Osteoarthritis & Gouty Arthritis
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Transcript of Osteoarthritis & Gouty Arthritis
OSTEOARTHRITIS & GOUTY ARTHRITIS
Maria Carmela L. Domocmat, RN, MSN
Instructor, School of Nursing Northern Luzon Adventist College
Overview 2
� Part 1: Degenerative & Metabolic bone disorders: � OA
� Gout and gouty arthritis
� Osteoporosis
� Paget’s dse
Osteomalacia
3/5/2012Maria Carmela L. Domocmat, RN, MSN
� Osteomalacia
� Part 2: Bone infections
� Part 3: Muscular disorders
� Part 4: Disorders of the hand
� Part 5: Spinal column deformities
� Part 6 : Disorders of foot
� Part 7: Sports Injuries
Osteoarthritis
� associated with the aging process and can affect any joint.
� The cartilage of the affected joint is
Maria Carmela L. Domocmat, RN, MSN
affected joint is gradually worn down, eventually causing bone to rub against bone.
� Bony spurs develop on the unprotected bones, causing pain and inflammation.
What’s the difference between RA and OA?
Maria Carmela L. Domocmat, RN, MSN
Maria Carmela L. Domocmat, RN, MSN
� Osteoarthritis is a deterioration of cartilage and overgrowth of bone often due to "wear and tear."
� Rheumatoid arthritis is the inflammation of a joint's
Maria Carmela L. Domocmat, RN, MSN
� Rheumatoid arthritis is the inflammation of a joint's connective tissues, such as the synovial membranes, which leads to the destruction of the joint's cartilage.
Osteoarthritis
� Known as the “wear-and-tear” kind of arthritis
� a chronic condition characterized by the breakdown of the joint’s cartilage.
� Cartilage is the part of the joint that cushions the ends
Maria Carmela L. Domocmat, RN, MSN
� Cartilage is the part of the joint that cushions the ends of the bones and allows easy movement of joints. The breakdown of cartilage causes the bones to rub against each other, causing stiffness, pain and loss of movement in the joint.
Osteoarthritis
� AKA
� degenerative joint disease,
� ostoarthrosis,
� hypertrophic arthritis
Maria Carmela L. Domocmat, RN, MSN
� degenerative arthritis.
Stages of osteoarthritis
� Cartilage loses elasticity and is more easily damaged by injury or use.
� Wear of cartilage causes changes to underlying bone. The bone thickens and cysts may occur under the
Maria Carmela L. Domocmat, RN, MSN
cartilage. Bony growths, called spurs or osteophytes, develop near the end of the bone at the affected joint.
Stages of osteoarthritis
� Bits of bone or cartilage float loosely in the joint space.
� The joint lining, or the synovium, becomes inflamed due to cartilage breakdown causing cytokines
Maria Carmela L. Domocmat, RN, MSN
(inflammation proteins) and enzymes that damage cartilage further.
� The main problem in knee OA is degeneration of the articular cartilage.
� Articular cartilage is the smooth lining that covers smooth lining that covers the ends of bones where they meet to form the joint. The cartilage gives the knee joint freedom of movement by decreasing friction.
Maria Carmela L. Domocmat, RN, MSN
� The articular cartilage is kept slippery by joint fluid made by the joint lining (the synovial
membrane). The fluid, membrane). The fluid, called synovial fluid, is contained in a soft tissue enclosure around synovial joints called the joint capsule.
Maria Carmela L. Domocmat, RN, MSN
� An important substance present in articular cartilage and synovial fluid is called hyaluronicacid. Hyaluronic acid acid. Hyaluronic acid helps joints collect and hold water, improving lubrication and reducing friction. It also acts by allowing cells to move and work within the joint.
Maria Carmela L. Domocmat, RN, MSN
� When the articular cartilage degenerates, or wears away, the bone underneath is uncovered and rubs uncovered and rubs against bone.
� Small outgrowths called bone spurs, or osteophytes, may form in the joint.
Maria Carmela L. Domocmat, RN, MSN
� Changes in the cartilage and bones of the joint can lead to pain, stiffness and use limitations. Deterioration of cartilage can:� Affect the shape and makeup of the joint so it doesn’t
function smoothly. - limp when walk or have trouble going
Maria Carmela L. Domocmat, RN, MSN
function smoothly. - limp when walk or have trouble going up and down stairs.
