PLEURAL EFFUSION, PYOTHORAX & PNEUMOTHORAX Dr Sarika Gupta, Asst. Professor.
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Transcript of PLEURAL EFFUSION, PYOTHORAX & PNEUMOTHORAX Dr Sarika Gupta, Asst. Professor.
![Page 1: PLEURAL EFFUSION, PYOTHORAX & PNEUMOTHORAX Dr Sarika Gupta, Asst. Professor.](https://reader034.fdocuments.us/reader034/viewer/2022042500/56649c945503460f949507f1/html5/thumbnails/1.jpg)
PLEURAL EFFUSION, PYOTHORAX & PNEUMOTHORAX
Dr Sarika Gupta, Asst. Professor
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DEFINITION
Pleural effusion: inflammation of the pleura, accompanied by collection of fluid in the pleural space.
Normal Pleural fluid: 0.3 ml/kg BWProtein: 1.5 g/dLpH: alkaline (7.60)Cells: 1700 cells/ml (75% macrophages, 23% lymphocytes & 2% mesothelial cells)
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Pleural space should be virtually fluid free
Pleural fluid is produced by the parietal pleura and absorbed by the visceral pleura as a continuous process
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Fluid accumulates in the pleural space by three mechanisms:
increased drainage of fluid into the space increased production of fluid by cells in the space decreased drainage of fluid from the space
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Development of Pleural Effusion pulmonary capillary pressure (CHF) capillary permeability (Pneumonia) intrapleural pressure (atelectasis) plasma oncotic pressure (hypoalbuminemia) pleural membrane permeability (malignancy) lymphatic obstruction (malignancy) diaphragmatic defect (hepatic hydrothorax) thoracic duct rupture (chylothorax)
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CAUSES
EXUDATIVE (usually unilateral)Parapneumonic effusionTuberculosisConnective tissue disordersMalignancyPancreatitisSubphrenic abscessSevere dengueRadiation pleuritis
TRANSUDATIVE (usually bilateral )Congestive heart failureCirrhosisNephrotic syndromeConstrictive pericarditisPeritoneal dialysis
CHYLOUSCongenital chylothoraxPost-traumatic
HEMOTHORAXBlunt traumaMalignancy
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CLINICAL FEATURES
History: Small pleural effusion: asymptomatic Large pleural effusion: pleuritic chest pain, abdominal pain,
pain during inspiration or coughing The child may prefer to lie on the affected side (to decrease
respiratory excursions) Cough Fever Respiratory distress, dyspnea, orthopnea, or cyanosis
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CLINICAL FEATURES
Examination: Tracheal deviation to the opposite side Bulging chest wall on the affected side with reduced movement Decreased vocal fremitus Dullness to percussion Decreased or absent breath sounds Diminished whispering pectoriloquy & decreased vocal
resonance Egophony-audible at the upper level of pleural effusion due to
prtially collapsed underlying lung
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CLINICAL FEATURES
Examination: Pleural friction rub: Inflamed parietal & visceral pleurae rub against each other leathery, rough in character Heared in both inspiration and expiration Disappears rapidly as the size of effusion increases If a child remains pyrexial or unwell 48 hours after admission
for pneumonia, parapneumonic effusion/empyema must be excluded.
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DIAGNOSIS
Chest radiograph (x-ray)
-able to distinguish >200ml of fluid (blunted costophrenic angles)
-Chest radiographs acquired in the lateral decubitus position are more sensitive and can pick up as little as 50 ml of fluid.
Pleural fluid analysis Chest ultrasound
-locates small amounts or isolated loculated pockets of fluid
-able to give precise position of accumulation Computed Tomography (CT) scan
-Differentiates between fluid collection, lung abscess, or tumor
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PLEUAL EFFUSION
Created by an abnormal collection of fluid in the pleural space
Seen in chest X-ray with presence of about 200ml pleural fluid
Fluid in X-ray seen as a dense, white shadow with a concave upper edge (fluid level)
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CT scan of chest showing loculated pleural effusion in left side. Some thickening of pleura is also noted.
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Pleural fluid analysis
1. Routine tests Gross examination Pleural fluid/serum protein ratio Pleural fluid/serum LDH ratio Cytology and culture
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Pleural fluid analysis
2. Tests in selected cases Pleural fluid cholesterol Pleural fluid/serum cholesterol ratio Lactate Enzymes Interferon ᵞ CRP Tumor markers
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Gross examination
Transudates: typically clear, pale yellow to straw-colored, odorless & do not clot.
