ntp.niehs.nih.govntp.niehs.nih.gov/ntp-db/NTP_Reports/NTP_Pathology_Tbls/88133_tables/... · C...
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C Number: C88133C Lock Date: 10/30/2007 Cage Range: ALL Date Range: ALL Reasons For Removal: ALL Removal Date Range: ALL Treatment Groups: Include ALL Study Gender: Both TDMSE Version: 2.2.0 TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010 Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41 Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05 Species/Strain: RATS/F 344/N Lab: SRI
Transcript of ntp.niehs.nih.govntp.niehs.nih.gov/ntp-db/NTP_Reports/NTP_Pathology_Tbls/88133_tables/... · C...
C Number: C88133C
Lock Date: 10/30/2007
Cage Range: ALL
Date Range: ALL
Reasons For Removal: ALL
Removal Date Range: ALL
Treatment Groups: Include ALL
Study Gender: Both
TDMSE Version: 2.2.0
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
DAY ON TEST
FISCHER 344 RATS MALE
0366
0015
0729
0015
0659
0730
0731
0674
0366
0729
0730
0731
0680
0366
0730
0550
0730
0366
0729
0591
0704
0702
0091
0730
0366
0 MG/KGANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020
00021
00022
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males(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + M + + + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + +Leukemia Mononuclear
Intestine Large, Colon + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + + + + + I + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + + +
Intestine Small, Ileum + A + + + + + + + + + + + + + + +
Intestine Small, Jejunum + A + + + + + + + + + + + + + + +
Liver + + + + + + + + + + + + + + + + +Hepatocellular Adenoma, MultipleHepatocellular CarcinomaLeukemia Mononuclear X X X X X X X X X X
Mesentery + + + + + +Osteosarcoma, Metastatic, Bone
Pancreas + + + + + + + + + + + + + + + + +Leukemia Mononuclear XMixed Tumor BenignAcinus, Adenoma
Salivary Glands + + + + + + + + + + + + + + + + +
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 2
DAY ON TEST
FISCHER 344 RATS MALE
0366
0015
0729
0015
0659
0730
0731
0674
0366
0729
0730
0731
0680
0366
0730
0550
0730
0366
0729
0591
0704
0702
0091
0730
0366
0 MG/KGANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020
00021
00022
00023
00024
00025
males(cont...)
CarcinomaLeukemia Mononuclear X
Stomach, Forestomach + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
Stomach, Glandular + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
Tongue +Squamous Cell Papilloma X
CARDIOVASCULAR SYSTEM
Blood Vessel +
Heart + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + +AdenomaLeukemia Mononuclear X X XOsteosarcoma, Metastatic, Bone
Adrenal Medulla + + + + + + + + + + + + + + + + +Leukemia Mononuclear XPheochromocytoma Benign X X X XPheochromocytoma Benign, Multiple X XPheochromocytoma Malignant
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 3
DAY ON TEST
FISCHER 344 RATS MALE
0366
0015
0729
0015
0659
0730
0731
0674
0366
0729
0730
0731
0680
0366
0730
0550
0730
0366
0729
0591
0704
0702
0091
0730
0366
0 MG/KGANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020
00021
00022
00023
00024
00025
males(cont...)
Islets, Pancreatic + + + + + + + + + + + + + + + + +Adenoma X X X X X XAdenoma, Multiple X
Parathyroid Gland + M + + + + + + M + + + + + + + +
Pituitary Gland + + + + + + + + A + + + + + + + +Leukemia Mononuclear XPars Distalis, Adenoma X X X X X X X X X X X X XPars Distalis, Adenoma, Multiple
Thyroid Gland + + + + + + + + + + + + + + + + +C-cell, Adenoma X XC-cell, Carcinoma
GENERAL BODY SYSTEM
Tissue NOSOsteosarcoma, Metastatic, Bone
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + +Leukemia Mononuclear
Preputial Gland + + + + + + + + + + + + + + + + +Adenoma
Prostate + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 4
DAY ON TEST
FISCHER 344 RATS MALE
0366
0015
0729
0015
0659
0730
0731
0674
0366
0729
0730
0731
0680
0366
0730
0550
0730
0366
0729
0591
0704
0702
0091
0730
0366
0 MG/KGANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020
00021
00022
00023
00024
00025
males(cont...)
Seminal Vesicle + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
Testes + + + + + + + + + + + + + + + + +Bilateral, Interstitial Cell, Adenoma X X X XInterstitial Cell, Adenoma X X X X X X X
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + A + +Leukemia Mononuclear X X X X X X XOsteosarcoma, Metastatic, Bone
Lymph Node + + + + + + + +Osteosarcoma, Metastatic, BoneDeep Cervical, Leukemia MononuclearMediastinal, Leukemia Mononuclear X X X XPancreatic, Leukemia Mononuclear X X X X
Lymph Node, Mandibular M M M M M M M M M M M + M + M M MLeukemia Mononuclear
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X X X
Spleen + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X X X X X X X
Thymus + + + + + + + + M + + + + + + + MLeukemia Mononuclear X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 5
DAY ON TEST
FISCHER 344 RATS MALE
0366
0015
0729
0015
0659
0730
0731
0674
0366
0729
0730
0731
0680
0366
0730
0550
0730
0366
0729
0591
0704
0702
0091
0730
0366
0 MG/KGANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020
00021
00022
00023
00024
00025
males(cont...)
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + +Fibroadenoma X
Skin + + + + + + + + + + + + + + + + +Keratoacanthoma XKeratoacanthoma, Multiple XSquamous Cell PapillomaSubcutaneous Tissue, Fibroma X XSubcutaneous Tissue, Lipoma X
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + +Osteosarcoma X
Skeletal MuscleOsteosarcoma, Metastatic, Bone
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
Peripheral Nerve
Spinal Cord
RESPIRATORY SYSTEM
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 6
DAY ON TEST
FISCHER 344 RATS MALE
0366
0015
0729
0015
0659
0730
0731
0674
0366
0729
0730
0731
0680
0366
0730
0550
0730
0366
0729
0591
0704
0702
0091
0730
0366
0 MG/KGANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020
00021
00022
00023
00024
00025
males(cont...)
Lung + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Adenoma, MultipleCarcinomaLeukemia Mononuclear X X X X X XOsteosarcoma, Metastatic, Bone X
Nose + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + +
Zymbal's Gland +Adenoma X
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + +Leukemia Mononuclear XOsteosarcoma, Metastatic, Bone
Urinary Bladder + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + +
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 7
DAY ON TEST
FISCHER 344 RATS MALE
0366
0015
0729
0015
0659
0730
0731
0674
0366
0729
0730
0731
0680
0366
0730
0550
0730
0366
0729
0591
0704
0702
0091
0730
0366
0 MG/KGANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020
00021
00022
00023
00024
00025
males(cont...)
Leukemia Mononuclear X X X X X X X X X X X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 8
DAY ON TEST
FISCHER 344 RATS MALE
0729
0439
0606
0015
0729
0676
0729
0702
0625
0015
0635
0091
0622
0731
0504
0581
0606
0730
0730
0567
0702
0015
0091
0652
0731
0 MG/KGANIMAL ID
00026
00027
00028
00029
00030
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050
males(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + M + + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + +
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + +
Intestine Small, Jejunum + + + + + + + + + + + + + + + + A + + +
Liver + + + + + + + + + + + + + + + + + + + +Hepatocellular Adenoma, Multiple XHepatocellular CarcinomaLeukemia Mononuclear X X X X X X X X
Mesentery + + + + + +Osteosarcoma, Metastatic, Bone X
Pancreas + + + + + + + + + + + + + + + + + + + +Leukemia MononuclearMixed Tumor Benign XAcinus, Adenoma
Salivary Glands + + + + + + + + + + + + + + + + + + + +
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 9
DAY ON TEST
FISCHER 344 RATS MALE
0729
0439
0606
0015
0729
0676
0729
0702
0625
0015
0635
0091
0622
0731
0504
0581
0606
0730
0730
0567
0702
0015
0091
0652
0731
0 MG/KGANIMAL ID
00026
00027
00028
00029
00030
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050
males(cont...)
CarcinomaLeukemia Mononuclear
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
Stomach, Glandular + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
TongueSquamous Cell Papilloma
CARDIOVASCULAR SYSTEM
Blood Vessel
Heart + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + +Adenoma XLeukemia Mononuclear X X XOsteosarcoma, Metastatic, Bone X
Adrenal Medulla + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X XPheochromocytoma Benign X XPheochromocytoma Benign, MultiplePheochromocytoma Malignant X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 10
DAY ON TEST
FISCHER 344 RATS MALE
0729
0439
0606
0015
0729
0676
0729
0702
0625
0015
0635
0091
0622
0731
0504
0581
0606
0730
0730
0567
0702
0015
0091
0652
0731
0 MG/KGANIMAL ID
00026
00027
00028
00029
00030
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050
males(cont...)
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + +Adenoma X X X X X X XAdenoma, Multiple
Parathyroid Gland M + + + + + + + + + + + + + + + + + + +
Pituitary Gland + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear XPars Distalis, Adenoma X X X X X X X X X X X XPars Distalis, Adenoma, Multiple
Thyroid Gland + + + + + + + + + + + + + + + + + + + +C-cell, Adenoma X X X XC-cell, Carcinoma
GENERAL BODY SYSTEM
Tissue NOS +Osteosarcoma, Metastatic, Bone X
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
Preputial Gland + + + + + + + + + + + + + + + + + + + +Adenoma X X X
Prostate + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 11
DAY ON TEST
FISCHER 344 RATS MALE
0729
0439
0606
0015
0729
0676
0729
0702
0625
0015
0635
0091
0622
0731
0504
0581
0606
0730
0730
0567
0702
0015
0091
0652
0731
0 MG/KGANIMAL ID
00026
00027
00028
00029
00030
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050
males(cont...)
Seminal Vesicle + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
Testes + + + + + + + + + + + + + + + + + + + +Bilateral, Interstitial Cell, Adenoma X X XInterstitial Cell, Adenoma X X X X X X X
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X XOsteosarcoma, Metastatic, Bone X
Lymph Node + + + + + + + +Osteosarcoma, Metastatic, Bone XDeep Cervical, Leukemia Mononuclear XMediastinal, Leukemia Mononuclear X X XPancreatic, Leukemia Mononuclear X
Lymph Node, Mandibular M + M M M M M M M M M M M M M M M M M MLeukemia Mononuclear
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X X
Spleen + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X X X X
Thymus + + M + + + I + + + + + + + + I + + + +Leukemia Mononuclear X X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 12
DAY ON TEST
FISCHER 344 RATS MALE
0729
0439
0606
0015
0729
0676
0729
0702
0625
0015
0635
0091
0622
0731
0504
0581
0606
0730
0730
0567
0702
0015
0091
0652
0731
0 MG/KGANIMAL ID
00026
00027
00028
00029
00030
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050
males(cont...)
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + +Fibroadenoma
Skin + + + + + + + + + + + + + + + + + + + +Keratoacanthoma XKeratoacanthoma, MultipleSquamous Cell PapillomaSubcutaneous Tissue, Fibroma XSubcutaneous Tissue, Lipoma X
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + +Osteosarcoma X
Skeletal Muscle + +Osteosarcoma, Metastatic, Bone X
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X
Peripheral Nerve + +
Spinal Cord + +
RESPIRATORY SYSTEM
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 13
DAY ON TEST
FISCHER 344 RATS MALE
0729
0439
0606
0015
0729
0676
0729
0702
0625
0015
0635
0091
0622
0731
0504
0581
0606
0730
0730
0567
0702
0015
0091
0652
0731
0 MG/KGANIMAL ID
00026
00027
00028
00029
00030
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050
males(cont...)
Lung + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Adenoma, Multiple XCarcinomaLeukemia Mononuclear X X X X XOsteosarcoma, Metastatic, Bone X
Nose + + + + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + + + + +
Zymbal's GlandAdenoma
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X XOsteosarcoma, Metastatic, Bone X
Urinary Bladder + + + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + +
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 14
DAY ON TEST
FISCHER 344 RATS MALE
0729
0439
0606
0015
0729
0676
0729
0702
0625
0015
0635
0091
0622
0731
0504
0581
0606
0730
0730
0567
0702
0015
0091
0652
0731
0 MG/KGANIMAL ID
00026
00027
00028
00029
00030
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050
males(cont...)
Leukemia Mononuclear X X X X X X X X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 15
DAY ON TEST
FISCHER 344 RATS MALE
0091
0708
0704
0693
0730
0729
0730
0690
0730
0091
0674
0730
0669
0729
0674
0 MG/KGANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060
00061
00062
00063
00064
00065 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + 48
Intestine Large, Cecum + + + + + + + + + + + + + 50Leukemia Mononuclear X 1
Intestine Large, Colon + + + + + + + + + + + + + 50
Intestine Large, Rectum + + + + + + + + + + + + + 49
Intestine Small, Duodenum + + + + + + + + + + + + + 50
Intestine Small, Ileum + + + + + + + + + + + + + 49
Intestine Small, Jejunum + + + + + + + + + + + + + 48
Liver + + + + + + + + + + + + + 50Hepatocellular Adenoma, Multiple 1Hepatocellular Carcinoma X 1Leukemia Mononuclear X X X X X X X 25
Mesentery + + + + + + 18Osteosarcoma, Metastatic, Bone 1
Pancreas + + + + + + + + + + + + + 50Leukemia Mononuclear 1Mixed Tumor Benign 1Acinus, Adenoma X 1
Salivary Glands + + + + + + + + + + + + + 50
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 16
DAY ON TEST
FISCHER 344 RATS MALE
0091
0708
0704
0693
0730
0729
0730
0690
0730
0091
0674
0730
0669
0729
0674
0 MG/KGANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060
00061
00062
00063
00064
00065 * TOTALS
Carcinoma X 1Leukemia Mononuclear 1
Stomach, Forestomach + + + + + + + + + + + + + 50Leukemia Mononuclear 1
Stomach, Glandular + + + + + + + + + + + + + 50Leukemia Mononuclear X 2
Tongue 1Squamous Cell Papilloma 1
CARDIOVASCULAR SYSTEM
Blood Vessel 1
Heart + + + + + + + + + + + + + 50Leukemia Mononuclear X X 5
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + 50Adenoma 1Leukemia Mononuclear X X X X 10Osteosarcoma, Metastatic, Bone 1
Adrenal Medulla + + + + I + + + + + + + + 49Leukemia Mononuclear X X X 7Pheochromocytoma Benign X 7Pheochromocytoma Benign, Multiple X X 4Pheochromocytoma Malignant 1
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 17
DAY ON TEST
FISCHER 344 RATS MALE
0091
0708
0704
0693
0730
0729
0730
0690
0730
0091
0674
0730
0669
0729
0674
0 MG/KGANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060
00061
00062
00063
00064
00065 * TOTALS
Islets, Pancreatic + + + + + + + + + + + + + 50Adenoma X X 15Adenoma, Multiple X X 3
Parathyroid Gland + M + + + + + + + + M + + 45
Pituitary Gland + + + + + + + + + + + + + 49Leukemia Mononuclear X X X 5Pars Distalis, Adenoma X X X X X X X 32Pars Distalis, Adenoma, Multiple X X 2
Thyroid Gland + + + + + + + + + + + + + 50C-cell, Adenoma X X 8C-cell, Carcinoma X 1
GENERAL BODY SYSTEM
Tissue NOS 1Osteosarcoma, Metastatic, Bone 1
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + 50Leukemia Mononuclear 1
Preputial Gland + + + + + + + + + + + + + 50Adenoma 3
Prostate + + + + + + + + + + + + + 50Leukemia Mononuclear 1
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 18
DAY ON TEST
FISCHER 344 RATS MALE
0091
0708
0704
0693
0730
0729
0730
0690
0730
0091
0674
0730
0669
0729
0674
0 MG/KGANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060
00061
00062
00063
00064
00065 * TOTALS
Seminal Vesicle + + + + + + + + + + + + + 50Leukemia Mononuclear 1
Testes + + + + + + + + + + + + + 50Bilateral, Interstitial Cell, Adenoma X 8Interstitial Cell, Adenoma X X X X X 19
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + 49Leukemia Mononuclear X X X X X X 18Osteosarcoma, Metastatic, Bone 1
Lymph Node + + + + 20Osteosarcoma, Metastatic, Bone 1Deep Cervical, Leukemia Mononuclear 1Mediastinal, Leukemia Mononuclear X X 9Pancreatic, Leukemia Mononuclear X X X 8
Lymph Node, Mandibular + M M M M M M M M M M M M 4Leukemia Mononuclear X 1
Lymph Node, Mesenteric + + + + + + + + + + + + + 50Leukemia Mononuclear X X X X X 18
Spleen + + + + + + + + + + + + + 50Leukemia Mononuclear X X X X X X X 26
Thymus + + + + + + + + + + + + + 45Leukemia Mononuclear X X X 6
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 19
DAY ON TEST
FISCHER 344 RATS MALE
0091
0708
0704
0693
0730
0729
0730
0690
0730
0091
0674
0730
0669
0729
0674
0 MG/KGANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060
00061
00062
00063
00064
00065 * TOTALS
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + 50Fibroadenoma 1
Skin + + + + + + + + + + + + + 50Keratoacanthoma X 3Keratoacanthoma, Multiple 1Squamous Cell Papilloma X 1Subcutaneous Tissue, Fibroma X 4Subcutaneous Tissue, Lipoma 2
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + 50Osteosarcoma 2
Skeletal Muscle 2Osteosarcoma, Metastatic, Bone 1
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + 50Leukemia Mononuclear X 4
Peripheral Nerve 2
Spinal Cord 2
RESPIRATORY SYSTEM
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 20
DAY ON TEST
FISCHER 344 RATS MALE
0091
0708
0704
0693
0730
0729
0730
0690
0730
0091
0674
0730
0669
0729
0674
0 MG/KGANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060
00061
00062
00063
00064
00065 * TOTALS
Lung + + + + + + + + + + + + + 50Alveolar/Bronchiolar Adenoma, Multiple 1Carcinoma X 1Leukemia Mononuclear X X X X X X X 18Osteosarcoma, Metastatic, Bone 2
Nose + + + + + + + + + + + + + 50
Trachea + + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + 50
Harderian Gland + + + + + + + + + + + + + 50
Zymbal's Gland 1Adenoma 1
URINARY SYSTEM
Kidney + + + + + + + + + + + + + 50Leukemia Mononuclear X X 6Osteosarcoma, Metastatic, Bone 1
Urinary Bladder + + + + + + + + + + + + + 50
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + 50
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 21
DAY ON TEST
FISCHER 344 RATS MALE
0091
0708
0704
0693
0730
0729
0730
0690
0730
0091
0674
0730
0669
0729
0674
0 MG/KGANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060
00061
00062
00063
00064
00065 * TOTALS
Leukemia Mononuclear X X X X X X X 26
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 22
DAY ON TEST
FISCHER 344 RATS MALE
0015
0729
0730
0552
0674
0318
0366
0670
0669
0015
0669
0730
0730
0317
0091
0015
0587
0652
0366
0279
0366
0511
0730
0366
0730
0.3 MG/KGANIMAL ID
00066
00067
00068
00069
00070
00071
00072
00073
00074
00075
00076
00077
00078
00079
00080
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090
males(cont...)
