SAFETY DATA SHEET - Agendia€¦ · 2015/830 - United Kingdom (UK) SECTION 1: Identification of the...

SAFETY DATA SHEETMammaPrint BluePrint NGS Target Enrichment (Post-PCR Box 1), Part Number 931282

Conforms to Regulation (EC) No. 1907/2006 (REACH), Annex II, as amended by Commission Regulation (EU)2015/830 - United Kingdom (UK)

SECTION 1: Identification of the substance/mixture and of the company/undertaking

MammaPrint BluePrint NGS Target Enrichment (Post-PCR Box 1), Part Number 931282Product name :

1.1 Product identifier

1.3 Details of the supplier of the safety data sheet

e-mail address of person responsible for this SDS

: [email protected]

1.2 Relevant identified uses of the substance or mixture and uses advised against

Part no. : Agendia NGS Nuclease-Free Water

931282-07

Agendia NGS Hyb 1 931282-01Agendia NGS Hyb 2 931282-02Agendia NGS Hyb 4 931282-03Agendia NGS Binding Buffer

931282-04

Agendia NGS Wash Buffer 1

931282-05


931282-06

Agendia NGS Nuclease-Free Water

931282-08

Agendia NGS Elution Buffer

931282-09

1.4 Emergency telephone number

Emergency telephone number (with hours of operation)

: +31 (0)20 462 1510

Agendia NV Science Park 406 1098 XH Amsterdam The NetherlandsTelephone:+31 (0)20 462 1510

Part no. (chemical kit) : 931282

Analytical reagent.

Agendia NGS Nuclease-Free Water 3 mlAgendia NGS Hyb 1 0.480 mlAgendia NGS Hyb 2 1.5 mlAgendia NGS Hyb 4 1.5 mlAgendia NGS Binding Buffer 15.5 mlAgendia NGS Wash Buffer 1 10 mlAgendia NGS Wash Buffer 2 29 mlAgendia NGS Nuclease-Free Water 0.96 mlAgendia NGS Elution Buffer 0.96 ml

Material uses :

Date of issue/Date of revision

: 1/4013/02/2018

MammaPrint BluePrint NGS Target Enrichment (Post-PCR Box 1), Part Number 931282


SECTION 2: Hazards identification

See Section 11 for more detailed information on health effects and symptoms.

Classification according to Regulation (EC) No. 1272/2008 [CLP/GHS]

2.1 Classification of the substance or mixture

Product definition : Agendia NGS Nuclease-Free Water

Mono-constituent substance

Agendia NGS Hyb 1 MixtureAgendia NGS Hyb 2 MixtureAgendia NGS Hyb 4 MixtureAgendia NGS Binding Buffer

Mixture


Mixture


Mixture


Mixture


Mixture

See Section 16 for the full text of the H statements declared above.

Ingredients of unknown toxicity

:

Ingredients of unknown ecotoxicity

:

2.2 Label elements

Agendia NGS Hyb 1H319 SERIOUS EYE DAMAGE/EYE IRRITATION - Category 2

Agendia NGS Hyb 2H373 SPECIFIC TARGET ORGAN TOXICITY - REPEATED EXPOSURE - Category 2

Agendia NGS Elution BufferH315 SKIN CORROSION/IRRITATION - Category 2H319 SERIOUS EYE DAMAGE/EYE IRRITATION - Category 2

Agendia NGS Hyb 1 Percentage of the mixture consisting of ingredient(s) of unknown dermal toxicity: 1 - 10%Percentage of the mixture consisting of ingredient(s) of unknown inhalation toxicity: 10 - 30%

Agendia NGS Hyb 2 Percentage of the mixture consisting of ingredient(s) of unknown dermal toxicity: 10 - 30%

Agendia NGS Hyb 4 Percentage of the mixture consisting of ingredient(s) of unknown dermal toxicity: 1 - 10%

Agendia NGS Binding Buffer

Percentage of the mixture consisting of ingredient(s) of unknown inhalation toxicity: 1 - 10%


Percentage of the mixture consisting of ingredient(s) of unknown dermal toxicity: 10 - 30%Percentage of the mixture consisting of ingredient(s) of unknown inhalation toxicity: 10 - 30%Percentage of the mixture consisting of ingredient(s) of unknown oral toxicity: 10 - 30%


Percentage of the mixture consisting of ingredient(s) of unknown hazards to the aquatic environment: 15.8%


: 2/4013/02/2018



SECTION 2: Hazards identificationHazard pictograms : Agendia NGS Hyb 1

Agendia NGS Hyb 2


Signal word :

Hazard statements :

Prevention :

Precautionary statements


No signal word.

Agendia NGS Hyb 1 WarningAgendia NGS Hyb 2 WarningAgendia NGS Hyb 4 No signal word.Agendia NGS Binding Buffer

No signal word.


No signal word.


No signal word.


No signal word.


Warning


No known significant effects or critical hazards.

Agendia NGS Hyb 1 H319 - Causes serious eye irritation.Agendia NGS Hyb 2 H373 - May cause damage to organs through prolonged or

repeated exposure.Agendia NGS Hyb 4 No known significant effects or critical hazards.Agendia NGS Binding Buffer









H319 - Causes serious eye irritation.

H315 - Causes skin irritation.


Not applicable.

Agendia NGS Hyb 1 P280 - Wear eye or face protection.P264 - Wash hands thoroughly after handling.

Agendia NGS Hyb 2 P260 - Do not breathe vapour.Agendia NGS Hyb 4 Not applicable.Agendia NGS Binding Buffer

Not applicable.


Not applicable.


Not applicable.

Agendia NGS Nuclease- Not applicable.


: 3/4013/02/2018




Response :

Storage :

Disposal :

Free WaterAgendia NGS Elution Buffer

P280 - Wear protective gloves. Wear eye or face protection.

P264 - Wash hands thoroughly after handling.


Not applicable.

Agendia NGS Hyb 1 P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Agendia NGS Hyb 2 P314 - Get medical attention if you feel unwell.Agendia NGS Hyb 4 Not applicable.Agendia NGS Binding Buffer

Not applicable.


Not applicable.


Not applicable.


Not applicable.


P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.


Not applicable.

Agendia NGS Hyb 1 Not applicable.Agendia NGS Hyb 2 Not applicable.Agendia NGS Hyb 4 Not applicable.Agendia NGS Binding Buffer

Not applicable.


