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Opportunities in biomedical data science · Opportunities in biomedical data science Karl Broman...
Transcript of Opportunities in biomedical data science · Opportunities in biomedical data science Karl Broman...
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Opportunities inbiomedical data science
Karl Broman
Biostatistics & Medical Informatics, UW–Madison
kbroman.orggithub.com/kbroman
@kwbromanSlides: bit.ly/carleton2019
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Biomedical data explosion
▶ Electronic health records (EHR)▶ Imaging▶ Genome/proteome/metabolome/microbiome data▶ Personal activity/health tracking devices
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Biomedical data explosion
▶ Electronic health records (EHR)▶ Imaging▶ Genome/proteome/metabolome/microbiome data▶ Personal activity/health tracking devices▶ High-throughput measurements in agriculture and ecology
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3
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Intercross
P1 P2
F1 F1
F2
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Genome scan
0
2
4
6
8
Chromosome
LOD
sco
re
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 X
BB BR RR
0.80.91.01.1
6
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Genome scan
0
2
4
6
8
Chromosome
LOD
sco
re
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 X
6
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High-throughput phenotypes
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High-throughput phenotypesislet
QTL position (cM)
Pro
be p
ositi
on (
cM)
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Multi-parent crossesG0
A B C D E F G H
G1
G2
G10
G15
G20
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The work
▶ Collaboration▶ Data exploration▶ Methods development▶ Software development
– R– C++– Coffeescript– Ruby
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The work
▶ Collaboration▶ Data exploration▶ Methods development▶ Software development
– R– C++– Coffeescript– Ruby
9
![Page 14: Opportunities in biomedical data science · Opportunities in biomedical data science Karl Broman Biostatistics & Medical Informatics, UW–Madison kbroman.org github.com/kbroman @kwbroman](https://reader030.fdocuments.us/reader030/viewer/2022040621/5f366cc48b3d126b1c2fc1a6/html5/thumbnails/14.jpg)
Qiongshi LuHuman genome-wide association studies
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Sündüz KeleşFunctional mediation analysis
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Christina KendziorskiClock genes in stem cells
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![Page 17: Opportunities in biomedical data science · Opportunities in biomedical data science Karl Broman Biostatistics & Medical Informatics, UW–Madison kbroman.org github.com/kbroman @kwbroman](https://reader030.fdocuments.us/reader030/viewer/2022040621/5f366cc48b3d126b1c2fc1a6/html5/thumbnails/17.jpg)
Tony GitterPathways disrupted by cancer
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Vikas SinghAnalysis of brain images
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Biomedical data science PhD at UW-Madison
▶ Faculty spanning biostatistics, bioinformatics, and computer science▶ Broad opportunities for scientific collaborations▶ Flexible course requirements▶ Research rotations▶ Literature and professional skills seminars
bit.ly/MadBDS
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Slides: bit.ly/carleton2019
kbroman.org
github.com/kbroman
@kwbroman
17