ALIMENTARY SYSTEM
Esophagus + + M + + + + + + + + + + + + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + +
Intestine Large, Colon + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + I + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + A + + +
Intestine Small, Ileum + + + + A + + + + + A + + + + + +
Intestine Small, Jejunum + + A + + A + + + + A A + A + + +
Liver + + + + + + + + + + + + + + + + +Hepatocellular Adenoma, Multiple XLeukemia Mononuclear X X X X X X
Mesentery + + +Leukemia MononuclearMesothelioma Malignant
Pancreas + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
Salivary Glands + + + + + + + + + + + + + + + + +
Stomach, Forestomach + + + + + + + + + + + + + + + + +
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 23
DAY ON TEST
FISCHER 344 RATS MALE
0015
0729
0730
0552
0674
0318
0366
0670
0669
0015
0669
0730
0730
0317
0091
0015
0587
0652
0366
0279
0366
0511
0730
0366
0730
0.3 MG/KGANIMAL ID
00066
00067
00068
00069
00070
00071
00072
00073
00074
00075
00076
00077
00078
00079
00080
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090
males(cont...)
Stomach, Glandular + + + + + + + + + + + + + + + + +
Tongue +
Tooth
CARDIOVASCULAR SYSTEM
Blood Vessel + +
Heart + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + +AdenomaLeukemia Mononuclear X
Adrenal Medulla + + + + + + + + + + + + + + + + +Leukemia Mononuclear XPheochromocytoma Benign X X XPheochromocytoma Benign, Multiple XPheochromocytoma Malignant X X
Islets, Pancreatic + + + + + + + + + + + + + + + + +Adenoma X X X X X XAdenoma, Multiple X
Parathyroid Gland + + + + + + + + + + + + + + + + +
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 24
DAY ON TEST
FISCHER 344 RATS MALE
0015
0729
0730
0552
0674
0318
0366
0670
0669
0015
0669
0730
0730
0317
0091
0015
0587
0652
0366
0279
0366
0511
0730
0366
0730
0.3 MG/KGANIMAL ID
00066
00067
00068
00069
00070
00071
00072
00073
00074
00075
00076
00077
00078
00079
00080
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090
males(cont...)
Pituitary Gland + + + + + + + + + + + + + + + + +Leukemia Mononuclear XPars Distalis, Adenoma X X X X X X X X X X X X X XPars Distalis, Adenoma, Multiple
Thyroid Gland + + + + + + + + + + + + + + + + +C-cell, AdenomaC-cell, Carcinoma X
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + +
Preputial Gland + + + + + + + + + + + + + + + + +Adenoma XCarcinoma X
Prostate + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
Seminal Vesicle + + + + + + + + + + + + + + + + +
Testes + + + + + + + + + + + + + + + + +Bilateral, Interstitial Cell, Adenoma X X XInterstitial Cell, Adenoma X X X X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 25
DAY ON TEST
FISCHER 344 RATS MALE
0015
0729
0730
0552
0674
0318
0366
0670
0669
0015
0669
0730
0730
0317
0091
0015
0587
0652
0366
0279
0366
0511
0730
0366
0730
0.3 MG/KGANIMAL ID
00066
00067
00068
00069
00070
00071
00072
00073
00074
00075
00076
00077
00078
00079
00080
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090
males(cont...)
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X
Lymph Node + + + +Deep Cervical, Leukemia Mononuclear XMediastinal, Leukemia Mononuclear XPancreatic, Leukemia Mononuclear X X
Lymph Node, Mandibular M M M M M M M M M M M M M M M M M
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X
Spleen + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X X XLymphoma Malignant X
Thymus + + + + + + + + + + + + M + + + +Leukemia Mononuclear X
INTEGUMENTARY SYSTEM
Mammary Gland + + + M + + + + + + + + + + + + +CarcinomaFibroadenoma X
Skin + + + + + + + + + + + + + + + + +Basal Cell Adenoma XBasal Cell Carcinoma
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 26
DAY ON TEST
FISCHER 344 RATS MALE
0015
0729
0730
0552
0674
0318
0366
0670
0669
0015
0669
0730
0730
0317
0091
0015
0587
0652
0366
0279
0366
0511
0730
0366
0730
0.3 MG/KGANIMAL ID
00066
00067
00068
00069
00070
00071
00072
00073
00074
00075
00076
00077
00078
00079
00080
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090
males(cont...)
Keratoacanthoma XTrichoepitheliomaSubcutaneous Tissue, Fibroma XSubcutaneous Tissue, Lipoma XSubcutaneous Tissue, Schwannoma Benign X
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + +
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + +
Peripheral Nerve
Spinal Cord
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Carcinoma XLeukemia Mononuclear X X X
Nose + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + +
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 27
DAY ON TEST
FISCHER 344 RATS MALE
0015
0729
0730
0552
0674
0318
0366
0670
0669
0015
0669
0730
0730
0317
0091
0015
0587
0652
0366
0279
0366
0511
0730
0366
0730
0.3 MG/KGANIMAL ID
00066
00067
00068
00069
00070
00071
00072
00073
00074
00075
00076
00077
00078
00079
00080
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090
males(cont...)
Harderian Gland + + + + + + + + + + + + + + + + +
Zymbal's GlandCarcinoma
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + +Leukemia Mononuclear XNephroblastoma XRenal Tubule, Carcinoma X
Urinary Bladder + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X X XLymphoma Malignant XMesothelioma Malignant
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 28
DAY ON TEST
FISCHER 344 RATS MALE
0529
0674
0729
0015
0365
0730
0663
0577
0091
0655
0472
0543
0091
0729
0730
0366
0729
0591
0729
0015
0730
0729
0669
0704
0443
0.3 MG/KGANIMAL ID
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100
00101
00102
00103
00104
00105
00106
00107
00108
00109
00110
00111
00112
00113
00114
00115
males(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + +
Intestine Large, Colon + M + + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + +
Intestine Small, Ileum + + + + + + + + + + + + + M + + + + + +
Intestine Small, Jejunum A + + + + + + + + + + + + + + + + + + +
Liver + + + + + + + + + + + + + + + + + + + +Hepatocellular Adenoma, MultipleLeukemia Mononuclear X X X X X X
Mesentery + + + + +Leukemia Mononuclear XMesothelioma Malignant X X
Pancreas + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
Salivary Glands + + + + + + + + + + + + + + + + + + + +
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + +
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 29
DAY ON TEST
FISCHER 344 RATS MALE
0529
0674
0729
0015
0365
0730
0663
0577
0091
0655
0472
0543
0091
0729
0730
0366
0729
0591
0729
0015
0730
0729
0669
0704
0443
0.3 MG/KGANIMAL ID
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100
00101
00102
00103
00104
00105
00106
00107
00108
00109
00110
00111
00112
00113
00114
00115
males(cont...)
Stomach, Glandular + + + + + + + + + + + + + + + + + + + +
Tongue
Tooth
CARDIOVASCULAR SYSTEM
Blood Vessel
Heart + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + +AdenomaLeukemia Mononuclear X X
Adrenal Medulla + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear XPheochromocytoma Benign X X XPheochromocytoma Benign, MultiplePheochromocytoma Malignant
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + +Adenoma X XAdenoma, Multiple X
Parathyroid Gland + + + M + + + + + + + + + M + + + + + +
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 30
DAY ON TEST
FISCHER 344 RATS MALE
0529
0674
0729
0015
0365
0730
0663
0577
0091
0655
0472
0543
0091
0729
0730
0366
0729
0591
0729
0015
0730
0729
0669
0704
0443
0.3 MG/KGANIMAL ID
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100
00101
00102
00103
00104
00105
00106
00107
00108
00109
00110
00111
00112
00113
00114
00115
males(cont...)
Pituitary Gland + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear XPars Distalis, Adenoma X X X X X X X X X X X X X X X X XPars Distalis, Adenoma, Multiple
Thyroid Gland + + + + + + + + + + + + + + + + + + + +C-cell, Adenoma XC-cell, Carcinoma
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + + + +
Preputial Gland + + + + + + + + + + + + + + + + + + + +Adenoma XCarcinoma
Prostate + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
Seminal Vesicle + + + + + + + + + + + + + + + + + + + +
Testes + + + + + + + + + + + + + + + + + + + +Bilateral, Interstitial Cell, Adenoma XInterstitial Cell, Adenoma X X X X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 31
DAY ON TEST
FISCHER 344 RATS MALE
0529
0674
0729
0015
0365
0730
0663
0577
0091
0655
0472
0543
0091
0729
0730
0366
0729
0591
0729
0015
0730
0729
0669
0704
0443
0.3 MG/KGANIMAL ID
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100
00101
00102
00103
00104
00105
00106
00107
00108
00109
00110
00111
00112
00113
00114
00115
males(cont...)
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X X
Lymph Node + + + + + + + + + +Deep Cervical, Leukemia MononuclearMediastinal, Leukemia Mononuclear X XPancreatic, Leukemia Mononuclear X X X
Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X
Spleen + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X XLymphoma Malignant
Thymus + M + + + I + + M + + + + + + + + + M +Leukemia Mononuclear
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + +Carcinoma XFibroadenoma X
Skin + + + + + + + + + + + + + + + + + + + +Basal Cell AdenomaBasal Cell Carcinoma X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 32
DAY ON TEST
FISCHER 344 RATS MALE
0529
0674
0729
0015
0365
0730
0663
0577
0091
0655
0472
0543
0091
0729
0730
0366
0729
0591
0729
0015
0730
0729
0669
0704
0443
0.3 MG/KGANIMAL ID
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100
00101
00102
00103
00104
00105
00106
00107
00108
00109
00110
00111
00112
00113
00114
00115
males(cont...)
Keratoacanthoma X XTrichoepitheliomaSubcutaneous Tissue, Fibroma XSubcutaneous Tissue, LipomaSubcutaneous Tissue, Schwannoma Benign
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + +
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + +
Peripheral Nerve +
Spinal Cord +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar CarcinomaLeukemia Mononuclear X X X
Nose + + + + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + +
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 33
DAY ON TEST
FISCHER 344 RATS MALE
0529
0674
0729
0015
0365
0730
0663
0577
0091
0655
0472
0543
0091
0729
0730
0366
0729
0591
0729
0015
0730
0729
0669
0704
0443
0.3 MG/KGANIMAL ID
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100
00101
00102
00103
00104
00105
00106
00107
00108
00109
00110
00111
00112
00113
00114
00115
males(cont...)
