Opioid Stewardship and Overdose Prevention...Jul 30, 2018 · The authors of this presentation have...
Transcript of Opioid Stewardship and Overdose Prevention...Jul 30, 2018 · The authors of this presentation have...
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Opioid Stewardship and Overdose Prevention
Jordan Marie Ballou, PharmD, BCACPClinical Assistant Professor of Pharmacy Practice
Melissa Reilly, PharmD, BCGPClinical Assistant Professor of Pharmacy Practice
Preceptor Conference 2019
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Disclosures
The authors of this presentation have no financial or other relationships to disclose
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Objectives
• Develop workflow best practices for opioid use in inpatient and outpatient settings
• Identify ways in which technology can be incorporated for safer practices
• Formulate strategies to engage patients and providers in opioid stewardship
• Review naloxone for community use, including administration and counseling points
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Opioid Deaths are an epidemic
• According to the CDC, opioids killed more than 47,600people in 2017
• 91 people die EVERY DAY in the United States fromopioid overdose (prescription + illegal)• This is more than the number of people that die
from motor vehicle collisions• Heroin overdoses have been on the rise since 2011
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https://www.cdc.gov/drugoverdose/data/statedeaths.html
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Not just a national problem
• In 2017, 354 people died in the state of Mississippi from drugoverdoses
• 723,508 Mississippians filled an opioid prescription in 2018• Down from 932,578 in 2014
https://www.cdc.gov/drugoverdose/data/statedeaths.htmlhttps://www.mbp.ms.gov/Documents/2_26_2019_Opioid_and_Benzo_Prescriptions_in_MS.pdf
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The number of prescriptions is down, but the potency of the prescriptions written isincreasing
https://www.mbp.ms.gov/Documents/2_26_2019_Opioid_and_Benzo_Prescriptions_in_MS.pdf
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Implementation Considerations
Goals
Interventions
Data monitoring
Resources
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Goals
• Improve patient safety
• Understand the current prescribing patterns
• Establish best practices for your company/institution
• Optimize pain management
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A. Information Technology B. Quality Improvement C. Administrative OfficersD. Healthcare ProfessionalsE. C & DF. All of the above
Audience Poll: Who would be appropriate personnel to include as stakeholders?
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A. Information Technology B. Quality Improvement C. Administrative OfficersD. Healthcare ProfessionalsE. C & DF. All of the above
Audience Poll: Who would be appropriate personnel to include as stakeholders?
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Data Monitoring
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Monitoring of Data
Monitor all available resources for data related to opioid use and overdose prevention
• CDC• Emergency departments• Medical Examiners• Prescription Monitoring Programs• Your pharmacy/EHR reports
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Increased Use of Prescription Monitoring Program
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Mississippi Prescription Monitoring Program
• Mississippi Prescription Monitoring Program (MS PMP) is a statewide electronic database that monitors Scheduled II-V controlled drugs being dispensed
• This program is designed to track any information speculated against drug diversion or abuse
• Provides physicians and pharmacists detailed information regarding patients controlled substance prescription history
http://www.mbp.state.ms.us/mbop/pharmacy.nsf/webpages/PMDB_PMDB?OpenDocument
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http://www.pdmpassist.org/pdf/PDMP_Program_Status_20180801.pdf
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Reporting Requirements• December 31, 2013
• Board of Medical Licensure required any physician licensed to practice in Mississippi who prescribes, administers, or dispenses any controlled substance to register with the MS PMP
• December 31, 2015• All pharmacists licensed in MS are required to register to
use the MS PMP
• Anyone misusing the PMP can result in a $50,000 penalty
http://www.mbp.state.ms.us/mbop/pharmacy.nsfhttp://www.namsdl.org/library/C605033C-EABE-8725-6763D1AD1F7159CB/
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Verification Regulations
• MS Pharmacy Practice Regulations Article XLIII (7/30/2018)
• “It is the intent of the Board that pharmacists utilize the PMP on a regular basis based on their professional judgment.”
• A pharmacist shall review the PMP if:
• The patient is a new customer
• The patient has not had an opioid at that pharmacy within 6 months
• Review PMP at least once every 6 months for any patient receiving controlled substances
https://www.mbp.ms.gov/Regulations/ARTICLE%20XLIII%20PRESCRIPTION%20MONITORING%20PROGRAM.pdf
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Challenges
• Incorporating into the work flow
• Registration and reporting requirements varies among states
• Locating patient information
• Inadequate training
• Errors with pharmacy data entry
• Errors with PMP software
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Best Practices
• According to the MS PMP Guidelines, a pharmacist can elect a “delegate” user, such as a pharmacy technician
• Document on hard copy prescriptions
• Use reports in your dispensing system or EHR
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Audience Poll: Which of the following is an appropriate use of the database?