Not applicable.


Not applicable.


Not applicable.


Not applicable.


Not applicable.

Agendia NGS Hyb 1 Not applicable.Agendia NGS Hyb 2 P501 - Dispose of contents and container in accordance

with all local, regional, national and international regulations.Agendia NGS Hyb 4 Not applicable.Agendia NGS Binding Buffer

Not applicable.


Not applicable.


Not applicable.


Not applicable.


Not applicable.

Hazardous ingredients : Agendia NGS Hyb 1 Not applicable.Agendia NGS Hyb 2 - Disodium dihydrogen ethylenediaminetetraacetateAgendia NGS Hyb 4 Not applicable.Agendia NGS Binding Buffer

Not applicable.


Not applicable.


: 4/4013/02/2018




:Other hazards which do not result in classification


None known.

Agendia NGS Hyb 1 None known.Agendia NGS Hyb 2 None known.Agendia NGS Hyb 4 None known.Agendia NGS Binding Buffer

None known.


None known.


None known.

Agendia NGS Nuclease- None known.

Supplemental label elements

Tactile warning of danger


Not applicable.


Not applicable.


Not applicable.


Not applicable.


Not applicable.


Not applicable.

:

: Agendia NGS Nuclease-Free Water

Not applicable.

Agendia NGS Hyb 1 Not applicable.Agendia NGS Hyb 2 Not applicable.Agendia NGS Hyb 4 Safety data sheet available on request.Agendia NGS Binding Buffer

Safety data sheet available on request.


Not applicable.


Not applicable.


Not applicable.


Not applicable.

Special packaging requirements

2.3 Other hazards

Annex XVII - Restrictions on the manufacture,placing on the market and use of certain dangerous substances,mixtures and articles


Not applicable.


Not applicable.


Not applicable.


Not applicable.


Not applicable.


Not applicable.


: 5/4013/02/2018



SECTION 2: Hazards identificationFree WaterAgendia NGS Elution Buffer

None known.

SECTION 3: Composition/information on ingredientsAgendia NGS Nuclease-Free Water

Mono-constituent substance

Agendia NGS Hyb 1 MixtureAgendia NGS Hyb 2 MixtureAgendia NGS Hyb 4 MixtureAgendia NGS Binding Buffer MixtureAgendia NGS Wash Buffer 1 MixtureAgendia NGS Wash Buffer 2 MixtureAgendia NGS Nuclease-Free Water

Mixture

Agendia NGS Elution Buffer Mixture

:3.1 Substances

Type

Product/ingredient name

Agendia NGS Nuclease-Free WaterWater REACH #: Annex IV

EC: 231-791-2CAS: 7732-18-5

100 Not classified. [A]

Agendia NGS Hyb 1Sodium chloride EC: 231-598-3

CAS: 7647-14-5≥10 - ≤25 Eye Irrit. 2, H319 [1]

Agendia NGS Hyb 2Disodium dihydrogen ethylenediaminetetraacetate

EC: 205-358-3CAS: 139-33-3

≥10 - ≤25 Acute Tox. 4, H302Acute Tox. 4, H332STOT RE 2, H373 (respiratory tract) (inhalation)

[1]

Agendia NGS Hyb 4Sulfuric acid monododecyl ester sodium salt (1:1)

CAS: 8012-56-4 ≤3 Acute Tox. 4, H302Acute Tox. 4, H332Skin Irrit. 2, H315Eye Irrit. 2, H319STOT SE 3, H335Aquatic Acute 1, H400 (M=1)Aquatic Chronic 3, H412

[1]

Agendia NGS Binding BufferSodium chloride EC: 231-598-3

CAS: 7647-14-5<10 Eye Irrit. 2, H319 [1]

Agendia NGS Elution Buffer2-Amino-2-(hydroxymethyl)propane-1,3-diol hydrochloride

EC: 214-684-5CAS: 1185-53-1

≥10 - <20 Skin Irrit. 2, H315Eye Irrit. 2, H319STOT SE 3, H335

[1]

Identifiers % TypeRegulation (EC) No. 1272/2008 [CLP]

See Section 16 for the full text of the H statements declared above.


: 6/4013/02/2018



SECTION 3: Composition/information on ingredients[1] Substance classified with a health or environmental hazard[2] Substance with a workplace exposure limit[3] Substance meets the criteria for PBT according to Regulation (EC) No. 1907/2006, Annex XIII[4] Substance meets the criteria for vPvB according to Regulation (EC) No. 1907/2006, Annex XIII[5] Substance of equivalent concern[6] Additional disclosure due to company policy[A] Constituent[B] Impurity[C] Stabilising additive

SECTION 4: First aid measures


Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Get medical attention if irritation occurs.

Agendia NGS Hyb 1 Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Continue to rinse for at least 10 minutes.Get medical attention.

Agendia NGS Hyb 2 Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Continue to rinse for at least 10 minutes.Get medical attention following exposure or if feeling unwell.

Agendia NGS Hyb 4 Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Get medical attention if irritation occurs.










Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Continue to rinse for at least 10 minutes.Get medical attention.

4.1 Description of first aid measures


Remove victim to fresh air and keep at rest in a position comfortable for breathing. Get medical attention if symptoms occur.

Agendia NGS Hyb 1 Remove victim to fresh air and keep at rest in a position comfortable for breathing. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. Get medical attention if adverse health effects persist or are severe. If unconscious, place in recovery position and get medical attention immediately.Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband.

Agendia NGS Hyb 2 Remove victim to fresh air and keep at rest in a position comfortable for breathing. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. Get medical attention following

Inhalation

Eye contact

:

:


: 7/4013/02/2018




Skin contact Agendia NGS Nuclease-Free Water

Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Get medical attention if symptoms occur.

Agendia NGS Hyb 1 Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Get medical attention if symptoms occur. Wash clothing before reuse. Clean shoes thoroughly before reuse.

Agendia NGS Hyb 2 Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Continue to rinse for at least 10 minutes. Get medical attention following exposure or if feeling unwell. Wash clothing before reuse. Clean shoes thoroughly before reuse.

Agendia NGS Hyb 4 Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Get medical attention if symptoms occur.









exposure or if feeling unwell. If unconscious, place in recovery position and get medical attention immediately.Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. In case of inhalation of decomposition products in a fire, symptoms may be delayed.The exposed person may need to be kept under medical surveillance for 48 hours.