Harderian Gland + + + + + + + + + + + + + + + + + + + +
Zymbal's Gland + +Carcinoma X X
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X XNephroblastomaRenal Tubule, Carcinoma
Urinary Bladder + + + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X XLymphoma MalignantMesothelioma Malignant X X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 34
DAY ON TEST
FISCHER 344 RATS MALE
0652
0730
0730
0682
0122
0730
0582
0639
0091
0091
0697
0436
0535
0729
0682
0.3 MG/KGANIMAL ID
00116
00117
00118
00119
00120
00121
00122
00123
00124
00125
00126
00127
00128
00129
00130 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + 49
Intestine Large, Cecum + + + + + + + + + + + + + 50
Intestine Large, Colon + + + + + + + + + + + + + 49
Intestine Large, Rectum + + I + + + + + + + + + + 48
Intestine Small, Duodenum + + + + + + + + + + + + + 49
Intestine Small, Ileum + + + + + + + + + + + + + 47
Intestine Small, Jejunum + + + + + + + + + + + + + 44
Liver + + + + + + + + + + + + + 50Hepatocellular Adenoma, Multiple 1Leukemia Mononuclear X X X X 16
Mesentery + + + + + 13Leukemia Mononuclear X 2Mesothelioma Malignant 2
Pancreas + + + + + + + + + + + + + 50Leukemia Mononuclear 1
Salivary Glands + + + + + + + + + + + + + 50
Stomach, Forestomach + + + + + + + + + + + + + 50
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 35
DAY ON TEST
FISCHER 344 RATS MALE
0652
0730
0730
0682
0122
0730
0582
0639
0091
0091
0697
0436
0535
0729
0682
0.3 MG/KGANIMAL ID
00116
00117
00118
00119
00120
00121
00122
00123
00124
00125
00126
00127
00128
00129
00130 * TOTALS
Stomach, Glandular + + + + + + + + + + + + + 50
Tongue 1
Tooth + 1
CARDIOVASCULAR SYSTEM
Blood Vessel 2
Heart + + + + + + + + + + + + + 50Leukemia Mononuclear 3
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + 50Adenoma X 1Leukemia Mononuclear X X X 6
Adrenal Medulla + + + + + + + + + + + + + 50Leukemia Mononuclear X X 4Pheochromocytoma Benign X X 8Pheochromocytoma Benign, Multiple X X X 4Pheochromocytoma Malignant X 3
Islets, Pancreatic + + + + + + + + + + + + + 50Adenoma X X X X X 13Adenoma, Multiple X 3
Parathyroid Gland + + + M M + + + + + + + + 46
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 36
DAY ON TEST
FISCHER 344 RATS MALE
0652
0730
0730
0682
0122
0730
0582
0639
0091
0091
0697
0436
0535
0729
0682
0.3 MG/KGANIMAL ID
00116
00117
00118
00119
00120
00121
00122
00123
00124
00125
00126
00127
00128
00129
00130 * TOTALS
Pituitary Gland + + + + + + + + + + + + + 50Leukemia Mononuclear X 3Pars Distalis, Adenoma X X X X X X X X X 40Pars Distalis, Adenoma, Multiple X 1
Thyroid Gland + + + + + + + + + + + + + 50C-cell, Adenoma X 2C-cell, Carcinoma 1
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + 50
Preputial Gland + + + + + + + + + + + + + 50Adenoma 2Carcinoma 1
Prostate + + + + + + + + + + + + + 50Leukemia Mononuclear 1
Seminal Vesicle + + + + + + + + + + + + + 50
Testes + + + + + + + + + + + + + 50Bilateral, Interstitial Cell, Adenoma 4Interstitial Cell, Adenoma X X X X X 13
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 37
DAY ON TEST
FISCHER 344 RATS MALE
0652
0730
0730
0682
0122
0730
0582
0639
0091
0091
0697
0436
0535
0729
0682
0.3 MG/KGANIMAL ID
00116
00117
00118
00119
00120
00121
00122
00123
00124
00125
00126
00127
00128
00129
00130 * TOTALS
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + 50Leukemia Mononuclear X X X X 15
Lymph Node + + + + + + 20Deep Cervical, Leukemia Mononuclear 1Mediastinal, Leukemia Mononuclear X 4Pancreatic, Leukemia Mononuclear X X 7
Lymph Node, Mandibular M M M M M M M M M M M M M 0
Lymph Node, Mesenteric + + + + + + + + + + + + + 50Leukemia Mononuclear X X 11
Spleen + + + + + + + + + + + + + 50Leukemia Mononuclear X X X X 17Lymphoma Malignant 1
Thymus + + + + + + + + + + + + M 44Leukemia Mononuclear 1
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + 49Carcinoma 1Fibroadenoma X 3
Skin + + + + + I + + + + + + + 49Basal Cell Adenoma X X 3Basal Cell Carcinoma X 2
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 38
DAY ON TEST
FISCHER 344 RATS MALE
0652
0730
0730
0682
0122
0730
0582
0639
0091
0091
0697
0436
0535
0729
0682
0.3 MG/KGANIMAL ID
00116
00117
00118
00119
00120
00121
00122
00123
00124
00125
00126
00127
00128
00129
00130 * TOTALS
Keratoacanthoma X X 5Trichoepithelioma X 1Subcutaneous Tissue, Fibroma X X 4Subcutaneous Tissue, Lipoma 1Subcutaneous Tissue, Schwannoma Benign 1
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + 50
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + 50
Peripheral Nerve + + 3
Spinal Cord + + 3
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + 50Alveolar/Bronchiolar Carcinoma X 2Leukemia Mononuclear X X X 9
Nose + + + + + + + + + + + + + 50
Trachea + + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + 50
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 39
DAY ON TEST
FISCHER 344 RATS MALE
0652
0730
0730
0682
0122
0730
0582
0639
0091
0091
0697
0436
0535
0729
0682
0.3 MG/KGANIMAL ID
00116
00117
00118
00119
00120
00121
00122
00123
00124
00125
00126
00127
00128
00129
00130 * TOTALS
Harderian Gland + + + + + + + + + + + + + 50
Zymbal's Gland 2Carcinoma 2
URINARY SYSTEM
Kidney + + + + + + + + + + + + + 50Leukemia Mononuclear X X 5Nephroblastoma 1Renal Tubule, Carcinoma 1
Urinary Bladder + + + + + + + + + + + + + 50
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + 50Leukemia Mononuclear X X X X 17Lymphoma Malignant 1Mesothelioma Malignant 2
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 40
DAY ON TEST
FISCHER 344 RATS MALE
0730
0730
0729
0538
0091
0015
0729
0730
0465
0705
0485
0730
0693
0729
0091
0729
0091
0729
0015
0366
0626
0416
0598
0366
0729
1.0 MG/KGANIMAL ID
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140
00141
00142
00143
00144
00145
00146
00147
00148
00149
00150
00151
00152
00153
00154
00155
males(cont...)
ALIMENTARY SYSTEM
Esophagus + M + + + + + + + + + + + + + + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + + +
Intestine Large, Colon + + + + + + + + + + + + + + + + + +Adenoma X
Intestine Large, Rectum + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + +Lymphoma Malignant X
Intestine Small, Ileum + + + + + + + + + + + + + + M + + +Lymphoma Malignant X
Intestine Small, Jejunum + + + A + + A + + + + + + + + + + +
Liver + + + + + + + + + + + + + + + + + +Hepatocellular AdenomaLeukemia Mononuclear X X X XLymphoma Malignant X
Mesentery + + + + + +Lipoma XLymphoma Malignant XMesothelioma Malignant
Oral Mucosa
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 41
DAY ON TEST
FISCHER 344 RATS MALE
0730
0730
0729
0538
0091
0015
0729
0730
0465
0705
0485
0730
0693
0729
0091
0729
0091
0729
0015
0366
0626
0416
0598
0366
0729
1.0 MG/KGANIMAL ID
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140
00141
00142
00143
00144
00145
00146
00147
00148
00149
00150
00151
00152
00153
00154
00155
males(cont...)
Pancreas + + + + + + + + + + + + + + + + + +Leukemia Mononuclear XLymphoma Malignant XMixed Tumor Benign XAcinus, Adenoma X X XAcinus, Adenoma, Multiple
Salivary Glands + + + + + + + + + + + + + + + + + +
Stomach, Forestomach + + + + + + + + + + + + + + + + + +Leukemia Mononuclear XLymphoma Malignant X
Stomach, Glandular + + + + + + + + + + + + + + + + + +Leukemia Mononuclear XLymphoma Malignant X
CARDIOVASCULAR SYSTEM
Blood Vessel
Heart + + + + + + + + + + + + + + + + + +Fibrous Histiocytoma, Metastatic, Skeletal
MuscleX
Leukemia Mononuclear X
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 42
DAY ON TEST
FISCHER 344 RATS MALE
0730
0730
0729
0538
0091
0015
0729
0730
0465
0705
0485
0730
0693
0729
0091
0729
0091
0729
0015
0366
0626
0416
0598
0366
0729
1.0 MG/KGANIMAL ID
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140
00141
00142
00143
00144
00145
00146
00147
00148
00149
00150
00151
00152
00153
00154
00155
males(cont...)
Adrenal Medulla + + + + + + + + + + + + + + + + + +Leukemia Mononuclear XPheochromocytoma Benign XPheochromocytoma Benign, MultiplePheochromocytoma Malignant
Islets, Pancreatic + + + + + + + + + + + + + + + + + +Adenoma X X X X X
Parathyroid Gland + + + + + + + + M M + + + + + + + +
Pituitary Gland + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X XPars Distalis, Adenoma X X X X X X X X X XPars Distalis, Adenoma, Multiple X X XPars Distalis, Carcinoma X
Thyroid Gland + + + + + + + + + + + + + + + + + +C-cell, Adenoma X X
GENERAL BODY SYSTEM
Tissue NOS +FibromaFibrous Histiocytoma, Metastatic, Skeletal
MuscleX
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + +
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 43
DAY ON TEST
FISCHER 344 RATS MALE
0730
0730
0729
0538
0091
0015
0729
0730
0465
0705
0485
0730
0693
0729
0091
0729
0091
0729
0015
0366
0626
0416
0598
0366
0729
1.0 MG/KGANIMAL ID
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140
00141
00142
00143
00144
00145
00146
00147
00148
00149
00150
00151
00152
00153
00154
00155
males(cont...)
Preputial Gland + + + + + + + + + + + + + + + + + +Carcinoma XLeukemia Mononuclear
Prostate + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
Seminal Vesicle + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
Testes + + + + + + + + + + + + + + + + + +Bilateral, Interstitial Cell, Adenoma X X XInterstitial Cell, Adenoma X X X X
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X XLymphoma Malignant X
Lymph Node + + + + + +Mediastinal, Leukemia Mononuclear X XPancreatic, Leukemia Mononuclear X XPancreatic, Lymphoma Malignant X
Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X XLymphoma Malignant X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 44
DAY ON TEST
FISCHER 344 RATS MALE
0730
0730
0729
0538
0091
0015
0729
0730
0465
0705
0485
0730
0693
0729
0091
0729
0091
0729
0015
0366
0626
0416
0598
0366
0729
1.0 MG/KGANIMAL ID
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140
00141
00142
00143
00144
00145
00146
00147
00148
00149
00150
00151
00152
00153
00154
00155
males(cont...)
Spleen + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X XLymphoma Malignant X
Thymus + + + + + + + + + + + + + + + + + +Fibrous Histiocytoma, Metastatic, Skeletal
MuscleX
Leukemia Mononuclear XLymphoma Malignant XThymoma Benign
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + M + + + + + + + + + +Fibroadenoma X
Skin + + + + + + + + + + + + + + + + + +Basal Cell Carcinoma XKeratoacanthomaSquamous Cell Papilloma, MultipleSubcutaneous Tissue, Fibroma XSubcutaneous Tissue, Lipoma X
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + +
Skeletal Muscle +Fibrous Histiocytoma XSarcoma
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 45
DAY ON TEST
FISCHER 344 RATS MALE
0730
0730
0729
0538
0091
0015
0729
0730
0465
0705
0485
0730
0693
0729
0091
0729
0091
0729
0015
0366
0626
0416
0598
0366
0729
1.0 MG/KGANIMAL ID
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140
00141
00142
00143
00144
00145
00146
00147
00148
00149
00150
00151
00152
00153
00154
00155
males(cont...)
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + +Carcinoma, Metastatic, Pituitary Gland XLeukemia Mononuclear X
Peripheral Nerve + +
Spinal Cord + +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + +Fibrous Histiocytoma, Metastatic, Skeletal
MuscleX
Leukemia Mononuclear X X X XLymphoma Malignant
Nose + + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + + +
Zymbal's Gland +Carcinoma X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 46
DAY ON TEST
FISCHER 344 RATS MALE
0730
0730
0729
0538
0091
0015
0729
0730
0465
0705
0485
0730
0693
0729
0091
0729
0091
0729
0015
0366
0626
0416
0598
0366
0729
1.0 MG/KGANIMAL ID
00131
00132
00133
00134
00135
00136
00137
00138
00139
00140
00141
00142
00143
00144
00145
00146
00147
00148
00149
00150
00151
00152
00153
00154
00155
males(cont...)
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X XLymphoma Malignant XRenal Tubule, Adenoma
Urinary Bladder + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X XLymphoma Malignant XMesothelioma Malignant
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 47
DAY ON TEST
FISCHER 344 RATS MALE
0091
0366
0730
0731
0669
0730
0366
0728
0729
0091
0443
0729
0729
0729
0729
0609
0730
0730
0730
0366
0571
0731
0715
0729
0543
1.0 MG/KGANIMAL ID
00156
00157
00158
00159
00160
00161
00162
00163
00164
00165
00166
00167
00168
00169
00170
00171
00172
00173
00174
00175
00176
00177
00178
00179
00180
males(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + +
Intestine Large, Cecum + + + + + + + + + + + A + + + + + + + +
Intestine Large, Colon + + + + + + + + + + + A + + + + + + + +Adenoma
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant
Intestine Small, Ileum + + + + + + + + + + + A + + + + + + + +Lymphoma Malignant
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + +
Liver + + + + + + + + + + + + + + + + + + + +Hepatocellular AdenomaLeukemia Mononuclear X X XLymphoma Malignant
Mesentery + + + + + + +LipomaLymphoma MalignantMesothelioma Malignant X X
Oral Mucosa
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 48
DAY ON TEST
FISCHER 344 RATS MALE
0091
0366
0730
0731
0669
0730
0366
0728
0729
0091
0443
0729
0729
0729
0729
0609
0730
0730
0730
0366
0571
0731
0715
0729
0543
1.0 MG/KGANIMAL ID
00156
00157
00158
00159
00160
00161
00162
00163
00164
00165
00166
00167
00168
00169
00170
00171
00172
00173
00174
00175
00176
00177
00178
00179
00180
males(cont...)
Pancreas + + + + + + + + + + + + + + + + + + + +Leukemia MononuclearLymphoma MalignantMixed Tumor BenignAcinus, AdenomaAcinus, Adenoma, Multiple X
Salivary Glands + + + + + + + + + + + + + + + + + + + +
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + +Leukemia MononuclearLymphoma Malignant
Stomach, Glandular + + + + + + + + + + + + + + + + + + + +Leukemia MononuclearLymphoma Malignant
CARDIOVASCULAR SYSTEM
Blood Vessel +
Heart + + + + + + + + + + + + + + + + + + + +Fibrous Histiocytoma, Metastatic, Skeletal
MuscleLeukemia Mononuclear X
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 49
DAY ON TEST
FISCHER 344 RATS MALE
0091
0366
0730
0731
0669
0730
0366
0728
0729
0091
0443
0729
0729
0729
0729
0609
0730
0730
0730
0366
0571
0731
0715
0729
0543
1.0 MG/KGANIMAL ID
00156
00157
00158
00159
00160
00161
00162
00163
00164
00165
00166
00167
00168
00169
00170
00171
00172
00173
00174
00175
00176
00177
00178
00179
00180
males(cont...)
Adrenal Medulla + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X XPheochromocytoma BenignPheochromocytoma Benign, Multiple X XPheochromocytoma Malignant X
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + +Adenoma X X X
Parathyroid Gland M + + M + + + + + + + M + + + + + + + +
Pituitary Gland + + + + + + + + + + + + + + + + + + + +Leukemia MononuclearPars Distalis, Adenoma X X X X X X X X X X X X X X X X X XPars Distalis, Adenoma, MultiplePars Distalis, Carcinoma
Thyroid Gland + + + + + + + + + + + A + + + + + + + +C-cell, Adenoma X X
GENERAL BODY SYSTEM
Tissue NOS +Fibroma XFibrous Histiocytoma, Metastatic, Skeletal
Muscle
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + + + +
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 50
DAY ON TEST
FISCHER 344 RATS MALE
0091
0366
0730
0731
0669
0730
0366
0728
0729
0091
0443
0729
0729
0729
0729
0609
0730
0730
0730
0366
0571
0731
0715
0729
0543
1.0 MG/KGANIMAL ID
00156
00157
00158
00159
00160
00161
00162
00163
00164
00165
00166
00167
00168
00169
00170
00171
00172
00173
00174
00175
00176
00177
00178
00179
00180
males(cont...)
Preputial Gland + + + + + + + + + + + + + + + + + + + +Carcinoma XLeukemia Mononuclear
Prostate + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
Seminal Vesicle + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
Testes + + + + + + + + + + + + + + + + + + + +Bilateral, Interstitial Cell, Adenoma X X X X XInterstitial Cell, Adenoma X X X X X X X
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + A + + + + + + + +Leukemia Mononuclear X XLymphoma Malignant
Lymph Node + + + + + + +Mediastinal, Leukemia Mononuclear XPancreatic, Leukemia Mononuclear X XPancreatic, Lymphoma Malignant
Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X XLymphoma Malignant
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 51
DAY ON TEST
FISCHER 344 RATS MALE
0091
0366
0730
0731
0669
0730
0366
0728
0729
0091
0443
0729
0729
0729
0729
0609
0730
0730
0730
0366
0571
0731
0715
0729
0543
1.0 MG/KGANIMAL ID
00156
00157
00158
00159
00160
00161
00162
00163
00164
00165
00166
00167
00168
00169
00170
00171
00172
00173
00174
00175
00176
00177
00178
00179
00180
males(cont...)
Spleen + + + + + + + + + + + A + + + + + + + +Leukemia Mononuclear X X XLymphoma Malignant
Thymus + + + + + + + + + + + + + + + + + + + +Fibrous Histiocytoma, Metastatic, Skeletal
MuscleLeukemia MononuclearLymphoma MalignantThymoma Benign X
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + +Fibroadenoma X
Skin + + + + + + + + + + + + + + + + + + + +Basal Cell CarcinomaKeratoacanthoma X XSquamous Cell Papilloma, MultipleSubcutaneous Tissue, Fibroma X X X X XSubcutaneous Tissue, Lipoma X X
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + +
Skeletal Muscle +Fibrous HistiocytomaSarcoma
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 52
DAY ON TEST
FISCHER 344 RATS MALE
0091
0366
0730
0731
0669
0730
0366
0728
0729
0091
0443
0729
0729
0729
0729
0609
0730
0730
0730
0366
0571
0731
0715
0729
0543
1.0 MG/KGANIMAL ID
00156
00157
00158
00159
00160
00161
00162
00163
00164
00165
00166
00167
00168
00169
00170
00171
00172
00173
00174
00175
00176
00177
00178
00179
00180
males(cont...)
