Physiology of local anasthesia
-
Upload
mohamed-rahil -
Category
Health & Medicine
-
view
351 -
download
12
Transcript of Physiology of local anasthesia
![Page 1: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/1.jpg)
Physiology of local Physiology of local anasthesiaanasthesia
Dr.Mohamed Rhael AliDr.Mohamed Rhael Ali2016-20172016-2017
![Page 2: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/2.jpg)
Nerve physiology
![Page 3: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/3.jpg)
Nerve anatomyNerve anatomy• Periphral nerve composed from hundreds to thousands of axonsPeriphral nerve composed from hundreds to thousands of axons• Each axon coverd by sheath called endoneurium Each axon coverd by sheath called endoneurium • Each group of axons bind togather in a special sheath called perineurium Each group of axons bind togather in a special sheath called perineurium
, these group of axons (bundle) called fasciculi which consider the main , these group of axons (bundle) called fasciculi which consider the main barrior to diffusion of local anasthesia in to the nerve .barrior to diffusion of local anasthesia in to the nerve .
• The whole bundles covered by loose connective tissue called epineurium The whole bundles covered by loose connective tissue called epineurium • Local anasthesia able to diffuse through this tissues because of its loose Local anasthesia able to diffuse through this tissues because of its loose
consistency .consistency .• nutrient blood vessels and lymphatics transverse the epineurium and nutrient blood vessels and lymphatics transverse the epineurium and
these vessels absorb local ansthesia and thus removing them from the these vessels absorb local ansthesia and thus removing them from the nervenerve
![Page 4: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/4.jpg)
![Page 5: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/5.jpg)
![Page 6: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/6.jpg)
![Page 7: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/7.jpg)
Nerve membrane Nerve membrane Two layers of lipid molecules with associated protein Two layers of lipid molecules with associated protein
and carbohydrates molecules and carbohydrates molecules
![Page 8: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/8.jpg)
![Page 9: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/9.jpg)
Properties of nerve membrane Properties of nerve membrane
• impermeable to water soluble moleculesimpermeable to water soluble molecules• selectively permeable to certain molecules via selectively permeable to certain molecules via
specialized channels specialized channels • Transduce information by protein receptors in Transduce information by protein receptors in
response to chemical or physical stimuliresponse to chemical or physical stimuli
![Page 10: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/10.jpg)
Nerve membarne selectively permeable so Nerve membarne selectively permeable so There is a diffrence between ions concentration There is a diffrence between ions concentration
around it around it
High concentration of k+ inside while high High concentration of k+ inside while high concentration of Na+ outside the nerve membraneconcentration of Na+ outside the nerve membrane
![Page 11: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/11.jpg)
![Page 12: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/12.jpg)
Resting stateResting state• In resting state nerve membrane have –ve resting In resting state nerve membrane have –ve resting
potential (-70 mv) potential (-70 mv) • Coming from different concentration of ions Coming from different concentration of ions
around the membrane around the membrane
![Page 13: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/13.jpg)
DepolarizationDepolarization
• Rabid influx of Na+ ions to the inside of nerveRabid influx of Na+ ions to the inside of nerve
• Must reach firing threshould which are Must reach firing threshould which are approximately ( -50 to -60 mv)approximately ( -50 to -60 mv)
![Page 14: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/14.jpg)
RepolarizationRepolarization
• Movement of K+ to outside which lead to return of Movement of K+ to outside which lead to return of nerve membrane to its resting potential ( - 70 mv )nerve membrane to its resting potential ( - 70 mv )
• Movement of ions in depolarization are passive Movement of ions in depolarization are passive process ( not required energy ) process ( not required energy )
• While movement of ions in depolarization are While movement of ions in depolarization are active processactive process
![Page 15: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/15.jpg)
ImpulseImpulse
• Function of nerve is to carry messages from Function of nerve is to carry messages from one part of the body anotherone part of the body another
• These messages called impulse These messages called impulse
• impulse initiated by chemical , thermal, impulse initiated by chemical , thermal, mechanical or electrical stimulimechanical or electrical stimuli
![Page 16: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/16.jpg)
![Page 17: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/17.jpg)
![Page 18: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/18.jpg)
Mechanism of action of local Mechanism of action of local anasthesiaanasthesia
• Local anastheesia act by prevention of both Local anastheesia act by prevention of both generation and conduction of nerve impulsegeneration and conduction of nerve impulse
• Nerve membrane consider the site at which Nerve membrane consider the site at which local anasthetic agents exert their local anasthetic agents exert their pharmacological actions pharmacological actions
![Page 19: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/19.jpg)
Theories for Theories for working of local working of local
anasthesia anasthesia
![Page 20: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/20.jpg)
Membrane expansion theoryMembrane expansion theory
• This theory explain that local anasthetic molecules This theory explain that local anasthetic molecules diffuse through the nerve membrane and causing diffuse through the nerve membrane and causing general disturbance in the bulk of of membrane general disturbance in the bulk of of membrane structure which lead to blockage of the membrane structure which lead to blockage of the membrane permeability to Na+ and so inhibit both conduction permeability to Na+ and so inhibit both conduction and nerve excitationand nerve excitation
![Page 21: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/21.jpg)
![Page 22: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/22.jpg)
Specific receptor theorySpecific receptor theory
• This theory propose that local anasthetics This theory propose that local anasthetics bind to specific receptors in sodium channel bind to specific receptors in sodium channel leading to direct decrease in permeability to leading to direct decrease in permeability to Na ions Na ions
• This theory is the most acceptable theoryThis theory is the most acceptable theory
![Page 23: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/23.jpg)
![Page 24: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/24.jpg)
Induction of local anasthesiaInduction of local anasthesia
In the tissue LA move according to its In the tissue LA move according to its concentrationconcentration
Diffusion Diffusion
•LA reach faster to mantle bundle(prephral LA reach faster to mantle bundle(prephral bundle ) than core bundle (central bundle)bundle ) than core bundle (central bundle)
![Page 25: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/25.jpg)
• Core bundle need need more volume and Core bundle need need more volume and longer time to get anasthesia due to barriers longer time to get anasthesia due to barriers and also absorbtion of LA by blood and also absorbtion of LA by blood cappilaries within the nerve fibercappilaries within the nerve fiber
![Page 26: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/26.jpg)
Factors affecting local Factors affecting local anasthetic actionsanasthetic actions
![Page 27: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/27.jpg)
PH valuePH valueAction of local anasthesia decrease in acidic Action of local anasthesia decrease in acidic
media as in inflamed areamedia as in inflamed area
![Page 28: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/28.jpg)
Lipid solubilityLipid solubility
Lipid soluble LA penetrate the nerve membrane Lipid soluble LA penetrate the nerve membrane more easymore easy
increase the increase the potencypotency of it of it
![Page 29: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/29.jpg)
Protein bindingProtein binding
It affect on the It affect on the durationduration of local anasthesia of local anasthesia Increase protein binding capacityIncrease protein binding capacity
Increase its durationIncrease its duration
![Page 30: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/30.jpg)
Nonnervous tissue diffusubilityNonnervous tissue diffusubility
• Affect on the Affect on the onsetonset of action (starting point) of action (starting point)
Increase infusibility of LA to the nerve Increase infusibility of LA to the nerve membrane membrane
Decrease time of onset Decrease time of onset
![Page 31: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/31.jpg)
Vasodilator activityVasodilator activity
Increase vasodilator activityIncrease vasodilator activity
Decrease Decrease potencypotency and and durationduration
![Page 32: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/32.jpg)
Factors affecting duration of anasthesiaFactors affecting duration of anasthesia
• Protein binding capacityProtein binding capacity
• Vascularity of the injected site Vascularity of the injected site
• Presence or absence of vasoactive substancePresence or absence of vasoactive substance
![Page 33: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/33.jpg)
Classification of local anasthesiaClassification of local anasthesia
• According to chemical linkage LA classify in to :According to chemical linkage LA classify in to :
• Ester groupEster group• Amide groupAmide group
• All LA molecules have both hydrophilic and All LA molecules have both hydrophilic and lipophilic characteristics at the opposing end of lipophilic characteristics at the opposing end of molecules but the lipophilic part represent the molecules but the lipophilic part represent the largest part of moleculelargest part of molecule
![Page 34: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/34.jpg)
Notes :• LA without hydrophilic part are not suitable for LA without hydrophilic part are not suitable for
injection .injection .
• Ester linked LA are readly hydrolized in aqueous Ester linked LA are readly hydrolized in aqueous solution while amide liked types are relatively solution while amide liked types are relatively resistant to hydrolysisresistant to hydrolysis
• great percentage of amide groups excreted great percentage of amide groups excreted unchanged in the urine than ester groupunchanged in the urine than ester group
• All LA readily cross the blood brain barrier and All LA readily cross the blood brain barrier and placentaplacenta
![Page 35: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/35.jpg)
Ester type local anastheticsEster type local anasthetics
1.Procaine 2.chloroprocaine 3. propxycaine1.Procaine 2.chloroprocaine 3. propxycaine 4. butacaine 5. cocaine 6. benzocaine4. butacaine 5. cocaine 6. benzocaine 7.hexylcaine 8.piperocaine7.hexylcaine 8.piperocaine
Amide type local anasthetcs:Amide type local anasthetcs:1.Lidocaine 2. prilocaine 3. articaine 4.bupivacaine1.Lidocaine 2. prilocaine 3. articaine 4.bupivacaine5.Dibucaine 6. etidocaine 7. mepivacain5.Dibucaine 6. etidocaine 7. mepivacain
![Page 36: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/36.jpg)
• To know which is this anasthetic are ester or To know which is this anasthetic are ester or amide groupamide group
All ester group have one All ester group have one ( i ) ( i ) except except piperocaine piperocaine like procaine ,butacaine ,propoxycaine , ……like procaine ,butacaine ,propoxycaine , ……
While amide group have double While amide group have double ( ii ) ( ii ) like lidocaine , like lidocaine , bupivacaine ,articaine , …… bupivacaine ,articaine , ……
![Page 37: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/37.jpg)
Pharmacokinetic of local Pharmacokinetic of local anasthesia anasthesia
![Page 38: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/38.jpg)
DistributionDistribution• After injection LA absorbed by blood vessels and After injection LA absorbed by blood vessels and
distribute to all body tissuedistribute to all body tissueFactors that influence the blood level of LA are :Factors that influence the blood level of LA are :1.Rate at which the drug is absorbed into the 1.Rate at which the drug is absorbed into the
cardiovascular sysytem.cardiovascular sysytem.2. Rate of distribution of the drug from the vascular 2. Rate of distribution of the drug from the vascular
compartment to the tissuescompartment to the tissues3. Elimination of the drug through the metabolic or 3. Elimination of the drug through the metabolic or
excretory pathwaysexcretory pathways
![Page 39: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/39.jpg)
MetabolismMetabolism
• Ester groups hydrolized in the plasma by the Ester groups hydrolized in the plasma by the enzyme pseudocholinesterase enzyme pseudocholinesterase
• Procaine hydrolysed to para-aminobenzoic Procaine hydrolysed to para-aminobenzoic acid ,this byproduct excreted unchanged in acid ,this byproduct excreted unchanged in the urine and most of allergic reactions the urine and most of allergic reactions occure due to this byproduct ( para-occure due to this byproduct ( para-aminobenzoic acid) and not to the original aminobenzoic acid) and not to the original local anasthetic (procaine)local anasthetic (procaine)
![Page 40: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/40.jpg)
Some people have atypical form of Some people have atypical form of pseudocholinesterase so they have inability to pseudocholinesterase so they have inability to
hydrolyse ester local anasthetics and so hydrolyse ester local anasthetics and so develop toxicity due to higher blood level of develop toxicity due to higher blood level of
these agent these agent
![Page 41: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/41.jpg)
Amide LAAmide LA
• Metabolism more compex than ester groupMetabolism more compex than ester group• occur in liveroccur in liver• Byproduct of some these agents may show Byproduct of some these agents may show
clinical activity clinical activity • e.g lidocaine not cause sedation but some pf e.g lidocaine not cause sedation but some pf
its byproduct component may cause sedation its byproduct component may cause sedation
![Page 42: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/42.jpg)
ExcretionExcretion• The Kidney is the primary site for the The Kidney is the primary site for the
excretion of both local anasthetic and its excretion of both local anasthetic and its byproductbyproduct
• Patients with renal failure have proplem in Patients with renal failure have proplem in excretion of local anasthetic and its excretion of local anasthetic and its byproductbyproduct
• So it represent a relative contraindication to So it represent a relative contraindication to the administration of local anastheticthe administration of local anasthetic
![Page 43: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/43.jpg)
constituents of local anasthesia constituents of local anasthesia 1. local anasthetic agent1. local anasthetic agent2. vasoconstrictor agent2. vasoconstrictor agent
3. reducing agent 3. reducing agent reducing agent as reducing agent as sodium bisulphate sodium bisulphate used to stabilize used to stabilize
vasoconstrictor agent vasoconstrictor agent 4. Preservative : 4. Preservative : used to maintain the sterility of LA ,but it may used to maintain the sterility of LA ,but it may
be the responsible for allergic reactions in some patiantbe the responsible for allergic reactions in some patiant5. Fungicide 5. Fungicide ; to prevent fungi growth which may lead to ; to prevent fungi growth which may lead to
cloudness of solutioncloudness of solution6.Vehicle : 6.Vehicle : all prevouse components dissolved in modified all prevouse components dissolved in modified
