PC Offsite Meeting Summary 12152011
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Transcript of PC Offsite Meeting Summary 12152011
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Draft Agenda for December 16 PC Off site:
8:30-9AM: Continental Breakfast
9:00-9:45 AM: State of the Department (Jim and Millo)
Vision (Tools and Biology) (Jim)
Goals for the day (Jim)
Recruiting and space status and challenges (Jim)
Departmental Finances and Staff organization (Millo)
9:45-10:30AM: Current teaching responsibilities and challenges for next 3 yrs (Steve, Norm, and Sue
to facilitate)
What are the current teaching assignments? Are there current gaps? Do we foresee
gaps in the next 3 yrs and how would you propose to adjust? Are there programatical
changes on the horizon?
10:30-10:45 Break
10:45-noon: Vision for Physical Biology (Al, John, Bo, Tom J; John and Bo will facilitate
discussion)
Mass Spec Recruitment and facility vision (Jim will update)
What are the most exciting prospects for the Physical Biology area and what kind of
folks should we recruit to replace Tom when he retires? (John and Bo)
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Noon-1PM: Working Lunch (Dan Santi, how we are faring on industrial collaborations? Can we
do better?)
1-2PM: Vision for Quantitative Pharmacology (Matt, Brian, Tom F; Matt will facilitate
discussion)
Where should we go here and why? What are examples of people we might recruit? What
recruiting recommendations would you make and space required?
2-3PM: Vision for Protein Engineering/ Biologics/ Synthetic Biology (Charly, Zev, Xiaokun;
Charly and Xiaokun will facilitate discussion)What are the hottest topics that we see in the next 10 yrs that fit with PC? Is there an
important distinction between these areas? Who is doing the best work we consider fitting
for PC? Should we recruit a junior person here?
3-4PM: Vision for Chemical Biology and Drug Discovery (Bill, Danica, and Pam will facilitate
discussion)
Should we recruit a junior person here now that CC has retired? How do we augment our
current faculty? Should we emphasize synthesis? Should we emphasize drug discovery?
Industry vs Acadmic trained? We have a lot of recruiting in other areas can we wait a year
or two (assuming James joins)?
4-5: Wine/beer and Top Action items for 2011-2012 (Jim to facilitate)
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Review Agenda and Goal of the Day
Vision - Wells All agreed on the shared vision taking on the
responsibility of being disease agnostic andcontributing to the biology and chemistry
All felt the burden of shouldering financial liabilitiesfor the entire campus to the technology enablingcenters recharge not recovering all costs anddepartment taking on risk of potential deficit
LRPD how does the enabling technology centers fitin relation to funding? Depreciation? R&D funding?
Advantage of PC faculty being on campus committees research
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Outstanding growth opportunities
4 open FTEs (Andrew Krutchinsky, Voigt, Dill, CC) plusfifth when Tom Retires
Two open searches:
Computational biologist (Matt)
Mass Spec (Al/Jim)
department will be close to half new faculty in near
future.
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Challenges
#1 Start up Funds:
PC has been successful in partnering with CVRI & using P30grant and minimize requests to dean and SOM.
Mass spec recruitment will be a bigger challenge. Search
committee is a lot outside of the department (CMP, CVRIesp) but may want to plan more partnership esp.biochemistry. Of 4 available candidates in the field, 2 areactively being recruited. Strategy to recruitment? Bestathlete or more narrow to satisfy void in department?
Start up costs indirect cost recovery responsibility, loss tocampus when faculty leave before full professorship.
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#2 - Finding great candidates
#3 - Developing new faculty
new lab set up has been on track. What are challengesto new faculty? More mentoring? Paul is currently theofficial mentorship coordinator for the department.Bo and Xiaokun feel mentorship provided is good andare getting help from a variety of people. Pam hasstepped up to help new faculty review R01s and was
nominated to be the next official mentorshipcoordinator.
ACTION ITEM discuss mentorship at the end of meeting
Cont. challenges
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#4: Space
less of a concern given partnership with CVRI and
Space in neuroscience building is also a potential. Plan for Parnassus space? could be tradable
space/money.
Last year of MOU with Susan Fisher 11th floor.
Lateral transfer of use within SOP with Clin Pharm
going on unofficially.
Cont. challenges
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Highlights from SOP LRDP
Grant revenue highest in Clin Pharm, but PC isdoing well and on track to go up given seniorrecruitment.
funding research sources going up in SOP, otherpublic sources is smaller than expected. Majorityis federal. Private non-profit has gone down.
ICR per PI highest in SOP. SOM second.