� Cause fragments of bone and cartilage to float in joint fluid causing irritation and pain.
� Cause bony spurs, called osteophytes, to develop near the ends of bones
� Mean the joint fluid doesn’t have enough hyaluronan, which affects the joint’s ability to absorb shock.
Maria Carmela L. Domocmat, RN, MSN
Causes and Risk factors
� There is no single known cause of osteoarthritis
� several risk factors
� Age
� Obesity
Maria Carmela L. Domocmat, RN, MSN
� Obesity
� Injury or Overuse
� Genetics or Heredity
� Muscle Weakness
� Other Diseases and Types of Arthritis
Maria Carmela L. Domocmat, RN, MSN
Long-Term Complications
Maria Carmela L. Domocmat, RN, MSN
Maria Carmela L. Domocmat, RN, MSN
Management
Maria Carmela L. Domocmat, RN, MSN
Management
�Weight reduction
�Use of splinting devices to support joints
�Occupational and physical therapy
�Pharmacologic management
Maria Carmela L. Domocmat, RN, MSN
�Pharmacologic management
Management
Maria Carmela L. Domocmat, RN, MSN
Paraffin wax
Maria Carmela L. Domocmat, RN, MSN
TENS
Maria Carmela L. Domocmat, RN, MSN
Physical Therapy
� There is no treatment to stop the erosion of cartilage in the joints, but there are ways to improve joint function. One of these is physical therapy to increase flexibility and is physical therapy to increase flexibility and strengthen the muscles around the affected joints. The therapist may also apply hot or cold therapies such as compresses to relieve pain.
Maria Carmela L. Domocmat, RN, MSN
Supportive Devices
� Supportive devices, such as finger splints or knee braces, can reduce stress on the joints and ease pain. If walking is difficult, canes, crutches, or walkers canes, crutches, or walkers may be helpful. People with osteoarthritis of the spine may benefit from switching to a firmer mattress and wearing a back brace or neck collar.
Maria Carmela L. Domocmat, RN, MSN
lumbosacral corsets
Maria Carmela L. Domocmat, RN, MSN
Osteoarthritis and Weight
� If you're overweight, one of the most effective ways to relieve pain in the knee or hip joints is to shed a few pounds.
� Even modest weight loss � Even modest weight loss has been shown to reduce symptoms of osteoarthritis by easing the strain on weight-bearing joints.
� Losing weight not only cuts down on pain, but may also reduce long-term joint damage.
Maria Carmela L. Domocmat, RN, MSN
Osteoarthritis and Exercise
� People with osteoarthritis may avoid exercise out of concern that it will cause pain.
� But low-impact activities such as swimming, walking, or bicycling can improve mobility and increase mobility and increase strength.
� Training with light weights can help by strengthening the muscles that surround your joints. For example, strengthening the quadriceps can reduce pain in the knees.
Maria Carmela L. Domocmat, RN, MSN
Let’s Exercise
� http://www.medicinenet.com/rheumatoid_arthritis_exercises_slideshow/article.htm
Maria Carmela L. Domocmat, RN, MSN
Treatment
� Acetaminophen (Tylenol)
� Topical analgesics OTC� Topical salicylates (Aspercreme)
� Capsaicin
� Nonsteroidal anti-inflammatory drugs (NSAIDs) or COX-2 medications
Maria Carmela L. Domocmat, RN, MSN
medications
� Tramadol
� Narcotic pain relievers
� Intra-articular steroids to decrease inflammation � Hyaluronans: Hyaluronate (Hyalgan) ad hylan GF 20 (Synvisc)
� Cyclobenzapine HCl (Flexeril)
� glucosamine and chondroitin sulfate
Acetaminophen
� Tylenol, Anacin-3, Panadal, Phenaphen, Valadol, and others)
� for mild to moderate osteoarthritis. � usually the first choice
Maria Carmela L. Domocmat, RN, MSN
usually the first choice
Nonsteroidal anti-inflammatory drugs (NSAIDs)
� for moderate to severe arthritic pain.� OTC NSAIDs� Prescription NSAIDs include
Maria Carmela L. Domocmat, RN, MSN
Drugs for Prevention NSAID-Induced
Ulcers
� If NSAID-induced ulcers are identified switch to alternative pain relievers.
