Rakesh K. Jain Scientific American 2014...Rakesh K. Jain Scientific American Image of snake removed...
Transcript of Rakesh K. Jain Scientific American 2014...Rakesh K. Jain Scientific American Image of snake removed...
![Page 1: Rakesh K. Jain Scientific American 2014...Rakesh K. Jain Scientific American Image of snake removed due to copyright restrictions. Source: Jain, Rakesh K. "An indirect way to tame](https://reader034.fdocuments.us/reader034/viewer/2022042713/5fa85bce9912563be45edfe4/html5/thumbnails/1.jpg)
Rakesh K. Jain Scientific American
Image of snake removed due to copyright restrictions. Source: Jain, Rakesh K. "An indirect way to tame cancer." Scientific American 310, no. 2 (2014): 46-53.
2014
1
![Page 2: Rakesh K. Jain Scientific American 2014...Rakesh K. Jain Scientific American Image of snake removed due to copyright restrictions. Source: Jain, Rakesh K. "An indirect way to tame](https://reader034.fdocuments.us/reader034/viewer/2022042713/5fa85bce9912563be45edfe4/html5/thumbnails/2.jpg)
Figures from Box 1 removed due to copyright restrictions. Source: Jain, Rakesh K. "An indirect way to tame cancer." Scientific American 310, no. 2 (2014): 46-53.
2
![Page 3: Rakesh K. Jain Scientific American 2014...Rakesh K. Jain Scientific American Image of snake removed due to copyright restrictions. Source: Jain, Rakesh K. "An indirect way to tame](https://reader034.fdocuments.us/reader034/viewer/2022042713/5fa85bce9912563be45edfe4/html5/thumbnails/3.jpg)
Figures from Box 2 removed due to copyright restrictions. Source: Jain, Rakesh K. "An indirect way to tame cancer." Scientific American 310, no. 2 (2014): 46-53.
3
![Page 4: Rakesh K. Jain Scientific American 2014...Rakesh K. Jain Scientific American Image of snake removed due to copyright restrictions. Source: Jain, Rakesh K. "An indirect way to tame](https://reader034.fdocuments.us/reader034/viewer/2022042713/5fa85bce9912563be45edfe4/html5/thumbnails/4.jpg)
Cortical myosin
assembly
Cortical actin
assembly
Courtesy of Macmillan Publishers Limited. Used with permission. Source: Charras, Guillaume T. et al. "Non-equilibration of hydrostatic pressure in blebbing cells." Nature 435, no. 7040 (2005): 365-369.
4
Cortical myosin
assembly
![Page 5: Rakesh K. Jain Scientific American 2014...Rakesh K. Jain Scientific American Image of snake removed due to copyright restrictions. Source: Jain, Rakesh K. "An indirect way to tame](https://reader034.fdocuments.us/reader034/viewer/2022042713/5fa85bce9912563be45edfe4/html5/thumbnails/5.jpg)
Microplast (cell fragment) volume remains constant during blebbing
Courtesy of Macmillan Publishers Limited. Used with permission. Source: Charras, Guillaume T. et al. "Non-equilibration of hydrostatic pressure in blebbing cells." Nature 435, no. 7040 (2005): 365-369.
5
![Page 6: Rakesh K. Jain Scientific American 2014...Rakesh K. Jain Scientific American Image of snake removed due to copyright restrictions. Source: Jain, Rakesh K. "An indirect way to tame](https://reader034.fdocuments.us/reader034/viewer/2022042713/5fa85bce9912563be45edfe4/html5/thumbnails/6.jpg)
Increasing extracellular osmolarity makes blebs smaller
Courtesy of Macmillan Publishers Limited. Used with permission. Source: Charras, Guillaume T. et al. "Non-equilibration of hydrostatic pressure in blebbing cells." Nature 435, no. 7040 (2005): 365-369.
6
![Page 7: Rakesh K. Jain Scientific American 2014...Rakesh K. Jain Scientific American Image of snake removed due to copyright restrictions. Source: Jain, Rakesh K. "An indirect way to tame](https://reader034.fdocuments.us/reader034/viewer/2022042713/5fa85bce9912563be45edfe4/html5/thumbnails/7.jpg)
Increasing membrane rigidity inhibits blebbing
Courtesy of Macmillan Publishers Limited. Used with permission. Source: Charras, Guillaume T. et al. "Non-equilibration of hydrostatic pressure in blebbing cells." Nature 435, no. 7040 (2005): 365-369.
7
![Page 8: Rakesh K. Jain Scientific American 2014...Rakesh K. Jain Scientific American Image of snake removed due to copyright restrictions. Source: Jain, Rakesh K. "An indirect way to tame](https://reader034.fdocuments.us/reader034/viewer/2022042713/5fa85bce9912563be45edfe4/html5/thumbnails/8.jpg)
cortical acto-myosin contraction bleb forms (rupture event)
pore-size or fluid flows mesh-size through pores due
to hydrostatic pressure
Courtesy of Macmillan Publishers Limited. Used with permission. Source: Charras, Guillaume T. et al. "Non-equilibration of hydrostatic pressure in blebbing cells." Nature 435, no. 7040 (2005): 365-369.
8
![Page 9: Rakesh K. Jain Scientific American 2014...Rakesh K. Jain Scientific American Image of snake removed due to copyright restrictions. Source: Jain, Rakesh K. "An indirect way to tame](https://reader034.fdocuments.us/reader034/viewer/2022042713/5fa85bce9912563be45edfe4/html5/thumbnails/9.jpg)
σ11
Figures 7.14 and 7.15 removed due to copyright restrictions. Source: Grodzinsky, Alan. Field, Forces and Flows in Biological Systems. Garland Science, 2011.
Fields, Forces, & Flows, Figures 7.14 & 7.15
9
![Page 10: Rakesh K. Jain Scientific American 2014...Rakesh K. Jain Scientific American Image of snake removed due to copyright restrictions. Source: Jain, Rakesh K. "An indirect way to tame](https://reader034.fdocuments.us/reader034/viewer/2022042713/5fa85bce9912563be45edfe4/html5/thumbnails/10.jpg)
MIT OpenCourseWare http://ocw.mit.edu
20.430J / 2.795J / 6.561J / 10.539J Fields, Forces, and Flows in Biological SystemsFall 2015
For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms.