RSC 325: Clinical Pathophysiology

SYLLABUS

Summer Semester 2012

Course Coordinator and Faculty

Dr. Mahmoud Kaddoura, PhD, CAGS, MSN, MED

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Massachusetts College of Pharmacy and Health SciencesSchool of Radiologic Sciences

RSC 325Clinical Pathophysiology

Summer 20124 Credits

Course Coordinator and FacultyMahmoud Kaddoura PhD, CAGS, MSN, MEDOffice Hours: Mondaya and Thursdays 10:30 a.m. – 12 Noon Griffin 304Phone: 617-274-3381Email: Mahmoud.kaddoura@mcphs.edu

Course Meetings Day/Time: Mondays and Thursdays 8 a.m. – 10:30 a.m. and as designated by faculty, Online Location: Fennel, Room 113Campus: Boston

Course Description: Students build on prerequisite biological sciences courses and gain foundational knowledge regarding normal and abnormal pathophysiological principles. Students learn the etiology, pathogenesis and clinical manifestations of selected health problems across the lifespan in diverse populations. Students explore current research findings relevant to the pathophysiology of common illnesses. Students analyze laboratory data in light of actual and potential pathophysiological processes. Special emphasis is given to the case study analysis of pathophysiological manifestations and related complications of common health problems.

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Course objectives: Upon completion of the course the student will be able to:

1. Describe the pathophysiology for selected health problems across the lifespan.2. Explain the developmental physiology, usual etiologies, pathogenesis, and clinical

manifestations of commonly seen altered health states.3. Describe the genetic relationship, cultural and ethnic considerations of relevant health

problems across the lifespan.4. Analyze the relationship between normal physiology and pathological phenomena

produced by altered states across the life span.5. Explain the complications associated with selected health problems.6. Analyze evidence-based research literature and use it to explain the diagnosis,

mechanisms of signs and symptoms, and treatment of selected case studies.

Required texts and materials:

Required:

Gould, B. & Dyer, R. (2012). Pathophysiology for the Health Professions (4th ed.). St. Louis, MO: Saunders/Elsevier. ISBN-13: 978-1-4377-0965-0.

Recommended:

Gould, B. & Dyer, R. (2012). Study Guide for Pathophysiology for the Health Professions (4th ed.). St. Louis, MO: Saunders/Elsevier. ISBN-13: 978-1-4377-1456-2.

Methods of Instruction : Methods of instruction for the course may include, lecture, on-line content, use of technology and media, guest speakers, discussion, weekly assignments, and case studies. Learning in the course will be enhanced by the use of Blackboard technology.

Methods of Evaluation:1. Quizzes (4 total- 12.5% each) 50%2. Case Studies 20%3. Comprehensive Final Examination 20%4. Pop quizzes, prompt attendance and active participation 10%

100%QuizzesThere will be five quizzes that will measure student progress on a sequential basis during the course. Questions on the quizzes will be derived from the content of the course prior to each quiz, including questions from the text book, online content, power point slides, and/or other appropriate resources. The quizzes are not cumulative and will include only the content not tested on prior to each quiz. Some of the quizzes will be taken in class and some others will be taken online, according to the discretion of the course faculty.RSC 325Summer 2012

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Case Studies

Students will respond to the case studies related to the online content of this course. For each of the case studies, students are required to read the assigned readings and related evidence-based research literature first, and then analyze the cases to answer the open-ended questions related to the diagnosis, pathophysiology of signs and symptoms, and treatment of the clients in the selected case studies. The answers to each case study should be concise (less than one page per case using any format). Completed responses should be posted in the Case Studies Forum on blackboard and a hardcopy should be handed to the professor on or before the due deadline. Though this is not a group project, please take the opportunity to read other responses and feel free to add comments and discuss why you agree or disagree with the postings of your peers based on evidence-based practice and research. Please complete your answer to each case study within one page, single spaced, and using 12 point font.

Final ExaminationThe comprehensive final examination will measure students’ understanding of the entire content covered throughout the course. Questions on the comprehensive final exam will be derived from all sources of learning materials utilized in the course to include the text book, online content, power point slides, and/or other appropriate resources.

