact Teri Arri, SMi Marketing on +44 (0) 207 827 6162, or email: [email protected]
your registration to +44 (0)870 9090 712 or call +44 (0)870 9090 711
Supported by
Workshop leader: Aamir Ahmed, Head of Stem Cell and Prostate Cancer
Group, Kings College London
Overview of the workshop:The workshop will focus upon cutting edge science andtechnology in cell and tissue based assays utilizing high-throughput screening (HTS), high-content screening (HCS)methods and high-content analytical (HCA) tools. Expertsfrom King’s College and University College, London, UK willparticipate to discuss and present latest findings andthoughts.
Nikon, UK will give an interactive presentation on combiningthe future of screening with high-resolution microscopy andapplication of imaging techniques to screens. This will includehow the latest generation of microscopes can be employedin HTS/HCS/HCA applications for live cell imaging, such as:
1. Conditional imaging2. FRAP3. Confocal4. DMD5. FRET and others
The presentation will show how these could be done for singleor long-term screens (or both) with flexibility of setting upseparate experiments within each well.
Why should delegates attend this workshop:This workshop contains a unique mixture of top scientists fromtwo of the best UK institutions and Nikon, UK who will presentthe cutting-edge and the future of biological assays andscreening. The workshop is designed to include a mix of latestscientific discoveries using technologies that are evolving.Anyone interested in cell and tissue based assays will benefitfrom attending this workshop.
Programme:8.30 Coffee & Registration
9.00 Opening remarks & introduction
9.10 Use of microfluidic chambers to facilitate livecalcium imaging for kinetic analysis of drugscreening• Learn state-of-the-art advanced imaging
analysis for screening cancer and stem cells
9.50 Technologies to identify diagnostic and prognosticprotein biomarkers using HCS and quantitativeanalysis on large numbers of confocal and de-convolved images • What new mechanisms can be found and what
can be gained from these understandings • What knowledge can be translated into better
therapies
10.30 Morning Coffee
11.00 Featured Interactive session with Nikon, UK:• Combining the latest generation of microscopes
d in HTS/HCS/HCA applications for live cellimaging, such as:
1. Conditional imaging 2. FRAP 3. Confocal 4. DMD 5. FRET and others
11.45 Pros and cons of high-resolution and confocalimaging for HTS and HTA• Learn techniques and best practices to reap
optimum benefits• Use of HCS for the characterization of stem cells
and development of tools for HCA
12.20 Closing remarks
12.30 Close of workshop
About the workshop leader Dr Aamir Ahmed:Aamir obtained his Ph D from the University ofDundee where he also served as an HonoraryLecturer and Group Leader. He then joined YaleUniversity as research faculty to work on ionchannels. Aamir was awarded a Wellcome TrustFellowship at the Department of Physiology,
University College London, where he established his researchgroup. This was followed by his appointment as the Head ofStem Cell Group at the Prostate Cancer Research Centre,also at the University College London. He joined the Centrefor Stem Cell and Regenerative Medicine, King’s College,London in January 2015.
HALF-DAY POST-CONFERENCE WORKSHOP AThursday 12th November 2015
8.30am - 12.30pmHoliday Inn Kensington Forum, London, UK
Latest GenerationMicroscopes in HTS/HCS/HCA
for live cell imaging in Cellsand Tissue Based Assays
PLUS A FEATURED
INTERACTIVESESSION WITHNIKON, UK!
HALF-DAY POST-CONFERENCE WORKSHOP BThursday 12th November 2015
1.30pm - 5.30pm Holiday Inn Kensington Forum, Central London, UK
Applying Tissue Engineering to Develop3D Cell Based Assays
Workshop leader: Felicity Rose, Associate Professor in Tissue
Engineering, University of Nottingham
Overview of workshop:This workshop will explore the application of tissueengineering to the generation of 3D in vitro models fordisease modeling, toxicology testing and drugscreening. The session will be kicked-off with apresentation of work that has aimed to develop a 3Dmodel of the human bronchial mucosa and willinclude case studies from industry where drugmolecules have failed in clinical trials despite havingpassed in vitro testing.
Why should delegates attend this workshop: If you have an interest in developing 3D in vitro tissuemodels or would like to know more about how tissueengineering can be applied to in vitro testing, thenthis workshop is for you. We are particularly keen tohear from potential end users to understandlimitations in current in vitro tests being used and whatthey would like to be able to implement into theirpanel of in vitro assays available to them.
Programme
1.30 Registration and Coffee
2.00 Introductions and opening remarks
2.10 Topic discussions and review• Materials for building tissue scaffolds for
'live' models • Biomaterial formulations that are
compatible with recreatingmicroenviroments in tissue architecture
2.30 Presentation: Tissue engineering an in vitromodel of the human bronchiole mucosa: A tale of four papers
3.30 Coffee Break
4.00 Case Studies and Analysis• Strategies and performance analysis in 3D
in vitro models employed in toxicity testingand disease modeling
• Understand where the failures occur andlessons learned
5.00 DISCUSSION: Highlighting key requirementsfor 3D cell based assay development• Planning for robust 3D builds, including
biomaterial constructs to replicate in vivoprocesses.
• Incorporation of live cells and activetherapeutic proteins for tissue regeneration
5.30 Close of Workshop
About the workshop leader:Dr Felicity Rose is an Associate Professor inTissue Engineering at the University ofNottingham and previously held aUniversity of Nottingham sponsored AnnMcLaren Research Fellowship. She now
leads activities at Nottingham on animalreplacement, mucosal tissue regeneration, and hasa long term interest in modelling of 3D tissue growth.
About the organisation: The University of Nottingham is global university withcampuses in China and Malaysia. It is ranked in theworld’s top one per cent of universities by the QSWorld University Rankings, and 8th in the UK byresearch power according to REF 2014. The School ofPharmacy leads the UK in the training of futurePharmacists and are recognised as a world leader forresearch in the design and use of drugs andmedicines. The Tissue Engineering Group forms part ofthe Wolfson Centre for Stem Cells, Tissue Engineeringand Modelling (STEM) and we lead the UKRegenerative Medicine Platform Hub in AcellularApproaches for Therapeutic Delivery.
FAX your booking form to +44 (0) 870 9090 712PHONE on +44 (0) 870 9090 711
POST your booking form to: Events Team, SMi Group Ltd, 2nd FloorSouth, Harling House, 47-51 Great Suffolk Street, London, SE1 0BS, UK
ADVANCES IN CELL BASED ASSAYS Conference: Tuesday 10th & Wednesday 11th November 2015, Holiday Inn Kensington Forum, London, UK
Workshops: Thursday 12th November 2015, Holiday Inn Kensington Forum, London, UK
4 WAYS TO REGISTERwww.cellbasedassay.co.uk
If you have any further queries please call the Events Team on tel +44 (0) 870 9090 711 or you can email [email protected]
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