SA SIG Small Animal Imaging SA SIG. FACT Most humans are all animal Not all animals are human You...
-
Upload
brianne-jackson -
Category
Documents
-
view
212 -
download
0
Transcript of SA SIG Small Animal Imaging SA SIG. FACT Most humans are all animal Not all animals are human You...
SA SIG
Small Animal Imaging
SA SIG
SA SIG
FACT
• Most humans are all animal
• Not all animals are human
• You have a head on your shoulders…
SA SIG
Quick History
• Long long ago… Beginnings of Human Imaging.
• Late ‘70s digital imaging “tomography.”
• Human based on the *scientific concept of the crown.
*Archimedes
SA SIG
State-of-the-Art
Human Imaging
VS
non-human animal imaging.
THUS
Reverse Translation of Human Imaging to Animal Imaging Technology Required.
SA SIG
Visualization and Quantification of Fat
SA SIG
Models: Prostate Cancer
QuickTime™ and aTIFF (LZW) decompressor
are needed to see this picture.
SA SIG
Imaging: Radiology to Histology
SA SIG
Imaging: MRI Histology
SA SIG
Novel Contrast Agents
SA SIG
Contrast Agents: In-Vivo, In-Vitro
NISTNINDSGUMC
SA SIG
Concept of Integrated Imaging
SA SIG
Pre-Post Intervention Link
• Free text is perhaps not the best annotation for preclinical research data. Classification may be needed. VOCABULARY
*Adapted from Dr. T. J. FitzGerald, Quality Assurance Review Center Director’s Thursday Presentation.
*
SA SIG
Stereotaxic Surgery
SA SIG
Stereotaxic Imaging
SA SIG
Histological Sectioning
SA SIG
Today’s Products
SA SIG
Some Industry SAI Leaders:
MRI/NMR Bruker-BioSpin Corp. Varian, Inc. Siemens AG Advanced Veterinary Technologies, Inc. microPet/SPECT Philips Medical Concorde Microsystems Proportional Technolo gies, Inc. Gamma Medica, Inc. Suinsa
Optical Imaging Advanced Research Technologies Berthold Techn ologies GmbH & Co. Comecer Corp. Kodak Scientific Imaging OptoSonincs, Inc. VisualSonics Xenogen Mauna Kea Technolog ies Hamamatsu Photonics LabLogic Systems Ltd. VisEN Medical
microCT GE Medical Imtek, Inc. Faxitron X-Ray Corporation SCANCO Medical AG SkyScan TeraRecon
Accessories Spin Systems Ltd Rapid Biomedical, GmbH Doty Scientific, Inc. Resonance Research, Inc. SA Instruments, Inc. Luxtron Corporation Tecomet Insight Neuroimaging Systems, Inc.
SA SIG
SOME Collaborating Institutions:
John's Hopkins University
U-Robotics Laboratory, Urological Institute (Baltimore, MD)
Johns Hopkins University, Bloomberg School, Neurotoxicology & Molecular Imaging (Baltimore, MD)
NIST, (Gaithersberg, MD)
University of Virginia, Radiology & Biomedical Engineering, Small Animal Multi-Modality Imaging Center (Charlottesville, VA)
NIH-NINDS, Laboratory of Functional and Molecular Imaging (Bethesda, MD)
Thomas Jefferson University
(Philadelphia, PA)
University of the District of Columbia
(Washington, DC)
Georgetown University
(Washington, DC)
ASI Instruments Inc.
(Warren, MI)
You Too can become a part of this!
SA SIG
Objectives:
• Establish overall structure and scope for Small Animal Imaging projects.
• Prioritize Small Animal imaging projects for Workspace.
• Define requirements for Small Animal Imaging data management standards.
• Propose integration requirements for “caBIG™ Compliant” In Vivo Imaging data management software and tools.
• Define operational requirements and procedures for caBIG™ integration of relevant small animal medical imaging commercial software systems.
• Prioritize tool and software development requirements.
• Create specifications against prioritized tools and activities.
• Develop test and validation requirement standards for Workspace software and tools.
• Review completed tools and projects, and evaluate against initial specification, test and validation requirements.
SA SIG
Establish overall structure and scope for Small Animal Imaging projects.
• Call to Industry and SAILs centers• Import/export of image data, meta file data.• Link to associated data, spectroscopy,
histology, etc. (to be defined.)• Visualization tools (“veterinary radiology”
space.), mapping of multimodality data.• Identifier/classification labeling.• Annotation + CAD.
SA SIG
Prioritize Small Animal imaging projects for Workspace.
• Call to Industry.
• Call to major small animal imaging centers.
• Use of survey material
SA SIG
Define requirements for Small Animal Imaging data management standards.
• Read/import image data from all digital imaging sources (DICOM may not be correctly implemented on these systems.)
• Read/import metafile information (not always part of header, sometimes separate file or not available.)
• Link radiological image data to histological image data and potentially.
• Map animal data to relevant human disease (Jackson Lab).
SA SIG
Define requirements for Small Animal Imaging data management standards.
(Continued)
• White paper on SAI data sources/formats.• Identifier/classification labeling (modality(ies),
species, type of animal model (genetic, induced, xenograft, mode of induction)
• Link data to genetic/other data.• Veterinary coordinate system
SA SIG
Propose integration requirements for “caBIG™ Compliant” In Vivo Imaging data management
software and tools.
• Linear Methodology.• Call to Standards and Interoperability (SIO).• Call to Software • Suggest standards to industry and SAILs perhaps
through NCI, NCRR and other relevant funding agencies.
SA SIG
Define operational requirements and procedures for caBIG™ integration of relevant
small animal medical imaging commercial software systems.
SA SIG
Prioritize tool and software development requirements.
SA SIG
Create specifications against prioritized tools and activities.
SA SIG
Develop test and validation requirement standards for Workspace software and
tools.
• Call to test bed “what are you doing” (remember: emulation is the highest form of flattery) I.e. evaluate tumor volume with model (growth) and treatment (smaller??).
• Co-register modalities, phantom work.
SA SIGReview completed tools and projects, and
evaluate against initial specification, test and validation requirements.
SA SIG
Summary
• Vocabulary: Species, Models, contrast agents/tracers/ligans, Coordinates (rostral…), “Identifiers”.