Pop quizzes, prompt attendance and active participation Students are expected to have a pop quiz any time the professor decides, at the beginning of any session he chooses. The questions of the pop quizzes are derived from the assigned readings for the day of the pop quiz. Students are required to attend all classes and participate actively in the discussion of each session to foster their active learning. Although the pop quizzes, prompt attendance, and active participation are allotted 10% of the final grade, the course coordinator and faculty reserves the right to add up to 10% to the grade of those students who always show up to class on time and come very well prepared, participate actively in the classroom discussion, perform excellently in the pop quizzes, and reflect their adequate preparation and understanding of the content in class.

Grading Criteria:A 4.0 100-94A- 3.7 93-90B+ 3.3 89-87B 3.0 86-83B- 2.7 82-80C+ 2.3 79-78

C 2.0 77-73 (minimum passing grade is 75%)C- 1.7 72-70D 1.0 69-60F 0.0 <60

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The MCPHS School of Radiologic Sciences practice is to eliminate decimal points and to assign whole numbers as final course grades. The "rounding up” of a final grade is based on 0.50 or above, not 0.49, 0.48, etc. For example, if the student grade is 72.49 or less, his/her final grade of record is 72. On the other hand, if the student grade is 72.50 or above, then his/her final grade of record is 73.

Course Requirements: It is the responsibility of the student to complete all reading assignments prior to lecture and lab. All students are expected to be punctual for every class and very well prepared to take a pop quiz at the beginning of each in class session. Cell phones or any other electronic device are not to be used in the lecture hall. Any student using one of these devices will be asked to leave the class immediately. Please note; A ringing phone means you are using it. So turn phones off when you come to class. Failure to comply will result in the student being asked to leave the class. Assessment of Student Learning and Teaching Effectiveness Students will be asked to provide regular class evaluations via ‘minute paper’ submission (anonymous) and through Socratic dialogue. In addition, students will participate in computerized end of course evaluations (confidential).

Students with DisabilitiesStudents with documented disabilities who wish to request reasonable accommodations under section 504 of the Rehabilitation Act and the Americans with Disabilities Act should contact the Coordinator of Disability Support Services in the Academic Support services office (Boston Campus 617-732-2755) to discuss the accommodations process.

PlagiarismStudents are expected to abide by the College’s Academic Honesty Policy as explained in the MCPHS Student Handbook. Plagiarism is considered a violation of this policy. Plagiarism is defined as submitting another person’s work as one’s own without proper acknowledgment or using the words or ideas of others without crediting the source of those words or ideas.

E-mail:All MCPHS students are required to open, utilize, and maintain (i.e. keep storage within the maximum set by IS) an MCPHS e-mail account. All students are responsible for regularly checking their MCPHS e-mail and for the information contained therein. Please check and empty your email accounts regularly, if your email account is full you will not receive email sent by the instructor. Only MCPHS accounts will be used in all matters related to academics, student life, and College notifications. The College does not forward MCPHS e-mail to personal e-mail accounts.

*Please check and empty your email accounts regularly, if your email account is full you will not receive email sent by the professor. This will not be considered an adequate excuse for not completing assignments.

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*Please email course faculty via mcphs.edu accounts and not via my.mcphs.edu (Blackboard). Additionally, please allow 24-48 hours for faculty response.

Quiz/Exam ReviewsAll students will have the opportunity to review exams.  This process is used to help students determine how to improve the way they prepare for and take tests.  After the exam is taken and the grade is posted by the respective faculty member, there will be a designated time to allow students to review the exam. If the student has any questions or concerns regarding the exam they should meet with respective faculty during posted office hours or by appointment. Once the review has taken place, students will have no further access to their quizzes/exams for security reasons.

Attendance and Absences from ExaminationsRegular class attendance is mandatory. Absences of more than six (6) didactic hours will result in a final grade reduction of one full letter grade (e.g. B to C). Absences of more than nine (9) didactic hours will result in a failing grade for the course. 

In the case of illness or prolonged absence, it is the student’s responsibility to notify the office of Academic Support Services (Boston) and his/her course faculty within 24-48 hours from the first date of absence.  With acceptable documentation from a student, an official memorandum will be issued notifying faculty of an excused absence.  In the case of an approved, excused absence, the course faculty will make reasonable attempts to assist the student to satisfy requirements of the course (e.g., make up exams). 

