RREEFFEERREENNCCEESS

R1

Abelev GI. Study of the regulation of alpha fetoprotein synthesis in ontogenesis and carcinogenesis. In: Skulachev VP, ed Soviet Science Review (section D) Biological Reviews. New York: Harwood AcadPubl. 1980; 1:371-397.

Abelev GI and Elgort DA. Alpha-fetoprotein. In: Holland J, Frei E, eds. Cancer Medicine, 2nd edition. New York: Lea and Febiger. 1982; 1089-1099.

Acikel M, Buyukokuroglu ME, Erdogan F, Aksoy H, Bozkurt E and Senocak H. Protective effect of dandroline against myocardial injury induced by isoproterenol in rats: biochemical and histological findings. Int. J. Cardiol. 2005; 98:389–394.

Adlercreutz CH, Goldin BR, Gorbach SL, Hockerstedt KA, Watanabe S, Hamalainen EK, Markkanen MH, Makela TH, Wahala KT and Adlercreutz T. Soybean phytoestrogen intake and cancer risk. J Nutr. 1995; 125:757S-770S.

Adlercreutz H, and Mazur W. Phyto-estrogens and western diseases. Ann. Med. 29 1997; 29: 95-120.

Agarwal KC. Therapeutic values of garlic constituents. Med.Res.Review 1996; 6:111-124.

Ahmed KK, Mueen Rana AC and Dixit VK. Effect of Calotropis procera latex on isoproterenol induced myocardial infarction in albino rats. International Journal of Phytotherapy and Phytopharmacology. 2004; 327-330.

Akihiro Tamori , Shuhel Nishiguchi , Tetsuo Kuroki , Shuichi Seki, Kenzo Kobayashi, Hiroaki Kinoshita and Shuzo Otani. Hepatology. 1994; 20(5):1179-1186.

American Cancer Society. Cancer Facts and Figures. American Cancer Society, Atlanta, 2005.

Anderson JS, Svensson B, Roepstorff P. Electrospray ionization and matrix assisted laser desorption / ionization mass spectrometry: powerful analytical tools in recombinant protein chemistry. Nat Biotechnol. 1996; 14:449-457.

Anderson JW, Johnstone BM, and Cook-Newell ME. Meta-analysis of effects of soy protein intake on serum lipids in humans. N Engl J Med. 1995; 333:276-282.

Anthony MS, Clarkson TB, and Williams JK. Effects of soy isoflavones on athero- sclerosis: potential mechanisms. Am J Clin Nutr. 1998; 68:1390S-1393S.

Anuraj P. and Rajamohan T. Cardioprotective effect of tender coconut water in experimental myocardial infarction. Plant Foods Hum Nutr. 2003; 58:1-12.

Appelt LC, and Reicks MM. Soy feeding induces phase II enzymes in rat tissues. Nutr. Cancer. 1997; 28:270-275.

R2

Arai Y, Uehara M, Sato Y, Kimira M, Eboshida A, Adlercreutz H and Watanabe S. Comparison of isoflavones among dietary intake, plasma concentration and urinary excretion for accurate estimation of phytoestrogen intake. J Epidemiol. 2000; 10:127-135.

Ashton E, and Ball M. Effects of soy as tofu vs meat on lipoprotein concentrations. Europen Journal of Clinical Nutrition. 2000; 54:14-19.

Badger TM and Ronis MJ. Reduction in 7,12-Dimethylbenz[a]anthracene-Induced Hepatic Cytochrome-P450 1A1 Expression Following Soy Consumption in Female Rats Is Mediated by Degradation of the Aryl Hydrocarbon Receptor. J. Nutr. 2007; 137(1):19-24.

Badger TM, Hakkak R, Korourian S and Ronis MJJ. In: Proceedings of International Conference on Diet and Prevention of Cancer, Tampere, Finland. 1999, A7.31.

Bailey MA and Brunt EM. Hepatocellular carcinoma: predisposing conditions and precursor lesions. Gastroenterol Clin North Am. 2002; 31:641-662.

Banerjee SK, Maulik M, Mancahanda SC, Dinda AK, Gupta SK and Maulik SK. Dose-dependent induction of endogenous antioxidants in rat heart by chronic administration of garlic. Life Sci. 2002; 70(13):1509-1518.

Bansal AK, Trivedi R, Soni GL, and Bhatnagar D. Hepatic and renal oxidative stress in acute toxicity of N-nitrosodiethylamine in rats. Indian J Exp Biol. 2000; 38:916-920.

Baranov VN and Engelhardt NV. Immunoperoxidase technique in electron microscopy: theoretical and practical aspects and use of localization of alpha-fetoprotein synthesis. In: Blokhin NN, Trapeznikov NN, eds. Soviet Medical Reviews (Section F) Oncology. New York: Harwood Acad Publ; 1987; 1:119-163.

Barbul A, Sisto DA, Waserkrug HL and Efron G. Arginine stimulates lymphocyte immune response in healthy human beings. Surgery.1981; 90(2):244-251.

Barta O, Barta VD, Crisman MV and Akers RM. Inhibition of lymphocyte blastogenesis by whey. American Journal of Veterinary Research. 1991; 52:247-253.

Bax L, Algra A, Mali WP, Edlinger M, Beutler JJ, van der Graaf Y. "Renal function as a risk indicator for cardiovascular events in 3216 patients with manifest arterial disease". Atherosclerosis. 2008.

Beckman KB and Bruce AN. The free radical theory of ageing matures. Physiological review.1998; 78(2): 548-571.

Belobrajdic DP, McIntosh GH and Owens JA. A high whey protein diet reduces body weight gain and alters insulin sensitivity relative to red meat in Wistar rats. J Nutr. 2004; 134:1454-1458.

R3

Belobrajdic DP, McIntosh GH and Owens JA. The effects of Dietary protein on rat growth, body composition and insulin sensitivity. Asia Pac J Clin Nutr. 2003; 12. Suppl., S42.

Belobrajdic DP, McIntosh GH and Owensa JA. Whey proteins protect more than red meat against azoxymethane induced ACF in Wistar rats. Cancer Letters. 2003; 198:43-51.

Benjamin Lewin, Lynne Cassimeris, Vishwanath R Lingappa and George Plopper. Cells. 2007, Jones and Bartlett Publishers, Sudbury, Massachusetts.

Beutler B, Milsark L and Cerami A. Passive immunization against Cachectin / Tumour necrosis factor protects mice from lethal effects of endotoxin. Science. 1985; 867-871.

Biju C Mathew and Augusti KT. Biochemical effects of garlic protein diet and garlic oil on glycosaminoglycan metabolism in cholesterol fed rats. Indian Journal of Experimental Biology. 1996; 34:346-350.

Billings PC, Newberne PM and Kennedy AR. Protease inhibitor suppression of colon and anal gland carcinogenesis induced by dimethylhydrazine. Carcinogenesis. 1990; 10083-10086.

Block G, Patterson B and Subar A. Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr Cancer. 1992; 18:129.

Boger RH, Bode-Boger SM and Brandes RP. Dietary L-arginine reduces the progression of atherosclerosis in cholesterol-fed rabbits: comparison with lovastatin. Circulation. 1997; 96:1282-1290.

Boger RH, Bode-Boger SM, Thiele W, Creutzig A, Alexander K and Frolich JC. Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease. J Am Coll Cardiol. 1998; 32:1336-1344.

Bordia A, Verma SK, Vyas AK, Khabya BL, Rathore AS, Bhu N and Bedi HK. Effect of essential oil of onion and garlic on experimental atherosclerosis in rabbits. Atherosclerosis. 1977; 26(3):379-386.

Borzio M, Fargion S, Borzio F, Fracanzani AL, Croce AM, Stroffolini T and Oldani S. Impact of large regenerative, low grade and high grade dysplastic nodules in hepatocellular carcinoma development. J Hepatol. 2003;39:208-14.

Bosch FX, Ribes J, Cleries R and Diaz M. Epidemiology of hepatocellular carcinoma. Clin Liver Dis. 2005; 9:191-211.

Bounous G. Whey protein concentrates and glutathione modulation in cancer treatment. Anticancer Research. 2000; 20:4785-4792.