A. Your teenage daughter has a new boyfriend and you want to know if he takes any concerning medications
B. A patient comes in and asks to pay cash for a prescription of generic Norco 5/325mg because her insurance is “messed up right now”
C. Your friend has been acting strange lately, showing up late to events and dressing sloppier than usual
D. You want to make sure that no one has been filling controlled substances under your name
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Audience Poll: Which of the following is an appropriate use of the database?
A. Your teenage daughter has a new boyfriend and you want to know if he takes any concerning medications
B. A patient comes in and asks to pay cash for a prescription of generic Norco 5/325mg because her insurance is “messed up right now”
C. Your friend has been acting strange lately, showing up late to events and dressing sloppier than usual
D. You want to make sure that no one has been filling controlled substances under your name
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Develop “Report Cards”
Kalichira A., et al. (2018) HIT-ing the Crisis on Its Head: Examining the Use of Health Information Technology to Change Opiate Prescribing Practices [PowerPoint Slides]. Retrieved from: https://8c00cf55b4d710b367a6-1b5311869a16b9ad87a739ea0c86498b.ssl.cf1.rackcdn.com/679450.pdf
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Kalichira A., et al. (2018) HIT-ing the Crisis on Its Head: Examining the Use of Health Information Technology to Change Opiate Prescribing Practices [PowerPoint Slides]. Retrieved from: https://8c00cf55b4d710b367a6-1b5311869a16b9ad87a739ea0c86498b.ssl.cf1.rackcdn.com/679450.pdf
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Kalichira A., et al. (2018) HIT-ing the Crisis on Its Head: Examining the Use of Health Information Technology to Change Opiate Prescribing Practices [PowerPoint Slides]. Retrieved from: https://8c00cf55b4d710b367a6-1b5311869a16b9ad87a739ea0c86498b.ssl.cf1.rackcdn.com/679450.pdf
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Interventions
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• Prescriber Education
• Identify High Risk Patients
• Order Sets/Policies
• E-Prescribing
• Patient Education
Leverage EHR
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• The “Problem”
• Impact of initial prescribing
• Use of pain care plans
• Safety and best practices
• Requirements
Prescriber Education
https://www.cdc.gov/drugoverdose/prescribing/clinical-tools.html
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Opioid Prescribing Guidelines
• Opioids are not first-line for chronic pain• Use non-opioids whenever possible• Start low and go slow • Use immediate release whenever possible• Establish goals for treatment early and re-evaluate every 3
months• Avoid concurrent prescribing of opioids and benzodiazepines
Dowell D, Haegerich TM, Chou R. CDC Guideline for Prescribing Opioids for Chronic Pain — United States, 2016. MMWR Recomm Rep 2016;65(No. RR-1):1–49. DOI: http://dx.doi.org/10.15585/mmwr.rr6501e1
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Identify High Risk Patients
• Chronic vs. Acute
• Cancer vs. Non-Cancer
• Palliative or Hospice Care
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Order Sets/Policies
Kalichira A., et al. (2018) HIT-ing the Crisis on Its Head: Examining the Use of Health Information Technology to Change Opiate Prescribing Practices [PowerPoint Slides]. Retrieved from: https://8c00cf55b4d710b367a6-1b5311869a16b9ad87a739ea0c86498b.ssl.cf1.rackcdn.com/679450.pdf
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Order Sets/Policies
Kalichira A., et al. (2018) HIT-ing the Crisis on Its Head: Examining the Use of Health Information Technology to Change Opiate Prescribing Practices [PowerPoint Slides]. Retrieved from: https://8c00cf55b4d710b367a6-1b5311869a16b9ad87a739ea0c86498b.ssl.cf1.rackcdn.com/679450.pdf
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E-Prescribing
• Documentation • Pain Care Plan• E-PDMP attestation
• E-prescribe controlled substances • Except CIIs (with some exceptions)• Automatic day supply 3-7 days for acute needs
Kalichira A., et al. (2018) HIT-ing the Crisis on Its Head: Examining the Use of Health Information Technology to Change Opiate Prescribing Practices [PowerPoint Slides]. Retrieved from: https://8c00cf55b4d710b367a6-1b5311869a16b9ad87a739ea0c86498b.ssl.cf1.rackcdn.com/679450.pdf
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Patient Education
• After Visit Summary• Opioid information• Safety plan• Resources
https://www.cdc.gov/drugoverdose/patients/materials.html
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Pharmacy Controlled Substance Policy
• What information should you require from the patient?• Will you only fill prescriptions within a certain mile radius?• When should you check the PMP?• Will you require diagnosis codes to document medical
necessity?• What do you do for an early refill? What about habitual early
refills?