Student-faculty ratios highest in SOP (11:1) forprofessional students.
Space requests made to chancellor by dean(Mary Anne slide 16).
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Finance-Operation
Reviewed bottom-line of department revenue
and comp plan.
Discussed current staff org chart and plans.
Concerned about HR and pre award staff
impact by OE.
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Teaching
Coordination and teaching load transitioning with
retirement
Dicks last year on recall (PC 111, 163 student-run)
John Gross will be course director next year PC111 (18)
Brian continues 5
Need to identify another lecturer
Pam taking over PC 123
To discuss with Paul to add lecturers to PC 114 in the
future
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Cont. teaching
Apples for TeachersPaul consistently gets 4.5 rating and receive Deansaward in large lecture course. Steve and Brian also have been highly ratedand honored by dean
Adjunct professors have contributed to many courses and valued, butshould be at least in 4-5 hour blocks for consistency.
Performance now being evaluated on computer. In general SOP did well inSpring 011.
Compare departments, PC rated much higher even compared todedicated teachers in SOM
Ilos and CLE-being mandated by dean to help curriculum sharing andaccreditation.
Faculty facing challenge putting materials online Students are slow to adapt to new system and lecturers work is
doubled
A few TAs hired as curriculum liaison to help bridge this new process
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Physical Biology where should we grow?
(Gross & Huang)
Wish list mid year and junior Crystallographer, NMR,EM, long-term support for beamline
Need to partner with Biochemistry to coordinate ondirection & potentially CVRI or BTS
CVRI hired Natalia and interested in more Jamie Fraser is a potential with BTS
The future
In cell studies of macromolecular dynamics; structure Methods to study complexes and transient interactions
Allostery: need innovative approaches to study
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Strengths at UCSF - facility is phenomenal
and support is adequate but could be better
NMR facility: DNP, 400, 500, 600(x2)and 800 MHz
NMR; solid-state capabilities, Berkeley 900
SLAC and ALS 30 minute drive
MSG
Centers-HARC, Membrane proteins
EM resources
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Opportunities in NMR
NMR of membrane proteins, solids
In cell NMR, eukaryotes
Allostery, dynamics; drug discovery centric?
Innovation in combining methods, x-ray NMR,
NMR and microfluidics, NMR and Single-Molecule
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Traditional single-molecule biophysics
Single-molecule FRET
TJ Ha, Xiaowei Zhuang and other Steve Chu lab people
Single-molecule tracking
Paul Sevin, Toshio Yanagida
Single-molecule force
Carlos Bustamante, Steve Block
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A broader view of single-molecule BP
The physical biology philosophy
High sensitivity, high precision quantitative measurements
Physical aspects of biology
Rapidly evolving fields
Not necessarily single-molecule
Tightly associated to systems biology
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The new opportunity
Molecule conformation, dynamics and interactions
inside a cell
Sunney Xie
Examples at UCSF
Orion Weiner
Wallace Marshall Ron Vale / Dyche Mullins
Sophie Dumont
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What to look for in physical biology
Aiming at the philosophy, junior level for new ideas andnew techniques
Example: Adam Cohen (I don't think that we will be able to recruit him
here) How can we look for others who are producing results Can we think about grad students that UCSF can provide to
them
Best athlete approach works for this type of search
Very possible collaboration with Biochemistry or CMPdepartment.
Potentially associated with systems biology
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Mass Spec Search Update (Wells)
4 people on the market in the field, 2 are tooexpensive, 2 are not the right fit.
Committee want to go after Garcia or Coon.Space in Byers Hall (Voigt space 4N).
Challenge is start up package and dean is onboard.
This recruit is to be the expert for the campus.There is a great need for nuts and bolts person.Technology-capability vs. biology-oriented.Potential transition issue for senior people in theBurlingame lab.
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Industry Update (Santi)
Program have been in place for about 2 years and havebeen affected by recession
Brought in large companies and now focusing on local onesabout half a dozen.
New format to take UCSF faculty to present at companies &mixer at Bayer meeting
Formed board in summer to help direction; smallbenefactors are better than no programs at all. Connections made so far: Chem group Genentech, Giliard, Bayer
To be arranged: Amgen in Jan, Novartis, Merck, Cabo, Biotechconference in MB again next May
XXX (I stepped out at this point during lunch)
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UCSF School of Pharmacy LRDP response
Organizing concepts/major themes
December 14, 2011
Mary Anne Koda-Kimble, Dean
UCSF School of Pharmacy
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The six LRDP questions
1. Does your school anticipate future growth? How muchand where?
2. Would growth be in research or non-research areas?
3. How would the school be optimally arranged across
UCSF sites into the future?4. What would make Parnassus and Mission Bay equally
desirable?