Caldwell DR and Danzer CJ. Effects of allylsulfides on the growth of predominant gut anaerobes. Microbiol. 1988; 16:237-241.

R4

Calver A, Collier J, Moncada S and Vallance P. Effect of local intraarterial NG-monomethyl-L-arginine in patients with hypertension: the nitric oxide dilator mechanism appears abnormal. J Hypertens. 1992; 10:1025-1031.

Cameron CB. Enzyme assays in malignant disease. J. Clin Path. 1971; 24(4):80-84.

Candipan RC, Wang B, Buitrago R, Tsao PS and Cooke JP. Regression or progression: dependency on vascular nitric oxide. Arterioscler Vasc Biol. 1996; 16:44-50.

Carolina Villadóniga, Julio Battistoni, Ana María B and Cantera. Monitoring immunoreactivity reduction of whey proteins hydrolysates by latex agglutination. Enzyme and Microbial Technology. 2007; 40(3):481-484.

Casino PR, Kilcoyne CM, Quyymi AA, Hoeg JM and Panaza JA. Investigation of decreased availability of nitric oxide precursor as the mechanism responsible for impaired endothelium-dependent vasodilatation in hypercholesterolemic patients. J Am Coll Cardiol. 1994; 23:844-850.

Cavin LG, Venkatraman M, Factor VM, Kaur S, Schroeder I, Mercurio F, Beg AA, Thorgeirsson SS and Arsura M. Regulation of alpha-fetoprotein by nuclear factor-kappa B protects hepatocytes from tumor necrosis factor-alpha cytotoxicity during fetal liver development and hepatic oncogenesis. Cancer Res. 2004; 64(19):7030-7038.

Chan DI, Prenner EJ and Vogel HJ. Tryptophan-and arginine-rich antimicrobial peptides: structures and mechanisms of action, Biomembranes. 2006; 1758:1184-1202.

Chen HM, Muramoto K, Yamauchi F, Fujimoto K and Nokihara K. Antioxidative properties of histidine-containing peptide fragments found in the digests of a soybean protein. J. Agric. Food Chem. 1998; 46:49-53.

Chen HM, Muramoto K and Yamauchi F. Structural analysis of antioxidative peptides from soybean beta-conglycinin. J Agric Food Chem. 1995; 43:574-578.

Chukwu E, Onyeneke, Kayode E, Adebisi, George E, Eriyamremu, Samuel I, Ojeaburu, Samuel O, Asagba, Olaruwaju M and Oluba. Effect of lipid-based diet on some lipid-metabolizing enzymes. Journal of Medical Sciences. 2007.

Chunmei Gu, Yonghui Shi and Guowei Le. Effect of dietary protein level and origin on the redox status in the digestive tract of mice. Int J Mol Sci. 2008; 9(4):464-475.

Cleary MP, Phillips FC and Morton RA. Genotype and diet effects in lean and obese Zucker rats fed either safflower or coconut oil diets. Proceedings of the Society for Experimental Biology and Medicine. 1999; 220:153-161.

Cohen G and Heikkila RE. The generation of hydrogen peroxide, superoxide radical and hydroxyl radical by 6-hydroxydopamine, dialuric acid and related cytotoxic agents. J. Biol. Chem. 1974; 249:2447-2452.

R5

Cohen GM. Caspases: the executioners of apoptosis. Biochem J. 1997; 326(Pt1):1-16.

Cooke JP and Dzau VJ. Nitric oxide synthase: role in the genesis of vascular disease. Annu Rev Med. 1997; 48:489-509.

Cordle Christopher T. Soy protein Allergy: Incidence and Relative Severity. Fifth International Symposium on the Role of Soy in Preventing and treating chronic disease. J. Nutr. 2004; 134:1213S-1219S.

Costa RL and Summa MA. Soy protein in the management of hyperlipidemia. Ann Pharm. 2000; 34:931-935.

Coste M and Tome D. Milk peptides with physiological activities. II Opioid and immunostimulating peptides derived from milk proteins. Lait. 1991; 71:241-247.

Crastes de Paulet A. Free radicals and ageing. Ann Biol Clin. 1990; 48:323-330.

Critselis AN, et al., Federation Proceedings. 1977; 36:1163. C.F: Karen Railey. Arginine in the Treatment of Cancerous Tumors

Cross ML and Gill HS. Modulation of immune function by a modified bovine whey protein concentrate. Immunology and Cell Biology. 1999; 77:345-350.

Daniel Motola-Kuba, Daniel Zamora-Valdés, Misael Uribe and Nahum Méndez-Sánchez. Hepatocellular carcinoma. An overview. Annals of Hepatology. 2006; 5(1):16-24

De Bono DP and Boon NA. Diseases of the cardiovascular system. In: Edwards, C.R.W., Boucheir, I.A. (Eds.), Davidson’s Principles and Practice of Medicine. Churchill Livingstone, Hong Kong. 1992; 249-340.

DeFelice SL. FIM Rationale and Proposed Guidelines for the Nutraceutical Research and Education Act - NREA, Foundation for Innovation in Medicine. 2002; 10.

Deng-Fu Yao, Zhi-Zhen Dong and Min Yao. Specific molecular markers in hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int. 2007; 6:241-247.

Devi Sampath P and Vijayaraghavan K. Cardioprotective effect of alpha-mangostin, a xanthone derivative from mango stem on tissue defense system against isoproterenol-induced myocardial infarction in rats. J Biochem Mol Toxicol. 2007; 21(6):336-9.

Devika PT and Prince PS. Preventive effect of epigallocatechin-gallate on lysosomal enzymes in heart and subcellular fractions in isoproterenol-induced myocardial infarcted Wistar rats. Chem Biol Interact. 2008; 172(3):245-252.

Devika PT and Stanely Mainzen Prince P. Protective effect of epigallocatechin-gallate (EGCG) on lipid peroxide metabolism in isoproterenol induced myocardial infarction in male Wistar rats: A histopathological study. Biomedicine and Pharmacotherapy. 2007; 8.

R6

Dietary Supplement Education Alliance. Dietary Supplement Barometer Survey. Rochester, NY, USA: Harris Interactive. 2001.

Duilio Divisi, Sergio Di Tommaso, Salvatore Salvemini, Margherita Garramone and Roberto Crisci. Diet and cancer. Acta Biomed 2006; 77: 118-123.

Dürr UHN, Sudheendra US and Ramamoorthy A. LL-37, the only human member of the cathelicidin family of antimicrobial peptides, BBA. Biomembranes. 2006; 1758:1408-1425.

El-Serag HB. Epidemiology of hepatocellular carcinoma. Clin Liver Dis. 2001; 5:87-107.

Emerson E. The condensation of aminoantipyrine II. A new color test for phenolic compounds. J. Org. Chem.1943; 8(5):417-428.

Erdmann, Belinda WY, Cheung and Henning Schröder. The possible roles of food-derived bioactive peptides in reducing the risk of cardiovascular disease. Journal of Nutritional Biochemistry. 2008; 19: 643-654.

Erkilic K, Evereklioglu C, Cekmen M, Ozkiris A, Duygulu F and Dogan H. Adenosine deaminase enzyme activity is increased and negatively correlates with catalase, superoxide dismutase and glutathione peroxidase in patients: original contributions/clinical and laboratory investigations. Mediat Inflamm. 2003; 12:107-116.

Etminan M, Gill SS and Samii A. Intake of vitamin E, vitamin C, and carotenoids and the risk of Parkinson’s disease: a meta-analysis. Lancet Neurol. 2005; 4:362-365.

Fang YZ, Yang S and Wu G. Free radicals, antioxidants, and nutrition. Nutrition. 2002; 18:872-879.

Food labeling health claims; soy protein and coronary heart disease. Food and Drug Administration, HHS. Final rule. Fed Regist. 1999; 64:700-733.

Frohlich RH, Kunze M and Kiefer I. Cancer preventive value of natural, non-nutritive food constituents. Acta Med Austriaca. 1997; 24:108-113.

Ghaffar A, Reddy KS and Singhi M. "Burden of non-communicable diseases in South Asia". BMJ. 2004; 328: 807–810.