Agendia NGS Hyb 4 Remove victim to fresh air and keep at rest in a position comfortable for breathing. Get medical attention if symptoms occur.










Remove victim to fresh air and keep at rest in a position comfortable for breathing. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. Get medical attention if adverse health effects persist or are severe. If unconscious, place in recovery position and get medical attention immediately.Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. In case of inhalation of decomposition products in a fire, symptoms may be delayed.The exposed person may need to be kept under medical surveillance for 48 hours.

:


: 8/4013/02/2018





Wash out mouth with water. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Do not induce vomiting unless directed to do so by medical personnel. Get medical attention if symptoms occur.

Agendia NGS Hyb 1 Wash out mouth with water. Remove dentures if any.Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Stop if the exposed person feels sick as vomiting may be dangerous. Do not induce vomiting unless directed to do so by medical personnel. If vomiting occurs,the head should be kept low so that vomit does not enter the lungs. Get medical attention if adverse health effects persist or are severe. Never give anything by mouth to an unconscious person. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband.

Agendia NGS Hyb 2 Wash out mouth with water. Remove dentures if any.Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Stop if the exposed person feels sick as vomiting may be dangerous. Do not induce vomiting unless directed to do so by medical personnel. If vomiting occurs,the head should be kept low so that vomit does not enter the lungs. Get medical attention following exposure or if feeling unwell. Never give anything by mouth to an unconscious person. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway.Loosen tight clothing such as a collar, tie, belt or waistband.

Agendia NGS Hyb 4 Wash out mouth with water. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Do not induce vomiting unless directed to do so by medical personnel. Get medical attention if symptoms occur.







Agendia NGS Nuclease- Wash out mouth with water. Remove victim to fresh air and


Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Continue to rinse for at least 10 minutes. Get medical attention. Wash clothing before reuse. Clean shoes thoroughly before reuse.

Ingestion :


: 9/4013/02/2018



SECTION 4: First aid measuresFree Water keep at rest in a position comfortable for breathing. If

material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Do not induce vomiting unless directed to do so by medical personnel. Get medical attention if symptoms occur.


Wash out mouth with water. Remove dentures if any.Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Stop if the exposed person feels sick as vomiting may be dangerous. Do not induce vomiting unless directed to do so by medical personnel. If vomiting occurs,the head should be kept low so that vomit does not enter the lungs. Get medical attention if adverse health effects persist or are severe. Never give anything by mouth to an unconscious person. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband.

Protection of first-aiders : Agendia NGS Nuclease-Free Water

No action shall be taken involving any personal risk or without suitable training.

Agendia NGS Hyb 1 No action shall be taken involving any personal risk or without suitable training. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation.

Agendia NGS Hyb 2 No action shall be taken involving any personal risk or without suitable training. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation.

Agendia NGS Hyb 4 No action shall be taken involving any personal risk or without suitable training.










No action shall be taken involving any personal risk or without suitable training. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation.

4.2 Most important symptoms and effects, both acute and delayed

Potential acute health effects



Agendia NGS Hyb 1 Causes serious eye irritation.Agendia NGS Hyb 2 No known significant effects or critical hazards.Agendia NGS Hyb 4 No known significant effects or critical hazards.Agendia NGS Binding Buffer









Causes serious eye irritation.

:Eye contact


: 10/4013/02/2018



SECTION 4: First aid measuresInhalation : Agendia NGS Nuclease-

Free WaterNo known significant effects or critical hazards.

Agendia NGS Hyb 1 No known significant effects or critical hazards.Agendia NGS Hyb 2 No known significant effects or critical hazards.Agendia NGS Hyb 4 No known significant effects or critical hazards.Agendia NGS Binding Buffer






















:Ingestion

Skin contact : Agendia NGS Nuclease-Free Water











Causes skin irritation.

Over-exposure signs/symptoms

Eye contact : Agendia NGS Nuclease-Free Water

No specific data.

Agendia NGS Hyb 1 Adverse symptoms may include the following:pain or irritationwateringredness

Agendia NGS Hyb 2 No specific data.Agendia NGS Hyb 4 No specific data.Agendia NGS Binding Buffer

No specific data.


No specific data.


No specific data.

Agendia NGS Nuclease- No specific data.


: 11/4013/02/2018




Skin contact

Ingestion

Inhalation Agendia NGS Nuclease-Free Water

No specific data.

Agendia NGS Hyb 1 No specific data.Agendia NGS Hyb 2 No specific data.Agendia NGS Hyb 4 No specific data.Agendia NGS Binding Buffer

No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


Adverse symptoms may include the following:

irritationredness

:

:

:

Free WaterAgendia NGS Elution Buffer


pain or irritationwateringredness

4.3 Indication of any immediate medical attention and special treatment needed


: 12/4013/02/2018



SECTION 4: First aid measuresNotes to physician Agendia NGS Nuclease-

Free WaterTreat symptomatically. Contact poison treatment specialist immediately if large quantities have been ingested or inhaled.

Agendia NGS Hyb 1 Treat symptomatically. Contact poison treatment specialist immediately if large quantities have been ingested or inhaled.

Agendia NGS Hyb 2 In case of inhalation of decomposition products in a fire,symptoms may be delayed. The exposed person may need to be kept under medical surveillance for 48 hours.

Agendia NGS Hyb 4 Treat symptomatically. Contact poison treatment specialist immediately if large quantities have been ingested or inhaled.


Treat symptomatically. Contact poison treatment specialist immediately if large quantities have been ingested or inhaled.








In case of inhalation of decomposition products in a fire,symptoms may be delayed. The exposed person may need to be kept under medical surveillance for 48 hours.

:

Specific treatments Agendia NGS Nuclease-Free Water

No specific treatment.

Agendia NGS Hyb 1 No specific treatment.Agendia NGS Hyb 2 No specific treatment.Agendia NGS Hyb 4 No specific treatment.Agendia NGS Binding Buffer










:

SECTION 5: Firefighting measures


Use an extinguishing agent suitable for the surrounding fire.

Agendia NGS Hyb 1 Use an extinguishing agent suitable for the surrounding fire.Agendia NGS Hyb 2 Use an extinguishing agent suitable for the surrounding fire.Agendia NGS Hyb 4 Use an extinguishing agent suitable for the surrounding fire.Agendia NGS Binding Buffer










5.1 Extinguishing media


None known.

