Research at Karolinska Institutet2010

Karolinska InstitutetA leading medical university

Dedicated to improving people’s health through research and higher education

The largest centre for medical education and research in Sweden

Research– from molecule to patient

22 departments

600 research groups

1,500 researchers/teachers

including 328 professors

2,000 doctoral students

Traditions and innovations

A few examples of our notable research achievements: SR – sedimentation rate Purification of insulin and heparin Sulphasalazin Antibodies from plasma cells Seldinger catheter Pacemaker Gamma knife Growth hormones

Nanna Svartz, the first female professor at Karolinska Institutet

1937-1957, developed one of the first anti-inflammatory drugs

for rheumatoid arthritis

Swedish Nobel Prize Laureates in Physiology or Medicine – 5 of 8 are from Karolinska Institutet:

1955 Hugo Theorell, - the oxidation enzymes

1967 Ragnar Granit, - the visual processes

1970 Ulf von Euler, - noradrenaline

1982 Sune Bergström & Bengt Samuelsson, - prostaglandins

Scientific publications 2009

About 3,000 original articles and 1,000 other publications were written by researchers at Karolinska Institutet 2009

60 per cent have co-authors outside Sweden

Cited approx 50 per cent more often than the global average (2008)

Research funding accounts for 83 per cent of Karolinska Institutet’s total income

Undergraduate education

Research and doctoraleducation

9

Research revenue 2009 total SEK: 4,057 million (2008: 3,586 million)

Swedish foundations and organisations

16%

Non-Swedish foundations and organisations 3%

EU 6%

Swedish business sector 5%

Non-Swedish business sector

2%

Research councils12%

Other government funding 8%

County and municipal councils

14%

KI-funds 1%

Fin. revenue 0%

Appropriations33%

Februari 2010 10

Research funding

Februari 2010 11

Revenue from EU and USA

Organisation

Board of Research Strategy Research funding and recruitment Research networks Centres of excellence Core facilities Junior faculty Biosafety and ethics Veterinary unit

22 Departments Research Doctoral education

The Stockholms Academic Healthcare System

Cancer Circulation and respiration Endocrinology and metabolism Infection Inflammation and immunology Neuroscience Public and international health Reproduction, growth and development Tissue and motion

Fields of research

Nationally funded Centres of Excellence (Linné)

Centre of Excellence in Developmental Biology for Regenerative Medicine

STARGET – a cancer research network

Center for Research on Inflammation and Cadiovascular Disease, CERIC

The Human Regenerative Map

Linné Centre for Prevention of Breast and Prostate Cancer

Other nationally funded Centres of Excellence

Aging Research Centre Centre for Allergy Research Centre for Health Equity Studies Centre for Infectious Medicine Stockholm Brain Institute Strategic Research Centre for Studies of Integrative

Recognition in the Immune System Structural Genomics Consortium Swedish Brain Power

Core facilities in many areas

KI Biobank Registers Bioinformatics and biostatistics Clinical trial centres Experimental models Expression analysis Genomics Proteomics Visualisation techniques

Strong Research Potential Basic Research and Clinical Research Come Together

Translational Research

Research profile Epidemiology

KI Biobank - core facility for all research contains samples of tissue, blood, serum,

plasma, DNA and other biological specimens

Twin Registry – the largest in the world invaluable resource when correlating

between genes, lifestyle and environment

Medical informatics strong competences in health informatics and biostatistics

Research profile Cellterapy – from stem cell to therapy

Advanced stem cell research Strong clinical expertise in cell therapy and transplantation medicine International leadership in developmental biology Embryonic stem cell lines

Research focus on Parkinson’s disease Spinal cord injuries Diabetes Musculature disease Tissue impairment after cardiac infarction

Research profile Neuroscience

Approx. 20 per cent of all research at Karolinska Institutet is in neuroscience

Three world-leading research centres

Spinal Cord Research Centre Gather about 10 research groups

Stockholm Brain Institute Interdisciplinary research in neuroscience,

psychology and computer science Alzheimer Centre

Translational research in brain aging, dementia and Alzheimer's disease

Leading researchers in virology, bacteriology, parasitology and immunology

Neighbouring the largest infection clinic in Sweden Advanced laboratory facilities Strong international collaborations

Research focus Global infections – HIV, malaria, tuberculosis,

pneumonia Basic immunology, inflammation and infection

medicine

Research profile Infectious diseases and immunology

Basic research in the emergence/origin and development of cancer

Cancer epidemiology Therapy research, e.g. hormone,

immune, and gene therapy Optimizing of radio therapy Clinical trials Quality of life

Research profile Cancer

Reumatoid arthritis Multipel sclerosis Nerve and muscle inflammation Immune defects Autoimmunity Allergies and eczema Asthma and COPD Atherosclerosis

Research profile Inflammatory diseases and allergy

Obesity Advanced research in adult and child obesity Close clinical collaboration

Diabetes Basic research in diabetes

research Treatment research Stem cell research

Cardiovascular research Inflammatory factors Cholesterol metabolism Gender aspects in diagnosis and care

Research profile Metabolic diseases

Aging Research Centre Research from a medical, psychological and

socioeconomic perspective

Dementia Early diagnosis and treatment of cognitive impairment Alzheimer Centre

Swedish Brain Power A national research consortium in

neurodegenerative diseases

Research profile Aging research

Vaccines – HIV, malaria, tuberculosis Reproductive medicine Occupational medicine Psychiatry Geriatrics Humanitarian disaster assistance

Research profile Global health

Partnerships on all continentsResearch focus on poverty and health

Research collaborations

Health care sector Swedish and foreign universities Industrial partners International agreements with

organizations in Europe, North America, Africa and Asia

Offices in China and Singapore

Karolinska Institutet Innovation- from brains to business Promotes the results of biomedical

research to be developed into new products and applications

Provides the means for researchers to develop their research results commercially

Offer project management, funding for patent protection, legal advice and business development

Allows researchers access to an extensive network of contacts within the international pharmaceutical industry

Karolinska Institutet Innovation

Reviewed more that 1 100 academic inventions

More than 40 companies formed since 1996

35 license agreements concluded The system’s portfolio

companies own about 100 patents

30 development project are in its portfolio pipeline

More information: ki.se

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