Pfizer: Our Purpose, Our Culture, and YOU! · Pfizer takes teams with a diversity of skills,...
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Pfizer: Our Purpose, Our Culture, and YOU! On behalf of Pfizer WWRD Groton, CT La Jolla, CA Cambridge, MA A 160 acre site with 2.8 million square feet of state of the art facility space in Groton. A 280,000 square foot, state of the art R&D hub located in the heart of Kendall Square. Key Groups : Design Chemistry; Biology; Pharmacokinetics, Dynamics & Drug Metabolism; Pharmaceutical and Biotherapeutic/Biologics Research, Biotechnology Units; Development and Medical Support Functions A 25 acre campus with more than 500,000 square feet of state of the art facilities with specialized laboratories and equipment. Key Groups: Design Chemistry; Synthetic chemistry; Biology; Pharmacokinetics, Dynamics & Drug Metabolism, Drug Safety; Pharmaceutical Sciences; Comparative Medicine; Immunology and Clinical Development Our Purpose: Breakthroughs that change patients’ lives. Our Culture: Our Chemistry Research Hubs Chemistry Roles at Pfizer: Molecular Design Chemistry uses organic chemistry knowledge—structure, reactivity, molecular properties and interactions—together with multi-dimensional data analysis to lead our drug discovery teams through an iterative process of structural optimization resulting in the discovery of clinical drug candidates. Synthetic Chemistry routinely solves difficult problems: From providing quick, flexible syntheses of milligram quantities of compounds for rapid exploration of SAR, to enabling challenging reactions, synthesizing hundreds of grams of material for safety studies, or generating initial routes for Process Chemistry Research to scale compounds to kilogram scale, synthesis is pivotal to the drug discovery process. Computational Chemistry uses theoretical physics, and chemistry−based computer models and simulations to impact the drug discovery process. Applications include the prediction of structures, properties, molecular interactions and chemical reaction mechanisms in combination with large−scale data analytics to discover new medicines. Chemical Biology applies chemical and genetic techniques, often coupled with multi-omics approaches, to the study and manipulation of molecular events in biological systems. Chemical Biology provides an enhanced understanding of biology, drug mechanisms, target engagement and selectivity. Chemical biologists routinely engage with colleagues with a variety of backgrounds in a highly matrixed, dynamic, and multidisciplinary environment. Analytical Chemistry develops analytical methods for the characterization of chemical entities, including active pharmaceutical ingredients, and drug product formulations using a range of instruments and techniques. The analytical chemist also provides data for structural elucidation, chemical purity, drug product potency and performance, as well as methods for purification of compounds. Process Chemistry Research identifies viable routes to allow the synthesis of lead compounds to the multi- kilogram scale typically needed for regulatory safety testing and clinical trials in humans. For compounds that go on to commercial production, they are responsible for devising the manufacturing route utilized. A key goal for process chemistry is to develop synthetic routes that are safe, cost- effective, environmentally friendly, and efficient. Drug Product Design designs, characterizes and develops the solid form of active pharmaceutical ingredient (API) and drug product formulations from discovery to commercial launch. At Pfizer we deliver Breakthroughs That Change Patients’ Lives. Pfizer’s Medicine Design group plays a vital role in this mission through the discovery of small molecule and synthetically-derived drugs. Discovering new medicines at Pfizer takes teams with a diversity of skills, behaviors and approaches. Creativity, scientific excellence, tenacity, passion, hard work, organization, teamwork, courage, open- mindedness, curiosity—these are just some of the traits successful Drug Discovers display at Pfizer. Examples of Pfizer Small Molecule Drugs Our Pipeline Pipeline Snapshot as of April 30, 2019 Our priority is researching and developing products and treatments that will benefit patients around the world. Our efforts in internal medicine, inflammation and immunology, biosimilars, rare disease, oncology, and vaccines, illustrate that we are committed to developing medical solutions that will matter most to the people we serve. Oncology Vaccines Rare Disease Key Groups: Synthetic Chemistry; Biology; Pharmacokinetics, Dynamics & Drug Metabolism; Drug Safety; Pharmaceutical Sciences; Clinical Trial Operations;Comparative Medicine; Regulatory Medicine Design Discovery Projects Phase 1 34 Phase 2 30 Phase 3 23 Registration 10 Total 97 Internal Medicine Inflammation & Immunology
Transcript of Pfizer: Our Purpose, Our Culture, and YOU! · Pfizer takes teams with a diversity of skills,...