Maria Carmela L. Domocmat, RN, MSN
Topical NSAIDs
Maria Carmela L. Domocmat, RN, MSN
$63.07
Capsaicin (Zostrix)
� is an ointment prepared from the active ingredient in hot chili peppers that has been helpful for relieving painful areas in other disorders.
Maria Carmela L. Domocmat, RN, MSN
� SALONPAS PAIN PATCH WITH CAPSAICIN
Maria Carmela L. Domocmat, RN, MSN
Tramadol (Ultram)
� is a pain reliever that has some properties that are similar to narcotics.
� not as addictive, however, and may be an alternative for patients who do not respond to
Maria Carmela L. Domocmat, RN, MSN
alternative for patients who do not respond to NSAIDs or less potent agents.
Maria Carmela L. Domocmat, RN, MSN
Narcotic pain relievers
� oxycodone, oxymorphone, or morphine� may be necessary for severe pain that does not
respond to less potent pain relievers.
Maria Carmela L. Domocmat, RN, MSN
Maria Carmela L. Domocmat, RN, MSN http://differncebetween.infoloommedia.netdna-cdn.com/wp-content/uploads/2009/11/oxycodone.png
Supplements
� Overall studies suggest no benefits of glucosamine and chondroitin –supplements available at pharmacies and health food stores touted for relieving pain and food stores touted for relieving pain and stiffness for people with osteoarthritis.
� Check with doctor before using chondroitin, especially if taking blood-thinners.
Maria Carmela L. Domocmat, RN, MSN
Intra-articular steroids
Generic Name Brand Name
betamethasone Celestone
methylprednisolone Depo-Medrolmethylprednisolone Depo-Medrol
triamcinolone Kenalog
Maria Carmela L. Domocmat, RN, MSN
Intra-articular steroids
Maria Carmela L. Domocmat, RN, MSN
Surgical treatment
Maria Carmela L. Domocmat, RN, MSN
Preventing Osteoarthritis
� The most important thing you can do to ward off osteoarthritis is keep your weight in check. Over the years, extra weight puts stress on the joints and may even alter the normal joint structure.
� Preventing injuries is also important. important.
� Take precautions to avoid repetitive motion injuries on the job.
� If you play a sport, use proper equipment and observe safety guidelines.
Maria Carmela L. Domocmat, RN, MSN
Maria Carmela L. Domocmat, RN, MSN
Gouty arthritis
� is a disease characterized by an abnormal metabolism of uric acid, resulting in an excess of uric acid in the tissues and blood causing inflammation
Maria Carmela L. Domocmat, RN, MSN
� People with gout either produce too much uric acid, or more commonly, their bodies have a problem in removing it.
Gouty arthritis
� AKA
� Gout
� The disease of kings
� The king of diseases
Maria Carmela L. Domocmat, RN, MSN
� The king of diseases
Gouty arthritis
� 2 major types
� Primary
� Secondary
Maria Carmela L. Domocmat, RN, MSN
Primary Gouty arthritis
� Inherited X-lined trait
� Caused by several inborn errors of purine metabolism � Uric acid- is the end-product of purine metabolism;
excreted in urine
Maria Carmela L. Domocmat, RN, MSN
excreted in urine
� Production of uric acid exceeds the excretion capability of kidneys
� Sodium urate is deposited in the synovium and other tissues which results in inflammation
� Males, 30’s and 40’s
Secondary Gouty arthritis
� Affects all ages
� Hyperuricemia : Excessive uric acid in blood caused by another diseaseRenal insufficiencyDiuretic therapy
Maria Carmela L. Domocmat, RN, MSN
Diuretic therapyMultiple myelomaCarcinomas
� Causes: � decreased normal excretion of uric acid and other waste
products� Increased production of uric acid
Four Stages Of Gouty Arthritis
� Asymptomatic Hyperuricemia
� Acute Gout / Acute Gouty Arthritis
Maria Carmela L. Domocmat, RN, MSN
� Interval / Intercritical
� Chronic Tophaceous Gout
Four Stages Of Gouty Arthritis
� (1) Asymptomatic Hyperuricemia:
� Asypmptomatic but with elevated blood uric acid levels
Serum uric acid level (mg/dl) Incidence of gout
Maria Carmela L. Domocmat, RN, MSN
�Serum uric acid level (mg/dl) Incidence of gout
>9.0 7.0-8.9
7.0-8.9 0.5-0.37
<7.0 0.1%
Four Stages Of Gouty Arthritis
� (2) Acute Gout / Acute Gouty Arthritis
� First “attack” of GA
� hyperuricemia has caused deposits of uric acid crystals in joint spaces, leading to gouty attacks.