Agendia NGS Hyb 1 None known.Agendia NGS Hyb 2 None known.Agendia NGS Hyb 4 None known.Agendia NGS Binding Buffer

None known.

Agendia NGS Wash None known.

Suitable extinguishing media

:

Unsuitable extinguishing media

:


: 13/4013/02/2018




Hazardous combustion products

Hazards from the substance or mixture


No specific data.

Agendia NGS Hyb 1 Decomposition products may include the following materials:phosphorus oxideshalogenated compoundsmetal oxide/oxides

Agendia NGS Hyb 2 Decomposition products may include the following materials:carbon dioxidecarbon monoxidenitrogen oxidesmetal oxide/oxides

Agendia NGS Hyb 4 Decomposition products may include the following materials:carbon dioxidecarbon monoxidesulfur oxidesmetal oxide/oxides


Decomposition products may include the following materials:

halogenated compoundsmetal oxide/oxides


No specific data.


No specific data.


No specific data.


Decomposition products may include the following materials:

carbon dioxidecarbon monoxidenitrogen oxideshalogenated compounds


In a fire or if heated, a pressure increase will occur and the container may burst.

Agendia NGS Hyb 1 In a fire or if heated, a pressure increase will occur and the container may burst.













:

:

Buffer 1Agendia NGS Wash Buffer 2

None known.


None known.


None known.

5.2 Special hazards arising from the substance or mixture


: 14/4013/02/2018





Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training.

Agendia NGS Hyb 1 Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training.














Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode. Clothing for fire-fighters (including helmets, protective boots and gloves)conforming to European standard EN 469 will provide a basic level of protection for chemical incidents.

Agendia NGS Hyb 1 Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode. Clothing for fire-fighters (including helmets, protective boots and gloves)conforming to European standard EN 469 will provide a basic level of protection for chemical incidents.






Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode. Clothing for

Special protective equipment for fire-fighters

:

5.3 Advice for firefighters

Special precautions for fire-fighters

:


: 15/4013/02/2018



SECTION 5: Firefighting measuresfire-fighters (including helmets, protective boots and gloves)conforming to European standard EN 469 will provide a basic level of protection for chemical incidents.







SECTION 6: Accidental release measures6.1 Personal precautions, protective equipment and emergency procedures

For non-emergency personnel


No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas.Keep unnecessary and unprotected personnel from entering.Do not touch or walk through spilt material. Put on appropriate personal protective equipment.

Agendia NGS Hyb 1 No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas.Keep unnecessary and unprotected personnel from entering.Do not touch or walk through spilt material. Avoid breathing vapour or mist. Provide adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Put on appropriate personal protective equipment.

Agendia NGS Hyb 2 No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas.Keep unnecessary and unprotected personnel from entering.Do not touch or walk through spilt material. Avoid breathing vapour or mist. Provide adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Put on appropriate personal protective equipment.

Agendia NGS Hyb 4 No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas.Keep unnecessary and unprotected personnel from entering.Do not touch or walk through spilt material. Put on appropriate personal protective equipment.






No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas.Keep unnecessary and unprotected personnel from entering.


: 16/4013/02/2018



SECTION 6: Accidental release measures

6.2 Environmental precautions


Avoid dispersal of spilt material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air).

Agendia NGS Hyb 1 Avoid dispersal of spilt material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air).

Agendia NGS Hyb 2 Avoid dispersal of spilt material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant

For emergency responders

:

Do not touch or walk through spilt material. Put on appropriate personal protective equipment.




No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas.Keep unnecessary and unprotected personnel from entering.Do not touch or walk through spilt material. Avoid breathing vapour or mist. Provide adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Put on appropriate personal protective equipment.


If specialised clothing is required to deal with the spillage,take note of any information in Section 8 on suitable and unsuitable materials. See also the information in "For non-emergency personnel".

Agendia NGS Hyb 1 If specialised clothing is required to deal with the spillage,take note of any information in Section 8 on suitable and unsuitable materials. See also the information in "For non-emergency personnel".













:


: 17/4013/02/2018



SECTION 6: Accidental release measuresauthorities if the product has caused environmental pollution (sewers, waterways, soil or air).

Agendia NGS Hyb 4 Avoid dispersal of spilt material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air).












Stop leak if without risk. Move containers from spill area.Dilute with water and mop up if water-soluble. Alternatively,or if water-insoluble, absorb with an inert dry material and place in an appropriate waste disposal container. Dispose of via a licensed waste disposal contractor.

Agendia NGS Hyb 1 Stop leak if without risk. Move containers from spill area.Dilute with water and mop up if water-soluble. Alternatively,or if water-insoluble, absorb with an inert dry material and place in an appropriate waste disposal container. Dispose of via a licensed waste disposal contractor.








Stop leak if without risk. Move containers from spill area.Dilute with water and mop up if water-soluble. Alternatively,or if water-insoluble, absorb with an inert dry material and

Methods for cleaning up :

6.3 Methods and material for containment and cleaning up


: 18/4013/02/2018



SECTION 6: Accidental release measuresplace in an appropriate waste disposal container. Dispose of via a licensed waste disposal contractor.


Stop leak if without risk. Move containers from spill area.Contain and collect spillage with non-combustible, absorbent material e.g. sand, earth, vermiculite or diatomaceous earth and place in container for disposal according to local regulations. Dispose of via a licensed waste disposal contractor.



6.4 Reference to other sections

See Section 1 for emergency contact information.See Section 8 for information on appropriate personal protective equipment.See Section 13 for additional waste treatment information.

:

SECTION 7: Handling and storage7.1 Precautions for safe handling

Protective measures :

Advice on general occupational hygiene

:


Put on appropriate personal protective equipment (see Section 8).

Agendia NGS Hyb 1 Put on appropriate personal protective equipment (see Section 8). Do not ingest. Avoid contact with eyes, skin and clothing. Avoid breathing vapour or mist. Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use.Empty containers retain product residue and can be hazardous. Do not reuse container.

Agendia NGS Hyb 2 Put on appropriate personal protective equipment (see Section 8). Do not breathe vapour or mist. Do not ingest.Avoid contact with eyes, skin and clothing. Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use.Empty containers retain product residue and can be hazardous. Do not reuse container.

Agendia NGS Hyb 4 Put on appropriate personal protective equipment (see Section 8).