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + +Carcinoma, Metastatic, Pituitary GlandLeukemia Mononuclear X
Peripheral Nerve + + +
Spinal Cord + + +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + +Fibrous Histiocytoma, Metastatic, Skeletal
MuscleLeukemia Mononuclear X X XLymphoma Malignant
Nose + + + + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + + + + +
Zymbal's GlandCarcinoma
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 53
DAY ON TEST
FISCHER 344 RATS MALE
0091
0366
0730
0731
0669
0730
0366
0728
0729
0091
0443
0729
0729
0729
0729
0609
0730
0730
0730
0366
0571
0731
0715
0729
0543
1.0 MG/KGANIMAL ID
00156
00157
00158
00159
00160
00161
00162
00163
00164
00165
00166
00167
00168
00169
00170
00171
00172
00173
00174
00175
00176
00177
00178
00179
00180
males(cont...)
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X XLymphoma MalignantRenal Tubule, Adenoma
Urinary Bladder + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X XLymphoma MalignantMesothelioma Malignant X X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 54
DAY ON TEST
FISCHER 344 RATS MALE
0543
0535
0652
0730
0015
0730
0729
0730
0015
0731
0655
0723
0015
0535
0662
1.0 MG/KGANIMAL ID
00181
00182
00183
00184
00185
00186
00187
00188
00189
00190
00191
00192
00193
00194
00195 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + M + + + + + + + + + 48
Intestine Large, Cecum + + + + + + + + + + + + 49
Intestine Large, Colon + + + + + + + + + + + + 49Adenoma 1
Intestine Large, Rectum + + + + + + + + + + + + 50
Intestine Small, Duodenum + + + + + + + + + + + + 50Lymphoma Malignant 1
Intestine Small, Ileum + + + + + + + + + + + + 48Lymphoma Malignant 1
Intestine Small, Jejunum + + + + + + + + + + + + 48
Liver + + + + + + + + + + + + 50Hepatocellular Adenoma X 1Leukemia Mononuclear X X X X X 12Lymphoma Malignant X 2
Mesentery + + + 16Lipoma 1Lymphoma Malignant 1Mesothelioma Malignant 2
Oral Mucosa + 1
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 55
DAY ON TEST
FISCHER 344 RATS MALE
0543
0535
0652
0730
0015
0730
0729
0730
0015
0731
0655
0723
0015
0535
0662
1.0 MG/KGANIMAL ID
00181
00182
00183
00184
00185
00186
00187
00188
00189
00190
00191
00192
00193
00194
00195 * TOTALS
Pancreas + + + + + + + + + + + + 50Leukemia Mononuclear X 2Lymphoma Malignant X 2Mixed Tumor Benign 1Acinus, Adenoma 3Acinus, Adenoma, Multiple 1
Salivary Glands + + + + + + + + + + + + 50
Stomach, Forestomach + + + + + + + + + + + + 50Leukemia Mononuclear X 2Lymphoma Malignant 1
Stomach, Glandular + + + + + + + + + + + + 50Leukemia Mononuclear X 2Lymphoma Malignant 1
CARDIOVASCULAR SYSTEM
Blood Vessel 1
Heart + + + + + + + + + + + + 50Fibrous Histiocytoma, Metastatic, Skeletal
Muscle1
Leukemia Mononuclear X 3
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + 50Leukemia Mononuclear X 4
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 56
DAY ON TEST
FISCHER 344 RATS MALE
0543
0535
0652
0730
0015
0730
0729
0730
0015
0731
0655
0723
0015
0535
0662
1.0 MG/KGANIMAL ID
00181
00182
00183
00184
00185
00186
00187
00188
00189
00190
00191
00192
00193
00194
00195 * TOTALS
Adrenal Medulla + + + + + + + + + + + + 50Leukemia Mononuclear X 4Pheochromocytoma Benign X 2Pheochromocytoma Benign, Multiple 2Pheochromocytoma Malignant 1
Islets, Pancreatic + + + + + + + + + + + + 50Adenoma X 9
Parathyroid Gland + + + + + + + + + + + + 45
Pituitary Gland M + + + + + + + + + + + 49Leukemia Mononuclear X 3Pars Distalis, Adenoma X X X X X X X X 36Pars Distalis, Adenoma, Multiple 3Pars Distalis, Carcinoma 1
Thyroid Gland + + + + + + + + + + + + 49C-cell, Adenoma X X 6
GENERAL BODY SYSTEM
Tissue NOS 2Fibroma 1Fibrous Histiocytoma, Metastatic, Skeletal
Muscle1
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + 50
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 57
DAY ON TEST
FISCHER 344 RATS MALE
0543
0535
0652
0730
0015
0730
0729
0730
0015
0731
0655
0723
0015
0535
0662
1.0 MG/KGANIMAL ID
00181
00182
00183
00184
00185
00186
00187
00188
00189
00190
00191
00192
00193
00194
00195 * TOTALS
Preputial Gland + + + + + + + + + + + + 50Carcinoma X 3Leukemia Mononuclear X 1
Prostate + + + + + + + + + + + + 50Leukemia Mononuclear 1
Seminal Vesicle + + + + + + + + + + + + 50Leukemia Mononuclear X 1
Testes + + + + + + + + + + + + 50Bilateral, Interstitial Cell, Adenoma X X X 11Interstitial Cell, Adenoma X X X X X 16
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + 49Leukemia Mononuclear X X X 8Lymphoma Malignant X 2
Lymph Node + + + + 17Mediastinal, Leukemia Mononuclear X X 5Pancreatic, Leukemia Mononuclear 4Pancreatic, Lymphoma Malignant 1
Lymph Node, Mandibular M M M M M M M M M M M M 0
Lymph Node, Mesenteric + + + + + + + + + + + + 50Leukemia Mononuclear X X 8Lymphoma Malignant 1
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 58
DAY ON TEST
FISCHER 344 RATS MALE
0543
0535
0652
0730
0015
0730
0729
0730
0015
0731
0655
0723
0015
0535
0662
1.0 MG/KGANIMAL ID
00181
00182
00183
00184
00185
00186
00187
00188
00189
00190
00191
00192
00193
00194
00195 * TOTALS
Spleen + + + + + + + + + + + + 49Leukemia Mononuclear X X X X X 13Lymphoma Malignant X 2
Thymus + + + M + + + + + + + + 49Fibrous Histiocytoma, Metastatic, Skeletal
Muscle1
Leukemia Mononuclear X 2Lymphoma Malignant 1Thymoma Benign 1
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + 49Fibroadenoma 2
Skin + + + + + + + + + + + + 50Basal Cell Carcinoma 1Keratoacanthoma 2Squamous Cell Papilloma, Multiple X 1Subcutaneous Tissue, Fibroma X X X X 10Subcutaneous Tissue, Lipoma 3
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + 50
Skeletal Muscle + 3Fibrous Histiocytoma 1Sarcoma X 1
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 59
DAY ON TEST
FISCHER 344 RATS MALE
0543
0535
0652
0730
0015
0730
0729
0730
0015
0731
0655
0723
0015
0535
0662
1.0 MG/KGANIMAL ID
00181
00182
00183
00184
00185
00186
00187
00188
00189
00190
00191
00192
00193
00194
00195 * TOTALS
NERVOUS SYSTEM
Brain + + + + + + + + + + + + 50Carcinoma, Metastatic, Pituitary Gland 1Leukemia Mononuclear X 3
Peripheral Nerve 5
Spinal Cord 5
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + 50Fibrous Histiocytoma, Metastatic, Skeletal
Muscle1
Leukemia Mononuclear X X 9Lymphoma Malignant X 1
Nose + + + + + + + + + + + + 50
Trachea + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + 50
Harderian Gland + + + + + + + + + + + + 50
Zymbal's Gland 1Carcinoma 1
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 60
DAY ON TEST
FISCHER 344 RATS MALE
0543
0535
0652
0730
0015
0730
0729
0730
0015
0731
0655
0723
0015
0535
0662
1.0 MG/KGANIMAL ID
00181
00182
00183
00184
00185
00186
00187
00188
00189
00190
00191
00192
00193
00194
00195 * TOTALS
URINARY SYSTEM
Kidney + + + + + + + + + + + + 50Leukemia Mononuclear X 5Lymphoma Malignant 1Renal Tubule, Adenoma X 1
Urinary Bladder + + + + + + + + + + + + 50Leukemia Mononuclear X 1
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + 50Leukemia Mononuclear X X X X X 14Lymphoma Malignant X 2Mesothelioma Malignant 2
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 61
DAY ON TEST
FISCHER 344 RATS MALE
0730
0366
0731
0591
0366
0729
0730
0518
0730
0690
0626
0638
0366
0715
0723
0731
0704
0673
0729
0015
0454
0091
0729
0582
0729
3.0 MG/KGANIMAL ID
00196
00197
00198
00199
00200
00201
00202
00203
00204
00205
00206
00207
00208
00209
00210
00211
00212
00213
00214
00215
00216
00217
00218
00219
00220
males(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + +
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + +
Intestine Small, Ileum + + + + + + + + + + + + + + + + M + + +Leukemia MononuclearLymphoma Malignant X
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X
Liver + + + + + + + + + + + + + + + + + + + +Hepatocellular CarcinomaLeukemia Mononuclear X X X X X X XLymphoma Malignant X
Mesentery + + + + +FibrosarcomaLeukemia Mononuclear XMesothelioma Malignant X X X
Oral Mucosa
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 62
DAY ON TEST
FISCHER 344 RATS MALE
0730
0366
0731
0591
0366
0729
0730
0518
0730
0690
0626
0638
0366
0715
0723
0731
0704
0673
0729
0015
0454
0091
0729
0582
0729
3.0 MG/KGANIMAL ID
00196
00197
00198
00199
00200
00201
00202
00203
00204
00205
00206
00207
00208
00209
00210
00211
00212
00213
00214
00215
00216
00217
00218
00219
00220
males(cont...)
Squamous Cell Papilloma
Pancreas + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear XLymphoma Malignant X
Salivary Glands + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear XLymphoma Malignant X
Stomach, Glandular + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear XLymphoma Malignant X
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X XLymphoma Malignant
Adrenal Medulla + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X XLymphoma Malignant
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 63
DAY ON TEST
FISCHER 344 RATS MALE
0730
0366
0731
0591
0366
0729
0730
0518
0730
0690
0626
0638
0366
0715
0723
0731
0704
0673
0729
0015
0454
0091
0729
0582
0729
3.0 MG/KGANIMAL ID
00196
00197
00198
00199
00200
00201
00202
00203
00204
00205
00206
00207
00208
00209
00210
00211
00212
00213
00214
00215
00216
00217
00218
00219
00220
males(cont...)
Pheochromocytoma Benign X XPheochromocytoma Benign, MultiplePheochromocytoma MalignantPheochromocytoma Malignant, Multiple
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + +Adenoma X X X X X X X X X
Parathyroid Gland + + + + + + + + + + + + + + + + + + + +Adenoma
Pituitary Gland + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X XLymphoma Malignant XPars Distalis, Adenoma X X X X X X X X X X X XPars Distalis, Adenoma, Multiple X XPars Distalis, Carcinoma XPars Intermedia, Adenoma
Thyroid Gland + + + + + + + + + + + + + + + + + + + +C-cell, Adenoma X X XFollicular Cell, Adenoma
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 64
DAY ON TEST
FISCHER 344 RATS MALE
0730
0366
0731
0591
0366
0729
0730
0518
0730
0690
0626
0638
0366
0715
0723
0731
0704
0673
0729
0015
0454
0091
0729
0582
0729
3.0 MG/KGANIMAL ID
00196
00197
00198
00199
00200
00201
00202
00203
00204
00205
00206
00207
00208
00209
00210
00211
00212
00213
00214
00215
00216
00217
00218
00219
00220
males(cont...)
Preputial Gland + + + + + + + + + + + + + + + + + + + +Adenoma XLeukemia Mononuclear X
Prostate + + + + + + + + + + + + + + + + + + + +AdenomaLeukemia Mononuclear X XLymphoma Malignant X
Seminal Vesicle + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
Testes + + + + + + + + + + + + + + + + + + + +Bilateral, Interstitial Cell, Adenoma X X X XInterstitial Cell, Adenoma X X X X X X X
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X XLymphoma Malignant X
Lymph Node + + + + + + +Leukemia Mononuclear XDeep Cervical, Leukemia MononuclearMediastinal, Leukemia Mononuclear X X XMediastinal, Lymphoma Malignant XPancreatic, Leukemia Mononuclear X X XPancreatic, Lymphoma Malignant X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 65
DAY ON TEST
FISCHER 344 RATS MALE
0730
0366
0731
0591
0366
0729
0730
0518
0730
0690
0626
0638
0366
0715
0723
0731
0704
0673
0729
0015
0454
0091
0729
0582
0729
3.0 MG/KGANIMAL ID
00196
00197
00198
00199
00200
00201
00202
00203
00204
00205
00206
00207
00208
00209
00210
00211
00212
00213
00214
00215
00216
00217
00218
00219
00220
males(cont...)
Lymph Node, Mandibular M M M M M M M M M + M M M M M M M M M MLeukemia Mononuclear X
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X XLymphoma Malignant X
Spleen + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X X X XLymphoma Malignant XMesothelioma Malignant
Thymus + + + + + + + + + + + + + M + + M + + +Leukemia Mononuclear X XLymphoma Malignant X
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + M + + + + + + + + + + +Fibroadenoma X
Skin + + + + + + + + + + + + + + + + + + + +Basal Cell Adenoma X XKeratoacanthoma X XLeukemia Mononuclear XSubcutaneous Tissue, FibromaSubcutaneous Tissue, Fibroma, MultipleSubcutaneous Tissue, Lipoma X X
MUSCULOSKELETAL SYSTEM
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 66
DAY ON TEST
FISCHER 344 RATS MALE
0730
0366
0731
0591
0366
0729
0730
0518
0730
0690
0626
0638
0366
0715
0723
0731
0704
0673
0729
0015
0454
0091
0729
0582
0729
3.0 MG/KGANIMAL ID
00196
00197
00198
00199
00200
00201
00202
00203
00204
00205
00206
00207
00208
00209
00210
00211
00212
00213
00214
00215
00216
00217
00218
00219
00220
males(cont...)
Bone + + + + + + + + + + + + + + + + + + + +Chordoma XOsteosarcoma X
Skeletal Muscle
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + +Carcinoma, Metastatic, Pituitary Gland XLeukemia Mononuclear X X
Peripheral Nerve + M
Spinal Cord + +Leukemia Mononuclear X
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Adenoma X XLeukemia Mononuclear X X X X XLymphoma Malignant XOsteosarcoma, Metastatic, Bone XPheochromocytoma Malignant, Metastatic,
Adrenal Medulla
Nose + + + + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + + + + +
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 67
DAY ON TEST
FISCHER 344 RATS MALE
0730
0366
0731
0591
0366
0729
0730
0518
0730
0690
0626
0638
0366
0715
0723
0731
0704
0673
0729
0015
0454
0091
0729
0582
0729
3.0 MG/KGANIMAL ID
00196
00197
00198
00199
00200
00201
00202
00203
00204
00205
00206
00207
00208
00209
00210
00211
00212
00213
00214
00215
00216
00217
00218
00219
00220
males(cont...)
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
Zymbal's Gland +Carcinoma X
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X XLymphoma Malignant X
Urethra +
Urinary Bladder + + + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X X X XLymphoma Malignant XMesothelioma Malignant X X X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 68
DAY ON TEST
FISCHER 344 RATS MALE
0730
0693
0157
0662
0729
0588
0015
0366
0722
0091
0711
0652
0646
0674
0015
0617
0729
0015
0091
0332
0730
0730
0729
0091
0669
3.0 MG/KGANIMAL ID
00221
00222
00223
00224
00225
00226
00227
00228
00229
00230
00231
00232
00233
00234
00235
00236
00237
00238
00239
00240
00241
00242
00243
00244
00245
males(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + + +
Intestine Large, Colon + + + + + + + + + + + + + + + + + +Lymphoma Malignant
Intestine Large, Rectum + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + +
Intestine Small, Ileum + + + + + M + + + + + + + + + + + +Leukemia MononuclearLymphoma Malignant
Intestine Small, Jejunum + + + + + + + + A + + + + + + + + +Lymphoma Malignant
Liver + + + + + + + + + + + + + + + + + +Hepatocellular Carcinoma XLeukemia Mononuclear X XLymphoma Malignant X
Mesentery + + + + + + +Fibrosarcoma XLeukemia MononuclearMesothelioma Malignant X
Oral Mucosa +
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 69
DAY ON TEST
FISCHER 344 RATS MALE
0730
0693
0157
0662
0729
0588
0015
0366
0722
0091
0711
0652
0646
0674
0015
0617
0729
0015
0091
0332
0730
0730
0729
0091
0669
3.0 MG/KGANIMAL ID
00221
00222
00223
00224
00225
00226
00227
00228
00229
00230
00231
00232
00233
00234
00235
00236
00237
00238
00239
00240
00241
00242
00243
00244
00245
males(cont...)