Maria Carmela L. Domocmat, RN, MSN
� Excruciating pain and inflammation of one or more joints – esp metatarsophalangeal joints of the great toe (podagra)
� Increased ESR, WBC
� Note: Excessive alcohol and fad “starvation” diets can cause acute gouty attacks
Maria Carmela L. Domocmat, RN, MSN
Maria Carmela L. Domocmat, RN, MSN
Maria Carmela L. Domocmat, RN, MSN
http://cdn.nursingcrib.com/wp-content/uploads/gouty-arthritis.jpg
http://img.medscape.com/slide/migrated/editorial/cmecircle/2004/3689/images/cohen/slide019.gif
Maria Carmela L. Domocmat, RN, MSN
Four Stages Of Gouty Arthritis
� (3) Interval / Intercritical
� the periods between acute gouty attacks – may be months or years after the 1st attack
� Asymptomatic period
Maria Carmela L. Domocmat, RN, MSN
� No abnormality in joints
� (4) Chronic Tophaceous Gout:
� the disease has caused permanent damage
� Deposits or urate crytals under skin and within major organs (i.e., urate kidney stone formation)
Tophi
� Tophi – deposits of sodium urate crystals
� May occur anywhere; common in outer ear
Maria Carmela L. Domocmat, RN, MSN
http://www.hopkins-arthritis.org/images/gout_fig7.gif
Maria Carmela L. Domocmat, RN, MSN
http://www.cdaarthritis.com/images_slides/40_gout_b_toe1_360.jpg
http://img.medscape.com/slide/migrated/editorial/cme
Maria Carmela L. Domocmat, RN, MSN
ated/editorial/cmecircle/2004/3689/images/cohen/slide019.gif
Maria Carmela L. Domocmat, RN, MSN
http://img.medscape.com/slide/migrated/editorial/cmecircle/2004/3689/images/cohen/slide019.gif
Maria Carmela L. Domocmat, RN, MSN
http://msnbcmedia1.msn.com/i/msnbc/Components/Interactives/Health/MiscHealth/GOUT.gif
Maria Carmela L. Domocmat, RN, MSN
http://img.medscape.com/slide/migrated/editorial/cmecircle/2004/3689/images/cohen/slide019.gif
Dx tests
� Synovial fluid analysis (shows uric acid crystals)
� Uric acid - blood
� Joint x-rays (may be normal)
� Synovial biopsy
Maria Carmela L. Domocmat, RN, MSN
� Synovial biopsy
� Uric acid - urine
Maria Carmela L. Domocmat, RN, MSN
Management
� Drug therapy
� Diet therapy
Maria Carmela L. Domocmat, RN, MSN
Management
� Drug therapy� acute gouty arthritis – inflammation subsides
spontaneously within 3 to 5 days
� But if cannot tolerate pain
� Colchicine (Colsalide, Novocolchicine) and NSAIDs
Maria Carmela L. Domocmat, RN, MSN
� Colchicine (Colsalide, Novocolchicine) and NSAIDs � Taken for 4-7 days
� (NSAIDs) -Indomethacin (Indocin), ibuprofen (Advil), and naproxen (Aleve), celecoxib (Celebrex)
� painkillers such as codeine, hydrocodone, and oxycodone
� Corticosteroids
Management
� Drug therapy: Chronic or repeated acute episodes
� Uricosuric drug
� 1. Allopurinol (Zyloprim)
� 2. Probenecid (Benemid, Benuryl)
Maria Carmela L. Domocmat, RN, MSN
� 2. Probenecid (Benemid, Benuryl)
� Combination drug� Probenecid and Colchicine (ColBenemid)
Management
� Drug therapy: Chronic or repeated acute episodes
� Uricosuric drug – promotes excretion of excess uric acid Promote uric acid excretion or reduce its production
� 1. Allopurinol (Zyloprim)
Maria Carmela L. Domocmat, RN, MSN
� A xanthine oxidase inhibitor – prevents conversion of xanthine to uric acid
� 2. Probenecid (Benemid, Benuryl)
� drink at least 2 liters of fluid a day while taking this medication (to help prevent uric acid kidney stones from forming).