Put on appropriate personal protective equipment (see Section 8). Keep away from acids.


Put on appropriate personal protective equipment (see Section 8). Do not ingest. Avoid contact with eyes, skin and clothing. Avoid breathing vapour or mist. Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use.Empty containers retain product residue and can be hazardous. Do not reuse container.


Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed.Workers should wash hands and face before eating,drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures.

Agendia NGS Hyb 1 Eating, drinking and smoking should be prohibited in areas


: 19/4013/02/2018



SECTION 7: Handling and storage


Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabelled containers. Use appropriate containment to avoid environmental contamination. See Section 10 for incompatible materials before handling or use.

Agendia NGS Hyb 1 Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and

7.2 Conditions for safe storage, including any incompatibilities

where this material is handled, stored and processed.Workers should wash hands and face before eating,drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures.

Agendia NGS Hyb 2 Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed.Workers should wash hands and face before eating,drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures.

Agendia NGS Hyb 4 Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed.Workers should wash hands and face before eating,drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures.











Storage :


: 20/4013/02/2018



SECTION 7: Handling and storagewell-ventilated area, away from incompatible materials (see Section 10) and food and drink. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabelled containers. Use appropriate containment to avoid environmental contamination. See Section 10 for incompatible materials before handling or use.

Agendia NGS Hyb 2 Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabelled containers. Use appropriate containment to avoid environmental contamination. See Section 10 for incompatible materials before handling or use.

Agendia NGS Hyb 4 Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabelled containers. Use appropriate containment to avoid environmental contamination. See Section 10 for incompatible materials before handling or use.








Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Separate from acids. Keep


: 21/4013/02/2018



SECTION 7: Handling and storagecontainer tightly closed and sealed until ready for use.Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabelled containers. Use appropriate containment to avoid environmental contamination. See Section 10 for incompatible materials before handling or use.



7.3 Specific end use(s)

Recommendations :

:Industrial sector specific solutions


Not applicable.


Not applicable.


Not applicable.


Not applicable.


Not applicable.


Not applicable.


Industrial applications, Professional applications.

Agendia NGS Hyb 1 Industrial applications, Professional applications.Agendia NGS Hyb 2 Industrial applications, Professional applications.Agendia NGS Hyb 4 Industrial applications, Professional applications.Agendia NGS Binding Buffer










SECTION 8: Exposure controls/personal protection8.1 Control parameters

Occupational exposure limits

No exposure limit value known.


: 22/4013/02/2018



SECTION 8: Exposure controls/personal protectionRecommended monitoring procedures

If this product contains ingredients with exposure limits, personal, workplace atmosphere or biological monitoring may be required to determine the effectiveness of the ventilation or other control measures and/or the necessity to use respiratory protective equipment. Reference should be made to monitoring standards, such as the following: European Standard EN 689 (Workplace atmospheres - Guidance for the assessment of exposure by inhalation to chemical agents for comparison with limit values and measurement strategy) European Standard EN 14042 (Workplace atmospheres - Guide for the application and use of procedures for the assessment of exposure to chemical and biological agents) European Standard EN 482 (Workplace atmospheres - General requirements for the performance of procedures for the measurement of chemical agents) Reference to national guidance documents for methods for the determination of hazardous substances will also be required.

Hand protection

Based on the hazard and potential for exposure, select a respirator that meets the appropriate standard or certification. Respirators must be used according to a respiratory protection program to ensure proper fitting, training, and other important aspects of use.

Chemical-resistant, impervious gloves complying with an approved standard should be worn at all times when handling chemical products if a risk assessment indicates this is necessary.

Safety eyewear complying with an approved standard should be used when a risk assessment indicates this is necessary to avoid exposure to liquid splashes, mists,gases or dusts. If contact is possible, the following protection should be worn, unless the assessment indicates a higher degree of protection: safety glasses with side-shields.

Eye/face protection

Respiratory protection :

:

:

:

Skin protection

Personal protective equipment for the body should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product.

:

Environmental exposure controls

: Emissions from ventilation or work process equipment should be checked to ensure they comply with the requirements of environmental protection legislation. In some cases, fume scrubbers, filters or engineering modifications to the process equipment will be necessary to reduce emissions to acceptable levels.

Appropriate engineering controls

: Good general ventilation should be sufficient to control worker exposure to airborne contaminants.

Wash hands, forearms and face thoroughly after handling chemical products, before eating, smoking and using the lavatory and at the end of the working period.Appropriate techniques should be used to remove potentially contaminated clothing.Wash contaminated clothing before reusing. Ensure that eyewash stations and safety showers are close to the workstation location.

8.2 Exposure controls

Hygiene measures :

No DNELs/DMELs available.

PNECs

No PNECs available

DNELs/DMELs

Individual protection measures

Body protection :

Other skin protection Appropriate footwear and any additional skin protection measures should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product.


: 23/4013/02/2018



SECTION 9: Physical and chemical properties

Physical state Agendia NGS Nuclease-Free Water

Liquid.

Agendia NGS Hyb 1 Liquid.Agendia NGS Hyb 2 Liquid.Agendia NGS Hyb 4 Liquid.Agendia NGS Binding Buffer

Liquid.


Liquid.


Liquid.


Liquid.


Liquid.


Odourless.

Agendia NGS Hyb 1 Not available.Agendia NGS Hyb 2 Not available.Agendia NGS Hyb 4 Not available.Agendia NGS Binding Buffer

Not available.


Not available.


Not available.


Not available.


Not available.

Odour


Colourless.


Not available.


Not available.


Not available.


Not available.


Not available.

Colour


Not available.


Not available.


Not available.


Not available.


Not available.

Odour threshold

:

:

:

:

9.1 Information on basic physical and chemical properties

Appearance


: 24/4013/02/2018





100°C

Agendia NGS Hyb 1 Not available.Agendia NGS Hyb 2 Not available.Agendia NGS Hyb 4 100°CAgendia NGS Binding Buffer

Not available.


100°C


100°C


100°C


Not available.

Melting point/freezing point

Initial boiling point and boiling range


0°C

Agendia NGS Hyb 1 Not available.Agendia NGS Hyb 2 Not available.Agendia NGS Hyb 4 0°CAgendia NGS Binding Buffer

Not available.


0°C


0°C


0°C


Not available.

pH

Flash point Agendia NGS Nuclease-Free Water

Not applicable.