Ghazanfari T, Hassan ZM and Ebrahimi M. Immunomodulatory activity of a protein isolated from garlic extract on delayed type hypersensitivity. International Immunopharmacology. 2002; 2:1541-1549.

Gill HS and Cross ML. Anticancer properties of bovine milk. British Journal of Bovine Milk. 2000; 84:161-165.

Goli Kov PA, Polumsikor VV, Darydov BV, Karev VA, Bashkator VG, Belezerov G, GoliKov PP and Berestova AA. Lipid peroxidation and the major factor for its activation in patients with myocardial infarction. Kardiologia. 1989; 29:53.

R7

Goodwin BF. IgE antibody levels to ingested soya protein determined in a normal adult population. Clin Alergy. 1982; 12(1):55-62.

Grimble RF and Grimble GK. Immunomodulation: Role of sulfur amino acids, and polyamines. Nutrition. 1998; 14:605-610.

Groziak SM and Miller GD. Natural bioactive substances in milk and colostrums: effects on the arterial blood pressure system. Br. J. Nutr. 2000; 84(1):S119-S125.

Guarnieri C, Flamigni F and Caldarera CM. Role of oxygen in the cellular damage induced by re-oxygenation of hypoxic heart. J Mol Cell Cardiol. 1980; 12(8):797-808.

Guimont C, Marchall E, Girardet JM and Linden G. Biologically active factors in bovine milk and dairy byproducts, Influence on cell culture. Critical Reviews in Food Science and Nutrition. 1997; 374:393-410.

Gulizar Atmaca. Antioxidant effects of sulphur containing aminoacids. Yonsei Medical Journal. 2004; 45(5):776-788.

Gupta R, Joshi P, Mohan V, Reddy KS and Yusuf S. Epidemiology and causation of coronary heart disease and stroke in India. Heart. 2008; 94(1):16-26.

Hakkak R, Korourian S, Ronis MJ, Johnston JM and Badger TM. Dietary whey protein protects against azoxymethane induced colon tumors in male rats. Cancer Epidemiol.Biomark. Prev. 2001; 10:555-558.

Hakkak R, Korourian S, Shelnutt SR, Lensing S, Ronis MJJ and Badger TM. Diets containing whey protein or soy protein isolate protect against 7,12-dimethylbenzanthracene-induced mammary tumors in female rats, Cancer Epidemiol. Biomarkers Prev. 2000; 9:113-117.

Hall WL, Millward DJ, Long SJ and Morgan LM. Casein and whey exert different effects on plasma amino acid profiles, gastrointestinal hormone secretion and appetite. Br J Nutr. 2003; 89:239-248.

Halliwell B and Gutteridge JMC. Free Radicals in Biology and Medicine (2nd ed.). Oxford, UK: Clarendon, 1989.

Halliwell B. Oxidative stress, nutrition and health. Experimental strategies for optimization of nutritional antioxidant intake in humans. Free Rad. Res. 1996; 25:57-74.

Hanigan MH and Pitot HC. Gamma-glutamyl transpeptidase -its role in hepatocarcinogenesis. Carcinogenesis. 1985; 6:165-172.

Hawrylewicz EJ, Zapata JJ and Blair WH. Soy and experimental cancer: animal studies. J Nutr. 1995; 125:698S-708S.

Heby O and Persson L. Molecular genetics of polyamine synthesis in eukaryotic cells. Trends Biochem Sci. 1990; 15:153-158.

R8

Herbert JR, Hurley TG, Olendzki BC, Teas J, Ma Y and Hampl JS. Nutritional and socioeconomic factors in relation to prostate cancer mortality: a cross-national study. J Natl Cancer Inst. 1998; 90:1637-1647.

Hisa Aoki, Yukiko Otaka, Kiharu Igarashi and Asako Takenaka. Soy Protein Reduces Paraquat-Induced Oxidative Stress in Rats. J. Nutr. 2002; 132:2258-2262.

Holmgren A. Regulation of ribonucleotide reductase. Curr. Top. Cell. Regul. 1981; 19:47-76.

Honore EK, Williams JK, Anthony MS and Clarkson TB. Soy isoflavones enhance coronary vascular reactivity in atherosclerotic female macaques. Fertil Steril. 1997; 67:148-154.

Hoskin David W and Ayyalusamy Ramamoorthy. Studies on anticancer activities of antimicrobial peptides. Biochimica et Biophysica Acta. 2008; 1778:357-375.

Hutchins AM, Lampe JW, Martini MC, Campbell DR and Slavin JL. Vegetables, fruits, and legumes: Effect on urinary isoflavonoid phytoestrogen and lignan excretion. J Am Diet Assoc. 1995; 95:769-774.

Hytiroglou P. Morphological changes of early human hepatocarcinogenesis. Semin Liver Dis. 2004; 24:65-75.

Hyunki Hong, Michael R Landauer, Mark A Foriska and David Ledney G. Antibacterial activity of the soy isoflavone genistein. Journal of Basic Microbiology. 2005; 46(4):329-335.

IARC. N-nitrosodiethanolamine. IARC Monogr Eval Carcinog Risks Hum. 2000; 77:403-438.

Indu MN, Hatha AAM, Abirosh C, Harsha U and Vivekanandan G. Antimicrobial activity of some of the South-Indian spices against serotypes of Escherichia coli, Salmonella, Listeria monocytogenes and Aeromonas hydrophila. Brazilian Journal of Microbiology. 2006; 37:153-158.

Ithayarasi AP and Devi CSS. Effect of alpha tocopherol on lipid peroxidation in isoproterenol induced myocardial infarction in rats. Indian Journal of Physiology and Pharmacology. 1997; 41:369-376.

Ito A, Tsao PS, Adimoonlam S, Kimoto M, Ogawa T and Cooke JP. A novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. Circulation. 1999; 99:3092-3095.

Ivan Lopez Exposito and Isidra Recio. Antibacterial activity of peptides and folding variants from milk proteins. International Dairy Journal. 2006; 16(11):1294-1305.

Jacobsen BK, Knutsen SF and Fraser GE. Does high soy milk intake reduce prostate cancer incidence? The Adventist Health Study (United States). Cancer Causes Control. 1998; 9:553-557.

R9

James E Haddow, Edward M Kloza, George J Knight and Dwight E Smith. Relation between Maternal weight and serum alpha-fetoprotein concentration during the second trimester. Clin. Chem. 1981; 27(1):133-134.

Jason TF, Chun WW and Ian GC. Effects of dietary protein types on immune responses and levels of infection with Eimeria vermiformis in mice. Immunology and Cell Biology. 2001; 79:23-28.

Jayagopal V, Albertazzi P and Kilpatrick ES. Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes. Diabetes Care. 2002; 25(10):1709-1714.

Jeena K, Joy KL and Ramadasan K. Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on N-nitrosodiethylamine induced hepatocarcinogenesis. Cancer letters. 1999; 136:11-16.

Johnson PJ. The epidemiology of hepatocellular carcinoma. Eur J Gastroenterol Hepatol. 1996; 8(9):845-849.

Jolles P, Fiat A-M, Migliore-Samour D, Drouet L, Caen J, Brenner and Sawatzki G. Peptides from milk proteins implicated in antithrombosis and immunomodulation, New Perspectives in Infant Nutrition. Symposium Antwerp. 1992; 160-172.

Jolles P, Levy-Toledano S, Fiat AM, Soria C, Gillessen D and Thomaidis A. Analogy between fibrinogen and casein Effect of an decapeptide isolated from kappa-casein on platelet function. Eur J Biochem. 1986; 158:379-382.

Kaplan D and Reddy KR. Rising incidence of hepatocellular carcinoma: the role of hepatitis B and C; the impact of transplantation and out comes. Clin Liver Dis. 2003; 7:683-714.

Kaunitz H and Dayrit CS. Coconut oil consumption and coronary heart disease. Philippine Journal of Internal Medicine. 1992; 30:165-171.

Kayser H and Meisel H. Stimulation of human peripheral blood lymphocytes by bioactive peptides derived from bovine milk proteins. FEBS Letters. 1996; 383:18-20.

Keen CL, Tamura T, Lonnerdal B, Hurley LS and Halsted CH. Changes in hepatic superoxide dismutase activity in alcoholic monkeys. Am J Clin Nutr. 1985; 41:929-932.

