PREPARATIONS OF SUPPOSITORYBY: MASH’HOOD MAHMOOD KHAN SHAHID …………….……. D14E121

INTRODUCTION• Solid unit dosage form intended for insertion into

body orifices where it melts, soften or dissolves and exerts systemic or localized effects.

PREPARATIONFollowings are the methods meant for manufacturing of suppositories; a. HAND ROLLING b. COMPRESSION MOLDING c. FUSION MOLDING d. AUTOMATIC MOLDING MECHINE

HAND MOLDING• It is the oldest and simplest method. • This method is employed for small scale

production. The drug is made into

fine powder

Incorporated into

suppository base

By trituration

or kneading

Mass is rolled into rod shape by fingers

Rods are cut into pieces

Desired shape is given by

hand

COMPRESSION MOLDING• This method follows the same procedure as that of hand

molding except the base containing the drug is compressed into suppositories using a hand operated machine.

ADVANTAGES: • It is a simple method skipping the task of hand rolling. • Suppository formed is more elegant than hand molded one.• It avoids the possibility of sedimentation of the insoluble

solids in the suppository base.DISADVANTAGES: Entrapping of air may occur causinga. Weight variationb. Oxidation of drug or base used.

FUSION MOLDING• This is the approach exercised on both small and

large scale industry due to its efficacy.• The melted mass of the base containing the drug

is poured into suppository molds.

Melt the base

Cool it to consistency of thick cream

Add finely powdered solid drug

Stir until fully dissolved

Proceed in usual way

AUTOMATIC MOLDING MECHINE• This is the modern and automated method for

formulation of suppositories. • The molding function is completely done by

machine. • Typical rotary machine turn out 3500-6000

suppositories per hour.

MOLD• Omitting hand molding, rest of the methods

engage a die for imparting specific shape to the mold.

• These could of different shapes.

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