Results of the COSDT study. Erectile Dysfunction and Metabolic Syndrome in a population of men with...
-
Upload
red-espanola-de-investigacion-en-salud-del-hombre -
Category
Health & Medicine
-
view
53.244 -
download
4
Transcript of Results of the COSDT study. Erectile Dysfunction and Metabolic Syndrome in a population of men with...
![Page 1: Results of the COSDT study. Erectile Dysfunction and Metabolic Syndrome in a population of men with Testosterone Deficiency.](https://reader035.fdocuments.us/reader035/viewer/2022062706/55772e8fd8b42a13308b524d/html5/thumbnails/1.jpg)
RELATIONSHIP BETWEEN ERECTILE FUNCTION AND METABOLIC SYNDROME IN A COHORT OF MEN WITH LOW
TESTOSTERONE LEVELS.
Eduardo García-Cruz* ***, Marta Piqueras*. Óscar Cardeñosa**, Pilar Luque*, Antonio Alcaraz**Hospital Clínic de Barcelona
**BAYER España*** Red Española de Investigación en Salud del Hombre
Conflict of interest: this initiative was conducted with a grant for investigation from BAYER España. García-Cruz had received funding for investigation from Lilly, Pfizer, Bayer, Auxilium and Janssen and had formed part of advisory comittees for Bayer, Lilly, Janssen, Italpharmaco and Menarini.
![Page 2: Results of the COSDT study. Erectile Dysfunction and Metabolic Syndrome in a population of men with Testosterone Deficiency.](https://reader035.fdocuments.us/reader035/viewer/2022062706/55772e8fd8b42a13308b524d/html5/thumbnails/2.jpg)
TESTOSTERONE DEFICIENCYSYNDROME
METABOLIC SYNDROME
ERECTILE DYSFUNCTION
![Page 3: Results of the COSDT study. Erectile Dysfunction and Metabolic Syndrome in a population of men with Testosterone Deficiency.](https://reader035.fdocuments.us/reader035/viewer/2022062706/55772e8fd8b42a13308b524d/html5/thumbnails/3.jpg)
OBJECTIVE:to determine the relationship between erectile function and Metabolic Syndrome (MS) in a cohort of men with low testosterone (T) levels.
METHODS:a multi-centre, cross-sectional study recruited 1094 consecutive men older than 45 years old with low T levels (<12nmol/L).
MS was defined as 3 or more of the following factors: abdominal obesity ≥ 94cm, triglycerides ≥150 mg/dl, Hypertension ≥130/85 mmHg, HDL-cholesterol <40mg/dL or Fasting Glucose ≥100 mg/dl.
IIEF questionnaire was used to assess erectile function.
Multivariate analysis was carried out to determine the variables related to ED and MS. P<0,05 was considered statistically significant.
![Page 4: Results of the COSDT study. Erectile Dysfunction and Metabolic Syndrome in a population of men with Testosterone Deficiency.](https://reader035.fdocuments.us/reader035/viewer/2022062706/55772e8fd8b42a13308b524d/html5/thumbnails/4.jpg)
Normal Erection
Mild ED Mild to moderate
ED
Moderate ED
Severe ED0
5
10
15
20
25
30
35
0%
5%
10%
15%
20%
25%
30%
35%
40%
2.10%
8.40%
20.50%
33.50%
27.40%
8.00%
No. of MetS factors
![Page 5: Results of the COSDT study. Erectile Dysfunction and Metabolic Syndrome in a population of men with Testosterone Deficiency.](https://reader035.fdocuments.us/reader035/viewer/2022062706/55772e8fd8b42a13308b524d/html5/thumbnails/5.jpg)
Mean testosterone levels (95%CI) and IIEF scores according to the number of MetS components (p for linear trend p=0,006).
Met Sy No Met Sy6.2
6.3
6.4
6.5
6.6
6.7
6.8
6.9
Testosterone levels regarding Met Sy (yes/no);P<0,02.