Kelloff GJ, Crowell JA, Steele VE, Lubet RA, Malone WA and Boone CW. Progress in cancer chemoprevention: development of diet-related chemopreventive agents. J Nutr. 2000; 130:467S-471S.

Kent KD, Harper WJ and Bomser JA. Effect of whey protein isolate on intracellular glutathione and oxidant-induced cell death in human prostate epithelial cells. Toxicology In Vitro, 2003; 17:27-33.

R10

Keri Marshall. User's Guide to Protein and Amino Acids. American Physiological Society. 2004.

Kidon MI, Lim S, Loo A, Wee A, Ling S, Liew W, Chiang W and Chew L. Coconut allergy in two children of asian origins and identification of the IgE binding components. J Allergy Clin Immunol. 2009; 115(2): Abstracts, S31.

Kim SM, Kubota K, Kobayashi A. Antioxidative activity of sulfur-containing flavor compounds in garlic. Biosci Biotech. Biochem 1997; 61:1482-1485.

Kirtchevsky D, Teepper SA, Czarnecki SK, Klurfeld DM and Story JA. Experimental atherosclerosis in rabbits fed cholesterol-free diets, part 9: beef protein and textured vegetable protein. Atherosclerosis. 1981; 39:169-175.

Kissileff HR, Pi-Sunyer FX, Thornton J and Smith GP. C-terminal octapeptide of cholecystokinin decreases food intake in man. Am J Clin Nutr. 1981; 34:154-160.

Kitchin KT and Brown JL. Biochemical studies of promotes of carcinogenesis in rat liver. Teratogenesis, carcinogenesis, and Mutagenesis. 1989; 9:273-285.

Kodera T and Nio N. Identification of an Angiotensin I converting enzyme inhibitory peptides from protein hydrolysates by a soybean protease and the antihypertensive effects of hydrolysates in spontaneously hypertensive model rats. J Food Sci. 2006; 71:164-173.

Komlosh A, Volohonsky G, Porat N, Tuby C, Bluvshtein E and Steinberg P. Gamma-Glutamyl transpeptidase and glutathione biosynthesis in non-tumorigenic and tumorigenic rat liver oval cell lines.Carcinogenesis. 2002; 23(4):671-678.

Konda TS, Davis JS, Standaert ML, Pollet RJ and Cooper DR. Insulin rapidly increases diacylglycerol by activating de novo phosphatidic acid synthesis. Science. 1987; 236(4801):586–589.

Krauss RM, Deckelbaum RJ and Ernst N. Dietary guidelines for healthy American adults. Circulation. 1996; 94:1795-1800.

Kumar A and Sharma VD. Inhibitory effect of garlic (Allium sativum linn.) on enterotoxigenic Escherichia coli. Indian J. Med. Res. 1982; 76:66-70.

Kumar R, Sukumar S and Barbacid M. Activation of ras oncogenes preceding the onset of neoplasia. Science. 1990; 248:1100-1102.

Kurowska EM and Carroll KK. Hypercholesterolemic responses in rabbits to selected groups of dietary essential amino acids. J Nutr. 1994; 124:364-370.

Lahov E and Regelson W. Antibacterial and immunostimulating casein-derived substances from milk, casecidin, isracidin peptides. Food and Chemical Toxicology. 1996; 34:131-145.

Lamartiniere CA. Protection against breast cancer with genistein: a component of soy. Am J Clin Nutr. 2000; 71:1705S-1707S.

R11

Lee HP, Gourley L, Duffy SW, Esteve J, Lee J and Day NE. Dietary effects on breast cancer risk in Singapore. Lancet 1991; 337:1197-1200.

Lee YI, Lee S, Das GC, Park US and Park SM. Activation of the insulin-like growth factor II transcription by aflatoxin B1 induced p53 mutant 249 is caused by activation of transcription complexes; implications for a gain-of-function during the formation of hepatocellular carcinoma. Oncogene. 2000;19:3717-3726.

Leoppky RN and Li YE. Nitrosamine activation and detoxification through free radicals and their derived cations, in; I.K.O’Neill, J, Chen H. Bartsch(Eds.), Relevance to Human Cancer of N-Nitroso Compounds, Tobacco and mycotoxins. IARC Scientific Publications, Lyon. 1991; 105:375-382.

Lerman A, Burnett JC, Higano ST, McKinley LJ and Holmes DR. Long-term L-arginine supplementation improves small-vessel coronary endothelial function in humans. Circulation. 1998; 97:2123-2128.

Li D, Yee JA, McGuire MH, Murphy PA and Yan L. Soybean isoflavones reduce experimental metastasis in mice. J Nutr. 1999; 129:1075-1078.

Libbrecht L, Desmet V and Roskams T. Preneoplastic lesions in human hepatocarcinogenesis. Liver Int. 2005; 25:16-27.

Lieverse RJ, Jansen JB, Masclee AA, Rovathi LC and Lamers CB. Effect of a low dose intraduodenal fat on satiety in humans: studies using the type A cholecystokinin receptor antagonist loxiglumide. Gut. 1994; 35:501-505.

Lin CH, Correia L, Tolia K, Gesell MS, Tolia V, Lee PC and Luk GD. Early weaning induces jejunal ornithine decarboxylase and cell proliferation in neonatal rats. J. Nutr. 1998; 128:1636-1642.

Little RA, Frayn KN, Randall PE, Stoner HB, Morton C, Yates DW and Laing GS. Plasma catecholamines in the acute phase of the response to myocardial infarction. Arch Emerg Med. 1986; 3(1):20-27.

Liu GY, Hung YC, Hsu PC, Liao YF, Chang WH, Tsay HC and Hung HC. Ornithine decarboxylase prevents tumour necrosis factor alpha induced apoptosis by decreasing intracellular reactive oxygen species. Apoptosis. 2005; 10:569-581.

Liu J, Atamna H, Kuratsune H and Ames BN. Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites. Ann NY Acad Sci. 2002; 959:133-166.

Loeppky RN. The mechanism of bioactivation of N-nitrosodiethanolamine. Drug Metab Rev. 1999; 31:175-193.

Lu SC. Regulation of hepatic glutathione synthesis: current concepts and controversies. Faseb J. 1999; (10):1169-1183.

R12

Macdonald GA. Pathogenesis of hepatocellular carcinoma. Clin Liver Dis. 2001; 5:69-85.

MacIntosh GH, Regester GO, Le Leu RK, Royle PJ and Smithers GW. Dairy proteins protect against dimethylhydrazine induced intestinal cancers in rats. Journal of Nutrition. 1995; 125:809-816.

Mader JS and Hoskin DW. Cationic antimicrobial peptides as novel cytotoxic agents for cancer treatment. Expert Opin. Investig. Drugs. 2006; 15:933-946.

Malstrom B, Andreasson L and Reinhammer B. The Enzymes. Boyer P, editor. XII B, Academic Press, New York. 1975; 533.

Manjula JS and Shymaladevi CS. Effect of aspirin on lipid peroxidation in experi- mental myocardial infarction in rats. Journal of Nutritional Biochemistry. 1994; 5:95.

Manjula TS and Devi CS. Effect of aspirin in mitochondrial lipids in experimental myocardial infarction in rats. Biochem Mol Bio lint. 1993; 29:921-928.

Marcus GM, CohenvJ and Varosy PD. The utility of gestures in patients with chest discomfort. Am. J. Med. 2007;120 (1): 83-89.

Marinho HS, Baptista M and Pinto RE. Glutathione metabolism in hepatomous liver of rats treated with diethylnitrosamine. Biochim. Biophys. Acta. 1997; 1360 (2):157-168.

Matsuok H, Itoh S, Kimoto M, Kohno K, Tamai O, Wada Y, Yasukawa H, Iwami G, Okuda S and Imaizumi T. Asymmetrical dimethylarginine, an endogenous inhibitor, in experimental hypertension. Hypertension. 1997; 29:242-247.

Maxwell AJ, Schauble E, Bernstein D and Cooke JP. Limb blood flow during exercise is dependent upon nitric oxide. Circulation. 1998; 98:369-364.

