R& D Initiativeshrdc.uok.edu.in/Files/c2ce2564-691e-4c9a-ae8a... · Guidelines for submission of...
Transcript of R& D Initiativeshrdc.uok.edu.in/Files/c2ce2564-691e-4c9a-ae8a... · Guidelines for submission of...
R& D Initiatives
Dr Meenakshi Munshi
Director,
Department of Biotechnology,
Ministry of Science & Technology, GOI
New Delhi, India
15th May 2015
Organization Structure
MINISTRY OF SCIENCE & TECHNOLOGY
GOVERNMENT OF INDIA
Department of Science & Technology (DST)
Department of Biotechnology (DBT)
Department of Scientific & Industrial Research (DSIR)
Council of Scientific & Industrial Research (CSIR)
All areas of basic sciences
Biotechnology
Technology and Industrial Development
Mission
Central coordinating and policy making organization in biotechnology
Funds research and development in biotechnology
Developing critical mass of skilled human resource
Establishment of state-of-the-art infrastructure facilities
Establishment of centers of excellence
Provide framework and guidelines for regulatory policies
• Annual Budget : 1400 crores
• Provides Extramural grants to : All universities / research institutions (CSIR, ICAR
and ICMR) and other institutions all over the country
Provides R&D support to NGOs and Industry • Core funding to 16 autonomous institutes
Funding
National Institute of Immunology (NII), Delhi Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad National Centre for Cell Science (NCCS), Pune National Brain Research Centre (NBRC), Manesar National Institute of Plant Genome Research (NIPGR), Delhi Institute of Life Sciences (ILS), Bhubaneshwar Institute of Bioresource and Sustainable Development (IBSD), Manipur Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapura National Agri-Food Biotechnology Institution (NABI), Mohali Translational Health Science & Technology Institute (THSTI), Faridabad Regional Centre for Biotechnology (RCB), Faridabad Stem Cell Institute (InStem), Bangalore National Institute of Animal Biotechnology (NIAB), Hyderabad National Institute of Biomedical Genomics (NIBMG), Kolkata Bio-processing Unit (BPU), Chandigarh Bio-clusters
Autonomous Institutes of DBT
DBT-THE KNOWLEDGE
BASE
BIONERGY
Second & third generation biofuels
BASIC BIOTECHNOLOGY Genomics
Proteomics Metabolomics
Structural Biology
MEDICALBIOTECHNOLOGY Vaccines Bioactive Therapeutic Proteins Stem cell research Infectious -, Non-infectious; chronic -, neurodegenerative diseases
AGRICULTURE
Basic Research; Crop genomics GM Crops- Biotic & Abiotic stress Bio-fortification Marker assisted breeding Biopesticides Biocontrol
ENVIRONMENT BIOTECHNOLOGY Bioprospecting Biomolecule characterization-
Medicinal Plants Bioremediation for treatment of waste
ANIMAL BIOTECHNOLOGY
Molecular epidemiology : diagnostics & vaccine Breed improvement by transgenics Immuno-stimulants Animal feed
AQUACULTURE&MARINE BIOLOGY Molecular epidemiology : diagnostics & vaccines Cell line development Immunostimulants; antibacterial & anti- cancerous agents from marine sources
FOOD BIOTECHNOLOGY Neutraceuticals probiotics
DEVELOPMENT OF NEW PRODUCTS Bioinstrumentation, biomaterials and biodevices
Funding schemes
Research and Development projects through
competitive research grant schemes
Centers of Excellence/programme support
Public-Private Partnerships through
– Small Business Innovation Research Initiative (SBIRI)
– Biotechnology Research Assistance Council (BIRAC)
– Biotechnology Industry Partnership Programme (BIPP) – Details available website http://www.birapdbt.nic.in
Grand challenges programme
International Collaborations
Competitive R & D
schemes
COMPETITIVE R&D SCHEME AS AN INDIVIDUAL OR IN A COLLABORATIVE MODE
RAPID GRANT FOR YOUNG INVESTIGATORS (RGYI), GLUE GRANT
SPECIFIC PROGRAMME FOR NER
CENTRES OF EXCELLENCE AND INNOVATION IN BIOTECHNOLOGY
BIOCARE, SOCIETAL PROGRAMMES
Rapid grant for young
investigators (RGYI)
Fosters creative research in various fields of Biotechnology for
investigators below 40 yrs of age with a promising track record
A single investigator proposal or a team of young investigators
with interdisciplinary multi-institutional collaboration, holding
independent position , the CO-PI should also be a young faculty
The grant is sanctioned within 2-3 months of submitting
application without making a presentation.