Not available.


Not available.


Not available.


Not available.

Agendia NGS Elution Not available.


7

Agendia NGS Hyb 1 7.4Agendia NGS Hyb 2 8Agendia NGS Hyb 4 5.2 to 6.2Agendia NGS Binding Buffer

7.1 to 8.1


6.5 to 7.5


6.8 to 7.8


12.2 to 13.4


Not available.


Not available.

:

:

:

:


: 25/4013/02/2018




Vapour pressure Agendia NGS Nuclease-Free Water

3.2 kPa [room temperature]


Not available.


Not available.


Not available.


Not available.


Not available.

Evaporation rate Agendia NGS Nuclease-Free Water

Not available.


Not available.


Not available.


7.3 (butyl acetate = 1)


Not available.


Not available.

Buffer


Not available.


Not available.


Not available.


Not available.


Not available.


Not available.

Upper/lower flammability or explosive limits

:

:

:

Flammability (solid, gas) : Agendia NGS Nuclease-Free Water

Not applicable.


Not applicable.


Not applicable.


Not applicable.


Not applicable.


Not applicable.


: 26/4013/02/2018




Relative density

Vapour density

Solubility(ies)


1


Not available.


Not available.


Not available.


Not available.


Not available.


0.62 [Air = 1]


Not available.


Not available.


Not available.


Not available.


Not available.


Easily soluble in the following materials: cold water and hot water.

Agendia NGS Hyb 1 Soluble in the following materials: cold water and hot water.

Agendia NGS Hyb 2 Soluble in the following materials: cold water and hot water.

Agendia NGS Hyb 4 Easily soluble in the following materials: cold water and hot water.








Not available.


Soluble in the following materials: cold water and hot water.


-1.38


Not available.


Not available.


Not available.


Not available.

Partition coefficient: n-octanol/water

:

:

:

:


: 27/4013/02/2018




Auto-ignition temperature Agendia NGS Nuclease-Free Water

Not applicable.


Not available.


Not available.


Not available.


Not available.


Not available.


Not available.


Not available.


Not available.


Not available.


Not available.

Agendia NGS Elution Not available.


Not available.

Viscosity Agendia NGS Nuclease-Free Water

Not available.


Not available.


Not available.


Not available.


Not available.


Not available.

Explosive properties

:

:

:

Decomposition temperature : Agendia NGS Nuclease-Free Water

Not available.


Not available.


Not available.


Not available.


Not available.


Not available.


: 28/4013/02/2018



SECTION 9: Physical and chemical propertiesBuffer


Not applicable.


Not available.


Not available.


Not available.


Not available.


Not available.

Oxidising properties :

9.2 Other information

No additional information.

SECTION 10: Stability and reactivity


The product is stable.

Agendia NGS Hyb 1 The product is stable.Agendia NGS Hyb 2 The product is stable.Agendia NGS Hyb 4 The product is stable.Agendia NGS Binding Buffer










10.2 Chemical stability :

10.1 Reactivity : Agendia NGS Nuclease-Free Water

No specific test data related to reactivity available for this product or its ingredients.

Agendia NGS Hyb 1 No specific test data related to reactivity available for this product or its ingredients.














: 29/4013/02/2018



SECTION 10: Stability and reactivity

10.6 Hazardous decomposition products

10.4 Conditions to avoid Agendia NGS Nuclease-Free Water

No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


Under normal conditions of storage and use, hazardous decomposition products should not be produced.

Agendia NGS Hyb 1 Under normal conditions of storage and use, hazardous decomposition products should not be produced.



:

:

10.5 Incompatible materials

:

10.3 Possibility of hazardous reactions


Under normal conditions of storage and use, hazardous reactions will not occur.

Agendia NGS Hyb 1 Under normal conditions of storage and use, hazardous reactions will not occur.














May react or be incompatible with oxidising materials.

Agendia NGS Hyb 1 May react or be incompatible with oxidising materials.Agendia NGS Hyb 2 May react or be incompatible with oxidising materials.Agendia NGS Hyb 4 May react or be incompatible with oxidising materials.Agendia NGS Binding Buffer







Reactive or incompatible with the following materials:

acidsAgendia NGS Elution Buffer



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SECTION 10: Stability and reactivityAgendia NGS Binding Buffer










SECTION 11: Toxicological information

Acute toxicity

Agendia NGS Hyb 1Sodium chloride LD50 Oral Rat 3000 mg/kg -


LD50 Oral Rat 2 g/kg -

Agendia NGS Hyb 4Sulfuric acid monododecyl ester sodium salt (1:1)

LD50 Oral Rat 1288 mg/kg -

Agendia NGS Binding BufferSodium chloride LD50 Oral Rat 3000 mg/kg -

Product/ingredient name Result Species Dose Exposure

Carcinogenicity

Mutagenicity

Conclusion/Summary : Not available.

Irritation/Corrosion

Agendia NGS Hyb 1Sodium chloride Eyes - Moderate irritant Rabbit - 24 hours 100

milligrams-

Eyes - Moderate irritant Rabbit - 10 milligrams -Skin - Mild irritant Rabbit - 24 hours 500

milligrams-

Agendia NGS Binding BufferSodium chloride Eyes - Moderate irritant Rabbit - 24 hours 100

milligrams-

Eyes - Moderate irritant Rabbit - 10 milligrams -Skin - Mild irritant Rabbit - 24 hours 500

milligrams-

Product/ingredient name Result Score Exposure Observation

Sensitiser


Species

11.1 Information on toxicological effects


Teratogenicity


Reproductive toxicity



: 31/4013/02/2018




Potential acute health effects


Not available.

Agendia NGS Hyb 1 Routes of entry anticipated: Oral, Dermal, Inhalation.Agendia NGS Hyb 2 Routes of entry anticipated: Oral, Dermal, Inhalation.Agendia NGS Hyb 4 Routes of entry anticipated: Oral, Dermal, Inhalation.Agendia NGS Binding Buffer

Not available.


Not available.


Not available.


Routes of entry anticipated: Oral, Dermal, Inhalation.


Routes of entry anticipated: Oral, Dermal, Inhalation.

Information on likely routes of exposure

:

Inhalation : Agendia NGS Nuclease-Free Water
























:Ingestion

Skin contact : Agendia NGS Nuclease-Free Water










Agendia NGS Elution Causes skin irritation.


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SECTION 11: Toxicological informationBuffer



Agendia NGS Hyb 1 Causes serious eye irritation.Agendia NGS Hyb 2 No known significant effects or critical hazards.Agendia NGS Hyb 4 No known significant effects or critical hazards.Agendia NGS Binding Buffer









Causes serious eye irritation.

:Eye contact

Symptoms related to the physical, chemical and toxicological characteristics

Skin contact

Ingestion

Inhalation Agendia NGS Nuclease-Free Water

No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.


No specific data.

:

:

:


: 33/4013/02/2018




Potential chronic health effects



Agendia NGS Hyb 1 No known significant effects or critical hazards.Agendia NGS Hyb 2 May cause damage to organs through prolonged or

repeated exposure.Agendia NGS Hyb 4 No known significant effects or critical hazards.Agendia NGS Binding Buffer










General :



irritationredness

Eye contact : Agendia NGS Nuclease-Free Water

No specific data.

Agendia NGS Hyb 1 Adverse symptoms may include the following:pain or irritationwateringredness

Agendia NGS Hyb 2 No specific data.Agendia NGS Hyb 4 No specific data.Agendia NGS Binding Buffer

No specific data.


No specific data.


No specific data.


No specific data.



pain or irritationwateringredness

Delayed and immediate effects as well as chronic effects from short and long-term exposure

Short term exposure

Long term exposure

Potential immediate effects

Potential delayed effects

:

:

Potential immediate effects

Potential delayed effects

:

:

Not available.

Not available.

Not available.

Not available.


: 34/4013/02/2018



SECTION 11: Toxicological informationAgendia NGS Nuclease-Free Water












Carcinogenicity :













Mutagenicity :













Teratogenicity :

Developmental effects : Agendia NGS Nuclease-Free Water













: 35/4013/02/2018



SECTION 11: Toxicological informationFertility effects : Agendia NGS Nuclease-

Free WaterNo known significant effects or critical hazards.











SECTION 12: Ecological information12.1 Toxicity

Agendia NGS Hyb 1Sodium chloride Acute EC50 4.74 g/L Fresh water Algae - Chlamydomonas

reinhardtii96 hours

Acute EC50 519.6 mg/l Fresh water Crustaceans - Cypris subglobosa

48 hours

Acute EC50 402600 μg/l Fresh water Daphnia - Daphnia magna 48 hoursAcute IC50 6.87 g/L Fresh water Aquatic plants - Lemna minor 96 hoursAcute LC50 1000000 μg/l Fresh water Fish - Morone saxatilis - Larvae 96 hoursChronic LC10 781 mg/l Fresh water Crustaceans - Hyalella azteca -

Juvenile (Fledgling, Hatchling,Weanling)

3 weeks

Chronic NOEC 6 g/L Fresh water Aquatic plants - Lemna minor 96 hoursChronic NOEC 0.314 g/L Fresh water Daphnia - Daphnia pulex 21 daysChronic NOEC 100 mg/l Fresh water Fish - Gambusia holbrooki -

Adult8 weeks


Acute LC50 320 mg/l Fresh water Fish 96 hours

Agendia NGS Binding BufferSodium chloride Acute EC50 4.74 g/L Fresh water Algae - Chlamydomonas

reinhardtii96 hours

Acute EC50 519.6 mg/l Fresh water Crustaceans - Cypris subglobosa

48 hours

Acute EC50 402600 μg/l Fresh water Daphnia - Daphnia magna 48 hoursAcute IC50 6.87 g/L Fresh water Aquatic plants - Lemna minor 96 hoursAcute LC50 1000000 μg/l Fresh water Fish - Morone saxatilis - Larvae 96 hoursChronic LC10 781 mg/l Fresh water Crustaceans - Hyalella azteca -

Juvenile (Fledgling, Hatchling,Weanling)

3 weeks

Chronic NOEC 6 g/L Fresh water Aquatic plants - Lemna minor 96 hoursChronic NOEC 0.314 g/L Fresh water Daphnia - Daphnia pulex 21 daysChronic NOEC 100 mg/l Fresh water Fish - Gambusia holbrooki -

Adult8 weeks

Product/ingredient name SpeciesResult Exposure

12.2 Persistence and degradability

Not available.


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SECTION 12: Ecological information

Mobility Not available.:

LogPow BCF Potential

12.3 Bioaccumulative potential

12.6 Other adverse effects No known significant effects or critical hazards.

Product/ingredient name

Agendia NGS Nuclease-Free WaterWater -1.38 - low


-4.3 1.8 low

Product/ingredient name Aquatic half-life Photolysis Biodegradability

Agendia NGS Nuclease-Free WaterWater - - Readily

PBT : Not applicable.

vPvB : Not applicable.

12.4 Mobility in soil

Soil/water partition coefficient (KOC)

Not available.:

12.5 Results of PBT and vPvB assessment

:

SECTION 13: Disposal considerations

Within the present knowledge of the supplier, this product is not regarded as hazardous waste, as defined by EU Directive 2008/98/EC.

Hazardous waste :

The generation of waste should be avoided or minimised wherever possible. Disposal of this product, solutions and any by-products should at all times comply with the requirements of environmental protection and waste disposal legislation and any regional local authority requirements. Dispose of surplus and non-recyclable products via a licensed waste disposal contractor. Waste should not be disposed of untreated to the sewer unless fully compliant with the requirements of all authorities with jurisdiction.

:Methods of disposal

13.1 Waste treatment methods

Product

Packaging

Methods of disposal :

Special precautions :

The generation of waste should be avoided or minimised wherever possible. Waste packaging should be recycled. Incineration or landfill should only be considered when recycling is not feasible.

This material and its container must be disposed of in a safe way. Empty containers or liners may retain some product residues. Avoid dispersal of spilt material and runoff and contact with soil, waterways, drains and sewers.


: 37/4013/02/2018



SECTION 14: Transport information

14.7 Transport in bulk according to Annex II of Marpol and the IBC Code

: Not available.

ADR/RID / IMDG / IATA Not regulated.:

14.6 Special precautions for user

: Transport within user’s premises: always transport in closed containers that are upright and secure. Ensure that persons transporting the product know what to do in the event of an accident or spillage.

SECTION 15: Regulatory information

Other EU regulations


Not applicable.