McCord JM. Free radicals and myocardial ischemia. Radical Biology Medica. 1988; 4:9.

McSweeney Jean C, marisue Cody, Patricia O’ Sullivan, Karen Elberson, Debra K. Moser, Bonnie J. Garvin. Women’s Early Warning Symptoms of Acute Myocardial Infarction. Circulation. 2003; 108:2619.

Mendis S and Kumarasunderam R. The effect of daily consumption of coconut fat and soya-bean fat on plasma lipids and lipoproteins of young normolipidemic men. British Journal of Nutrition. 1990; 63:547-552.

Meng SD, Song J, Rao Z, Tien P, Gao GF. Three-step purification of gp96 from human liver tumor tissues suitable for isolation of gp96-bound peptides. J Immunol Methods. 2002; 264:29-35.

R13

Mengsen Li, Sheng Zhou, Xinhua Liu, Pingfeng Li, Mcnutt Michael A and Gang Li. Αlpha fetoprotein shields hepatocellular carcinoma cells from apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand. Cancer letters. 2007; 249(2):227-234.

Mepba HD and Achinewhu SC. Effects of processing on protein nutritive quality of coconut Cocos nucifera products. Plant foods for human nutrition. 2003; 58(1):15-25.

Mercier A, Gauthier SF and Fliss I. Immunomodulating effects of whey proteins and their enzymatic digests. International Dairy Journal. 2004; 14:175-183.

Messina M. Modern applications for an ancient bean: soybeans and the prevention and treatment of chronic disease. J Nutr. 1995; 125:567S-569S.

Meziani K, Benamouzig R, Mahé S, Martin A, Bouras M, Rautureau J and Tomé D. Effects of a high soy protein diet on intestinal polyamines and ornithine decarboxylase activity in rats. J Nutr Biochem. 1999; 10(7):405-410.

Micheau O and Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell. 2003; 114:181-190.

Migliore-Samour D and Jolles P. Casein, a prohormone with an immunomodulating role for the newborn? Experientia. 1988; 44: 188-193.

Milner, JA, Stepanovich LV. Inhibitory effect of dietary arginine on growth of Ehrlich ascites tumor cells in mice. Journal of Nutrition. 1979; 109:489-494.

Mini S and Rajamohan T. Cardioprotective effect of kernel protein in isoporterenol administered rats. Indian Journal of Biochemistry and Biophysics. 2002; 39:197-200.

Mirhadi SA, Singh S and Gupta PP. Effect of garlic supplementation to cholesterol-rich diet on development of atherosclerosis in rabbits. Indian J Exp Biol. 1991; 29(2): 162-168.

Mizejewski GI. The filogeny of alpha-fetoprotein in vertebrates: survey of biochemical and physiological data. Critical Reviews in Eucariotic Gene Expression. 1995; 5:281-316.

Mizejewski GJ and Butterstein G. Survey of functional activities of alpha-fetoprotein derived growth inhibitory peptides: review and prospects. Curr Protein Pept Sci. 2006; 7(1):73-100.

Mohanty I, Arya DS, Dinda A, Talwar KK, Joshi S and Gupta SK. Mechanisms of cardio protective effect of Withania somnifera in experimentally induced myocardial infarction. Basic. Clin. Pharmacol. 2004; 94:184-190.

Monaci L, Tregoat V, Van Hengel AJ and Anklam E. Milk allergens, their characteristics and their detection in food: A review article. Eur Food Res Technol. 2006; 223:149-179.

R14

Monserrat AJ, Romero M, Lago N and Aristi C. Protective effect of coconut oil on renal necrosis occurring in rats fed a methyl-deficient diet. Renal failure. 1995; 17:525-537.

Morioka N, Sze LL, Moron DL and Irie RF. A protein fraction from aged garlic extract enhances cytotoxicity and proliferation of human lymphocytes mediated by IL-2 and concanavalin A. Cancer Immunol Immunother. 1993; 37:316-322.

Moss DW, Edith Muller and Pearse AGE. The inducible alkaline phosphatase of rat heart. Some properties of the enzyme and factors influencing its activity. Biochem J. 1971; 123(5):895-900.

Muraleedharakurup G. Ph.D. thesis, University of Kerala. 1984; India.

Murray J, Barbara J, Dunkley S, Lopez A, Van Ostade X, Condliffe I and Chilvers E. Regulation of neutrophil apoptosis by Tumour necrosis factor alpha: Requirements for TNF-R55 and TNF-R75 for induction of apoptosis In vitro. 1997; 90(7):2772-2783.

Muzio G, Marengo B and Salvo R. Liver cancer is induced by a subnecrogenic dose of DEN when associated with fasting / refeeding: role of glutathione-transferase and lipid peroxidation. Free radic Biol Med. 1999; 26:1314-1320.

Nagase S, Takemura K and Ueda A. A novel nonenzymatic pathway for the generation of nitric oxide by the reaction of hydrogen peroxide and D- or L-arginine. Biochem Biophys Res Commun. 1997; 233:150-153.

Nakajima K, Tamura N, Kobayashi-Hattori K, Yoshida T, Hara-Kudo Y, Ikedo M, Sugita-Konishi Y and Hattori M. Prevention of intestinal infection by glycomacropeptide. Bioscience, Biotechnology and Biochemistry. 2005; 69:2294-2301.

Neilsen F, Mikkelsen B, Neilsen JB, Andersen HR and Grandjean P. Plasma malondialdehyde as biomarker for oxidative stress reference interval and effects of life-style factors. Clin Chemist .1990; 47:1209-1214.

Nermin AH, Sadik, Shohda A, Maraghy EL, Manal F and Ismail. Diethylnitrosamine-induced hepatocarcinogenesis in rats: possible chemoprevention by blue berries. African Journal of Biochemistry Research. 2008; 2(3):81-87.

Nikolov I, Pavlov V, Minkov I and Danijanov D. Purification and some properties of an amine oxidase from soybean seedlings. Experimentia. 1990; 46:765-767.

Nima Hosseini Jazani, Shahram Shahabi, Ahya Adbi Ali, Sarhar Zarrin and Nasim Ali Daie. In vitro antibacterial activity of garlic against isolates of Acinetobacter sp. Journal of Biological Sciences. 2007; 7(5):819-822.

Otani H and Hata I. Inhibition of proliferative responses of mouse spleen lymphocytes and rabbit Peyer's patch cells by bovine milk caseins and their digests. Journal of Dairy Research. 1995; 62:339-348.

R15

Ozturk M. Genetic aspects of hepatocellular carcinogenesis. Semin Liver Dis. 1999; 19:235-242.

Padmakumaran Nair KG, Rajamohan T and Kurup PA. Coconut kernel protein modifies the effect of coconut oil on serum lipids. Plant Foods Human Nutr. 1998; 53:133-144.

Parodi PW. A role for milk proteins and their peptides in cancer prevention. Curr Pharm Des. 2007; 13(8):813-828.

Parodi PW. A role for milk proteins in cancer prevention. Australian Journal of Dairy Science. 1998; 53:37-47.

Patrick Gomez. Ph D thesis, Maharaj Sayajiro University, Baroda. 1983; 67.

Peers FG and Linsell CA. Dietary aflatoxins and primary liver cancer: a population based study in Kenya. Br. J. Cr. 1973; 27:473-484.

Pegg AE. Polyamine metabolism and its importance in neoplastic growth and as a target for chemotherapy. Cancer Res. 1988; 48:759-774.

Perez C, Albert I, Defay K, Zachariades N, Gooding L and Michael K. A nonsecretable cell surface mutant of tumour necrosis factor kills by cell to cell contact. Cell. 1990; 63:251-258.

Peter J. Jones. Clinical nutrition: Functional foods - more than just nutrition. Journal of Canadian Medical Association. 2002; 166 (12):1555-1563.

Peter L Bordi, George Salvaterra, Constance Cole, David A Cranage, Marianne Borja and Youngsoo Choi. A taste comparison of an isolated soy protein carbohydrate-protein beverage and an isolated whey protein carbohydrate-protein beverage. Food Service research International. 2002; 14(1):23-33.

Peterson J and Dwyer J. Flavonoids: dietary occurrence and biochemical activity. Nutr Res. 1998; 18:1995-2018.

Pingoud A, Urbanke C, Hogget J and Jeltsch. A Concise guide for students and researchers in Biochemical Methods. 2002. Wiley VCH publication.

Plaa GL and Zimmerson HJ. Evaluation of hepatotoxicity: physiological and biochemical measures of hepatic function. In: Mc Cuskey, R.S., Earnest, D.L. (Eds.), Comprehensive Toxicology. Cambridge University Press, Cambridge. 1997; 97-109.

Plebani M and D'Amico DF. Role of blood Alpha fetoprotein mRNA and tumor grade in the preoperative prognostic evaluation of patients with hepatocellular carcinoma. World J Gastroenterol. 2005; 11:6920-6925.

Popov I, Blumstein A and Lewin G. Antioxidant effects of aqueous garlic extract. Arzneim Forsch. 1994; 44:602-604.

R16

Porta C, Subhra Kumar B, Larghi P, Rubino L, Mancino A and Sica A. Tumor promotion by tumor-associated macrophages. Adv Exp Med Biol. 2007; 604:67-86.

Potter SM. Overview of proposed mechanisms for the hypocholesterolemic effect of soy. J Nutr. 1995; 125:606S-611S.

Prenowl J and Wang QD. Acta Physiol Scand .1999; 167: 151-159. C.F: Mini S and Rajamohan T. Cardioprotective effect of kernel protein in isoporterenol administered rats. Indian Journal of Biochemistry and Biophysics. 2002; 39:197-200.

Pryme, If, Cancer Letters. 1978; l5 (9):1978.

Raeger MA, Cooke JP, Mendelsohn ME, Gallagher SJ, Coleman SM, Loscalzo J and Dzau VJ. Impaired vasodilatation of forearm resistance vessels in hyperchole- sterolemic humans. J Clin Invest. 1990; 86:228-234.

Raha S, Dosquet C, Abgrall JF, Jolles P, Fiat AM and Caen JP. KRDS-a tetrapeptide derived from lactotransferrin-inhibits binding of monoclonal antibody against glycoprotein IIb–IIIa on ADP-stimulated platelets and megakaryocytes. Blood 1988; 72:172-8.

Rajadurai M and Stanely Mainzen Prince. Preventive effect of naringin on cardiac markers, electrocardiographic patterns and lysosomal hydrolases in normal and isoproterenol-induced myocardial infarction in Wistar rats. Toxicology. 2007; 230:178–188.

Rajamohan T and Kurup PA. Indian Journal Biochem Biophys. 1986; 23:294-296. C.F: Mini S and Rajamohan T. Cardioprotective effect of kernel protein in isoporterenol administered rats. Indian Journal of Biochemistry and Biophysics. 2002; 39:197-200.

Rangsithienchai1 PA, Sheehan WJ, Stutius LM, Schneider LC and Phipatanakul W. Prevalence of coconut allergy in children with tree nut and peanut allergies. J Allergy Clin Immunol. 2009; 115(2): Abstracts, S31.

Rao CV, Wang C, Simi B, Lubet R, Kellof GJ, Steele V and Reddy BS. Enhancement of experimental colon cancer by genistein. Cancer Res. 1997; 57:3717-3722.

Ravichandran LV, Puvanakrishnan R and Joseph KT. Alterations in the heart lysosomal stability in isoproterenol-induced myocardial infarction in rats. Biochem. 1990; 22:387-396.

Rees LP, Minney SF, Plummer NT, Slater JH and Skyrme DA. A quantitative assessment of the antimicrobial activity of garlic (Allium sativum). World J. Microbiol. Biotech. 1993; 9:303-307.

Reeves PG, Nielson FH and Fahey GC. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr. 1993; 123:1939-1951.

R17

Reeves PG. Components of the AIN-93 Diets as improvements in the AIN-76A Diet. J Nutr. 1997; 127:838S-841S.

Reitman S and Frankel S. A colorimetric method for determination of serum glutamic oxaloacetic and glutamic pyruvic transaminase. Am J Clin Pathol. 1957; 28:56-63.

Reyes A, Karl IE and Klahr S. Role of arginine in health and in renal disease. Am J Physiol Renal Physiol. 1994; 267:F331-F346.

Reynolds JV, Daly JM, Shou J, Sigal R, Ziegler MM, Naji A. Immunologic effects of arginine supplementation in tumor-bearing and non-tumor-bearing hosts. Annals of Surgery. 1990;211(2): 202-210.

Reynolds JV, Thom A, Zhang S, Ziegler M, Naji A, Daly J. Arginine, protein malnutrition and cancer. Journal of Surgical Research. 1988; 45(6):513-522.

Reza Hakkak. Diets containing whey protein or soy protein isolate protect against 7, 12-DMBA induced mammary tumor in female rats. Cancer Epidemiology Biomarkers and Prevention. 2000; 9:113-117.

Reza Hakkaka, Soheila Korouriana, Martin JJ Ronisa, Jeffery M. Johnstona and Thomas M. Badgera. Soy protein isolate consumption protects against azoxymethane-induced colon tumors in male rats. Cancer Letters. 2001; 166:27-32.

Rosendal A and Barkholt V. Detection of potentially allergenic material in 12 hydrolyzed milk formulas. J Dairy Sci. 2000; 83:2200-2210.

Rosonaivo and Rastimange Unverg. Biological Evolution of plants with reference to the Malagasy flora monograph for the first Napreca Workshop on bio-assays, Antanavio Madagascar. 1993; 72-79.

Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG and Hoekstra WG. Selenium : Biochemical Role as a Component of Glutathione Peroxidase. Science. 1973; 179(4073):588-590.

Rowlands JC, He L, Hakkak R, Ronis MJJ and Badger TM. Soy and whey proteins down regulate DMBA-induced liver and mammary gland CYP1 expression in female rats. Journal of Nutrition. 2001; 131: 3281-3287.

Royle PJ, Grame HM and Peter MC. Whey protein isolate and glycomacropeptide decrease weight gain and alter body composition in male wistar rats. British Journal of Nutrition. 2008; 100:88-93.

Ruhan Elliott and Teng Jin Ong. Nutritional Genomics. B. M. J.2002;234:1438-1442.

Rumsey GL, Siwicki AK, Anderson DP and Bowser PR. Effect of soybean protein on serological response, non-specific defense mechanisms, growth, and protein utilization in rainbow trout. Vet. Immunol. Immunopathol. 1994; 41:323-39.

R18

Rushmore TH and Picket CB. Glutathione -S-transferase, structure, regulation and therapeutic implication. J Biol Chem. 1993; 268:11475-11478.

Ryder SD. Guidelines for the diagnosis and treatment of hepatocellular carcinoma in adults. Gut. 2003; 52(3):1-8.

Sadik, Shohda A, Maraghy EL, Manal F and Ismail. Diethylnitrosamine-induced hepatocarcinogenesis in rats: possible chemoprevention by blue berries. African Journal of Biochemistry Research. 2008; 2 (3): 81-87.

Safford SE, Oberley TD, Urano M and St Clair DK. Suppression of fibrosarcoma metastasis by elevated expression of manganese superoxide dismutase. Cancer Res. 1994; 54:4261-4265.

Salil G and Rajamohan T. Hypolipedemic and antiperoxidative effect of coconut protein in hypercholestermic rats. Indian J Exp Biol. 2001; 39(10):1028-1034.

Sampson HA. Part-I: Immunopathogenesis and clinical disorders. J. Allergy Clin. Immunol. 1999; 103:717-728.

Sangeetha T and Darlin Quine. Preventive effect of S-allyl cysteine sulfoxide on cardiac marker enzymes and lipids in isoproterenol-induced myocardial injury. Journal of Pharmacy and Pharmacology. 2006; 58(5):617-623.

Sanjay Kumar Banerjee, Amit Kumar Dinda, Subhash Chandra Manchanda and Subir Kumar Maulik. Chronic garlic administration protects rat heart against oxidative stress induced by ischemic reperfusion injury. BMC Pharmacology. 2002; 2:16.

Saravanan G and Prakash J. Effect of garlic (Allium sativum) on lipid peroxidation in experimental myocardial infarction in rats. Journal of Ethnopharmacology. 2004; 94:155-158.