Preference is usually given to candidates who are applying for
the first time
Glue Grant
The scheme has been designed to link clinical science departments through inter-institutional linkages with basic science institutes & university departments with medical or veterinary school departments. The scheme is under implementation since 2010-11 and its purpose is to establish a long term partnership programmes between clinical and basic sciences.
Twining programme NE
region
• This programme is for institutes of N-E
regions who can collaborate with
Institute/University from any part of the
country in any broad field of Biotechnology
with aim to help establish & strengthen
Biotechnology based areas.
Twinning program for
NER (few examples)
IIT - G
IGIB CFTRI
IIAR
BTI-Mersra
Ranchi DUSC
MS Swaminathan
Res Foundation
JNU
Thapar
Univ
Tezpur Univ
CDFD
Madras
Univ
Univ of Mysore
IIT-Bombay
Visva-Bharati
Shantiniketan
JNU
ICPO
Noida
NEHU
Manipur
Univ NIPER
JNU
Bose Institute
Visva-Bharati Shantiniketan
Univ of Madras
ICGEB
AAU,Jorhat
Mahyco
CIMAP
ICGEB
Funding schemes at institution
level
Centers of Excellence
Programme Support
BUILDER Programme
13
Centers of excellence
The objectives of this programme are:
(1) to strengthen an institution's research infrastructure through the establishment of a thematic research centre with multi-disciplinary research effort
(2) to enhance the ability of investigators to compete independently for complementary individual research grant or other external peer-reviewed support.
14
DBT-BUILDER programme
– Boost to university interdisciplinary life
science departments for education &
research programme for upgrading and
developing research & advanced technical
capabilities, adequate competency and
skill development of students/faculty in life
science & biotechnology
15
Bio-CARe
A new scheme for women scientists to enhance the
participation of women scientists in biotechnology research
Targeted towards career development of
employed/unemployed women scientists
Operates under two categories:
• Scheme I – Research Grant Opportunity
• Scheme II – Career Re-orientation Fellowship
Scheme I – Research Grant
Opportunity
To build capacities for women scientists employed
fulltime in Universities and small research laboratories
or unemployed women scientist after a career break so
as to help them undertake independent R&D projects
Eligibility criteria for RGO
Employed or unemployed women scientist up to
55 years of age for whom it is the first grant
M.D/M. Tech /Ph. D/ Equivalent degree in any
branch of Life Sciences
Guidelines for submission of
application
Submit a LOI for preliminary screening
For unemployed candidates, a letter from the Mentor
Scientist/Institute in whose lab she proposes to work should
accompany the LOI
For the R&D grant, journal impact factor or even nil publications
would not be a limiting factor
Project proposal can be for a 3+2 years
First successful application and execution of the project need
not debar the women scientist from a second application
Budget/stipend for RGO
The 3 slabs stipend for fellowship would be
decided based on post Ph. D experience
For employed candidate an additional
amount of Rs. 5,000/- over her salary would
be provided as an incentive • Grade – I Rs. 35,000/- (Ph.D+ 0-5 years)
• Grade – II Rs. 40,000/-(Ph.D + 5-10 years
research/industrial experience)
• Grade – III Rs. 45,000/-(Ph.D+ more than
10 years research/industrial
experience)
Scheme II - Career re-orientation
fellowship
Women scientist trained in a particular area, but leave their
permanent jobs/or are unemployed and would like to change their
career path to take newer areas
Require training in the relevant field such as IP management,
bioinformatics, policy research and analysis, translational research,
regulation, clinical research management, etc.
Period : 3-12 months
Stipend for unemployed candidate: Rs. 25,000/-
For employed candidate an additional amount of Rs. 5,000/- over her
salary would be provided as an incentive
Eligibility criteria for CRF
M.D/M. Tech /Ph. D/Equivalent degree in any
branch of Life Sciences
Women scientists who are currently unemployed
or are presently working temporary capacity
Employed scientist, who are looking for a change
in career path
Women scientists up to the age of 55
Guidelines for submission of
application
Identify a specific area and the required skill sets
Identify a mentor/laboratory where she would like to take up this training.