Students are expected to abide by instructions in each course syllabus regarding student responsibilities related to class absences.  Students who fail to do so may be ineligible to receive an excused absence, regardless of the reason for the absence.  With respect to completion of work missed, if an acceptable agreement between the student and professor cannot be reached, the School Dean will serve as arbitrator (reference MCPHS Catalog 2009-2012, p.71).  The faculty has the right whether or not to allow make up tests.

Late Papers (Case Studies)Students may only make up missed class assignments, quizzes, and exams if an “excused absence” has been granted and if the faculty approves. Graded work that is missed due to an “unexcused absence” will be assigned a grade of ZERO. Students are expected to submit all papers on the dates listed in the syllabus unless an extension has been granted by course faculty. Late papers will be marked down by 5 points for each late day, including weekends and holidays. Issues/concerns regarding the completion and or submission of the assignment must be brought to the attention of the course faculty prior to the due date of the assignment. Grades will not be re-considered after submission of the assignment and subsequent posting of the grade.

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Attendance PolicyMCPHS supports a learner-centered environment. Attendance and participation in classroom learning experiences directly correlates with successful course completion and represents a basic professional behavior. Therefore, students are responsible to come to class on time prepared, and engage in their own learning and professional comportment.

Students are expected to attend all classes. Regardless of whether they attend all classes or not, students are responsible for all class content and assignments.

Under no circumstances may lectures be recorded. Students may only make up missed class assignments, quizzes, and exams if an

excused absence has been granted and if the faculty approves a makeup. Graded work that is missed due to an unexcused absence will be assigned a grade of “0”.

The course faculty/school administrative assistant must be notified of an absence as soon as possible the morning of the day of the absence. If reasons prevent the student from providing prior notice, the students must inform the appropriate Dean and responsible faculty member/ administrative assistant of the absence as soon as possible, not after 3:00 pm of the same day.

PunctualityPunctuality is expected of students for all classes. Neither tardiness nor leaving early will be tolerated, as it impacts adversely upon the student’s learning experience and is disruptive to fellow students and faculty. The faculty has adopted a standard practice to minimize disruption to the classroom learning environment by closing the classroom at the start of the class session. Students who arrive to a class session after the door is closed must wait to enter the classroom at the first break. Students will be held accountable for all missed material.

Other policies pertaining to punctuality are as follows: Students who are late to class without an approved excused absence may be

denied the opportunity to take a scheduled examination, quiz, or pop quiz at the faculty’s discretion. Students with an excused absence, tardiness, or early departure are expected to complete the required work and obtain handouts, etc., from classmates, and are responsible for learning the missed material.

Students are expected to stay for the entire duration of the class. If a student must leave early, it is expected that the student will present an approved excused reason for leaving early (approved by the appropriate Dean/Assistant Dean in advance). If a student leaves early without a prior excused reason for doing so, the final course grade will be dropped by ½ letter grade. More than one unexcused early departure may result in failure of the course.

Disclaimer: Please note that this syllabus is not a contract. The course coordinator and faculty (Dr. Kaddoura) will make every possible attempt to abide by the information and policies/ guidelines contained within this syllabus. In the event of a change to anything in this document, students will be given advanced notice.

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RSC 325: Clinical Pathophysiology Course Outline

Date Course Content Assigned ReadingWeek 1 Monday14 May

Review of Syllabus and Course Requirements

Introduction to Pathophysiology o Cellular Structure and Functiono Cellular responses to stress, injury and agingo Cell Proliferation and tissue regeneration and repairo Genetic control of cellular function

Gould/WB Chapter 1, 7, 12

Week 1Thursday17 May

Disorders of Fluid and Electrolytes Disorders of Nutrition

Gould/WB Chapter 6

Week 2Monday21 May

Immune Disorders o Hypersensitivity disorderso Autoimmune diseaseso Immunodeficiency disorders

Gould/WB Chapter 3

Week 2Thursday24 May

Pathophysiology of Inflammation , Inflammatory Response and fever

Infectiono Infectious Diseaseso New and emerging infectious diseases

Gould/WB Chapters 2,4

Week 3Monday28 May

ONLINE SESSION (NOT in Class) MEMORIAL DAY Cancer and Oncology Disorders

Week 3Thursday31 May

Quiz 1 Online Due (Content of Weeks 1 and 2) ONLINE SESSION (NOT in Class) Various Types of Cancers