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Resources
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Substance Abuse Treatment Services
• There are a number of treatment facilities in Mississippi• Medication-assisted treatment
• Methadone• Buprenorphine• Naltrexone
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Other Preventative Efforts
• Community Groups• School-based programs• Pain Management Support Groups• Special use of drug diversion law enforcement• Tool kits from other institutions
• http://www.safemedia.org/• Stakeholder involvement
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Medication Disposal
• Partner with your local law enforcement for National Drug Take Back Day – April 27, 2019 from 10AM-2PM
• Register as a DEA authorized collector• http://www.deadiversion.usdoj.gov/index.html• Registrations Tab• “Registration for Disposal of Controlled Substances”
• DEA Number• Business Name• SSN• Tax ID• Zip Code• Current DEA Expiration Date
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Medication Disposal
• Collection Receptacle Options• MedSafe• WasteManagement• Stericycle• CleanHarbors
• Requirements of a receptacle• Securely placed and maintained• Securely locked• Permanent outer container and removable inner liner• Removable inner liner must have a unique ID number that can be tracked
Drug Enforcement Agency – http://www.deadiversion.usdoj.gov/
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Audience Poll: Which of the following medications is recommended to flush down the toilet if other
disposal options are not available?
A. lorazepamB. carisoprodolC. oxycodoneD. A, B, and CE. none of the above
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A. lorazepamB. carisoprodolC. oxycodoneD. A, B, and CE. none of the above
Audience Poll: Which of the following medications is recommended to flush down the toilet if other
disposal options are not available?
https://www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/ensuringsafeuseofmedicine/safedisposalofmedicines/ucm186187.htm#Medicines_recommended
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Medication Safety at Home
• Medication Disposal• Mix medications in an undesirable substance (coffee grounds, kitty litter) in a
plastic bag in the trash• Narcotics should be flushed down the toilet as they are especially harmful and
the benefits of getting rid of them outweighs the potential risk to the water supply
• Be sure patients keep medications in a cool, dry place • Out of reach of children• In a lockbox• In the original, labeled container
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Increased access to Naloxone
• Proactive approach to the failure to prevent opioid overdoses
• CDC recommended guidelines for use
• Utilization of a standing order
• Encourage local law enforcement/first responders to possess
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Naloxone
• Naloxone is a pure opioid antagonist
• Available as IV, IM, nasal spray, auto-injector
• Indicated for the “complete or partial reversal of opioid depression (including respiratory depression) induced by natural and synthetic opioids.”
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CDC Guidelines for Naloxone use
• History of overdose• History of substance use disorder• Taking benzodiazepines with opioids• At risk for returning to high dose to which they are no longer
tolerant (recently released from incarceration)• Taking higher than 50 morphine mg equivalents per day
Dowell D, Haegerich TM, Chou R. CDC Guideline for Prescribing Opioids for Chronic Pain — United States, 2016. MMWR Recomm Rep 2016;65(No. RR-1):1–49. DOI: http://dx.doi.org/10.15585/mmwr.rr6501e1
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Signs of an Opioid Overdose
• Softened breathing or breathing that has stopped altogether; also shallow breathing
• Blue or purple lips or fingernails• Unresponsive to outside stimuli• Inability to respond• Pinpoint pupils
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What to do in an overdose situation
• Attempt to wake the individual• If the person isn’t breathing, do rescue breathing for 3-4 breaths
first• Prepare the naloxone for use and administer • Call 911• If the person isn’t breathing, continue to perform rescue breaths or
CPR (if trained) while waiting for the naloxone to take effect• After 3 minutes, if no change, administer a second dose of naloxone
as above and continue rescue breathing until help arrives• If you must leave the person for any reason, place them in the
recovery position
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Rescue Breathing
• Make sure nothing is in the person’s mouth• Tilt the head back, lift the chin, and pinch nose shut• Give one slow breath every 5 seconds
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Recovery Position
• Position the person’s arm farthest from you across the person’s body and the arm closest to you above the head
• Grasp the person at the shoulder and hips and roll them towards you
• Bend both legs so the person is stabilized with the top knee out in front a few inches
• Tilt the head back to make sure their airway is open
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Narcan (naloxone) Nasal Spray
• Narcan is a nasal spray • Available as 4mg• To use:
• Remove Narcan from the foil packaging• Place fingers on either side of the nozzle• Place the nozzle in one nostril only• Depress the plunger to administer the full
dose• Use a new device to give additional dose if