Exudates: show variable degrees of cloudiness or turbidity & they often clot if not heparinized
A feculent odor may be detected in anaerobic infections
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Gross examination
A bloody pleural effusion (hematocrit >1%) suggests trauma, malignancy, or pulmonary infarction.
A pleural fluid hematocrit greater than 50% of the blood hematocrit is good evidence for a hemothorax
Turbid, milky, and/or bloody specimens should be centrifuged and the supernatant examined. If the supernatant is clear, the turbidity is most likely due to cellular elements or debris. If the turbidity persists after centrifugation, a chylous effusion is likely
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Chemical analysis
Light’s Criteria (Sensitivity 99%, Specificity 98%)
) Criteria Transudate Exudate
Pleural fluid protein:serum protein ratio
≤0.5 > 0.5
Pleural fluid LDH:serum LDH
≤0.6 > 0.6
Pleural fluid LDH ≤200 >200
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Microbiological examination: The sensitivity of the Gram stain is approximately 50% For patients with suspected M. tuberculosis, direct staining of
tuberculous effusions for acid-fast bacteria has a sensitivity of 20%–30% and positive cultures are found in 50%–70% of cases
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Chemical analysis
Glucose: The glucose level of normal pleural fluid, transudates, and
most exudates is similar to serum levels
Decreased pleural fluid glucose, accepted as a level below 60 mg/dL (3.33 mmol/L) or a pleural fluid/serum glucose ratio less than 0.5, is most consistent and dramatic in rheumatoid pleuritis and grossly purulent parapneumonic exudates
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Lactate: Pleural fluid lactate levels: useful adjunct in the rapid
diagnosis of infectious pleuritis Levels are significantly higher in bacterial and tuberculous
pleural infections than in other pleural effusions Values greater than 90 mg/dL (10 mmol/L) have a positive
predictive value for infectious pleuritis of 94% and a negative predictive value of 100%
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Amylase: Elevations above the serum level (usually 1.5–2.0 or more
times greater) indicate the presence of pancreatitis, esophageal rupture, or malignant effusion
Elevated amylase derived from esophageal rupture or malignancy is the salivary isoform, which differentiates it from pancreatic amylase
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Lactate dehydrogenase: Pleural fluid LD levels rise in proportion to the degree of
inflammation In addition to their use in separating exudates from
transudates, declining LD levels during the course of an effusion indicate that the inflammatory process is resolving
Conversely, increasing levels indicate a worsening condition requiring aggressive workup or treatment
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Adenosine deminase: >40 unit/l Tuberculosis
Interferon-γ: Pleural fluid interferon (IFN)-γ levels are significantly
increased in the pleural fluid of patients with tuberculous pleuritis
The sensitivity of levels of 3.7 IU/L or greater is 99%, and the specificity is 98%
Consider when ADA is unavailable or nondiagnostic
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pH: Pleural fluid pH measurement has the highest diagnostic
accuracy in assessing the prognosis of parapneumonic (pneumonia-related) effusions
A parapneumonic exudate with a pH greater than 7.30 generally resolves with medical therapy alone
A pH less than 7.20 indicates a complicated parapneumonic effusion (loculated or associated with empyema), requiring surgical drainage.
A pH below 6.0 is characteristic of esophageal rupture, although the pH in severe empyema may be 6.0 or less
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Lipids: Helpful in identifying chylous effusions Pleural fluid triglyceride levels > 110 mg/dL indicate a
chylous effusion values from 60–110 mg/dL require lipoprotein
electrophoresis to confirm a chylothorax Nonchylous effusions : triglyceride levels <50 mg/dL & no
chylomicrons on electrophoresis
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Immunologic studies: Approximately 5% of patients with RA and 50% with SLE
develop pleural effusions RF is commonly present in pleural effusions associated with
seropositive RA ANA titers may be useful in the diagnosis of effusion due to
lupus pleuritis
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TREATMENT
1. Therapy should be aimed at the underlying disease
Transudative effusion by fluid overload as in cardiac or renal failure: diuretics & fluid management
Nephrotic syndrome and cirrhosis of liver: Albumin infusion
Tubercular pleural effusion: Anti-tubercular drugs
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TREATMENT
Chylous pleural effusion: Thoracocentesis or placement of ICD tube followed by
feeding with MCT Continuous development: discontinuation of oral feeds and
TPN Somatostatin & Octreotide Traumatic hemothorax: drainage of blood with proper
replacement Recurrent pleural effusion due to malignancies: prolonged
placement of catheter or pleurodesis
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TREATMENT
Parapneumonic effusion Analgesia Supplemental oxygen Systemic antibiotics based on the in vitro sensitivities of the responsible organism
(Staphylococcus, S. pneumoniae, and H. influenzae) Duration: 2 wk. With staphylococcal infections: systemic
antibiotic therapy for 3-4 wk; anaerobic empyema-6-12 weeks
Instillation of antibiotics into the pleural cavity does not improve results
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TREATMENT
Thoracentesis Diagnostic thoracentesis
A needle is inserted into
the chest wall to remove the
collection of fluid 50-100ml of fluid is sent
for analysis; Determines the type of fluid (transudate or exudate)
temporarily relieve symptoms Potential complications: bleeding, infection & pneumothorax
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TREATMENT
BUT if sufficient fluid reaccumulates to cause respiratory embarrassment, chest tube drainage should be performed
Rapid removal of ≥1 L of pleural fluid may be associated with the development of reexpansion pulmonary edema
Chest tube drainage
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TREATMENT
Thrombolytic therapy Promote drainage, decrease fever, lessen need for surgical
intervention & shorten hospitalization Streptokinase 15,000 U/kg in 50 mL of 0.9% saline daily for
3-5 days and urokinase 40,000 U in 40 mL saline every 12 hr for 6 doses
Anaphylaxis with streptokinase & both drugs can be associated with hemorrhage
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TREATMENT
Video-assisted thoracoscopic surgery (VATS) or Open decortication
The child who remains febrile & dyspneic >72 hr after initiation of therapy with intravenous antibiotics and thoracostomy tube drainage, surgical decortication via VATS or, less often, open thoracotomy may speed recovery
If pleural fluid septa are detected on ultrasound, immediate VATS can be associated with a shortened hospital course
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EMPYEMA
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DEFINITION
Empyema or Purulent Pleurisy: Empyema is an accumulation of pus in the pleural space
Most often associated with pneumonia due to Staphylococcus aureus & Streptococcus pneumoniaea
The relative incidence of Haemophilus influenzae empyema has decreased (Hib vaccination)
Also produced by rupture of a lung abscess into the pleural space, by contamination introduced from trauma or thoracic surgery or by mediastinitis or the extension of intra-abdominal abscesses
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EPIDEMIOLOGY
Most frequently encountered in infants & preschool children Predisposing factors: preceding history of pustules, blunt
trauma to the chest, viral infection, severe malnutrition, contiguous extension
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PATHOLOGY
Empyema has 3 stages: exudative, fibrinopurulent, and organizational
Exudative stage: 1-3 days Fibrinopurulent stage: 4-14 days Organizational stage: After 14 days
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PATHOLOGY
Exudative stage: fibrinous exudate forms on the pleural surfaces
Fibrinopurulent stage: fibrinous septa form, causing loculation of the fluid & thickening of the parietal pleura
If the pus is not drained, it may dissect through the pleura into lung parenchyma, producing bronchopleural fistulas and pyopneumothorax, or into the abdominal cavity or through the chest wall (empyema necessitatis)
Organizational stage: fibroblast proliferation; pockets of loculated pus develop into thick-walled abscess cavities or the lung may collapse & become surrounded by a thick, inelastic envelope (peel)
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CLINICAL MANIFESTATIONS
The initial signs & symptoms are primarily those of bacterial pneumonia
Children treated with antibiotic agents may have an interval of a few days between the clinical pneumonia phase & the evidence of empyema
Most patients are febrile (fever may be absent in immunocompromised patients), develop increased work of breathing or respiratory distress & often appear more ill
Physical findings are identical to those for uncomplicated parapneumonic effusion & the 2 conditions are differentiated only by thoracentesis