Agendia NGS Hyb 1 Not applicable.Agendia NGS Hyb 2 Not applicable.Agendia NGS Hyb 4 Not applicable.Agendia NGS Binding Buffer Not applicable.Agendia NGS Wash Buffer 1 Not applicable.Agendia NGS Wash Buffer 2 Not applicable.Agendia NGS Nuclease-Free Water

Not applicable.

Agendia NGS Elution Buffer Not applicable.

Annex XVII - Restrictions on the manufacture,placing on the market and use of certain dangerous substances,mixtures and articles

:

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture

EU Regulation (EC) No. 1907/2006 (REACH)

Annex XIV - List of substances subject to authorisation

Substances of very high concern

None of the components are listed.

Seveso Directive

This product is not controlled under the Seveso Directive.

Annex XIV

None of the components are listed.

Ozone depleting substances (1005/2009/EU)

Not listed.

Prior Informed Consent (PIC) (649/2012/EU)

Not listed.

International regulations

Chemical Weapon Convention List Schedules I, II & III Chemicals

Montreal Protocol (Annexes A, B, C, E)

Not listed.

Stockholm Convention on Persistent Organic Pollutants

Not listed.

Rotterdam Convention on Prior Informed Consent (PIC)

Not listed.

Not listed.

UNECE Aarhus Protocol on POPs and Heavy Metals

Not listed.

Inventory list


: 38/4013/02/2018



SECTION 15: Regulatory information

15.2 Chemical safety assessment

This product contains substances for which Chemical Safety Assessments might still be required.

:

Europe : Not determined.

Australia : Not determined.

Canada : Not determined.

China : Not determined.

Japan : Japan inventory (ENCS): All components are listed or exempted.Japan inventory (ISHL): All components are listed or exempted.

Republic of Korea : Not determined.

Malaysia : Not determined.

New Zealand : Not determined.

Philippines : Not determined.

Taiwan : Not determined.

United States : Not determined.

Turkey : Not determined.

Thailand : Not determined.

Viet Nam : Not determined.

SECTION 16: Other informationIndicates information that has changed from previously issued version.

Abbreviations and acronyms

: ATE = Acute Toxicity EstimateCLP = Classification, Labelling and Packaging Regulation [Regulation (EC) No.1272/2008]DNEL = Derived No Effect LevelEUH statement = CLP-specific Hazard statementPNEC = Predicted No Effect ConcentrationRRN = REACH Registration Number

Full text of abbreviated H statements

Procedure used to derive the classification according to Regulation (EC) No. 1272/2008 [CLP/GHS]

Classification Justification

Agendia NGS Hyb 1Eye Irrit. 2, H319 Calculation method

Agendia NGS Hyb 2STOT RE 2, H373 Calculation method

Agendia NGS Elution BufferSkin Irrit. 2, H315 Calculation methodEye Irrit. 2, H319 Calculation method

Agendia NGS Hyb 1H319 Causes serious eye irritation.

Agendia NGS Hyb 2H302 Harmful if swallowed.H332 Harmful if inhaled.H373 (inhalation) May cause damage to organs through prolonged or repeated

exposure if inhaled.H373 May cause damage to organs through prolonged or repeated

exposure.

Agendia NGS Hyb 4H302 Harmful if swallowed.


: 39/4013/02/2018



SECTION 16: Other information

Date of issue/ Date of revision

Version

Notice to reader

Date of previous issue

:

:

:

13/02/2018

No previous validation

1

To the best of our knowledge, the information contained herein is accurate. However, neither the above-named supplier, nor any of its subsidiaries, assumes any liability whatsoever for the accuracy or completeness of the information contained herein.Final determination of suitability of any material is the sole responsibility of the user. All materials may present unknown hazards and should be used with caution. Although certain hazards are described herein, we cannot guarantee that these are the only hazards that exist.

Full text of classifications [CLP/GHS]

H315 Causes skin irritation.H319 Causes serious eye irritation.H332 Harmful if inhaled.H335 May cause respiratory irritation.H400 Very toxic to aquatic life.H412 Harmful to aquatic life with long lasting effects.

Agendia NGS Binding BufferH319 Causes serious eye irritation.

Agendia NGS Elution BufferH315 Causes skin irritation.H319 Causes serious eye irritation.H335 May cause respiratory irritation.

Agendia NGS Hyb 1Eye Irrit. 2, H319 SERIOUS EYE DAMAGE/EYE IRRITATION - Category 2

Agendia NGS Hyb 2Acute Tox. 4, H302 ACUTE TOXICITY (oral) - Category 4Acute Tox. 4, H332 ACUTE TOXICITY (inhalation) - Category 4STOT RE 2, H373 (inhalation) SPECIFIC TARGET ORGAN TOXICITY - REPEATED EXPOSURE

(inhalation) - Category 2STOT RE 2, H373 SPECIFIC TARGET ORGAN TOXICITY - REPEATED EXPOSURE

- Category 2

Agendia NGS Hyb 4Acute Tox. 4, H302 ACUTE TOXICITY (oral) - Category 4Acute Tox. 4, H332 ACUTE TOXICITY (inhalation) - Category 4Aquatic Acute 1, H400 SHORT-TERM (ACUTE) AQUATIC HAZARD - Category 1Aquatic Chronic 3, H412 LONG-TERM (CHRONIC) AQUATIC HAZARD - Category 3Eye Irrit. 2, H319 SERIOUS EYE DAMAGE/EYE IRRITATION - Category 2Skin Irrit. 2, H315 SKIN CORROSION/IRRITATION - Category 2STOT SE 3, H335 SPECIFIC TARGET ORGAN TOXICITY - SINGLE EXPOSURE

(Respiratory tract irritation) - Category 3

Agendia NGS Binding BufferEye Irrit. 2, H319 SERIOUS EYE DAMAGE/EYE IRRITATION - Category 2

Agendia NGS Elution BufferEye Irrit. 2, H319 SERIOUS EYE DAMAGE/EYE IRRITATION - Category 2Skin Irrit. 2, H315 SKIN CORROSION/IRRITATION - Category 2STOT SE 3, H335 SPECIFIC TARGET ORGAN TOXICITY - SINGLE EXPOSURE

(Respiratory tract irritation) - Category 3


: 40/4013/02/2018

SAFETY DATA SHEET - Agendia€¦ · 2015/830 - United Kingdom (UK) SECTION 1: Identification of the...

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