VITILIGOCARLOS ALBERTO GONZÁLEZ SOLANO

¿WHAT IS VITILIGO?Vitiligo is a common depigmenting skin disorder, characterized by acquired, idiopathic, progressive, circumscribed hypomelanosis of the skin and hair, with total absence of melanocytes microscopically.

The causes of this condition are uncertain but seem to be dependent on the interaction of genetic, immunological and neurological factors.

GENESVitiligo is a multifactorial disorder, related to both genetic and non-genetic factors.

Only a few vitiligo susceptibility genes have been identified with reasonable certainty. Currently, there is strong support only for:

• HLA • PTPN22

• NALP1 • CTLA4

CLINICAL MANIFESTATIONS

• Patches on the skin.

• The hairs in the vitiliginous areas usually become white also.• Initial lesions occur most frequentlyon the hands, forearms, feet and face.

CLASSIFICATIONVitiligo is currently classified into two major subtypes:

• Segmental vitiligo (type B). Is more rare

• Non-segmental vitiligo (type A). Is the most common.

• Quadrichrome vitiligo refers to the additional presence of marginal or perifollicular hyperpigmentation. This variant is recognized more

frequently in darker skin types, particularly in areas of repigmentation.

TREATMENTSun protection of the vitiliginous areas with sunblocks is important.

Corticosteroids

Transfer Factor

Antioxidants