Sinapse BOOF.ppt
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Transcript of Sinapse BOOF.ppt
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Sinaptička Sinaptička transmisijatransmisija
Akcioni potencijalEkscitatorni
postsinaptički potencijal
(EPSP)
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Akcioni potencijal i Akcioni potencijal i postsinapti~ke promene postsinapti~ke promene
membranskog potencijalamembranskog potencijala
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IPSP-i moduliše “snagu” EPSP-a
Figure from: Principles of Neural Science 3rd Edition 1991 by E.R. Kandel, J.H. Schwartz & T.M. Jessell. Elsevier, New York, NY, USA. 3
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JONSKI KANALI - vrsteJONSKI KANALI - vrste
voltavoltažžno-no-zavisanzavisan kanalkanal
ligand-ligand-zavisan zavisan kanalkanal
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Loewi-jev eksperiment koji demonstrira princip hemijske
transmisije
a potom je predat drugom srcu
“Vagus stoff” koji je oslobodio n.vagus izazvao je usporavanje srčane ritmike kod prvog srca
Fundamental Neuroscience 1999 by M.J. Zigmond, F.E. Bloom, S.C. Landis, J.L. Roberts & L.R.Squire. Academic Press, San Diego CA, USA. ISBN: 0-12-780870-1
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Primeri neurotransmitera
aminokiseline
amini
peptidi
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Životni ciklus neurotransmitera
Presinaptički završetak
Postsinaptički deo
Vezikule oslobađaju transmiter
Sinaptički jaz
Presinaptički završetak “isporučuje” transmiter
Postsinaptički završetak “odgovara” na transmiter
Životni ciklusSintezaSkladištenjeOslobadjanjeVezivanjeRazgradnja
Fundamental Neuroscience 1999 by M.J. Zigmond, F.E. Bloom, S.C. Landis, J.L. Roberts & L.R.Squire. Academic Press, San Diego CA, USA. ISBN: 0-12-780870-1
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Oslobadjanje transmitera u “brzoj” ESCITATORNOJ hemijskoj sinapsi
generiše EKSCITATORNI POSTSINAPTIČKI POTENCIJAL (EPSP)
Neuroscience – Exploring the Brain 2nd Edition 2001 by M.F. Bear, B.W. Connors & M.A. Paradiso. Lippincott, Williams & Wilkins, Baltimore MD, USA. ISBN: 0683-30596-4
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Oslobadjanje transmitera u “brzoj” INHIBITORNOJ sinapsi izaziva genezu
INHIBITORNIH POSTSINAPTIČKIH POTENCIJALA (IPSP)
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Možemo da primenimo Nernstovu jednačinu da bismo odredili gde se obrće polaritet sinaptičkog potencijala, pošto je GABAA
receptorski kanal specifično propustljiv za jone Cl-
Pretpostavimo da je [Cl-]i = 7 mM [Cl-]o = 130 mM i temperatura = 20 C
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AChRs are permeable to both Na+ and K+ ions since the end plate potential
reverses direction around 0 mV
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Primeri IPSP-a izazvanih preko GABA receptora pri različitim potencijalima
membrane
Potencijal reverzije odgovara Nernstovom potencijalu za Cl-
jone (oko –80 mV)
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Glutamate ‘ionotropic’ receptors have three transmembrane domains and a
re-entrant loop
nAChR or GABAA
Glutamate (NMDA, AMPA or kainate)
Fundamental Neuroscience 1999 by M.J. Zigmond, F.E. Bloom, S.C. Landis, J.L. Roberts & L.R.Squire. Academic Press, San Diego CA, USA. ISBN: 0-12-780870-1
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Dva tipa glutamatnih receptora postoje u centralnim sinapsama – NMDA i
AMPA receptori
Neuroscience – Exploring the Brain 2nd Edition 2001 by M.F. Bear, B.W. Connors & M.A.
Paradiso. Lippincott, Williams & Wilkins, Baltimore MD, USA. ISBN: 0683-30596-4
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Sinaptičke struje gutamatskih sinapsi imaju brzu i sporu komponentu
Kontrola
10 pA25 ms
U prisustvu AP5, antagonista NMDA, preostaje samo “brza “komponenta
“Brza” komponenta posredovana AMPA receptorima
”Spora” komponenta posredovanaNMDA receptorima
Figure from: Clark, Farrant & Cull-Candy (1997) Journal of Neuroscience 17, 107-116.
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NMDA receptori su blokirani jonima Mg2+ u zavisnosti od voltaže
Neuroscience – Exploring the Brain 2nd Edition 2001 by M.F. Bear, B.W. Connors & M.A. Paradiso. Lippincott, Williams & Wilkins, Baltimore MD, USA. ISBN: 0683-30596-4
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NMDA receptori se blokiraju Mg2+ jonima na voltažno-zavisan način
Fundamental Neuroscience 1999 by M.J. Zigmond, F.E. Bloom, S.C. Landis, J.L. Roberts & L.R.Squire. Academic Press, San Diego CA, USA. ISBN: 0-12-780870-1
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NMDA receptorima je potreban ko-agonist
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NMDA receptori su blokirani/modulisani raznim agensima
Fundamental Neuroscience 1999 by M.J. Zigmond, F.E. Bloom, S.C. Landis, J.L. Roberts & L.R.Squire. Academic Press, San Diego CA, USA. ISBN: 0-12-780870-1
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Sinteza GABA-e
NH2CH2CH2CH2COOH
COOH
NH2CHCH2CH2COOH
Neuroscience – Exploring the Brain 2nd Edition 2001 by M.F. Bear, B.W. Connors & M.A. Paradiso. Lippincott, Williams & Wilkins, Baltimore MD, USA. ISBN: 0683-30596-4
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GABAA receptor - mesto delovanja lekova
Neuroscience – Exploring the Brain 2nd Edition 2001 by M.F. Bear, B.W. Connors & M.A. Paradiso. Lippincott, Williams & Wilkins, Baltimore MD, USA. ISBN: 0683-30596-4
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Glicin kao inibitorni transmiter u sadejstvu sa acetilholinom
Transmiter jeGLICIN
Transmiter JEACETILHOLIN
Figure from: Principles of Neural Science 3rd Edition 1991 by E.R. Kandel, J.H. Schwartz & T.M. Jessell. Elsevier, New York, NY, USA. 22
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Voltažno zavisni Na kanali nervaVoltažno zavisni K kanali nerva
Voltažno zavisni Ca kanali nervaNikotinski acelholinski receptor
Voltažno zavisni Na kanali mišića
Voltažno zavisni Cl kanali mišićaVoltažno zavisni Ca kanali T tubula
Ca kanali sarkoplazmatskog retikuluma 23