Pfizer: Our Purpose, Our Culture, and YOU!On behalf of Pfizer WWRD
Groton, CT
La Jolla, CA
Cambridge, MA
A 160 acre site with 2.8 million square feet of state of the art facility space in Groton.
A 280,000 square foot, state of the art R&D hub located in the heart of Kendall Square.
Key Groups: Design Chemistry; Biology; Pharmacokinetics, Dynamics & Drug Metabolism; Pharmaceutical and Biotherapeutic/Biologics Research, Biotechnology Units; Development and Medical Support Functions
A 25 acre campus with more than 500,000 square feet of state of the art facilities with specialized laboratories and equipment.
Key Groups: Design Chemistry; Synthetic chemistry; Biology; Pharmacokinetics, Dynamics & Drug Metabolism, Drug Safety; Pharmaceutical Sciences; Comparative Medicine; Immunology and Clinical Development
Our Purpose: Breakthroughs that change patients’ lives.
Our Culture:
Our Chemistry Research Hubs Chemistry Roles at Pfizer:
Molecular Design Chemistry uses organic chemistryknowledge—structure, reactivity, molecular properties andinteractions—together with multi-dimensional data analysisto lead our drug discovery teams through an iterativeprocess of structural optimization resulting in the discoveryof clinical drug candidates.
Synthetic Chemistry routinely solves difficult problems:From providing quick, flexible syntheses of milligramquantities of compounds for rapid exploration of SAR, toenabling challenging reactions, synthesizing hundreds ofgrams of material for safety studies, or generating initialroutes for Process Chemistry Research to scalecompounds to kilogram scale, synthesis is pivotal to thedrug discovery process.
Computational Chemistry uses theoretical physics, andchemistry−based computer models and simulations toimpact the drug discovery process. Applications include theprediction of structures, properties, molecular interactionsand chemical reaction mechanisms in combination withlarge−scale data analytics to discover new medicines.
Chemical Biology applies chemical and genetictechniques, often coupled with multi-omics approaches, tothe study and manipulation of molecular events inbiological systems. Chemical Biology provides anenhanced understanding of biology, drug mechanisms,target engagement and selectivity. Chemical biologistsroutinely engage with colleagues with a variety ofbackgrounds in a highly matrixed, dynamic, andmultidisciplinary environment.
Analytical Chemistry develops analytical methods for thecharacterization of chemical entities, including activepharmaceutical ingredients, and drug product formulationsusing a range of instruments and techniques. Theanalytical chemist also provides data for structuralelucidation, chemical purity, drug product potency andperformance, as well as methods for purification ofcompounds.
Process Chemistry Research identifies viable routes toallow the synthesis of lead compounds to the multi-kilogram scale typically needed for regulatory safety testingand clinical trials in humans. For compounds that go on tocommercial production, they are responsible for devisingthe manufacturing route utilized. A key goal for processchemistry is to develop synthetic routes that are safe, cost-effective, environmentally friendly, and efficient.
Drug Product Design designs, characterizes anddevelops the solid form of active pharmaceutical ingredient(API) and drug product formulations from discovery tocommercial launch.
At Pfizer we deliver Breakthroughs That Change Patients’Lives. Pfizer’s Medicine Design group plays a vital role in thismission through the discovery of small molecule andsynthetically-derived drugs. Discovering new medicines atPfizer takes teams with a diversity of skills, behaviors andapproaches. Creativity, scientific excellence, tenacity,passion, hard work, organization, teamwork, courage, open-mindedness, curiosity—these are just some of the traitssuccessful Drug Discovers display at Pfizer.
Examples of Pfizer Small Molecule Drugs
Our PipelinePipeline Snapshot as of April 30, 2019
Our priority is researching and developing products andtreatments that will benefit patients around the world. Our effortsin internal medicine, inflammation and immunology, biosimilars,rare disease, oncology, and vaccines, illustrate that we arecommitted to developing medical solutions that will matter most tothe people we serve.
Oncology Vaccines RareDisease
Key Groups: Synthetic Chemistry; Biology;Pharmacokinetics, Dynamics & Drug Metabolism; Drug Safety; Pharmaceutical Sciences; Clinical Trial Operations;Comparative Medicine; Regulatory
Medicine Design
DiscoveryProjects
Phase 1
34Phase 2
30Phase 3
23Registration
10Total
97
InternalMedicine
Inflammation& Immunology