Sathish V, Ebenezar KK and Devaki T. Effect of arginine and lysine on mitochondrial function during isoproterenol induced myocardial infarction. Nut Res. 2003; 23:1269-77.

Schlimme E and Meisel H. Bioactive peptides derived from milk proteins. Structural, physiological and analytical aspects. Die Nahrung. 1995; 39:1-20.

Schulze-Osthoff K, Bakker AC, Vanhaesebroeck B, Beyaert R, Jacob WA and Fiers W. Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical genration. J Biol Chem. 1992; 267:5317-5323.

Schwarzacher SP, Lim TT, Wang BY, Kernoff RS, Niebauer J, Cooke JP and Yeung AC. Local intramural delivery of L-arginine enhances nitric oxide generation and inhibits lesion formation after balloon angioplasty. Circulation. 1997; 95:1863-1869.

R19

Sciherer SH, Monoz-Furlong, Murphy R, Wood RA and Sampson HA. Paediatric food Allergy. Pediatrics. 2003; 111:1591-1680.

Sciherer SH. Food Allergy. Lancet. 2002; 360:701-710.

Seifter, E, Rettura G, Barbul A, Levenson SM, Arginine: an essential amino acid for injured rats. Surgery. 1978; 84(2):224-230.

Seiler N. Pharmacological properties of the natural polyamines and their depletion by biosynthesis inhibitors as a therapeutic approach. Prog Drug Res. 1991; 37:107-109.

Seki KT, Tsuji K, Hayato Y, Moritomo T and Ariga T. Garlic and onion boils inhibit proliferation and induce differentaiation of HL-60 cells. Cancer Lett. 2000; 160:20-35.

Setchell KD. Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones. Am J Clin Nutr. 1998; 68:1333S-1346S.

Shai Y. Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. Biochim. Biophys. Acta. 1999; 1462:55-70.

Shalaby MR, Aggarwal BB, Rinderknech TE, Svedersky LP, Finkle BS and Palladino MA. Activation of human polymorphonuclear neutrophil functions by interferon- γ and tumor necrosis factors. J Immunol. 1985; 135:2069-2073.

Shane Bilsborough and Neil Mann. A review of issues of dietary protein intake in humans. International Journal of Sport nutrition and Exercise Metabolism. 2006; 16:129-152.

Shao Hsuan Kao, Ching Hsian Hsu, Song Nan Su, Wei Ting Hor, Wen Hong Chang T and Lu ping Chow. Identification and immunologic characterization of an allergen, allin lyase from garlic (Allium sativum). Journal of Allergy and Clinical Immunology 2004; 113(1):161-168.

Sharma RA, McLelland HR, Hill KA, Ireson CR, Euden SA, Manson MM, Pirmohamed M, Marnett LJ, Gescher AJ and Steward WP. Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Clin Cancer Res. 2001; 7:1894-1900.

Shayanthan Nanthakumaran, Iain Brown, Steven D. Heys and Andrew C. Schofield. Inhibition of gastric cancer cell growth by arginine: Molecular mechanisms of action. Clinical Nutrition. 2009; 28:65-70.

Sidhu GS and Oakenfull DG. A mechanism for the hypocholesterolemic activity of saponins. Br J Nutr. 1986; 55:643-649.

Sidoti-de Fraisse C, Rincheval V, Risler Y, Mignotte B and Vayssiere JL. TNF-alpha activates at least two apoptotic signaling cascades. Oncogene. 1998; 17:1639-1651.

R20

Sinha KA. Colorimetric assay of catalase. Anal Biochem. 1972; 47:3889-3894.

Sirtori CR, Lovati MR and Manzoni C, et al. Soy and cholesterol reduction: clinical experience. J Nutr. 1995; 125:598S-605S.

Sivapatham Sundaresan and Perumal Subramanian. Garlic modulates lipid per oxidation and antioxidant status during N-Nitrosodiethylamine-induced hepatic tumorigenesis. Plant Foods for Human nutrition. 2003; 58:3.

Somekawa Y, Chiguchi M, Ishibashi T and Aso T. Soy intake related to menopausal symptoms, serum lipids, and bone mineral density in postmenopausal Japanese women. Obstet Gynecol. 2001; 97:109-115.

Sreepriya M and Bali G. Chemopreventive effects of embelin and curcumin against N-nitrosodiethylamine / Phenobarbital induced hepatocarcinigenesis in wistar rats. Fitoterapia. 2005; 76:549-555.

Stadtman ER. Oxidation of free amino acids and amino acid residues in proteins by radiolysis and by metal-catalyzed reactions. Annu Rev Biochem. 1993; 62:797-821.

Stanton HC and Schwart ZA. Effects of hydrazine monoamine oxidase inhibitors on isoproterenol induced myocardiopathies in the rat. Journal of Pharmacology and Experimental Therapeutics. 1967; 157:640.

Steele E, Pereira MA, Sigman CC and Kelloff CJ. Cancer chemoprevention agent development strategies for genistein. J. Nutr. 1995; 125:713S-716S.

Stewart BH and Hoskin DW. Inhibition of protein tyrosine kinases or protein kinase C prevents nonspecific killer T lymphocyte mediated tumoricidal activity. Biochem. Biophys. Acta. 1997; 1356:333-342.

Subramanian P, Shankaran M, Kadiyala Babu D, Pandi Perumal R, Iiya Trakht and Daniel P. Prevention by melatonin hepatocarcinigenesis in rats injected with N-nitrosodiethylamine. J. Pineal Res. 2007; 43:305-312.

Suetsuna K, Ukeda H and Ochi H. Isolation and characterization of free radical scavenging activities peptides derived from casein. J Nutr Biochem. 2000; 11:128-131.

Suetsuna K. Separation and identification of peptides derived from soybean protein, and their active oxygen scavenging activity. J. Jpn. Soc. Nutr. Food Sci. 1999; 52:225-228.

Sumitra M, Manikandan P, Kumar DA, Arutselvan N, Balakrishna K, Manohar BM and Puvanakrishnan R. Experimental myocardial necrosis in rats: Role of arjunolic acid on platelet aggregation, coagulation and antioxidant status. Molecular and Cellular Biochemistry. 2001; 224:135-142.

Sun Y, Oberley LW, Elwell JH and Sierra Rivera E. Antioxidant enzyme activities in normal and transformed mice liver cells. Int J Cancer. 1989; 44:1028-1033.

R21

Sushama Kumari S, Jayadeep A, Suresh Kumar JS and Menon VP. Effects of carnitine on malondialdehyde, taurine, glutathione levels in heart of rats subjected to myocardial stress. Indian Journal of Experimental Biology. 1989; 27:134-137.

Tachibana K, Mukai K, Hiraoka I, Moriguchi S, Takama S and Kishino Y. Evaluation of the effect of arginine-enriched amino acid solution on tumor growth. J Parenter Enteral Nutr. 1985; 9:428-434.

Takeda Y, Tominaga T, Tei N, Kitamura M, Taga S, Murase J, Taguchi T, Miwatani T. Inhibitory effect of L-arginine on growth of rat mammary tumors induced by 7,12-dimethylbenz(a)anthracene. Cancer Research. 1975; 35:2390-2393.

Tanaka T, Kojima T, Suzuki M and Mori H. Chemoprevention of diethylnitrosamine-induced hepatocarcinogenesis by a simple phenolic acid protocatechuic acid in rats. Cancer Res. 1993; 53:3908-3913.

Tang JL, Zhan SY and Ernst E. Review of randomized controlled trials of traditional Chinese medicine. Br Med J. 1999; 319:160-161.

Tang QY, Yao DF, Lu JX, Wu XH and Meng XY. Expression and alterations of different molecular form gammaglutamyl transferase and total RNA concentration during the carcinogenesis of rat hepatoma. World J. Gastroenterol. 1999; 5:356-358.

Tarao K, Rino Y, Ohkawa S, Tamai S, Miyakawa K, Takakura H and Endo O. Close association between high serum Alanine aminotransferase levels and multicentric hepatocarcinogenesis in patients with hepatitis C virus-associated cirrhosis. Cancer. 2002; 94:1787-1795.