Management
� Drug therapy: Chronic or repeated acute episodes
� Combination drug� Probenecid and Colchicine (ColBenemid)
Maria Carmela L. Domocmat, RN, MSN
� Probenecid and Colchicine (ColBenemid)
� Note: avoid aspirin – it inactivates the drug
� Monitor serum uric acid level
Maria Carmela L. Domocmat, RN, MSN
� Febuxostat (Uloric)
� first new medication developed specifically for the control of gout in over 40 years.
� Decreases formation of uric acid by the body and is a
Maria Carmela L. Domocmat, RN, MSN
very reliable way to lower the blood uric acid level.
� can be used in patients with mild to moderate kidney impairment.
� should not be taken with 6-mercaptopurine (6-MP), or azathioprine.
http://www.emedicinehealth.com/gout/page7_em.htm#Medications
Maria Carmela L. Domocmat, RN, MSN
Management: Diet therapy
� Controversial
� Strict low-purine diet
� Limit protein foods
� Avoid alcohol and fad “starvation” diets
Maria Carmela L. Domocmat, RN, MSN
� Avoid alcohol and fad “starvation” diets
Starvation Diet
� A potentially dangerous fad diet that provides 300–700 kcal/day, which must be supplemented with high quality protein; given the risk of death through cardiac arrhythmias, starvation diets should be limited in duration
� Adverse effects � Orthostatic hypotension due to loss of sodium,
decreased norepinephrine secretion, xeroderma
Maria Carmela L. Domocmat, RN, MSN
� decreased norepinephrine secretion,
� fatigue,
� hypothermia,
� cold intolerance,
� xeroderma,
� hair loss,
� dysmenorrhoea
Segen's Medical Dictionary. © 2011 Farlex, Inc. All rights reserved.
xeroderma
Fad diet
� Any of a number of weight-reduction diets that either eliminate one or more of the essential food groups, or recommend consumption of one type of
Maria Carmela L. Domocmat, RN, MSN
groups, or recommend consumption of one type of food in excess at the expense of other foods; FDs rarely follow modern principles for losing weight.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
Management: Diet therapy
� Avoid
� alcohol
� anchovies
� sardines
� legumes (dried beans and peas)
� Gravies
� mushrooms� sardines
� oils
� organ meat (liver, kidney, and sweetbreads)
� spinach
� asparagus
� cauliflower
� baking or brewer's yeast
Maria Carmela L. Domocmat, RN, MSN
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001459/
Management: Diet therapy
� Limit meat
� Avoid fatty foods such as salad dressings, ice cream, and fried foods.
� Eat enough carbohydrates.
Maria Carmela L. Domocmat, RN, MSN
� Eat enough carbohydrates.
� If losing weight, lose it slowly. Quick weight loss may cause uric acid kidney stones to form.
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001459/
Maria Carmela L. Domocmat, RN, MSN http://s1.hubimg.com/u/1184832_f496.jpg
Management: Diet therapy
� Avoid all forms of aspirin and diuretics – may precipitate attack
� Excessive physical or emotional stress- can exacerbate disease
Maria Carmela L. Domocmat, RN, MSN
exacerbate disease
Prevention of kidney stone formation
� Increase fluid intake
� To prevent stone formation
� Dilute urine and prevent sediment formation
� Alkaline ash diet
Maria Carmela L. Domocmat, RN, MSN
� Alkaline ash diet
� Citrus fruits, juices, milk and certain dairy products
� Uric acid is more soluble in high pH urine – less likely to form urinary stones
Complications
� Chronic gouty arthritis
� Kidney stones
� Deposits in the kidneys, leading to chronic kidney failure
Maria Carmela L. Domocmat, RN, MSN
failure