Regen slideshow

The Role of Regenera-ve Medicine in the 100YSS

Contribu-on 128, ID 1172 100YSS Conference, Houston TX

2012 Sept 15 Mar-ne RothblaF, [email protected] United Therapeu-cs Corpora-on

100YSS Regenera-ve Medicine [email protected] 2

Regenera-ve Medicine in Film


Supernovas (eg Crab Nebula) èGalac-c Cosmic Rays, With The Ejected Protons Ricoche-ng Like Billiard Balls Against Galaxy’s Magne-c Field


Gamma Rays Produced when Ubiquitous Galac-c Cosmic Rays Interact with Interstellar Medium Reveals


Organ Transplants Extend Life



In Vivo Organ Regenera-on Via Stem Cell Transplanta-on

1st Genera-on iPS Technology


In Vivo Organ Regenera-on Via Stem Cell Transplanta-on

2nd Genera-on iPS Technology

Transplantable Differen-ated iPS Cells


In Vivo Liver Regenera-on


Rat Lungs Can Be Kept Breathing in a Fluid-‐Air System for a Week


Decellularized Pig Lungs


Ex Vivo Organ Regenera-on for Transplanta-on (Pig Lungs)


Human Peripheral Endothelial Progenitor Cells Can Be Cultured, Manipulated & SEEDED

Human Umbilical Vascular Endothelial Cells Used To Date 100YSS Regenera-ve Medicine

[email protected] 15

Timeframe Considera-on

•  Human Lung Has About 109 Endothelial Cells •  Within a Month, Endothelial Progenitor Cells Found in Peripheral Circula-on Can be Cultured to Around 106

•  Doubling Time of Around 30 Days •  May Require About a Year to Grow Lungs for Transplant Once Decide to Proceed


Xenogeneic Organ

Regenera-on

17 100YSS Regenera-ve Medicine [email protected]

Xenogeneic Pigs on O’Neill Habitat


hEPCR hVWF hCD73

pVWFKO hTFPI hTBM

hCD39

19

Coagulate

GP1b GP2b3q

GTKO hMCP HLA-‐E

hDAF hMIRL

Immune

SIRP/CD47 Lec-ns Sialyda-on Selec-ns

100YSS Regenera-ve Medicine [email protected]

Da Vinci Surgical Robot


Da Vinci Robots Have Now Explanted Livers for Transplanta-on


Robo-c Transplanta-on on 100YSS of Xenograis or Regen Organs Will Be Prac-cal


Just Like Shepard’s May 1961 Flight Was <.1% to the Moon


We Can Be 1000x Further Than We Are In Under Ten Years!


Regen slideshow

Health & Medicine

Transcript of Regen slideshow