Terentiev AA and Moldogazieva NT. Structural and functional mapping of alpha-fetoprotein. Biochemistry (Mosc). 2006; 71(2):120-132.

Thirunavukkarasu C, Premkumar K, Jagadeeswaran R and Sakthisekaran D. The inhibitory effect of sodium selenite on N-nitrosodiethylamine-induced and phenobarbital promoted liver tumourigenesis in rats based on the modulation of polyamine levels. Molecular and Cellular Biochemistry.2005; 280:165-172.

Thompson JA and Hess ML. The oxygen free radical system: a fundamental mechanism in the production of myocardial necrosis. Prog Cardiovasc Dis. 1986; 28:449-62.

Tikkanen MJ, Wahala K, Ojala S, Vihma V and Adlercreutz H. Effect of soybean phytoestrogen intake on low density lipoprotein oxidation resistance. Proc Natl Acad Sci USA. 1998; 95:3106-3110.

Torre Villalvazo, Armando R. Tovar, Victoria E. Ramos Barragan, Macro Antonio Cerbon Cervantes and Nimbe Torres. Soy protein ameliorates metabolic abnormalities in liver and adipose tissue of rats fed a high fat diet. J. Nutr. 2008; 138:462-468.

R22

Tsai WY, Chang WH, Chen CH and Lu FJ. Enchancing effect of patented whey protein isolate (immunocal) on cytotoxicity of an anticancer drug. Nutrition Cancer. 2000; 38:200-208.

Tsao SM, Yin MC, In vitro activity of four diallyl sulphides occurring naturally in garlic and Chinese leeks oils. J Med Microbiol 2001; 50:646-649.

Tsao SM, Yin MC and Liu WH. Oxidant stress and B vitamins status in patients with non-small cell lung cancer. Nutr Cancer. 2007; 59(1):8-13.

Tsuda H, Sekine K, Ushida Y, Kuhara T, Takasuka N and Iigo M. Milk and dairy products in cancer prevention: Focus on bovine lactoferrin. Mutation Research. 2000; 462:227-233.

USDA National Nutrient Database for Standard Reference, Release 2004, 16-1.

Usui M, Matsuoka H, Miyazaki H, Ueda S, Okuda S and Imaizumi T. Increased endogenous nitric oxide synthase inhibitor in patients with congestive heart failure. Life Sci.1998; 62:2425-2430.

Vaage J and Valen G. Pathophysiology and mediators of ischaemia-reperfusion injury with special reference to cardiac surgery. Scand. J. Cardiovasc. Surg. 1993; 41:1-18.

Valenzuela A. The biological significance of malondialdehyde determination in the assessment of tissue oxidative stress. Life Sc. 1990; 48:301-309.

Vallance P, Leone A, Calver A, Collier J and Moncada S. Endogenous dimethyl- arginine as an inhibitor of nitric oxide synthesis. J. Cardiovasc Pharmacol. 1992; 20(Suppl 12):S60-S62.

Van der Schouw YT, De Kleijn MJ, Peeters PH and Grobbee DE. Phyto-oestrogens and cardiovascular disease risk. Nutr Metab Cardiovasc Di. 2000; 10:154-167.

Vandana S. Panda and Suresh R. Naik. Cardioprotective activity of Ginkgo biloba Phytosomes in isoproterenol-induced myocardial necrosis in rats: A biochemical and histoarchitectural evaluation. Experimental and Toxicologic Pathology. 2008; 60:397-404.

Wallner S, Hermetter A, Mayer B and Wascher TC. The alpha-amino group of L-arginine mediates its antioxidant effect. Eur. J. Clin. Invest. 2001; 31:98-102.

Wang Z, Ruan YB, Guan Y and Liu SH. Expression of IGF in early experimental hepatocellular carcinomas and its significance in early diagnosis. World J. Gastroenterol. 1999; 9:267-270.

Wangen KE, Duncan AM, Xu X and Kurzer MS. Soy isoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women. American Journal of Clinical Nutrition. 2001; 73:225-231.

R23

Wargovich MJ, Chen CD, Jimenez A, Steele VE, Velasco M, Stephens LC, Price R, Gray K and Kelloff GJ. Aberrant crypts as biomarkers for colon cancer: evaluation of potential chemopreventive agents in the rat. Cancer Epidem Biomarkers & Prevent. 1996; 5:355-60.

Washburn S, Burke G.L, Morgan T and Anthony M. Effect of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women. Menopause. 1999; 6:7-13.

Wei H, Bowen R, Cai Q, Barnes S and Wang Y. Antioxidant and antipromotional effects of the soybean isoflavone genistein. Proc Soc Exper Biol Med. 1995; 208:124-130.

Werner GH, Floch F, Migliore-Samour D and Jolles P. Immunomodulating peptides. Experientia .1986; 42:521-531.

Wexler BC and Greenberg BP. Protective effects of clofibrate on isoproterenol-induced myocardial infarction in arteriosclerotic and non-arteriosclerotic rats. Atherosclerosis. 1978; 29:373-395.

Wilcox JN and Blumenthal BF. Thrombotic mechanisms in atherosclerosis: potential impact of soy proteins. J Nutr. 1995; 125:631S-638S.

Williams JK and Clarkson TB. Dietary soy isoflavones inhibit in vivo constrictor responses of coronary arteries to collagen-induced platelet activation. Coron Artery Dis. 1998; 9:759-764.

Wood RA. The natural history of food allergy. Pediatrics. 2003; 111:1631-1637.

World Cancer Research Fund and American Institute for Cancer Research. Food, nutrition and the prevention of cancer: a global perspective. Menasha: BANTA Book Group, 1997.

Wulf Droge. Free Radicals in the physiological control of cell function. Physiol. Rev. 2002; 82:47-95.

Xue KX. Molecular genetic and epigenetic mechanisms of hepatocarcinogenesis. Ai Zheng 2005; 24(6):757-768.

Yao DF, Dong ZZ and Yao DB, et al. Abnormal expression of hepatoma-derived gamma glutamyltransferase subtyping and its early alteration for carcino- genesis of hepatocytes. Hepatobiliary Pancreat Dis Int. 2004; 3:564-570.

Yates JC, Beamish RE and Dhalla NS. Ventricular dysfunction and necrosis produced by adrenochrome metabolite of epinephrine: relation to pathogenesis of catecholamine cardiomyopathy. Am Heart J. 1981; 102(2):210-222.

Yim MB, Chock PB and Stadtman ER. Copper, zinc superoxide dismutase catalyzes hydroxyl radical production from hydrogen peroxide. Proc Natl Acad Sci. 1990; 87(13): 5006-5010.

R24

Yogeshwer Shukla and Neetu Kalra. Cancer chemoprevention with garlic and its constituents. Cancer letters. 2007; 247:167-181.

Yvon M, Beucher S, Guilloteau P, Le Huerou-Luron I and Corring T. Effects of caseinomacropeptide on digestion regulation. Reprod Nutr Dev. 1994; 34:527-537.

Zasloff M. Antimicrobial peptides of multicellular organisms. Nature. 2002; 415:389 -395.

Zein M and Discombe G. Serum gamma-glutamyl transpeptidase as a diagnostic aid. Lancet. 1970; 2:748-750.

Zein NN, Poterucha JJ, Gross JB, Wiesner RH, Therneau TM, Gossard AA and Wendt NK. Increased risk of hepatocellularcarcinoma in patients infected with hepatitis C genotype 1b. Am. J Gastroenterol. 1996; 91:2560-2562.

Zhang X and Beynen AC. Lowering effect of dietary milk-whey protein v. casein on plasma cholesterol concentrations in rats. Br J Nutr. 1993; 70(1):139-146.

PUBLICATIONS

Aiyavu C and Patrick Gomez M. Action of crude garlic proteins and diallyldi sulfide(DADS) on diethylnitrosamine induced liver cancer in male albino mice. Indian J physiol Pharmacol 2005; 49(5):127S.

Aiyavu C and Patrick Gomez M. Anticancer activity of garlic proteins on 4-

dimethylaminobenzene induced liver cancer in male albino mice. Indian J physiol Pharmacol 2004; 48(5):189S.