LeukemiaBy: Dimple Patel

Overview-Thesis Statement-Relevance-What is leukemia?-Background on leukemia-Seeking medical advice-Tests for leukemia -Progression-Which cells affected?-Types of leukemia-Treatments/side effects-Follow up-Children with leukemia-Research-Hospitals in our area-Coping & support-Application-Conclusion-Class activity-Works cited

Though the cause of leukemia is still unknown, with new research and technology, many leukemia victims are surviving longer and are healthier than ever before.

Thesis STATEMENT

Relevance to ME

Majoring in Biochemistry at ASU next year

I want to work in the healthcare field

Relevance to YOU

-Everyone should know about treatment options when dealing with cancer

-Since cancer is one of the leading causes of death, you will know at least One person in your life with cancer and dealing with it

Leukemia is a type of cancer that occurs in blood forming tissues, such as the bone marrow and the lymphatic system.

This cancer starts in the white blood cells

The word “leuk” means white in Greek

What is leukemia?

Silverstein, Alvin, Virginia Silverstein, and Laura Silverstein Nunn.  

General information The body has three different types of cells

◦ Red blood cells◦ White Blood cells◦ Platelets

(Silverstein)

Causes and Risk

Factors

Not known exactly Abnormal

chromosomes Myelodysplasia

Environmental factors Pollution Household chemicals

Benzene and petroleum containing products

“few studies have examined the association between home use of solvents and the risk of childhood leukemia.”

Results: “ALL risk was significantly associated with paint exposure.”

(Scelo, Ghislaine)( 133-139)

Exposure to radiation and certain chemicals

GeneticsCancer therapy

◦ This is a rare and unfortunate risk , but it is certainly possible

◦ Scelo,  133-139.

Causes Cont’d

Fever and chills Frequent infections Loss of appetite Swollen lymph

nodes Enlarged liver or

spleen Shortness of breath Petechaie

◦ Tiny red spots on the skin

Bruising and bleeding very easily

Pain in the bones Lots of sweating,

mainly at night.

Symptoms

(Ball, Edward D, and Gregory A Lelek)

When common symptoms start to show more frequently and do not go away

May want to see your family doctor or oncologist

When to find medical advice

(Ball, Edward D, and Gregory A Lelek)

Physical examBlood TestsImmunophenotype

Cytogenetic analysis

Bone marrow samples

Tests

Chronic leukemia

Acute leukemia

Progression of Leukemia

(Silverstein)

Lymphocytic leukemia

Myelogenous leukemia

Which cells are affected?

Silverstein, Alvin, Virginia Silverstein, and Laura Silverstein Nunn.

Acute Myelogenous Leukemia (AML)

Acute Lymphocytic Leukemia (ALL)

Chronic lymphocytic Leukemia (CLL)

Chronic Myelogenous Leukemia (CML)

TYPES OF Leukemia

(Belson, Martin, Beverely Kingsley, and Adrianne Holmes) : p.138-145

Based on the type of leukemia◦ Present in cerebrospinal fluid◦ Treated before?◦ Features of leukemia cells◦ Patients symptoms and health

Influences of Treatments

(Ball, Edward D, and Gregory A Lelek)

Leukemia & chemotherapy

Single drug or combination of two or more drugsCan be given by

MouthInjection into veinCatheterInject directly into cerebrospinal

fluidInject straight into spine

(Silverstein)

Radiation therapy-high energy rays kills cancer cells

Large machine-rays are directed at body part

There are side effects to this treatment!

Leukemia & radiation therapy

(Silverstein)

Side effects of Treatments

•Chemotherapy

•Radiation

Bone marrow transplant

Silverstein, Alvin, Virginia Silverstein, and Laura Silverstein Nunn.

Side effects of Transplants

GVHD(Graft versus host disease)

Ball, Edward D, and Gregory A Lelek

◦ Peripheral Blood Stem Cell

PBSC

(Preidt)

Follow Up

.Ball, Edward D, and Gregory A Lelek

Children With Leukemia Each year about 2000

children in the United States are diagnosed with Leukemia.

Two main types of leukemia in children◦ Acute Lymphoblastic

Leukemia (ALL)◦ Acute Myelogenous

Leukemia (AML)

Belson, Martin, Beverely Kingsley, and Adrianne Holmes.

Childhood (ALL) risk factorsBelson, Martin, Beverely Kingsley, and Adrianne Holmes.

Symptoms of childhood leukemia•Looks pale•Feel weak and tired•Bleed or bruise very easily•Fever•Fatigue•Frequent infections•Painless blue or purple lumps in neck, underarm, stomach or groin area

Belson, Martin, Beverely Kingsley, and Adrianne Holmes.