necessarily in the other nostril
Narcan Nasal Spray - https://www.narcan.com/pharmacists/pharmacist-role
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naloxone for nasal use
http://harmreduction.org/issues/overdose-prevention/tools-best-practices/od-kit-materials/
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Evzio (naloxone) for auto-injection
• Evzio is a naloxone auto-injector with voice guidance• Available as 2mg • To use:
• Pull Evzio from the outer case• Pull off the red safety guard• Place the black end against the middle of the victim’s outer
thigh (does not require removal of clothing)• Press firmly for 5 seconds after you hear the click and hiss sound
• Each Evzio kit comes with a trainer for practice
Evzio auto-injector http://www.evzio.com/hcp/
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Naloxone
• Potential Side Effects/Symptoms of opioid withdrawal:• Anxiousness/nervousness• Body aches• Fever• Runny nose• N/V/D• Increased blood pressure
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Mississippi House Bill 996
“Emergency Response and Overdose Prevention Act”
“A practitioner acting in good faith and in compliance with the standard of care applicable to that practitioner may issue a standing order to one or more individual pharmacies that authorizes the pharmacy to dispense an opioid antagonist to a person at risk of experiencing an opioid-related overdose or to a family member, friend or other person in a position to assist such person at risk of experiencing an opioid-related overdose, without the person to whom the opioid antagonist is dispensed needing to have an individual prescription.”
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Statewide Standing Order
• A standing order is a written agreement between a medical practitioner and a pharmacy or pharmacist that authorizes the non-prescribing provider to dispense and/or administer naloxone to a patient without an individual prescription
• Should have the following (at a minimum):• Criteria for dispensing • Product to be dispensed• Signatures of participating physician(s) and pharmacist(s)• Method of tracking product dispensed
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Good Samaritan Law
"No duly licensed, practicing physician, physician assistant, dentist, registered nurse, licensed practical nurse, certified registered emergency medical technician, or any other person who, in good faith and in the exercise of reasonable care, renders emergency care to any injured person at the scene of an emergency, or in transporting the injured person to a point where medical assistance can be reasonably expected, shall be liable for any civil damages to the injured person as a result of any acts committed in good faith and in the exercise of reasonable care or omissions in good faith and in the exercise of reasonable care by such persons in rendering the emergency care to the injured person."
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Good Samaritan Law
• Anyone who administers naloxone to a person in good faith is immune from civil or criminal charges
• Physicians are authorized to prescribe naloxone to those in a position to assist a person at risk for an opiate-related overdose
• The Bottom Line: Do not fear any retribution in helping someone who is in dire need of medical attention, you are not liable for anything that may go wrong in the attempt to take care of this individual.
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Communicating with Patients
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Communicating with Patients
• Be empathetic
• Be non-threatening and non-accusatory
• Use objective facts• Pain scores over time• Functional change over time• Presence of adverse effects• Risk of overdose or addiction
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Communicating with Patients
• Explain your reasoning in a neutral tone
• Keep the patient in perspective
“I want to provide the best care for you”
“I can only dispense medications when it can be done safely”
“It looks like opioids are not working well for you” or “I have noticed that you are on a high dose of opioids and having side effects, although your pain is not being well managed”
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Communicating with Patients
• Ask open-ended questions
• Use active listening
• Include written information
• Summarize for clarification• “It sounds like you are saying the pain makes you feel
edgy”
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Conclusion
• Implementing an opioid stewardship program will require a multidisciplinary approach
• Make your technology work for you!
• Active and engaging communications with both patients and providers is essential
• Naloxone administration for emergent situations can save a life!
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• CDC Guideline for Prescribing for Chronic Pain
• VA/DoD Guidelines for Opioid Therapy for Chronic Pain
• National Quality Partners Opioid Stewardship Playbook
• National Institutes of Health National Pain Strategy
• Joint Commission 2018 Pain Assessment and Management Standards
Guidelines
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Questions?
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Opioid Stewardship and Overdose Prevention
Jordan Marie Ballou, PharmD, BCACPClinical Assistant Professor of Pharmacy Practice
Melissa Reilly, PharmD, BCGPClinical Assistant Professor of Pharmacy Practice
Preceptor Conference 2019