5. What aspirations/themes does the school have for
Phase 2 at Mission Bay?
6. What considerations should be kept in mind as we start
thinking about major site themes for the LRDP?
5/27/2012 23Mary Anne Koda-Kimble
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Questions 1 and 2
5/27/2012 24Mary Anne Koda-Kimble
1. Does your school anticipate future growth? How muchand where?
2. Would growth be in research or non-research areas?
We plan to grow in both
education and research.
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Education: Change the face of pharmacy education;
Bolster graduate and post-doctoral training
Space is tied to growth in faculty, staff, tools: Pharm D Program 8 new faculty members (8:1 ratio)
Increase 20/class to 145/class; 500 to 580 total
Add 20 post-BS PharmDs (virtual)
PhD, Masters and Post-doctoral fellowship Programs
Expand enrollment as driven by contemporary science and technology (e.g.MTM)
Residency positions Double from 16 PGY1 to 32 PGY1
Double from 10 PGY2 to 20 PGY2
Learner-centered, modular, virtual programs 20 new educational
technologists and related tools Advanced pharmacy practice and science ( 100s)
Drug development sciences ( 150)
Therapeutic sciences (BRIC countries) ( 30 students)
Translational medicine
5/27/2012 25Mary Anne Koda-Kimble
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Why grow our education enterprise?
More pharmacist leaders, clinicians, and translational researchscientists needed worldwide
Changes in health care delivery and drug delivery systems
Central role of increasingly complex medicines and therapeutics
Expanding roles require advanced training for pharmacists in newtechnologies and how to integrate them into clinical practice
UCSF PharmD has been top-ranked for over 30 years and needs to
stay ahead of the curve
UCSF is the best place to expand and shape pharmacy education:
leading edge science, health care, & education in a collaborativeenvironment
Increased revenue stream
5/27/2012 26Mary Anne Koda-Kimble
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Question 3
Department Parnassus Mission
Bay
Mt. Zion,
SFGH
Laurel
Heights
Remote
sites
Virtual
Distance
Clinical
Pharmacy 50% 25% 5%, 10% 5% 5% yesBioengineering
and Therapeutic
Sciences*
15% 85% yes
Pharmaceutical
Chemistry100% yes
Deans Office*
70% 30% yes
*Flexible
5/27/2012 27Mary Anne Koda-Kimble
3. How would the School be optimally arranged acrossUCSF sites in the future?
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Question 4
Space at both sites:
Modern. First rate teaching, clinical, research facilities.
Organized by themes. Must have magnet programs.
Seamlessly networked by technology
Equitable lab, office, and administrative space assignments
Scientific cores at each site based on research needs
5/27/2012 28Mary Anne Koda-Kimble
4. What would make Parnassus and MB equally desirablefrom the SOP perspective?
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Question 6
All sites need compelling research themes
All sites must have a strong educational component
School of Pharmacy research and education must be
integrated amongst departments and with other
schools at each site
Think beyond the current economic situation to what
could be.
5/27/2012 29Mary Anne Koda-Kimble
6. What considerations should we keep in mind as we startthinking about major site themes in the LRDP?
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Question 5
5/27/2012 30Mary Anne Koda-Kimble
5. What aspirations/themes does the SOP have forphase 2 at Mission Bay?
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Science is thriving within a School of Pharmacy-led research
building at Mission Bay that consolidates and incubatestherapeutics research and provides broadly accessible enablingtechnologies campuswide.
UCSF at Mission Bay is internationally recognized as the placefor innovative therapeutics research that integrates basic,
translational and clinical scientists.
UCSF at Mission Bay is home to a national think-tank for newdirections in therapeutic sciences and technologies -- conveningacademic, government, and industry leaders on a regular basis.
The UCSF Medical Center at Mission Bay is a world-class modelfor pharmaceutical care and pharmaceutical services. Residencypositions are highly competitive.
5/27/2012 Mary Anne Koda-Kimble 31
Imagine 15 years from now
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Quantitative Pharmacology (Jacobson)
Bring more basic science into drug discovery.
PC to play a leadership role. Existing faculty leaving/has left.
Systems biology and industrys vision of the field is not adequate.
Brian taking the lead w/ Kathy Giacomini support.
Education aspect of program: getting a training grant, combine with pspg
potentially and partnering with other ipqb programs.
Faculty recruitment not many left of core people in computational biology. Dill
FTE search open and would like another FTE and another FTE in BTS.