A brief Letter of Intent should be submitted giving her area of specialization and the specific area of training requested
A letter from the mentor/Institute agreeing to provide training for a stipulated time period
On successful completion of the training period a report from the Mentor/Institute will be essential. The training can be extended for another 6 months if required
On completion of the training or while in training the woman scientist is eligible to apply for R&D Scheme
Criteria for scoring LOI’s
Scientific/Research merit of the proposed work
Experience of the candidate
Publications in last 3 years in indexed journals
Criteria for evaluation of
proposal
PI ’s competence (Score : 5)
Scientific merit of the proposal (Score : 20)
Publication of PI (Score : 10)
Proposed Institute (Back-up support) (Score : 10)
Awards/special Distinction of PI (Score : 5)
Strengths and weaknesses of the proposal
A Public-Private Initiative to promote discovery and innovation in biotech
industry
BIRAC
A non-for-profit Section 8, schedule B, Public sector Enterprise, set up by the Department of Biotechnology (DBT) Govt. of India as an interphase agency to strengthen and empower the emerging Biotech enterprise to undertake strategic research & innovation, addressing nationally relevant product development needs
27
BIRAC key strategies and
Functions
Foster Innovation & entrepreneurship
Promote affordable innovation in key social sectors
Empowerment of start ups and small & medium enterprises
Contribute through partners for capability enhancement &
diffusion of innovation
Enable commercialization of discovery
Ensure global competitiveness of Indian enterprises
IP Management
Technology Transfer and Acquisition
Access to Research Acquisition
Mentoring & Capacity Building
28
BIOTECHNOLOGY IGNITION
GRANT (BIG)
SMALL BUSINESS INNOVATION RESEARCH
INITIATIVE (SBIRI)
BIOTECHNOLOGY INDUSTRY
PARTNERSHIP PROGRAMME
(BIPP)
CONTRACT RESEARCH SCHEME (CRS)
UNIVERSITY INNOVATION
CLUSTERS (UIC)
Phase I initiative with 5 Universities
BIRAC-DBT-BMGF
GRAND
CHALLENGE INDIA
SOCIAL INNOVATION
PROGRAMME FOR PRODUCTS
AFFORDABLE & RELEVANT TO
SOCIETAL HEALTH (SPARSH)
RESEARCH
ALLIANCE FOR
PRODUCT
INNOVATION &
DEVELOPMENT
(RAPID)
30
Guidelines
IP rights belong to industry
Varying models of grants, loans or grant / loan
Extent of support ranges between 30-50%
• LOAN
– up to Rs. 10.00 crore – 2% interest;
– above Rs. 10.00 crore – 3 % interest
• ROYALTY
– 5% of net sales for 5 years or
– twice the amount of grant
Small Business Innovative
Research Initiative (SBIRI)
The SBIRI aims to:
strengthen those existing private industrial units whose
product development is based on in-house innovative R&D
encourage other smaller businesses to increase their R&D
capabilities and capacity
create opportunities for starting new technology-based or
knowledge-based businesses by science entrepreneurs
stimulate technological innovation
31
SBIRI
use private industries as a source of innovation and
thereby fulfil government objectives in fostering
R&D, and increase private sector commercialisation
derived from Government funded R&D.
The funds are given under the scheme to the
participating industry and collaborating partners in
installments, the first one on signing of the
Agreement and the subsequent installments on
satisfactory progress of the project as determined
by the Apex Committee of SBIRI (ACS).
32
Research proposal
implementation-an outline
Proposal through RFPs
Discussion with the internal group
Technical peer review for: originality of the proposed research, quality of the
scientific plan, etc.
Communicate comments to the investigators for
clarifications
Consideration of proposal by specific Task Forces
Site visit to verify facilities, resources, etc. (If necessary
in case of mega projects)
Implementation of the programme
Post-implementation site visit, if necessary
Requirements for a research
proposal
Project Title and Affiliations
Abstract/Summary
Research Plan
• Specific Aims
• Background and Significance
• Preliminary Studies/Rationale
• Research Design and Methods including milestones
and time lines
References
Collaborative Interactions and future plans
Institutional approval
Budget and Budget justifications
Multi-institutional
collaborative projects
Key issues:
Concept development
Why multi-institutional?