Week 4Monday4 June

Disorders of Hematology System o Hematological system overviewo Disorders of red blood cells

Anemias Polycythemia Vera Age-related changes to RBC’s

o Disorders of white blood cells Neutropenia

o Neoplastic Disorders Leukemias Malignant lymphomas

Gould/WB Chapters 5,17

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Plasma Cell Dyscrasias

Week 4 Thursday7 June

ONLINE SESSION (NOT in Class) Thromboembolic Disorders

o Coagulopathieso Bleeding disorderso Coagulation disorderso DIC

Gould/WB Chapters 17,18,19 (focus reading on assigned topics)

Week 5Monday11 June

Case Studies Due in Class Cardiovascular Disorders

o Acute Coronary Syndromeso Hypertensiono Lipid Disorderso Heart Failureo Conduction disorderso Shock

Gould/WB Chapter 18

Week 5Thursday 14 June

Quiz 2 Online Due (Content of Weeks 3 and 4)ONLINE SESSION (NOT in Class) Pain o Headacheo Acute Paino Chronic Pain

Gould/WB Chapter 13

Week 6Monday18 June

Diseases of the Respiratory System o Asthmao Chronic Obstructive Airway Disorders

Emphysema Chronic Bronchitis

o Respiratory Tract Infections Pneumonia Common Cold Cystic Fibrosis Tuberculosis

Gould/WB Chapter 19

Week 6Thursday21 June

Diseases of Renal Function o Urinary Tract Infectionso Urolithiasiso Nephrosclerosiso Polycystic Kidney Diseaseo Renal Failure (Acute and Chronic)

Gould/WB Chapter 21

Week 7Monday25 June

Disorders of the Gastrointestinal tract, liver and biliary systemo Hiatal Hernia

Gould/WB Chapter 20

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o Gastroesophageal Reflux diseaseo Gastritis o Peptic Ulcer Diseaseo Dumping Syndromeo Gallbladder disorderso Jaundiceo Hepatitiso Cirrhosiso Acute Pancreatitiso Chronic Inflammatory Bowel Disorderso Appendicitiso Diverticular Disease

Week 7Thursday26 June

Quiz 3 Online Due (Content of Weeks 5 and 6) Diseases of the Nervous System

o Review of the nervous system, structure and function

o Disorders of neuromuscular function ALS MS Myasthenia Gravis

o Disorders of brain function Stroke Seizures Parkinson’s Disease Alzheimer’s Disease

Gould WB Chapters 22,23

Week 8Monday2 July

Diseases of Sensory Function o Disorders of Eye

Glaucoma Cataracts Macular degeneration

o Disorders of the Ear Hearing loss Ear infections

Gould/WB Chapter 24

Week 8Thursday5 July

ONLINE SESSION (NOT in Class) INDEPENDENCE Genitourinary and Reproduction

o Male genitourinary systemo Disorders of the male genitourinary systemo The female reproductive systemo Disorders of the female reproductive system

Sexually transmitted infections

Gould/WB Chapters 21

Week 9Monday

Diseases of Endocrine Glands o Pituitary and Growth Disorders

Gould/WB Chapter 25

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9 July o Thyroid Disorderso Disorders of Adrenal Cortical Function

Diseases of the Pancreas o Diabetes Mellitus

Week 9 Thursday12 July

Quiz 4 Online Due (Content of Weeks 7 and 8) Disorders of the musculoskeletal system

o Osteoporosiso Osteomalaciao Paget’s Diseaseo Osteoarthritiso Rheumatoid Arthritiso Fibromyalgiao Multiple Sclerosiso Gout

Gould/WB Chapters 26

Week 10Monday16 July

Diseases of the Skin o Contact dermatitiso Urticariao Eczemao Psoriasiso Sclerodermao Skin Cancers

Gould/WB Chapter 27

Week 10 Thursday19 July

Final Exam Review

Week 11 Monday23 July

Comprehensive Final Exam All the Best and God Bless

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