RESEARCH

(Preidt)

High risk jobs

Risky jobs that may cause Acute myelogenous leukemia

Hospitals in our area treating leukemiaUniversity of Pennsylvania Cancer Center

Thomas Jefferson Kimmel Cancer Center

Wistar Institute cancer Center of Philadelphia.

Mercy Suburban Cancer Center

“The latest cancer treatments aren’t always prescribed by doctors”

Look Good…Feel Better!

CTFA foundation

Living With Leukemia Challenging Support groups Depression Financial tensions Worrying about family

Apel

Helping yourself at home to make yourself healthier and better

Home Treatment

Bets Davis

The American Cancer Society

Support

American Cancer Society

Emotions

Thinking about death

Your life is not over

Bets Davis

My Application

Application Mr. Gohla passed

away a little less than a year ago, leaving his wife and three kids with no family income.

I met Mrs. Gohla in India in November through relatives. (she is not related to me)

Mrs. Gohla makes about 200 rupees a month working as a maid. 200 R = 5 US dollars

I am donating 7,500 rupees to the Gohla family! ($150)

Conclusion

Living with a disease such as cancer is very difficult to handle physically, mentally, and emotionally to not only the patient but also the family members and any other person associated with the patient.

Class Activity

I need your help to finish up my scrap book!

Everyone will get a strip of paper and I want everyone to write down their favorite quote or just a nice saying or a few words to inspire the Gohla family to not give up and stay strong.

Works Citedhttp://a.abcnews.com/images/Nightline/ht_00120760-181_081125_ssv.jpghttp://myhealth.hollandhospital.org/library/healthguide/en-us/illnessconditions/topic.asp?hwid=ncicdr0000258006

http://farm4.static.flickr.com/3062/2869815349_b08f18185d.jpg

http://chronicmyelogenousleukemia.net/images/leukemia/leukemia_250x251.jpg

www.uiowa.edu/~cemrf/archive/sem/large/

http://www.ottawahospital.on.ca/sc/cancer/img/linac2.jpg

http://www.adventisthealthcare.com/adam/graphics/images/en/12665.jpg

www.mdconsult.com/.../0/0/10041/12664_en.jpg

www.web-books.com/.../OPS/images/image022.jpghttp://www.flickr.com/photos/jasoncainephotography/2546899649/

http://zingasays.files.wordpress.com/2009/03/lab_research1.jpg

http://www.medcitynews.com/wordpress/wp-content/uploads/hospital-sign.jpg

http://prconversations.files.wordpress.com/2009/01/makeup.jpg

Works Citedhttp://www.stacyyork.com/img/kids/excercise.jpg

http://www.wichesrestaurant.com/main/assets/images/AMERICAN-CANCER-SOCIETY.jpg

worldofcure.comhttp://www.flickr.com/photos/shmoolio/319894626/

Apel, Melanie Ann. Coping with Leukemia. New York: Rosen Publishing Group, 2001. Print.

Ball, Edward D, and Gregory A Lelek. 100 Questions and Answers about Leukemia. Sudbury: Jones and Bartlett, 2003. Print

Belson, Martin, Beverely Kingsley, and Adrianne Holmes. "Risk Factors for Acute Lukemia in Children: A Review." Environmental Health Perspectives115.1 (2007): p.138-145. JSTOR. Web. 2 Dec. 2009. <http://www.jstor.org/stable/4133080>Lackritz, Barbara. Adult Leukemia. Ed. Linda Lamb. Beijing: O'Reilly, 2001.Print.Patenaude, Robert. Surviving Leukemia. Buffalo: Firefly , 1999. Print.

Works Cited Scelo, Ghislaine, et al. "Household Exposure to Paint and Petroleum Solvents, Chromosomal Translocations, and the Risk of Childhood Leukemia." Environmental Health Perspectives 117.1 (2009): 133-139. JSTOR. Web. 3 Jan. 2010. <http://www.jstor.org/stable/40066689>.

Silverstein, Alvin, Virginia Silverstein, and Laura Silverstein Nunn. Leukemia. Berkeley Heights: Enslow, 2000. Print.

Wilson, Henery E, and Geraldine Price. "Leukemia." American Journal of Nursing 56.5 (1956): p.601-605. Print.

http://www.poemhunter.com/poem/present-6/http://www.brainyquote.com/quotes/topics/topic_life.html http://www.umgcc.org/gjump/leukemia.html?gclid=COvK9IOo7qECFV_G3AodKkx1Kg