Define inter-disciplinary goals?
Expertise and experience of key professionals and technical staff
Availability of Research Resources
challenges
Good coordination at institutional level
Keeping institutional identity while fostering multi-institutional collaboration
Selection of an appropriate partner
Project management capability
Past performance factor
Multi-institutional proposals-
points for brainstorming within
the group
Significance
Investigator Expertise
Innovation
Approach
Scientific Environment
Partnership mechanisms
Signing of an Inter-institutional partnership
Agreement with in the partnering
institutes/industries for Intellectual Property (IP)
management; NDA; CDA; Revenue sharing; etc.
Signing of an Agreement with the funding Agency
DBT- AWARD
SCHEMES
Cutting-edge Research Enhancement and Scientific
Training (CREST)
National Bioscience
Award for Career Development
Women Biotechnologist Awards
Innovative Young Biotechnologist Award (IYBA)
DBT-Welcome Trust Alliance
Ramalingaswami
Re-entry Fellowship
Tata Innovation Fellowship
Products & Process Development Award
CREST
Earlier know as DBT Overseas fellowship; a candidate can work
in any overseas laboratory
Each fellow should have permanent faculty position & can avail
fellowship from 3-12 months
Monthly fellowship@ 3000 US$ are paid to university/institution
for onward transmission, to & fro economy class ticket ,
contingent grant Rs 50,000 for up to 6 months , Rs 1.00 lakh up
to 12 months duration
39
National Bioscience Award for
Career Development
This is for midcareer scientists ( 45 yrs age) who have
outstanding track record as evident by publications,
technologies developed, transferred etc.
Each awardee get cash award of Rs 1.00 lakh & Rs 3.0 lakh/yr
for 3 yrs to carry out the ongoing research activities with
regard to travel, both national & international, hiring of
manpower, purchase of minor equipment, & related
expenditure.
40
National Women
Biotechnologist Award
Senior Category for lifetime contribution in science, Each
awardee receives Rs 5.00 lakh cash prize, citation & a Gold
plated medal
Junior Category for outstanding research in basic and applied
science, candidate should be below 45 yrs of age, Each
awardee receives Rs 1.00 lakh cash prize, citation & a Gold
plated medal & a research grant of Rs 5.00 lakhs for 5yrs.
41
BIOTECH PRODUCT & PROCESS DEVELOPMENT AND
COMMERCIAZIATION AWARDS
outstanding contributions of scientists / innovators / entrepreneurs/ Indian institutions & companies both in public as well as private sector for a new process, product development and commercialization of a technology or a product in the areas of biotechnology and biological sciences including agriculture, biomedical and environmental sciences
Upto five awards shall be given every year. Each award will carry a cash amount of ` 2.00 lakhs along with a citation. ̀ 5.00 lakhs would be given if the product is commercialized and has much higher impact of utilization in the country
Innovative Young Biotechnologist
Award(IYBA)
The scheme is for young budding scientists with great passion for
doing outstanding basic & applied research in biology
Young scientists up to age of 35 yrs are eligible
Candidates with regular position receive cash award of Rs 1.00
lakh & grant Rs 50.00 lakhs for research
Candidate without regular position receive Rs 40,000 pm & Rs
50.00 lakhs for research but will be attached to a senior faculty of
the institute as mentor, awardee is expected to work
independently but will take help of mentor
43
Tata Innovation Fellowship
The scheme is aimed at rewarding interdisciplinary work where
major emphasis is on innovation and translational research
with a potential towards commercialization.
Scientists holding permanent position are eligible up to age of
55 yrs
Each awardee receives Rs 25,000 pm in addition to regular
salary & contingency grant Rs 6.00 lakhs for 3 yrs which can
be extended by 2 yrs depending on the progress
44
Ramalingaswami Re-entry
fellowship
For Indian nationals working in overseas laboratories & are
interested in returning to the home country to pursue their
research interests, those who have returned within less
than a year are also eligible
• Each fellow receives fellowship for 5 yrs @ Rs 85,000pm
HRA @ Rs 7500pm, research grant Rs 10.00 lakhs for ist
yr, 7.5 lakhs for 2nd yr & Rs 5 lakhs for subsequent 3 yrs.