![Page 6: Results of the COSDT study. Erectile Dysfunction and Metabolic Syndrome in a population of men with Testosterone Deficiency.](https://reader035.fdocuments.us/reader035/viewer/2022062706/55772e8fd8b42a13308b524d/html5/thumbnails/6.jpg)
![Page 7: Results of the COSDT study. Erectile Dysfunction and Metabolic Syndrome in a population of men with Testosterone Deficiency.](https://reader035.fdocuments.us/reader035/viewer/2022062706/55772e8fd8b42a13308b524d/html5/thumbnails/7.jpg)
0 (n=18) 1 (n=87) 2 (n=204) 3 (n=339) 4 (n=282) 5 (n=81)0
2
4
6
8
10
12
14
16
12.8314.18
12.7611.39
10.489.81
No. of MetS factors
Mea
n IIE
F sc
ore
No ED (n=24)
Mild ED (n=143)
Mild-to-moderate ED (n=323)
Moderate ED (n=302)
Severe ED (n=219)
0 0.5 1 1.5 2 2.5 3 3.5 4
2.54
2.48
2.94
3.09
3.41
Mean No. of MetS factors
![Page 8: Results of the COSDT study. Erectile Dysfunction and Metabolic Syndrome in a population of men with Testosterone Deficiency.](https://reader035.fdocuments.us/reader035/viewer/2022062706/55772e8fd8b42a13308b524d/html5/thumbnails/8.jpg)
![Page 9: Results of the COSDT study. Erectile Dysfunction and Metabolic Syndrome in a population of men with Testosterone Deficiency.](https://reader035.fdocuments.us/reader035/viewer/2022062706/55772e8fd8b42a13308b524d/html5/thumbnails/9.jpg)
TESTOSTERONE DEFICIENCYSYNDROME
METABOLIC SYNDROME
ERECTILE DYSFUNCTION
CONCLUSION: in a cohort of men with low T levels, erectile function and MS were related in a bidirectional manner: IIEF worsened as the number of MS raised and MS factors raised as IIEF worsened.
![Page 10: Results of the COSDT study. Erectile Dysfunction and Metabolic Syndrome in a population of men with Testosterone Deficiency.](https://reader035.fdocuments.us/reader035/viewer/2022062706/55772e8fd8b42a13308b524d/html5/thumbnails/10.jpg)
RELATIONSHIP BETWEEN ERECTILE FUNCTION AND METABOLIC SYNDROME IN A COHORT OF MEN WITH LOW
TESTOSTERONE LEVELS.
Eduardo García-Cruz* ***, Óscar Cardeñosa**, Pilar Luque*, Antonio Alcaraz**Hospital Clínic de Barcelona
**BAYER España*** Red Española de Investigación en Salud del Hombre
Conflict of interest: this initiative was conducted with a grant for investigation from BAYER España. García-Cruz had received funding for investigation from Lilly, Pfizer, Bayer, Auxilium and Janssen and had formed part of advisory comittees for Bayer, Lilly, Janssen, Italpharmaco and Menarini.
![Page 11: Results of the COSDT study. Erectile Dysfunction and Metabolic Syndrome in a population of men with Testosterone Deficiency.](https://reader035.fdocuments.us/reader035/viewer/2022062706/55772e8fd8b42a13308b524d/html5/thumbnails/11.jpg)
![Page 12: Results of the COSDT study. Erectile Dysfunction and Metabolic Syndrome in a population of men with Testosterone Deficiency.](https://reader035.fdocuments.us/reader035/viewer/2022062706/55772e8fd8b42a13308b524d/html5/thumbnails/12.jpg)
![Page 13: Results of the COSDT study. Erectile Dysfunction and Metabolic Syndrome in a population of men with Testosterone Deficiency.](https://reader035.fdocuments.us/reader035/viewer/2022062706/55772e8fd8b42a13308b524d/html5/thumbnails/13.jpg)