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DIAGNOSIS
The effusion is empyema if bacteria are present on Gram staining, the pH is <7.20, glucose<40 mg/dl and LDH>1000 IU/L and there are >100,000 neutrophils/µL
Cultures of the fluid must always be performed Blood cultures also have a high yield
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COMPLICATIONS
1. Bronchopleural fistulas Usually respond to adequate drainage, nutritional support &
sealing of the open communication over the lung surface Prolonged bronchopleural fistulas (>2-3 weeks) requires
decortication, lobectomy or thoracoplasty
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COMPLICATIONS
2. Pyopneumothorax
3. Purulent pericarditis & pulmonary abscesses
4. Peritonitis from extension through the diaphragm & osteomyelitis of the ribs
5. Septic complications: meningitis, arthritis
6. Septicemia is often encountered in H. influenzae and pneumococcal infections
7. Peel: may restrict lung expansion and may be associated with persistent fever and temporary scoliosis
8. Empyema necessitans
9. Gastropleural fistula
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TREATMENT
Systemic antibiotics Staphylococcus aureus: cloxacillin & aminoglycoside or 3 gen
cephlosporin & aminoglycoside Gram-ve organism: cefotaxim & aminoglycoside Gram stain inconclusive: cefotaxim & cloxacillin Resistant Staphylococcus: vancomycin, teicoplanin & linezolid Thoracentesis
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TREATMENT
Chest tube drainage with or without a fibrinolytic agent
Indications for surgical treatment:
a) Pleural thickening
b) Loculated empyema
c) Non-expansion of lungs with intercostal drainage
d) Bronchopeural fistula
1. Video-assisted thorascopic surgery: effective in lysis of adhesions in multiloculted effusions & removal of fibrinous material from pleural cavity
2. Open decortication: significant pleural thickening
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TREATMENT
The long-term clinical prognosis for adequately treated empyema is excellent & follow-up pulmonary function studies suggest that residual restrictive disease is uncommon, with or without surgical intervention
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PNEUMOTHORAX
PNEUMOTHORAX
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DEFINITION
Accumulation of extra pulmonary air within the chest, most commonly from leakage of air from within the lung
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ETIOLOGY
Closed pneumothorax-Pulmonary diseaseForeign bodyRDSRespiratory infectionsBronchial asthmaCystic fibrosisChemical pneumonitisDiffuse lung diseaseTumors-IatrogenicMechanical ventilationCentral venous catheterization
Open pneumothoraxInvasive pleural & pulmonary proceduresChest trauma
Spontaneous pneumothoraxIdiopathic (ruptured subpleural blebs)Familial
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PATHOGENESIS
The tendency of the lung to collapse is balanced in the normal resting state by the inherent tendency of the chest wall to expand outward, creating negative pressure in the intrapleural space
When air enters the pleural space, the lung collapses In simple pneumothorax, intrapleural pressure is atmospheric,
and the lung collapses up to 30%. In complicated, or tension pneumothorax, continuing leak
causes increasing positive pressure in the pleural space, with further compression of the lung, contralateral shift of mediastinal structures & decreases in venous return and cardiac output
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CLINICAL MANIFESTATIONS
Sudden onset Dyspnea, pain, & cyanosis Trachea & heart may be shifted toward the unaffected side Hyperinflation & reduced movements on affected side Respiratory distress with retractions Decreased vocal fremitus & vocal resonance Markedly decreased breath sounds and a tympanitic
percussion note over the involved hemithorax When fluid is present, there is usually a sharply limited area
of tympany above a level of flatness to percussion
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CLINICAL MANIFESTATIONS
Succussion splash: to rule out hydropneumothorax Coin test Friction test
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DIAGNOSIS
By radiographic examination When the possibility of diaphragmatic hernia is being
considered, a small amount of barium may be necessary to demonstrate that it is not free air but is a portion of the gastrointestinal tract that is in the thoracic cavity
Ultrasound can also be used to establish the diagnosis
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TREATMENT
Extent of the collapse & nature and severity of the underlying disease
A small (<5%) or even moderate-sized pneumothorax in an otherwise normal child may resolve without specific treatment, usually within about 1 wk
Needle aspiration: tension pneumothorax & primary spontaneous pneumothorax
If the pneumothorax is recurrent, secondary or under tension or there is >5% collapse: chest tube drainage
Pneumothorax complicating malignancy: chemical pleurodesis or surgical thoracotomy
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TREATMENT
Closed thoracotomy: adequate to reexpand the lung in most patients
Chemical pleurodesis: recurrent pneumothoraces; introduction of talc, doxycycline, or iodopovidone into the pleural space
Open thoracotomy: plication of blebs, closure of fistula, stripping of the pleura and basilar pleural abrasion; Stripping and abrading the pleura leaves raw, inflamed surfaces that heal with sealing adhesions
VATS: preferred therapy for blebectomy, pleural stripping, pleural brushing and instillation of sclerosing agents; less morbidity than with open thoracotomy