Fellowship could be renewed after 5 yrs on a fresh
appraisal
DBT-wellcome trust alliance
The Department of Biotechnology has partnered with Wellcome Trust (WT) to launch a three-tier fellowship programme on biomedical research at post-doctoral level.
The Department of Biotechnology and the Wellcome Trust each have committed Pounds Sterling 8 million per year, for a period of five years.
The programme is being administered by a Special Purpose Vehicle, which has been registered as The Wellcome Trust/DBT India Alliance, a public charitable trust in India.
The fellowships are open to all Indians working outside of India and within India. The fellowships are also open to non-Indians willing to work in India.
Three categories of fellowships are awarded every year:
40 Early-career fellowships (with one year post-doctoral experience)
20 Intermediate fellowships (with 3-6 years of post-doctoral experience)
10 Senior Fellowships
6 renewals of ongoing senior fellowships every year
Details of the Alliance and new call for applications are available on www.wellcomedbt.org
ONGOING BILATERAL/MULTILATERAL COLLABORATIONS
COUNTRY RESEARCH AREAS OF COLLABORATION
Australia • Agreement for collaboration in all areas of biotechnology, with the Australian
Department Of Education, Science and Training. Total 14 ongoing projects
Canada • Agreement on convergent medical technologies; application to clean technologies and
Bio-pharma & health with the International Science and Technology Partnerships
(ISTP); in plant sciences with National Research Council of Canada (NRC). Total 12
ongoing projects.
Denmark • Medical Biotechnology : Stem cell research; chronic and infectious diseases;
Agriculture biotechnology and Environmental biotechnology with Ministry of Science, Technology and Innovation , Denmark. Call for proposals announced in the area of health science biotechnology.
Finland • Vaccine development and technologies herein; Development of new innovative
diagnostics using different technologies & Computational biology related to drug
development with Academy of Finland (AoF) and Tekes, Finland.
Germany • Call for proposals in microbial biotechnology, bioprocess engineering, structural
biology, infectious diseases and neuroscience with International Bureau (IB) of the Federal Ministry of Education & Research (BMBF).
Netherlands • A Programme of Cooperation (PoC) has been signed between DBT and Directorate
General for Enterprise and Innovation, Ministry of Economic Affairs Agriculture and Innovation, Govt. of Netherlands in the area of Plant Sciences, Food & Nutrition and medical Biotechnology.
• A Letter of Intent (LoI) was signed between DBT and Erasmus Univ. 2 Projects
funded. 47
ONGOING BILATERAL/MULTILATERAL COLLABORATIONS: contd….
COUNTRY RESEARCH AREAS OF COLLABORATION
Norway • Vaccine development for human, fish and animal with National Research Council (NRC). Total 3 ongoing projects
Spain • A Programme of Cooperation (PoC) has been signed between DBT and Centre for Development
of Industrial Technology (CDTI), Spain. Call for proposals announced in the area of
biotechnology including biofuels and bioenergy and three proposals recommended for funding.
Sweden •Biology, diagnosis and treatment of Tuberculosis with VINNOVA. Call for proposals announced in the area of health science biotechnology. Total 12 ongoing projects.
Switzerland •Converting research leads into products and processes of social and economic value with a focus in agriculture biotechnology. Total 13 ongoing projects
United Kingdom •Main area of focus Agriculture research and Food Security with Biotechnology & Biological Sciences Research Council (BBSRC) and Department for International Development (DFID). 5 ongoing projects: 4 proposals in the area of Sustainable Crop Development; one project with Belfast University under Cancer Research Programme: Four Projects funded in the Bioenergy and Biofuels and Twelve projects under Farmed Animal Disease and Health (FADH) .
United States of America
•Vaccine Development Programme; Contraceptive Research and Reproductive Health; Agriculture Biotechnology and Vision Research with NIH. Biodesign programme with Stanford University.
EU • India-EU synchronized joint calls announced. 4 projects funded.
• New Indigo ERA-NET.
NGOs / Trusts • Wellcome Trust
• Bill and Melinda Gates Foundation 48
Concluding Remarks
DBT has various schemes which can help Indian
scientists to do research and make significant
contributions to the science and towards the
development of the nation.
A good project proposal which fulfills the defined
criteria will always be funded
Readiness to meet various models of collaborations, in
basic research or translational research involving
industry.