ringers solution which decrease the discomfort during injectionringers solution which decrease the discomfort during injection
![Page 44: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/44.jpg)
Role of vasoconstrictors in local Role of vasoconstrictors in local anasthesia anasthesia
• decrease rate of absorption decrease rate of absorption • Decrease plasm level of LA and so decrease Decrease plasm level of LA and so decrease
its toxicity its toxicity • Increase duration of local anasthesia Increase duration of local anasthesia • Decrease bleeding at the site of injectionDecrease bleeding at the site of injection
![Page 45: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/45.jpg)
Dilution of the vasoconstructorsDilution of the vasoconstructors• Dilution refered to ratio ( e.g 1 / 1000) (gram Dilution refered to ratio ( e.g 1 / 1000) (gram
/ml) which mean 1gram of vasoconstrictor in /ml) which mean 1gram of vasoconstrictor in 1000 ml of solution1000 ml of solution
• Availability in dentistry Availability in dentistry • 1:50000• 1:80000• 1:100000• 1:200000
![Page 46: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/46.jpg)
Specific types of vasoconstrictorSpecific types of vasoconstrictor
![Page 47: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/47.jpg)
1. adrenaline1. adrenaline• source : source : either synthetic or obtained from either synthetic or obtained from
adrenal medulla of animalsadrenal medulla of animals• Mode of action ; Mode of action ; act directly on both A and B act directly on both A and B
adrenergic receptorsadrenergic receptors• Heart ; Heart ; increase HR , O2 consumption, Blood increase HR , O2 consumption, Blood
pressurepressure• Blood vessels Blood vessels .. Vasoconstriction.. Vasoconstriction• Respiratory system Respiratory system … bronchodilator… bronchodilator• CNSCNS … not potent CNS stimulant at therapeutic … not potent CNS stimulant at therapeutic
dosesdoses
![Page 48: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/48.jpg)
Maximum dosesMaximum doses
•For pain control For pain control •Normal patients … Normal patients … 0.2 mg 0.2 mg per appointment per appointment
5 cartridges if percentage of dilution 1:500005 cartridges if percentage of dilution 1:50000 11 cartridge if percentage of dilution 1:10000011 cartridge if percentage of dilution 1:100000 22 cartridges if percentage of dilution 1:20000022 cartridges if percentage of dilution 1:200000
![Page 49: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/49.jpg)
. In patients with cardiovascular disease. In patients with cardiovascular disease
• Safe dose … Safe dose … 0.04 mg 0.04 mg per appointmentper appointment
• 1 cartidges if percentage of dilution 1:500001 cartidges if percentage of dilution 1:50000• 2 cartridges if percentage of dilution 1:1000002 cartridges if percentage of dilution 1:100000• 4 cartidges if percentage of dilution 1:2000004 cartidges if percentage of dilution 1:200000
![Page 50: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/50.jpg)
• For hemostatis : For hemostatis : 1:50000 more effective but 1:50000 more effective but 1:100000 solution better to use to avoid 1:100000 solution better to use to avoid vascularity compromisation vascularity compromisation
![Page 51: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/51.jpg)
noreadrenalinenoreadrenaline
• Its similar to adrenaline but it show more Its similar to adrenaline but it show more vascular periphral resistance , heart rate vascular periphral resistance , heart rate decrease ,and no effect on bronchial smooth decrease ,and no effect on bronchial smooth musclesmuscles
• Availabilty in dentistry Availabilty in dentistry • 1: 30000 dilution1: 30000 dilution
![Page 52: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/52.jpg)
Maximum doses Maximum doses •Noradrenaline Noradrenaline four times four times more potent than more potent than adrenaline so its used for pain control only and adrenaline so its used for pain control only and not as a heamostatenot as a heamostate• for normal patient for normal patient 0.034 mg 0.034 mg per appointmentper appointment•For patient with cardiovascular diseases : For patient with cardiovascular diseases : 0.14 0.14 mg mg per appointment per appointment
![Page 53: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/53.jpg)
LevonordefrinLevonordefrin• Synthetic vasoconstrictor Synthetic vasoconstrictor • Show less cardiac and CNS stimulation than Show less cardiac and CNS stimulation than
epinephrine epinephrine
• Availability in dentistry Availability in dentistry used with mepivacaine or with propoxycaine used with mepivacaine or with propoxycaine
procaine in 1:20000 dilutionprocaine in 1:20000 dilution
Maximum doses : for all patients maximum dose Maximum doses : for all patients maximum dose 1mg per appointment 1mg per appointment
![Page 54: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/54.jpg)
FelypressinFelypressin
• Synthetic analogue of vasopressin Synthetic analogue of vasopressin (antidiuretic hormone)(antidiuretic hormone)
• Mode of action: direct stimulant of vascular Mode of action: direct stimulant of vascular smooth muscles smooth muscles
• Act mainly on venous vesselsAct mainly on venous vessels• No effect on heart or CNS No effect on heart or CNS • It has both antidiuretic and oxytocic actions It has both antidiuretic and oxytocic actions
so its contraindicated in pregnant womens. so its contraindicated in pregnant womens.
![Page 55: Physiology of local anasthesia](https://reader035.fdocuments.us/reader035/viewer/2022062412/5875a0001a28ab6d198b654d/html5/thumbnails/55.jpg)
Thank You for Thank You for listeninglistening