Pathophysiology of CHOLELITHIASIS

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  • 8/10/2019 Pathophysiology of CHOLELITHIASIS

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    MRI RESULTS:

    1. Dilated cystic side branches in directcommunication with pancreatic duct in theregion of uncinate process for which an IPMTshould be excluded

    2. Multiple gallstones

    3. Left renal cysts with wall calcifications

    4. Tiny right renal corticocysts

    5. Ascending and descending diverticula

    PRECIPITATING FACTORS:Diet

    ObesityRapid weight loss

    Use of oral contraceptivesGallbladder, pancreatic or ileal disease

    Low HDL cholesterol levelHypertriglyceridemia

    CHOLELITHIASIS

    Gallstones in the Bile duct

    Increased Bile Cholesterol

    Irritation of Gallbladdermucosa

    Surface Changes

    Increased Mucus Secretion

    Impaired Gallbladderemptying

    Precipitate out of the bile

    Forms small crystals intoGallbladders mucosal surface

    Enlarges to grossly visible stones

    Several stones develop

    PREDISPOSING FACTORS:Family History

    FemaleMiddle age

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    Distension IntraductalPressure

    RUQPain

    BiliaryColic

    Injury

    ObstructionContractile

    function

    AnorexNauseVomit

    Weight lFlatulenDiarrh

    Fatintolera

    Bileaccumulates

    in Liver

    IncreaseSerum

    Bilirubin

    Prorates/Tea-collared

    UrineJaundice BiliaryCirrhosis

    Bile Stasis

    AbnormalFat

    Digestion

    I

    Inflammation ofGallbladder

    Cholecystitis