Action item: Asking for department commitment to launch a search Fall 2012, chaired
by Brian (independent from BTS replacing Chao)
Matts definition of systems pharmacology (pre-clinical quantitative PK/PD)
Target discovery systems biology
(aka atoms to cell, systems pharmacology)
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Wither Protein
Engineering/Synthetic Biology
Pharm Chem Off Site
December 14, 2011
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Wither Protein
Engineering/Synthetic BiologyEngineering small molecules,
macromolecules or materials to
understand a complex biological systemat the systems level.
3 Synthetic Biology/Protein Engineering: Chris Voit presented a compelling
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3. Synthetic Biology/Protein Engineering: Chris Voit presented a compelling
case that we are on the verge of a major break-through in developing the
machine language for programming cells. UCSF is at a sub-critical mass to
carry this out. He proposed hiring a mid-career scientist: Dan Gibson (JCVI), Yi
Tang (UCLA), Jeff Hasty (UCSD), Byung-Kwan Cho (KAIST), Tim Lu (MIT). There
was strong support to move forward.
Actions: Chris should put together a job description and I'll talk with Mary
Anne about opening a search this fall.I presented the case for hiring in the
Protein Engineering/Biotherapeutics area. Protein selection technologies and
biotherapeutics are burgeoning areas relevant to component design forsynthetic biology and understanding signaling modules in cells.
In the near future biotherapeutics will match or exceed the revenues from
small molecules. We have few to no scientists in this area. Several individuals
were discussed including: Danny Tawfik (Weizmann Institute), Dev Sidhu(University of Toronto), David Liu (Harvard). There was general support.
Action: Jim will discuss this with Kathy/Sarah to see if a joint recruitment
would be possible in this area
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Should we trim things down and not do a future hire in PE and
Synthetic Biology?
Many depts do many things. We should focus on our strengths and
build on them and PE and SB fit.
Regarding the Best Athlete Search Concept: Keep the searches broad
and attract the best athlete problem is hard to get buy in from X
though. So have a general search and then stratify.
What we are looking for are exceptional scientists that think
chemically (about macromolecules), work collaboratively and
interact well.
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For synthetic biology, cannot find another Chris right away.
Can we bring in people that think about complex systems and whodoes it from a chemical background. Ex is Zev
Examples: How does a complex system work? Look at multiple
things at once. Tool development to get at this imaging,
quantitative pharmacology, antiproteome, PE, Synthetic Biology,
Engineering small molecules or the protein.
Protein Engineering-someone like a Tanya K who can make
molecules but is not afraid to write code.
Another example: Jen Presser (Sam Gambir and Chris Contag)
Multimodal imaging agents.
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Junior vs Senior?
- Junior people have more plasticity and can change faster
in a rapidly developing field than a senior hire.
Action item:
- Looking for exceptional scientists that think chemically
should we reopen the search, should we reorganize thesearch?
- radar should be on even search will be on hold until
current 2 searches are finished.
- standalone, broad search for best athlete posting in fall2012
- should we put synthetic search on hold? Dean and
Wendell (cmp) have possibility to contribute
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Chem Bio & Drug Discovery (DeGrado & England)
James Fraser is a good candidate. Space in CVRI for molecule maker using hood,
only 40% of chemistry space is used.
Stan Pruisner looking for 5 FTEs in neuro building How to partner with neuro to bring people in that is
part of the broader UCSF
Jason ? is another good candidate
Jeff Kelly is another person (coming Jan)
-Currently have a tremendous opportunity andUCSF can be adding a couple of hires per year inthe next few years.
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Action Items
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Proposed Hiring's and Space
Dill to Comp Biophys (Matt) 2011 (QB3 or 4N) Krutchinsky to MS (Al/Jim) 2011 (QB3)
Voigt to PE/SynBiol 2012 (5S)
CC ?? 2013 Scanlon to James Chen 2010 (CVRI)
Tom James to Struct Biol with BTS (5S or QB3)2012
Systems Pharma with BTS (QB3 or 4N) 2012 Chem Biol (CVRI/Neuro)
Phys Biol 2013
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Green denotes that we have or will have soon open FTEs for these
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Admin Hiring
Jen Paloma took Anemishs position and we
will be looking for replacement in 2012
FTE admin addition for PC in CVRI in 2012
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Faculty Meetings
Be more flexible if important matters arise
5-10min max for admin at end
Be flexible about PP vs chalk
Generate discussion
Emphasis on future not past
Think about vetting specific aims for proposal
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Education
Think about possible masters program run
from PC in Drug Discovery. Jim to bring up
with SoP Leadership Group
How will e-education affect us?? Norm to
follow up