Siva Arunasalam, M.D.High Desert Heart Institute

ProArgi-9+ Active HDHI Study• 9 Healthy Subjects + Dan Austin• Ages: 22-54 + d60an

ProArgi-9+ Active HDHI Study• Measure lactic acid levels during vigorous exercise• Lactic acid accumulates when body goes into oxygen

debt• More vigorous the exercise the longer the duration of

exercise, higher the lactic acid accumulation• Lactic Acid causes muscle fatigue• Lactic acid accumulation decreases muscle

performance

ProArgi-9+ Active HDHI Study

Hypothesis:

If L-Arginine increases muscle blood flow, then there will be less lactic acid accumulation.

Thus increasing endurance & muscle recovery.

ProArgi-9+ Active Formulation

• Blocks oxidation of LDL cholesterol• Multiple studies performed with 100-200mg. with benefits

including helping maintain BP already in normal range• Ingredients of PA9Active have more than 200mg. per

serving of Quercetin• Protection: Antioxidant against factors such as

oxidative stress, radiation, cell damage

Quercetin: Broad Spectrum Protection

QuercetinMechanism of Action

• Free Radical scavenger (Antioxidant)• Promotes a healthy inflammation response,

especially in fat tissue• Regulates gene expression• Supports natural stress responses• Boosts immunity• Source of Quercetin: Grape skins, Red Onions,

Green Tea to Tomatoes --> Flavonoids

• Study Design• Subjects exercised maximally with and

without ProArgi-9+ Active (Control)• Lactic acid was measured pre,

immediately, 15 min, and 30 min post exercise

• ProArgi-9+ Active was given 60 min before exercise in study

ProArgi-9+ Active HDHI Study

ProArgi-9+ Active Results

Pre 0 mins 15 mins 30 mins0

20

40

60

80

100

120

control

Pro Active

ProArgi-9+ Active ResultsSubject Control ProArgi-9+ Active

1 18 23

2 29 36

3 40 46

4 20 25

5 9 11

6 9 11

7 28 32

8 14 17

9 56 64

10 39 43

Endurance in min. 15% increase with ProArgi9+ Active

ProArgi-9+ ActiveLow level exercise vs. High Intensity Exercise

control low pro active L control H pro active H

0102030405060708090

pre0 mins15min

WE GET A D84% of patients Screened for Vitamin D3 were deficient:

• 18% < 10• 32% 10-20• 34% 21-29• N=1038

WE GET A D• Average replacement instituted at HDHI 3500 units/day• Once target is attained( > 50 ng/dl )• Then maintenance dose: 2000-2500 units/day

WE GET A D• BREAST HEALTH• COLON HEALTH• ANTIOXIDANT• BONE HEALTH• IMMUNE SYSTEM• CARDIOVASCULAR HEALTH