Squamous Cell Papilloma X
Pancreas + + + + + + + + + + + + + + + + + +Leukemia MononuclearLymphoma Malignant X
Salivary Glands + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
Stomach, Forestomach + + + + + + + + + + + + + + + + + +Leukemia MononuclearLymphoma Malignant
Stomach, Glandular + + + + + + + + + + + + + + + + + +Leukemia Mononuclear XLymphoma Malignant
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + +Leukemia Mononuclear XLymphoma Malignant X
Adrenal Medulla + + + + + + + + + + + + + + + + + +Leukemia MononuclearLymphoma Malignant X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 70
DAY ON TEST
FISCHER 344 RATS MALE
0730
0693
0157
0662
0729
0588
0015
0366
0722
0091
0711
0652
0646
0674
0015
0617
0729
0015
0091
0332
0730
0730
0729
0091
0669
3.0 MG/KGANIMAL ID
00221
00222
00223
00224
00225
00226
00227
00228
00229
00230
00231
00232
00233
00234
00235
00236
00237
00238
00239
00240
00241
00242
00243
00244
00245
males(cont...)
Pheochromocytoma Benign X XPheochromocytoma Benign, Multiple X XPheochromocytoma Malignant XPheochromocytoma Malignant, Multiple X X
Islets, Pancreatic + + + + + + + + + + + + + + + + + +Adenoma X X
Parathyroid Gland + + M + + + + + + + + + + + M + + +Adenoma X
Pituitary Gland + + + + + + + + + + + + + + + + + +Leukemia MononuclearLymphoma MalignantPars Distalis, Adenoma X X X X X X X X XPars Distalis, Adenoma, MultiplePars Distalis, CarcinomaPars Intermedia, Adenoma X
Thyroid Gland + + + + + + + + + + + + + + + + + +C-cell, AdenomaFollicular Cell, Adenoma X
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + +Lymphoma Malignant
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 71
DAY ON TEST
FISCHER 344 RATS MALE
0730
0693
0157
0662
0729
0588
0015
0366
0722
0091
0711
0652
0646
0674
0015
0617
0729
0015
0091
0332
0730
0730
0729
0091
0669
3.0 MG/KGANIMAL ID
00221
00222
00223
00224
00225
00226
00227
00228
00229
00230
00231
00232
00233
00234
00235
00236
00237
00238
00239
00240
00241
00242
00243
00244
00245
males(cont...)
Preputial Gland + + + + + + + + + + + + + + + + + +Adenoma XLeukemia Mononuclear
Prostate + + + + + + + + + + + + + + + + + +AdenomaLeukemia Mononuclear XLymphoma Malignant
Seminal Vesicle + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
Testes + + + + + + + + + + + + + + + + + +Bilateral, Interstitial Cell, Adenoma X X X X X XInterstitial Cell, Adenoma X X X X
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X XLymphoma Malignant X
Lymph Node + + + + + +Leukemia Mononuclear XDeep Cervical, Leukemia Mononuclear XMediastinal, Leukemia Mononuclear XMediastinal, Lymphoma MalignantPancreatic, Leukemia Mononuclear X XPancreatic, Lymphoma Malignant X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 72
DAY ON TEST
FISCHER 344 RATS MALE
0730
0693
0157
0662
0729
0588
0015
0366
0722
0091
0711
0652
0646
0674
0015
0617
0729
0015
0091
0332
0730
0730
0729
0091
0669
3.0 MG/KGANIMAL ID
00221
00222
00223
00224
00225
00226
00227
00228
00229
00230
00231
00232
00233
00234
00235
00236
00237
00238
00239
00240
00241
00242
00243
00244
00245
males(cont...)
Lymph Node, Mandibular M M M M M M M M M M M M M M M M M MLeukemia Mononuclear
Lymph Node, Mesenteric + + + + + + + A + + + + + + + + + +Leukemia Mononuclear X XLymphoma Malignant X
Spleen + + + + + + + A + + + + + + + + + +Leukemia Mononuclear X XLymphoma Malignant XMesothelioma Malignant X
Thymus + + + + + + + + + + M + + + + + + MLeukemia Mononuclear X XLymphoma Malignant X
INTEGUMENTARY SYSTEM
Mammary Gland + + + M + + + + + + + + + + + + + +Fibroadenoma X
Skin + + + + + + + + + + + + + + + + + +Basal Cell AdenomaKeratoacanthoma XLeukemia MononuclearSubcutaneous Tissue, Fibroma X XSubcutaneous Tissue, Fibroma, Multiple X XSubcutaneous Tissue, Lipoma
MUSCULOSKELETAL SYSTEM
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 73
DAY ON TEST
FISCHER 344 RATS MALE
0730
0693
0157
0662
0729
0588
0015
0366
0722
0091
0711
0652
0646
0674
0015
0617
0729
0015
0091
0332
0730
0730
0729
0091
0669
3.0 MG/KGANIMAL ID
00221
00222
00223
00224
00225
00226
00227
00228
00229
00230
00231
00232
00233
00234
00235
00236
00237
00238
00239
00240
00241
00242
00243
00244
00245
males(cont...)
Bone + + + + + + + + + + + + + + + + + +ChordomaOsteosarcoma
Skeletal Muscle +
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + +Carcinoma, Metastatic, Pituitary GlandLeukemia Mononuclear X
Peripheral Nerve +
Spinal Cord +Leukemia Mononuclear
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar AdenomaLeukemia Mononuclear X XLymphoma MalignantOsteosarcoma, Metastatic, BonePheochromocytoma Malignant, Metastatic,
Adrenal MedullaX
Nose + + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + + +
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 74
DAY ON TEST
FISCHER 344 RATS MALE
0730
0693
0157
0662
0729
0588
0015
0366
0722
0091
0711
0652
0646
0674
0015
0617
0729
0015
0091
0332
0730
0730
0729
0091
0669
3.0 MG/KGANIMAL ID
00221
00222
00223
00224
00225
00226
00227
00228
00229
00230
00231
00232
00233
00234
00235
00236
00237
00238
00239
00240
00241
00242
00243
00244
00245
males(cont...)
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
Zymbal's Gland +Carcinoma X
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X XLymphoma Malignant X
Urethra
Urinary Bladder + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X XLymphoma Malignant XMesothelioma Malignant X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 75
DAY ON TEST
FISCHER 344 RATS MALE
0731
0730
0366
0091
0730
0015
0731
0715
0669
0526
0730
0678
0730
0729
0729
3.0 MG/KGANIMAL ID
00246
00247
00248
00249
00250
00251
00252
00253
00254
00255
00256
00257
00258
00259
00260 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + 50
Intestine Large, Cecum + + + + + + + + + + + + 50
Intestine Large, Colon + + + + + + + + + + + + 50Lymphoma Malignant 1
Intestine Large, Rectum + + + + + + + + + + + + 50
Intestine Small, Duodenum + + + + + + + + + + + + 50
Intestine Small, Ileum + + + + + + + + + + + + 48Leukemia Mononuclear X 1Lymphoma Malignant 1
Intestine Small, Jejunum + + + + + + + + + + + + 49Lymphoma Malignant 1
Liver + + + + + + + + + + + + 50Hepatocellular Carcinoma 1Leukemia Mononuclear X X X 12Lymphoma Malignant 2
Mesentery + + + + 16Fibrosarcoma 1Leukemia Mononuclear 1Mesothelioma Malignant X 5
Oral Mucosa 1
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 76
DAY ON TEST
FISCHER 344 RATS MALE
0731
0730
0366
0091
0730
0015
0731
0715
0669
0526
0730
0678
0730
0729
0729
3.0 MG/KGANIMAL ID
00246
00247
00248
00249
00250
00251
00252
00253
00254
00255
00256
00257
00258
00259
00260 * TOTALS
Squamous Cell Papilloma 1
Pancreas + + + + + + + + + + + + 50Leukemia Mononuclear X 2Lymphoma Malignant 2
Salivary Glands + + + + + + + + + + + + 50Leukemia Mononuclear 1
Stomach, Forestomach + + + + + + + + + + + + 50Leukemia Mononuclear 1Lymphoma Malignant 1
Stomach, Glandular + + + + + + + + + + + + 50Leukemia Mononuclear 2Lymphoma Malignant 1
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + 50Leukemia Mononuclear X 2
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + 50Leukemia Mononuclear X X 6Lymphoma Malignant 1
Adrenal Medulla + + + + + + + + + + + + 50Leukemia Mononuclear X 3Lymphoma Malignant 1
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 77
DAY ON TEST
FISCHER 344 RATS MALE
0731
0730
0366
0091
0730
0015
0731
0715
0669
0526
0730
0678
0730
0729
0729
3.0 MG/KGANIMAL ID
00246
00247
00248
00249
00250
00251
00252
00253
00254
00255
00256
00257
00258
00259
00260 * TOTALS
Pheochromocytoma Benign X X 6Pheochromocytoma Benign, Multiple X 3Pheochromocytoma Malignant 1Pheochromocytoma Malignant, Multiple 2
Islets, Pancreatic + + + + + + + + + + + + 50Adenoma X X X 14
Parathyroid Gland M + + + + + + + + + + + 47Adenoma 1
Pituitary Gland + + + + + + + + + + + + 50Leukemia Mononuclear X 3Lymphoma Malignant 1Pars Distalis, Adenoma X X X X X X X X X 30Pars Distalis, Adenoma, Multiple X X 4Pars Distalis, Carcinoma 1Pars Intermedia, Adenoma 1
Thyroid Gland + + + + + + + + + + + + 50C-cell, Adenoma X X 5Follicular Cell, Adenoma 1
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + 50Lymphoma Malignant 1
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 78
DAY ON TEST
FISCHER 344 RATS MALE
0731
0730
0366
0091
0730
0015
0731
0715
0669
0526
0730
0678
0730
0729
0729
3.0 MG/KGANIMAL ID
00246
00247
00248
00249
00250
00251
00252
00253
00254
00255
00256
00257
00258
00259
00260 * TOTALS
Preputial Gland + + + + + + + + + + + + 50Adenoma 2Leukemia Mononuclear 1
Prostate + + + + + + + + + + + + 50Adenoma X 1Leukemia Mononuclear X 4Lymphoma Malignant 1
Seminal Vesicle + + + + + + + + + + + + 50Leukemia Mononuclear X 3
Testes + + + + + + + + + + + + 50Bilateral, Interstitial Cell, Adenoma X X X 13Interstitial Cell, Adenoma X X X X 15
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + 50Leukemia Mononuclear X X X 11Lymphoma Malignant 2
Lymph Node + + + + + 18Leukemia Mononuclear 2Deep Cervical, Leukemia Mononuclear 1Mediastinal, Leukemia Mononuclear X 5Mediastinal, Lymphoma Malignant 1Pancreatic, Leukemia Mononuclear X X 7Pancreatic, Lymphoma Malignant 2
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 79
DAY ON TEST
FISCHER 344 RATS MALE
0731
0730
0366
0091
0730
0015
0731
0715
0669
0526
0730
0678
0730
0729
0729
3.0 MG/KGANIMAL ID
00246
00247
00248
00249
00250
00251
00252
00253
00254
00255
00256
00257
00258
00259
00260 * TOTALS
Lymph Node, Mandibular M M M M M M M M M M M M 1Leukemia Mononuclear 1
Lymph Node, Mesenteric + + + + + + + + + + + + 49Leukemia Mononuclear X X 9Lymphoma Malignant 2
Spleen + + + + + + + + + + + + 49Leukemia Mononuclear X X X X 14Lymphoma Malignant 2Mesothelioma Malignant 1
Thymus + + + + + + + + + + + + 46Leukemia Mononuclear X 5Lymphoma Malignant 2
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + 48Fibroadenoma 2
Skin + + + + + + + + + + + + 50Basal Cell Adenoma 2Keratoacanthoma X X 5Leukemia Mononuclear 1Subcutaneous Tissue, Fibroma X X 4Subcutaneous Tissue, Fibroma, Multiple 2Subcutaneous Tissue, Lipoma X 3
MUSCULOSKELETAL SYSTEM
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 80
DAY ON TEST
FISCHER 344 RATS MALE
0731
0730
0366
0091
0730
0015
0731
0715
0669
0526
0730
0678
0730
0729
0729
3.0 MG/KGANIMAL ID
00246
00247
00248
00249
00250
00251
00252
00253
00254
00255
00256
00257
00258
00259
00260 * TOTALS
Bone + + + + + + + + + + + + 50Chordoma 1Osteosarcoma 1
Skeletal Muscle 1
NERVOUS SYSTEM
Brain + + + + + + + + + + + + 50Carcinoma, Metastatic, Pituitary Gland 1Leukemia Mononuclear 3
Peripheral Nerve 2
Spinal Cord 3Leukemia Mononuclear 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + 50Alveolar/Bronchiolar Adenoma 2Leukemia Mononuclear X X 9Lymphoma Malignant 1Osteosarcoma, Metastatic, Bone 1Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla1
Nose + + + + + + + + + + + + 50
Trachea + + + + + + + + + + + + 50
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 81
DAY ON TEST
FISCHER 344 RATS MALE
0731
0730
0366
0091
0730
0015
0731
0715
0669
0526
0730
0678
0730
0729
0729
3.0 MG/KGANIMAL ID
00246
00247
00248
00249
00250
00251
00252
00253
00254
00255
00256
00257
00258
00259
00260 * TOTALS
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + 50
Harderian Gland + + + + + + + + + + + + 50Leukemia Mononuclear 1
Zymbal's Gland + 3Carcinoma X 3
URINARY SYSTEM
Kidney + + + + + + + + + + + + 50Leukemia Mononuclear X 6Lymphoma Malignant 2
Urethra 1
Urinary Bladder + + + + + + + + + + + + 50
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + 50Leukemia Mononuclear X X X X 14Lymphoma Malignant 2Mesothelioma Malignant X 5
*** END OF MALE DATA ***
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 82
DAY ON TEST
FISCHER 344 RATS FEMALE
0732
0366
0732
0732
0497
0091
0091
0616
0726
0698
0015
0732
0731
0606
0690
0735
0560
0649
0731
0731
0625
0626
0661
0585
0015
0 MG/KGANIMAL ID
00261
00262
00263
00264
00265
00266
00267
00268
00269
00270
00271
00272
00273
00274
00275
00276
00277
00278
00279
00280
00281
00282
00283
00284
00285
females(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + +
Intestine Large, Cecum + + + + + A + + + + + + + + + + + + + +
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + +
Intestine Small, Ileum + + + + + A A + + + + + + A + + + + + +
Intestine Small, Jejunum + + + + + A + + + A + + + A + + + + A +Sarcoma, Metastatic, Kidney
Liver + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X
Mesentery + + + + + + + + +
Pancreas + + + + + + + + + + + + + + + + + + + +Leukemia MononuclearSarcoma, Metastatic, Kidney
Salivary Glands + + + + + + + + + + + + + + + + + + + +
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + +
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 83
DAY ON TEST
FISCHER 344 RATS FEMALE
0732
0366
0732
0732
0497
0091
0091
0616
0726
0698
0015
0732
0731
0606
0690
0735
0560
0649
0731
0731
0625
0626
0661
0585
0015
0 MG/KGANIMAL ID
00261
00262
00263
00264
00265
00266
00267
00268
00269
00270
00271
00272
00273
00274
00275
00276
00277
00278
00279
00280
00281
00282
00283
00284
00285
females(cont...)
Stomach, Glandular + + + + + + + + + + + + + + + + + + + +
Tongue +
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
Adrenal Medulla + + + + + I + + + + + + + + + + + + + +Leukemia Mononuclear X
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + +Adenoma X
Parathyroid Gland M + M + + + + + + + + + + + + + + + + +
Pituitary Gland + + + + + + + + + + + + + + + + + + + +Pars Distalis, Adenoma X X X X X X X X X X X X X XPars Distalis, Adenoma, Multiple X XPars Distalis, Carcinoma XPars Intermedia, Adenoma XPars Nervosa, Craniopharyngioma X
Thyroid Gland + + + + + + + + + + + + + + + + + + + +
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 84
DAY ON TEST
FISCHER 344 RATS FEMALE
0732
0366
0732
0732
0497
0091
0091
0616
0726
0698
0015
0732
0731
0606
0690
0735
0560
0649
0731
0731
0625
0626
0661
0585
0015
0 MG/KGANIMAL ID
00261
00262
00263
00264
00265
00266
00267
00268
00269
00270
00271
00272
00273
00274
00275
00276
00277
00278
00279
00280
00281
00282
00283
00284
00285
females(cont...)
C-cell, Adenoma X
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + + + + + + + + + + +Adenoma X XCarcinoma X XCarcinoma, Multiple X
Ovary + + + + + + + + + + + + + + + + + + + +Granulosa Cell Tumor Malignant X
Uterus + + + + + + + + + + + + + + + + + + + +Polyp Stromal X X X X
Vagina + + + +Polyp X
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
Lymph Node + +Mediastinal, Leukemia Mononuclear
Lymph Node, Mandibular M M M + M M M M M M M M + M M M + M M M
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 85
DAY ON TEST
FISCHER 344 RATS FEMALE
0732
0366
0732
0732
0497
0091
0091
0616
0726
0698
0015
0732
0731
0606
0690
0735
0560
0649
0731
0731
0625
0626
0661
0585
0015
0 MG/KGANIMAL ID
00261
00262
00263
00264
00265
00266
00267
00268
00269
00270
00271
00272
00273
00274
00275
00276
00277
00278
00279
00280
00281
00282
00283
00284
00285
females(cont...)
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
Spleen + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X
Thymus + + + + + M + + + M + + + + + + + + + +Leukemia Mononuclear
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + +Adenoma X X XAdenoma, Multiple XCarcinoma X XFibroadenoma X X X X X X XFibroadenoma, Multiple X X
Skin + + + + + + + + + + + + + + + + + + + +Basal Cell AdenomaSubcutaneous Tissue, Schwannoma Benign X
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + +
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + +Carcinoma, Metastatic, Pituitary Gland
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 86
DAY ON TEST
FISCHER 344 RATS FEMALE
0732
0366
0732
0732
0497
0091
0091
0616
0726
0698
0015
0732
0731
0606
0690
0735
0560
0649
0731
0731
0625
0626
0661
0585
0015
0 MG/KGANIMAL ID
00261
00262
00263
00264
00265
00266
00267
00268
00269
00270
00271
00272
00273
00274
00275
00276
00277
00278
00279
00280
00281
00282
00283
00284
00285
females(cont...)
Peripheral Nerve + +
Spinal Cord + +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X
Nose + + + + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + + + + +
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + +Leukemia MononuclearSarcoma
Urinary Bladder + + + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 87
DAY ON TEST
FISCHER 344 RATS FEMALE
0722
0732
0366
0543
0712
0722
0732
0015
0732
0731
0732
0731
0732
0731
0652
0366
0653
0366
0732
0091
0735
0560
0366
0731
0015
0 MG/KGANIMAL ID
00286
00287
00288
00289
00290
00291
00292
00293
00294
00295
00296
00297
00298
00299
00300
00301
00302
00303
00304
00305
00306
00307
00308
00309
00310
females(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + + +
Intestine Large, Colon + + + + + + + + + + + + + A + + + +
Intestine Large, Rectum + + + + + + + + I + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + +
Intestine Small, Ileum + + + + + + + + + + + + + A + + + +
Intestine Small, Jejunum + + + A + + + + + + + + + A + + + +Sarcoma, Metastatic, Kidney X
Liver + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X X
Mesentery + + + + + + + + + +
Pancreas + + + + + + + + + + + + + + + + + +Leukemia MononuclearSarcoma, Metastatic, Kidney X
Salivary Glands + + + + + + + + + + + + + + + + + +
Stomach, Forestomach + + + + + + + + + + + + + + + + + +
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 88
DAY ON TEST
FISCHER 344 RATS FEMALE
0722
0732
0366
0543
0712
0722
0732
0015
0732
0731
0732
0731
0732
0731
0652
0366
0653
0366
0732
0091
0735
0560
0366
0731
0015
0 MG/KGANIMAL ID
00286
00287
00288
00289
00290
00291
00292
00293
00294
00295
00296
00297
00298
00299
00300
00301
00302
00303
00304
00305
00306
00307
00308
00309
00310
females(cont...)
Stomach, Glandular + + + + + + + + + + + + + + + + + +
Tongue
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
Adrenal Medulla + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
Islets, Pancreatic + + + + + + + + + + + + + + + + + +Adenoma X
Parathyroid Gland + + + + + + + + + + + + + + + M M +
Pituitary Gland + + + + + + + + + + + + + + + + + +Pars Distalis, Adenoma X X X X X X X X X X X XPars Distalis, Adenoma, MultiplePars Distalis, Carcinoma XPars Intermedia, AdenomaPars Nervosa, Craniopharyngioma
Thyroid Gland + + + + + + + + + + + + + + + + + +
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 89
DAY ON TEST
FISCHER 344 RATS FEMALE
0722
0732
0366
0543
0712
0722
0732
0015
0732
0731
0732
0731
0732
0731
0652
0366
0653
0366
0732
0091
0735
0560
0366
0731
0015
0 MG/KGANIMAL ID
00286
00287
00288
00289
00290
00291
00292
00293
00294
00295
00296
00297
00298
00299
00300
00301
00302
00303
00304
00305
00306
00307
00308
00309
00310
females(cont...)
C-cell, Adenoma X X
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + + + + + + + + +Adenoma XCarcinoma X XCarcinoma, Multiple X
Ovary + + + + + + + + + + + + + + + + + +Granulosa Cell Tumor Malignant
Uterus + + + + + + + + + + + + + + + + + +Polyp Stromal X X X
Vagina + + +Polyp
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
Lymph Node + + + + +Mediastinal, Leukemia Mononuclear X
Lymph Node, Mandibular + M M M M M M M M M M M M M M M M M
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 90
DAY ON TEST
FISCHER 344 RATS FEMALE
0722
0732
0366
0543
0712
0722
0732
0015
0732
0731
0732
0731
0732
0731
0652
0366
0653
0366
0732
0091
0735
0560
0366
0731
0015
0 MG/KGANIMAL ID
00286
00287
00288
00289
00290
00291
00292
00293
00294
00295
00296
00297
00298
00299
00300
00301
00302
00303
00304
00305
00306
00307
00308
00309
00310
females(cont...)
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X
Spleen + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X X
Thymus M + + + + + + + + + + + + + + + + +Leukemia Mononuclear
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + +AdenomaAdenoma, MultipleCarcinoma XFibroadenoma X X X X X XFibroadenoma, Multiple X X X
Skin + + + + + + + + + + + + + + + + + +Basal Cell Adenoma XSubcutaneous Tissue, Schwannoma Benign
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + +
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + +Carcinoma, Metastatic, Pituitary Gland X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 91
DAY ON TEST
FISCHER 344 RATS FEMALE
0722
0732
0366
0543
0712
0722
0732
0015
0732
0731
0732
0731
0732
0731
0652
0366
0653
0366
0732
0091
0735
0560
0366
0731
0015
0 MG/KGANIMAL ID
00286
00287
00288
00289
00290
00291
00292
00293
00294
00295
00296
00297
00298
00299
00300
00301
00302
00303
00304
00305
00306
00307
00308
00309
00310
females(cont...)
Peripheral Nerve + +
Spinal Cord + +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
Nose + + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + + +
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + +Leukemia MononuclearSarcoma X
Urinary Bladder + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 92
DAY ON TEST
FISCHER 344 RATS FEMALE
0731
0648
0597
0091
0091
0702
0732
0735
0015
0732
0598
0732
0731
0732
0731
0 MG/KGANIMAL ID
00311
00312
00313
00314
00315
00316
00317
00318
00319
00320
00321
00322
00323
00324
00325 * TOTALS
ALIMENTARY SYSTEM
Esophagus + M + + + + + + + + + + 49
Intestine Large, Cecum + + + + + + + + + + + + 49
Intestine Large, Colon + + + + + + + + + + + + 49
Intestine Large, Rectum + + I + + + + + + + + + 48
Intestine Small, Duodenum + + + + + + + + + + + + 50
Intestine Small, Ileum + + + + + + + A + + + + 45
Intestine Small, Jejunum + + + + + + + + + + + + 44Sarcoma, Metastatic, Kidney 1
Liver + + + + + + + + + + + + 50Leukemia Mononuclear X X X X 12
Mesentery + + + + + + + 26
Pancreas + + + + + + + + + + + + 50Leukemia Mononuclear X 1Sarcoma, Metastatic, Kidney 1
Salivary Glands + + + + + + + + + + + + 50
Stomach, Forestomach + + + + + + + + + + + + 50
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 93
DAY ON TEST
FISCHER 344 RATS FEMALE
0731
0648
0597
0091
0091
0702
0732
0735
0015
0732
0598
0732
0731
0732
0731
0 MG/KGANIMAL ID
00311
00312
00313
00314
00315
00316
00317
00318
00319
00320
00321
00322
00323
00324
00325 * TOTALS
Stomach, Glandular + + + + + + + + + + + + 50
Tongue 1
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + 50Leukemia Mononuclear X 1
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + 50Leukemia Mononuclear X X 3
Adrenal Medulla + + + + + + + + + + + M 48Leukemia Mononuclear X X 3
Islets, Pancreatic + + + + + + + + + + + + 50Adenoma X 3
Parathyroid Gland + + + + + + + + + M + + 45
Pituitary Gland + + + + + + + + + + + + 50Pars Distalis, Adenoma X X X X X X X X 34Pars Distalis, Adenoma, Multiple 2Pars Distalis, Carcinoma 2Pars Intermedia, Adenoma 1Pars Nervosa, Craniopharyngioma 1
Thyroid Gland + + + + + + + + + + + + 50
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 94
DAY ON TEST
FISCHER 344 RATS FEMALE
0731
0648
0597
0091
0091
0702
0732
0735
0015
0732
0598
0732
0731
0732
0731
0 MG/KGANIMAL ID
00311
00312
00313
00314
00315
00316
00317
00318
00319
00320
00321
00322
00323
00324
00325 * TOTALS
C-cell, Adenoma 3
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + + + 50Adenoma X 4Carcinoma 4Carcinoma, Multiple X 3
Ovary + + + + + + + + + + + + 50Granulosa Cell Tumor Malignant 1
Uterus + + + + + + + + + + + + 50Polyp Stromal X X 9
Vagina + 8Polyp 1
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + 50Leukemia Mononuclear X X 4
Lymph Node + + + + + 12Mediastinal, Leukemia Mononuclear X X 3
Lymph Node, Mandibular M M M M M M M M M M M M 4
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 95
DAY ON TEST
FISCHER 344 RATS FEMALE
0731
0648
0597
0091
0091
0702
0732
0735
0015
0732
0598
0732
0731
0732
0731
0 MG/KGANIMAL ID
00311
00312
00313
00314
00315
00316
00317
00318
00319
00320
00321
00322
00323
00324
00325 * TOTALS
Lymph Node, Mesenteric + + + + + + + + + + + + 50Leukemia Mononuclear X X 5
Spleen + + + + + + + + + + + + 50Leukemia Mononuclear X X X X 12
Thymus + + + + + + + + + + + + 47Leukemia Mononuclear X X 2
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + 50Adenoma 3Adenoma, Multiple 1Carcinoma 3Fibroadenoma X 14Fibroadenoma, Multiple X X X 8
Skin + + + + + + + + + + + + 50Basal Cell Adenoma 1Subcutaneous Tissue, Schwannoma Benign 1
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + 50
NERVOUS SYSTEM
Brain + + + + + + + + + + + + 50Carcinoma, Metastatic, Pituitary Gland 1
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 96
DAY ON TEST
FISCHER 344 RATS FEMALE
0731
0648
0597
0091
0091
0702
0732
0735
0015
0732
0598
0732
0731
0732
0731
0 MG/KGANIMAL ID
00311
00312
00313
00314
00315
00316
00317
00318
00319
00320
00321
00322
00323
00324
00325 * TOTALS
Peripheral Nerve 4
Spinal Cord 4
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + 50Leukemia Mononuclear X X 4
Nose + + + + + + + + + + + + 50
Trachea + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + 50
Harderian Gland + + + + + + + + + + + + 50
URINARY SYSTEM
Kidney + + + + + + + + + + + + 50Leukemia Mononuclear X 1Sarcoma 1
Urinary Bladder + + + + + + + + + + + + 50
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + 50Leukemia Mononuclear X X X X 12
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 97
DAY ON TEST
FISCHER 344 RATS FEMALE
0662
0655
0732
0735
0735
0735
0704
0732
0709
0715
0091
0735
0732
0735
0735
0735
0735
0697
0650
0015
0655
0015
0366
0638
0091
0.3 MG.KGANIMAL ID
00326
00327
00328
00329
00330
00331
00332
00333
00334
00335
00336
00337
00338
00339
00340
00341
00342
00343
00344
00345
00346
00347
00348
00349
00350
females(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + +
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + +
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + +
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + A + +
Liver + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X XLymphoma Malignant X
Mesentery + + + + + + +
Pancreas + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X
Salivary Glands + + + + + + + + + + + + + + + + + + + +
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + +
Stomach, Glandular + + + + + + + + + + + + + + + + + + + +
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 98
DAY ON TEST
FISCHER 344 RATS FEMALE
0662
0655
0732
0735
0735
0735
0704
0732
0709
0715
0091
0735
0732
0735
0735
0735
0735
0697
0650
0015
0655
0015
0366
0638
0091
0.3 MG.KGANIMAL ID
00326
00327
00328
00329
00330
00331
00332
00333
00334
00335
00336
00337
00338
00339
00340
00341
00342
00343
00344
00345
00346
00347
00348
00349
00350
females(cont...)
TongueSquamous Cell Papilloma
CARDIOVASCULAR SYSTEM
Blood Vessel
Heart + + + + + + + + + + + + + + + + + + + +Sarcoma, Metastatic, Tissue Nos
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + +Adenoma X XLeukemia Mononuclear X X
Adrenal Medulla + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X XPheochromocytoma Benign X
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + +Adenoma X
Parathyroid Gland + + + + + + + + + + + + + + + + M + + +
Pituitary Gland + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear XPars Distalis, Adenoma X X X X X X X X X X X XPars Distalis, Adenoma, Multiple X XPars Distalis, Carcinoma X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 99
DAY ON TEST
FISCHER 344 RATS FEMALE
0662
0655
0732
0735
0735
0735
0704
0732
0709
0715
0091
0735
0732
0735
0735
0735
0735
0697
0650
0015
0655
0015
0366
0638
0091
0.3 MG.KGANIMAL ID
00326
00327
00328
00329
00330
00331
00332
00333
00334
00335
00336
00337
00338
00339
00340
00341
00342
00343
00344
00345
00346
00347
00348
00349
00350
females(cont...)
Pars Intermedia, Adenoma
Thyroid Gland + + + + + + + + + + + + + + + + + + + +C-cell, Adenoma X XC-cell, CarcinomaFollicular Cell, Carcinoma
GENERAL BODY SYSTEM
Tissue NOSSarcoma
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + + + + + + + + + + +Adenoma X X XCarcinoma
Ovary + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
Uterus + + + + + + + + + + + + + + + + + + + +Polyp Stromal X XPolyp Stromal, Multiple X
Vagina + +
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 100
DAY ON TEST
FISCHER 344 RATS FEMALE
0662
0655
0732
0735
0735
0735
0704
0732
0709
0715
0091
0735
0732
0735
0735
0735
0735
0697
0650
0015
0655
0015
0366
0638
0091
0.3 MG.KGANIMAL ID
00326
00327
00328
00329
00330
00331
00332
00333
00334
00335
00336
00337
00338
00339
00340
00341
00342
00343
00344
00345
00346
00347
00348
00349
00350
females(cont...)
Lymphoma Malignant X
Lymph Node + + + + +Mediastinal, Leukemia MononuclearMediastinal, Lymphoma Malignant XPancreatic, Leukemia Mononuclear XPancreatic, Lymphoma Malignant X
Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X XLymphoma Malignant X
Spleen + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X XLymphoma Malignant X
Thymus + + + + + + + + + + + + + I + + + + + +Leukemia MononuclearLymphoma Malignant XThymoma Benign
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + +AdenomaCarcinomaCarcinoma, Multiple XFibroadenoma X X X X X X X X X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 101
DAY ON TEST
FISCHER 344 RATS FEMALE
0662
0655
0732
0735
0735
0735
0704
0732
0709
0715
0091
0735
0732
0735
0735
0735
0735
0697
0650
0015
0655
0015
0366
0638
0091
0.3 MG.KGANIMAL ID
00326
00327
00328
00329
00330
00331
00332
00333
00334
00335
00336
00337
00338
00339
00340
00341
00342
00343
00344
00345
00346
00347
00348
00349
00350
females(cont...)
Fibroadenoma, Multiple X X X X X X
Skin + + + + + + + + + + + + + + + + + + + +KeratoacanthomaControl, Basal Cell AdenomaSubcutaneous Tissue, Fibroma XSubcutaneous Tissue, Schwannoma Benign
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + +
Skeletal Muscle +Sarcoma X
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + +Carcinoma, Metastatic, Pituitary Gland XOligodendroglioma Malignant X
Peripheral Nerve
Spinal Cord
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X XSarcoma, Metastatic, Tissue Nos
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 102
DAY ON TEST
FISCHER 344 RATS FEMALE
0662
0655
0732
0735
0735
0735
0704
0732
0709
0715
0091
0735
0732
0735
0735
0735
0735
0697
0650
0015
0655
0015
0366
0638
0091
0.3 MG.KGANIMAL ID
00326
00327
00328
00329
00330
00331
00332
00333
00334
00335
00336
00337
00338
00339
00340
00341
00342
00343
00344
00345
00346
00347
00348
00349
00350
females(cont...)
Nose + + + + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + + + + +
Zymbal's Gland +Carcinoma X
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear XTransitional Epithelium, Carcinoma X
Urinary Bladder + + + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X XLymphoma Malignant X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 103
DAY ON TEST
FISCHER 344 RATS FEMALE
0704
0735
0715
0735
0091
0731
0714
0735
0732
0366
0732
0735
0091
0735
0015
0732
0366
0731
0732
0735
0622
0731
0680
0399
0091
0.3 MG.KGANIMAL ID
00351
00352
00353
00354
00355
00356
00357
00358
00359
00360
00361
00362
00363
00364
00365
00366
00367
00368
00369
00370
00371
00372
00373
00374
00375
females(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + M + + + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + +
Intestine Large, Colon + + + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + +
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + +
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + +
Liver + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X XLymphoma Malignant
Mesentery + + + + +
Pancreas + + + + + + + + + + + + + + + + + + +Lymphoma Malignant
Salivary Glands + + + + + + + + + + + + + + + + + + +
Stomach, Forestomach + + + + + + + + + + + + + + + + + + +
Stomach, Glandular + + + + + + + + + + + + + + + + + + +
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 104
DAY ON TEST
FISCHER 344 RATS FEMALE
0704
0735
0715
0735
0091
0731
0714
0735
0732
0366
0732
0735
0091
0735
0015
0732
0366
0731
0732
0735
0622
0731
0680
0399
0091
0.3 MG.KGANIMAL ID
00351
00352
00353
00354
00355
00356
00357
00358
00359
00360
00361
00362
00363
00364
00365
00366
00367
00368
00369
00370
00371
00372
00373
00374
00375
females(cont...)
TongueSquamous Cell Papilloma
CARDIOVASCULAR SYSTEM
Blood Vessel +
Heart + + + + + + + + + + + + + + + + + + +Sarcoma, Metastatic, Tissue Nos X
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + +Adenoma XLeukemia Mononuclear
Adrenal Medulla + + + + + + + + + + + + + + + + + + +Leukemia MononuclearPheochromocytoma Benign
Islets, Pancreatic + + + + + + + + + + + + + + + + + + +Adenoma
Parathyroid Gland + + + + + + + + + + + + + + + + + + +
Pituitary Gland + + + + + + + + + + + + + + + + + + +Leukemia MononuclearPars Distalis, Adenoma X X X X X X X X X X XPars Distalis, Adenoma, Multiple XPars Distalis, Carcinoma X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 105
DAY ON TEST
FISCHER 344 RATS FEMALE
0704
0735
0715
0735
0091
0731
0714
0735
0732
0366
0732
0735
0091
0735
0015
0732
0366
0731
0732
0735
0622
0731
0680
0399
0091
0.3 MG.KGANIMAL ID
00351
00352
00353
00354
00355
00356
00357
00358
00359
00360
00361
00362
00363
00364
00365
00366
00367
00368
00369
00370
00371
00372
00373
00374
00375
females(cont...)
Pars Intermedia, Adenoma X
Thyroid Gland + + + + + + + + + + + + + + + + + + +C-cell, Adenoma XC-cell, Carcinoma XFollicular Cell, Carcinoma X
GENERAL BODY SYSTEM
Tissue NOS +Sarcoma X
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + + + + + + + + + +AdenomaCarcinoma X X
Ovary + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
Uterus + + + + + + + + + + + + + + + + + + +Polyp Stromal X X XPolyp Stromal, Multiple X
Vagina + +
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 106
DAY ON TEST
FISCHER 344 RATS FEMALE
0704
0735
0715
0735
0091
0731
0714
0735
0732
0366
0732
0735
0091
0735
0015
0732
0366
0731
0732
0735
0622
0731
0680
0399
0091
0.3 MG.KGANIMAL ID
00351
00352
00353
00354
00355
00356
00357
00358
00359
00360
00361
00362
00363
00364
00365
00366
00367
00368
00369
00370
00371
00372
00373
00374
00375
females(cont...)
Lymphoma Malignant
Lymph Node + + + + +Mediastinal, Leukemia Mononuclear XMediastinal, Lymphoma MalignantPancreatic, Leukemia MononuclearPancreatic, Lymphoma Malignant
Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear XLymphoma Malignant X
Spleen + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X XLymphoma Malignant
Thymus + + + + + + + + + M + + + I + + + + +Leukemia Mononuclear XLymphoma MalignantThymoma Benign
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + +Adenoma XCarcinoma XCarcinoma, MultipleFibroadenoma X X X X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 107
DAY ON TEST
FISCHER 344 RATS FEMALE
0704
0735
0715
0735
0091
0731
0714
0735
0732
0366
0732
0735
0091
0735
0015
0732
0366
0731
0732
0735
0622
0731
0680
0399
0091
0.3 MG.KGANIMAL ID
00351
00352
00353
00354
00355
00356
00357
00358
00359
00360
00361
00362
00363
00364
00365
00366
00367
00368
00369
00370
00371
00372
00373
00374
00375
females(cont...)
Fibroadenoma, Multiple X X
Skin + + + + + + + + + + + + + + + + + + +KeratoacanthomaControl, Basal Cell Adenoma XSubcutaneous Tissue, Fibroma XSubcutaneous Tissue, Schwannoma Benign X
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + +
Skeletal MuscleSarcoma
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + +Carcinoma, Metastatic, Pituitary Gland XOligodendroglioma Malignant
Peripheral Nerve + +
Spinal Cord + +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + +Leukemia MononuclearSarcoma, Metastatic, Tissue Nos X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 108
DAY ON TEST
FISCHER 344 RATS FEMALE
0704
0735
0715
0735
0091
0731
0714
0735
0732
0366
0732
0735
0091
0735
0015
0732
0366
0731
0732
0735
0622
0731
0680
0399
0091
0.3 MG.KGANIMAL ID
00351
00352
00353
00354
00355
00356
00357
00358
00359
00360
00361
00362
00363
00364
00365
00366
00367
00368
00369
00370
00371
00372
00373
00374
00375
females(cont...)
Nose + + + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + + + +
Zymbal's GlandCarcinoma
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + +Leukemia MononuclearTransitional Epithelium, Carcinoma
Urinary Bladder + + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X XLymphoma Malignant X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 109
DAY ON TEST
FISCHER 344 RATS FEMALE
0731
0366
0639
0366
0732
0015
0732
0735
0732
0728
0577
0732
0731
0594
0015
0.3 MG.KGANIMAL ID
00376
00377
00378
00379
00380
00381
00382
00383
00384
00385
00386
00387
00388
00389
00390 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + 49
Intestine Large, Cecum + + + + + + A + + + + 49
Intestine Large, Colon + + + + + + + + + + + 50
Intestine Large, Rectum + + + + + + A + + + + 49
Intestine Small, Duodenum + + + + + + + + + + + 50
Intestine Small, Ileum + + + + + + A + + + + 49
Intestine Small, Jejunum + + + + + + A A + + + 47
Liver + + + + + + + + + + + 50Leukemia Mononuclear X X 12Lymphoma Malignant 1
Mesentery + + + 15
Pancreas + + + + + + + + + + + 50Lymphoma Malignant 1
Salivary Glands + + + + + + + + + + + 50
Stomach, Forestomach + + + + + + + + + + + 50
Stomach, Glandular + + + + + + + + + + + 50
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 110
DAY ON TEST
FISCHER 344 RATS FEMALE
0731
0366
0639
0366
0732
0015
0732
0735
0732
0728
0577
0732
0731
0594
0015
0.3 MG.KGANIMAL ID
00376
00377
00378
00379
00380
00381
00382
00383
00384
00385
00386
00387
00388
00389
00390 * TOTALS
Tongue + 1Squamous Cell Papilloma X 1
CARDIOVASCULAR SYSTEM
Blood Vessel 1
Heart + + + + + + + + + + + 50Sarcoma, Metastatic, Tissue Nos 1
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + 50Adenoma 3Leukemia Mononuclear 2
Adrenal Medulla + + + + + + + + + + + 50Leukemia Mononuclear 2Pheochromocytoma Benign 1
Islets, Pancreatic + + + + + + + + + + + 50Adenoma 1
Parathyroid Gland + + + + + + + + + + + 49
Pituitary Gland + + + + + + + + + + + 50Leukemia Mononuclear 1Pars Distalis, Adenoma X X X X X X X X X X X 34Pars Distalis, Adenoma, Multiple 3Pars Distalis, Carcinoma 2
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 111
DAY ON TEST
FISCHER 344 RATS FEMALE
0731
0366
0639
0366
0732
0015
0732
0735
0732
0728
0577
0732
0731
0594
0015
0.3 MG.KGANIMAL ID
00376
00377
00378
00379
00380
00381
00382
00383
00384
00385
00386
00387
00388
00389
00390 * TOTALS
Pars Intermedia, Adenoma 1
Thyroid Gland + + + + + + + + + + + 50C-cell, Adenoma 3C-cell, Carcinoma 1Follicular Cell, Carcinoma 1
GENERAL BODY SYSTEM
Tissue NOS 1Sarcoma 1
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + + 50Adenoma X 4Carcinoma 2
Ovary + + + + + + + + + + + 50Leukemia Mononuclear 1
Uterus + + + + + + + + + + + 50Polyp Stromal X X 7Polyp Stromal, Multiple 2
Vagina + 5
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + 50Leukemia Mononuclear X X 6
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 112
DAY ON TEST
FISCHER 344 RATS FEMALE
0731
0366
0639
0366
0732
0015
0732
0735
0732
0728
0577
0732
0731
0594
0015
0.3 MG.KGANIMAL ID
00376
00377
00378
00379
00380
00381
00382
00383
00384
00385
00386
00387
00388
00389
00390 * TOTALS
Lymphoma Malignant 1
Lymph Node + 11Mediastinal, Leukemia Mononuclear 1Mediastinal, Lymphoma Malignant 1Pancreatic, Leukemia Mononuclear 1Pancreatic, Lymphoma Malignant 1
Lymph Node, Mandibular M M M M M M M M M M M 0
Lymph Node, Mesenteric + + + + + + + + + + + 50Leukemia Mononuclear X X 6Lymphoma Malignant 2
Spleen + + + + + + + + + + + 50Leukemia Mononuclear X X 12Lymphoma Malignant 1
Thymus + + + + + + + + + + + 47Leukemia Mononuclear 1Lymphoma Malignant 1Thymoma Benign X 1
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + 50Adenoma 1Carcinoma X 2Carcinoma, Multiple 1Fibroadenoma X X X X X 18
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 113
DAY ON TEST
FISCHER 344 RATS FEMALE
0731
0366
0639
0366
0732
0015
0732
0735
0732
0728
0577
0732
0731
0594
0015
0.3 MG.KGANIMAL ID
00376
00377
00378
00379
00380
00381
00382
00383
00384
00385
00386
00387
00388
00389
00390 * TOTALS
Fibroadenoma, Multiple X 9
Skin + + + + + + + + + + + 50Keratoacanthoma X 1Control, Basal Cell Adenoma 1Subcutaneous Tissue, Fibroma X 3Subcutaneous Tissue, Schwannoma Benign 1
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + 50
Skeletal Muscle 1Sarcoma 1
NERVOUS SYSTEM
Brain + + + + + + + + + + + 50Carcinoma, Metastatic, Pituitary Gland 2Oligodendroglioma Malignant 1
Peripheral Nerve + 3
Spinal Cord + 3
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + 50Leukemia Mononuclear X 4Sarcoma, Metastatic, Tissue Nos 1
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 114
DAY ON TEST
FISCHER 344 RATS FEMALE
0731
0366
0639
0366
0732
0015
0732
0735
0732
0728
0577
0732
0731
0594
0015
0.3 MG.KGANIMAL ID
00376
00377
00378
00379
00380
00381
00382
00383
00384
00385
00386
00387
00388
00389
00390 * TOTALS
Nose + + + + + + + + + + + 50
Trachea + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + 50
Harderian Gland + + + + + + + + + + + 50
Zymbal's Gland 1Carcinoma 1
URINARY SYSTEM
Kidney + + + + + + + + + + + 50Leukemia Mononuclear 1Transitional Epithelium, Carcinoma 1
Urinary Bladder + + + + + + + + + + + 50
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + 50Leukemia Mononuclear X X 12Lymphoma Malignant 2
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 115
DAY ON TEST
FISCHER 344 RATS FEMALE
0591
0670
0600
0015
0732
0732
0735
0732
0731
0732
0690
0731
0704
0731
0682
0735
0732
0693
0735
0091
0091
0735
0366
0366
0652
1.0 MG/KGANIMAL ID
00391
00392
00393
00394
00395
00396
00397
00398
00399
00400
00401
00402
00403
00404
00405
00406
00407
00408
00409
00410
00411
00412
00413
00414
00415
females(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + +
Intestine Large, Colon + + M + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + +
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
Intestine Small, Jejunum + + A + + + + + + + + + + + + + + + + +
Liver + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X X
Mesentery + + + + +
Pancreas + + + + + + + + + + + + + + + + + + M +Leukemia Mononuclear X X
Salivary Glands + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 116
DAY ON TEST
FISCHER 344 RATS FEMALE
0591
0670
0600
0015
0732
0732
0735
0732
0731
0732
0690
0731
0704
0731
0682
0735
0732
0693
0735
0091
0091
0735
0366
0366
0652
1.0 MG/KGANIMAL ID
00391
00392
00393
00394
00395
00396
00397
00398
00399
00400
00401
00402
00403
00404
00405
00406
00407
00408
00409
00410
00411
00412
00413
00414
00415
females(cont...)
Stomach, Glandular + + + + + + + + + + + + + + + + + + + +
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
Adrenal Medulla + + + + + + + + + + + + + + + + + I + +Leukemia MononuclearPheochromocytoma Benign XPheochromocytoma Malignant, Multiple
Islets, Pancreatic + + + + + + + + + + + + + + + + + + M +Adenoma X X
Parathyroid Gland + + + + + + M + + + + + + + + + + M + +
Pituitary Gland + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear XPars Distalis, Adenoma X X X X X X X X XPars Distalis, Adenoma, Multiple XPars Distalis, Carcinoma X XPars Intermedia, Adenoma X
Thyroid Gland + + + + + + + + + + + + + + + + + + + +C-cell, Adenoma
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 117
DAY ON TEST
FISCHER 344 RATS FEMALE
0591
0670
0600
0015
0732
0732
0735
0732
0731
0732
0690
0731
0704
0731
0682
0735
0732
0693
0735
0091
0091
0735
0366
0366
0652
1.0 MG/KGANIMAL ID
00391
00392
00393
00394
00395
00396
00397
00398
00399
00400
00401
00402
00403
00404
00405
00406
00407
00408
00409
00410
00411
00412
00413
00414
00415
females(cont...)
C-cell, CarcinomaFollicular Cell, Adenoma X
GENERAL BODY SYSTEM
Tissue NOS
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + + + + + + + + + + +Adenoma X XCarcinoma X
Ovary + + + + + + + + + + + + + + + + + + + +Leukemia MononuclearThecoma Malignant X
Uterus + + + + + + + + + + + + + + + + + + + +Leukemia MononuclearPolyp Stromal X X X XPolyp Stromal, Multiple X
Vagina + +Leukemia Mononuclear
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X
Lymph Node + + +
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 118
DAY ON TEST
FISCHER 344 RATS FEMALE
0591
0670
0600
0015
0732
0732
0735
0732
0731
0732
0690
0731
0704
0731
0682
0735
0732
0693
0735
0091
0091
0735
0366
0366
0652
1.0 MG/KGANIMAL ID
00391
00392
00393
00394
00395
00396
00397
00398
00399
00400
00401
00402
00403
00404
00405
00406
00407
00408
00409
00410
00411
00412
00413
00414
00415
females(cont...)
Mediastinal, Leukemia Mononuclear XPancreatic, Leukemia Mononuclear X X
Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X
Spleen + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X X X
Thymus + + + + + + + M + + + + + + + M + + + MLeukemia Mononuclear X X
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + +Adenoma XCarcinoma XCarcinoma, MultipleFibroadenoma X X X X X X X XFibroadenoma, Multiple X X X X
Skin + + + + + + + + + + + + + + + + + + + +Keratoacanthoma X XSubcutaneous Tissue, FibromaSubcutaneous Tissue, Leukemia Mononuclear
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + +
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 119
DAY ON TEST
FISCHER 344 RATS FEMALE
0591
0670
0600
0015
0732
0732
0735
0732
0731
0732
0690
0731
0704
0731
0682
0735
0732
0693
0735
0091
0091
0735
0366
0366
0652
1.0 MG/KGANIMAL ID
00391
00392
00393
00394
00395
00396
00397
00398
00399
00400
00401
00402
00403
00404
00405
00406
00407
00408
00409
00410
00411
00412
00413
00414
00415
females(cont...)
Skeletal Muscle
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + +Carcinoma, Metastatic, Pituitary Gland X XLeukemia Mononuclear X
Peripheral Nerve +
Spinal Cord +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + +Carcinoma, Metastatic, Pituitary GlandLeukemia Mononuclear X XPheochromocytoma Malignant, Metastatic,
Adrenal Medulla
Nose + + + + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + + + + +
URINARY SYSTEM
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 120
DAY ON TEST
FISCHER 344 RATS FEMALE
0591
0670
0600
0015
0732
0732
0735
0732
0731
0732
0690
0731
0704
0731
0682
0735
0732
0693
0735
0091
0091
0735
0366
0366
0652
1.0 MG/KGANIMAL ID
00391
00392
00393
00394
00395
00396
00397
00398
00399
00400
00401
00402
00403
00404
00405
00406
00407
00408
00409
00410
00411
00412
00413
00414
00415
females(cont...)
Kidney + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
Urinary Bladder + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X X X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 121
DAY ON TEST
FISCHER 344 RATS FEMALE
0731
0732
0598
0732
0472
0091
0015
0731
0015
0449
0091
0571
0598
0338
0730
0511
0735
0662
0715
0366
0371
0366
0735
0715
0091
1.0 MG/KGANIMAL ID
00416
00417
00418
00419
00420
00421
00422
00423
00424
00425
00426
00427
00428
00429
00430
00431
00432
00433
00434
00435
00436
00437
00438
00439
00440
females(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + A + +
Intestine Large, Colon + + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + +
Intestine Small, Ileum + + + + A + + + + + + + + + + A + +Leukemia Mononuclear X
Intestine Small, Jejunum + + + + A + + + + A A + + + + A + +
Liver + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X X X
Mesentery + + + + + + + +
Pancreas + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
Salivary Glands + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
Stomach, Forestomach + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 122
DAY ON TEST
FISCHER 344 RATS FEMALE
0731
0732
0598
0732
0472
0091
0015
0731
0015
0449
0091
0571
0598
0338
0730
0511
0735
0662
0715
0366
0371
0366
0735
0715
0091
1.0 MG/KGANIMAL ID
00416
00417
00418
00419
00420
00421
00422
00423
00424
00425
00426
00427
00428
00429
00430
00431
00432
00433
00434
00435
00436
00437
00438
00439
00440
females(cont...)
Stomach, Glandular + + + + + + + + + + + + + + + + + +
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X
Adrenal Medulla + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X XPheochromocytoma Benign X XPheochromocytoma Malignant, Multiple X
Islets, Pancreatic + + + + + + + + + + + + + + + + + +Adenoma
Parathyroid Gland + + + + M + + + + + + + + M + + + +
Pituitary Gland + + + + + + + + + + + + + + + + + +Leukemia Mononuclear XPars Distalis, Adenoma X X X X X XPars Distalis, Adenoma, MultiplePars Distalis, CarcinomaPars Intermedia, Adenoma
Thyroid Gland + + + + + + + + + + + + + + + + + +C-cell, Adenoma X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 123
DAY ON TEST
FISCHER 344 RATS FEMALE
0731
0732
0598
0732
0472
0091
0015
0731
0015
0449
0091
0571
0598
0338
0730
0511
0735
0662
0715
0366
0371
0366
0735
0715
0091
1.0 MG/KGANIMAL ID
00416
00417
00418
00419
00420
00421
00422
00423
00424
00425
00426
00427
00428
00429
00430
00431
00432
00433
00434
00435
00436
00437
00438
00439
00440
females(cont...)
C-cell, Carcinoma XFollicular Cell, Adenoma
GENERAL BODY SYSTEM
Tissue NOS +
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + + + + + + + + +Adenoma XCarcinoma X X
Ovary + + + + + + + + + + + + + + + + + +Leukemia Mononuclear XThecoma Malignant
Uterus + + + + + + + + + + + + + + + + + +Leukemia Mononuclear XPolyp Stromal X X XPolyp Stromal, Multiple X
Vagina + +Leukemia Mononuclear X
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X X
Lymph Node + + +
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 124
DAY ON TEST
FISCHER 344 RATS FEMALE
0731
0732
0598
0732
0472
0091
0015
0731
0015
0449
0091
0571
0598
0338
0730
0511
0735
0662
0715
0366
0371
0366
0735
0715
0091
1.0 MG/KGANIMAL ID
00416
00417
00418
00419
00420
00421
00422
00423
00424
00425
00426
00427
00428
00429
00430
00431
00432
00433
00434
00435
00436
00437
00438
00439
00440
females(cont...)
Mediastinal, Leukemia Mononuclear X XPancreatic, Leukemia Mononuclear X X
Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X
Spleen + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X X X
Thymus + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + +AdenomaCarcinomaCarcinoma, MultipleFibroadenoma X X X XFibroadenoma, Multiple X X X
Skin + + + + + + + + + + + + + + + + + +Keratoacanthoma XSubcutaneous Tissue, Fibroma XSubcutaneous Tissue, Leukemia Mononuclear X
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + +
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 125
DAY ON TEST
FISCHER 344 RATS FEMALE
0731
0732
0598
0732
0472
0091
0015
0731
0015
0449
0091
0571
0598
0338
0730
0511
0735
0662
0715
0366
0371
0366
0735
0715
0091
1.0 MG/KGANIMAL ID
00416
00417
00418
00419
00420
00421
00422
00423
00424
00425
00426
00427
00428
00429
00430
00431
00432
00433
00434
00435
00436
00437
00438
00439
00440
females(cont...)
Skeletal Muscle +
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + +Carcinoma, Metastatic, Pituitary GlandLeukemia Mononuclear X
Peripheral Nerve +
Spinal Cord +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + +Carcinoma, Metastatic, Pituitary GlandLeukemia Mononuclear X X X XPheochromocytoma Malignant, Metastatic,
Adrenal MedullaX
Nose + + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + + +
URINARY SYSTEM
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 126
DAY ON TEST
FISCHER 344 RATS FEMALE
0731
0732
0598
0732
0472
0091
0015
0731
0015
0449
0091
0571
0598
0338
0730
0511
0735
0662
0715
0366
0371
0366
0735
0715
0091
1.0 MG/KGANIMAL ID
00416
00417
00418
00419
00420
00421
00422
00423
00424
00425
00426
00427
00428
00429
00430
00431
00432
00433
00434
00435
00436
00437
00438
00439
00440
females(cont...)
Kidney + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X
Urinary Bladder + + + + + + + + I + + + + + + + + +Leukemia Mononuclear X
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X X X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 127
DAY ON TEST
FISCHER 344 RATS FEMALE
0732
0735
0485
0366
0735
0731
0637
0015
0709
0682
0735
0502
0015
0625
0702
1.0 MG/KGANIMAL ID
00441
00442
00443
00444
00445
00446
00447
00448
00449
00450
00451
00452
00453
00454
00455 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + 50
Intestine Large, Cecum + + + + + + + + + + + + 49
Intestine Large, Colon + + + + + + + + + + + + 49
Intestine Large, Rectum + + + + + + + + + + + + 50
Intestine Small, Duodenum + + + + + + + + + + + + 50
Intestine Small, Ileum + + + + + + + + + + + + 48Leukemia Mononuclear 1
Intestine Small, Jejunum + + + + + A + + + + + + 44
Liver + + + + + + + + + + + + 50Leukemia Mononuclear X X X 16
Mesentery + + + + + + 19
Pancreas + + + + + + + + + + + + 49Leukemia Mononuclear X 4
Salivary Glands + + + + + + + + + + + + 50Leukemia Mononuclear 1
Stomach, Forestomach + + + + + + + + + + + + 50Leukemia Mononuclear 1
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 128
DAY ON TEST
FISCHER 344 RATS FEMALE
0732
0735
0485
0366
0735
0731
0637
0015
0709
0682
0735
0502
0015
0625
0702
1.0 MG/KGANIMAL ID
00441
00442
00443
00444
00445
00446
00447
00448
00449
00450
00451
00452
00453
00454
00455 * TOTALS
Stomach, Glandular + + + + + + + + + + + + 50
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + 50Leukemia Mononuclear X 5
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + 50Leukemia Mononuclear X X 6
Adrenal Medulla + + + + + + + + + + + + 49Leukemia Mononuclear X X 4Pheochromocytoma Benign X 4Pheochromocytoma Malignant, Multiple 1
Islets, Pancreatic + + + + + + + + + + + + 49Adenoma 2
Parathyroid Gland + + + + + + + + + + + + 46
Pituitary Gland + + + + + + + + + + + + 50Leukemia Mononuclear X 3Pars Distalis, Adenoma X X X X X X X X X 24Pars Distalis, Adenoma, Multiple 1Pars Distalis, Carcinoma X 3Pars Intermedia, Adenoma 1
Thyroid Gland + + + + + + + + + + + + 50C-cell, Adenoma 1
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 129
DAY ON TEST
FISCHER 344 RATS FEMALE
0732
0735
0485
0366
0735
0731
0637
0015
0709
0682
0735
0502
0015
0625
0702
1.0 MG/KGANIMAL ID
00441
00442
00443
00444
00445
00446
00447
00448
00449
00450
00451
00452
00453
00454
00455 * TOTALS
C-cell, Carcinoma 1Follicular Cell, Adenoma 1
GENERAL BODY SYSTEM
Tissue NOS 1
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + + + 50Adenoma 3Carcinoma X 4
Ovary + + + + + + + + + + + + 50Leukemia Mononuclear X 2Thecoma Malignant 1
Uterus + + + + + + + + + + + + 50Leukemia Mononuclear 1Polyp Stromal 7Polyp Stromal, Multiple 2
Vagina + + + + + 9Leukemia Mononuclear 1
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + 50Leukemia Mononuclear X X X 12
Lymph Node + + 8
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 130
DAY ON TEST
FISCHER 344 RATS FEMALE
0732
0735
0485
0366
0735
0731
0637
0015
0709
0682
0735
0502
0015
0625
0702
1.0 MG/KGANIMAL ID
00441
00442
00443
00444
00445
00446
00447
00448
00449
00450
00451
00452
00453
00454
00455 * TOTALS
Mediastinal, Leukemia Mononuclear 3Pancreatic, Leukemia Mononuclear X 5
Lymph Node, Mandibular M M M M M M M M M M M M 0
Lymph Node, Mesenteric + + + + + + + + + + + + 50Leukemia Mononuclear X X X 10
Spleen + + + + + + + + + + + + 50Leukemia Mononuclear X X X 17
Thymus + + M + + + + + + + + + 46Leukemia Mononuclear X 4
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + 50Adenoma 1Carcinoma 1Carcinoma, Multiple X 1Fibroadenoma X X X X X X X 19Fibroadenoma, Multiple 7
Skin + + + + + + + + + + + + 50Keratoacanthoma 3Subcutaneous Tissue, Fibroma X 2Subcutaneous Tissue, Leukemia Mononuclear 1
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + 50
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 131
DAY ON TEST
FISCHER 344 RATS FEMALE
0732
0735
0485
0366
0735
0731
0637
0015
0709
0682
0735
0502
0015
0625
0702
1.0 MG/KGANIMAL ID
00441
00442
00443
00444
00445
00446
00447
00448
00449
00450
00451
00452
00453
00454
00455 * TOTALS
Skeletal Muscle 1
NERVOUS SYSTEM
Brain + + + + + + + + + + + + 50Carcinoma, Metastatic, Pituitary Gland X 3Leukemia Mononuclear X 3
Peripheral Nerve + 3
Spinal Cord + 3
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + 50Carcinoma, Metastatic, Pituitary Gland X 1Leukemia Mononuclear X X X 9Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla1
Nose + + + + + + + + + + + + 50
Trachea + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + 50
Harderian Gland + + + + + + + + + + + + 50
URINARY SYSTEM
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 132
DAY ON TEST
FISCHER 344 RATS FEMALE
0732
0735
0485
0366
0735
0731
0637
0015
0709
0682
0735
0502
0015
0625
0702
1.0 MG/KGANIMAL ID
00441
00442
00443
00444
00445
00446
00447
00448
00449
00450
00451
00452
00453
00454
00455 * TOTALS
Kidney + + + + + + + + + + + + 50Leukemia Mononuclear X X 5
Urinary Bladder + + + + + + + + + + + + 49Leukemia Mononuclear 1
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + 50Leukemia Mononuclear X X X 17
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 133
DAY ON TEST
FISCHER 344 RATS FEMALE
0731
0471
0729
0731
0298
0735
0091
0732
0731
0366
0735
0448
0735
0464
0729
0669
0091
0091
0731
0722
0366
0366
0735
0731
0652
3.0 MG/KGANIMAL ID
00456
00457
00458
00459
00460
00461
00462
00463
00464
00465
00466
00467
00468
00469
00470
00471
00472
00473
00474
00475
00476
00477
00478
00479
00480
females(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + +
Intestine Large, Colon + + + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + +
Intestine Small, Ileum + + + + + + + + + A + + + + + + + + +
Intestine Small, Jejunum + A + + + + + + + + + + + + + + + + +
Liver + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X
Mesentery + + + + + + +Schwannoma Malignant
Pancreas + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
Salivary Glands + + + + + + + + + + + + + + + + + + +
Stomach, Forestomach + + + + + + + + + + + + + + + + + + +Squamous Cell Papilloma X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 134
DAY ON TEST
FISCHER 344 RATS FEMALE
0731
0471
0729
0731
0298
0735
0091
0732
0731
0366
0735
0448
0735
0464
0729
0669
0091
0091
0731
0722
0366
0366
0735
0731
0652
3.0 MG/KGANIMAL ID
00456
00457
00458
00459
00460
00461
00462
00463
00464
00465
00466
00467
00468
00469
00470
00471
00472
00473
00474
00475
00476
00477
00478
00479
00480
females(cont...)
Stomach, Glandular + + + + + + + + + + + + + + + + + + +
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
Adrenal Medulla + + + + + + + + + + + + + + + + + + +Leukemia MononuclearPheochromocytoma BenignPheochromocytoma Complex X
Islets, Pancreatic + + + + + + + + + + + + + + + + + + +Adenoma
Parathyroid Gland + + + + + + + + + M + + + + + + + + M
Pituitary Gland + + + + + + + + + + + + + + + + + + +Pars Distalis, Adenoma X X X X X X XPars Distalis, Adenoma, Multiple XPars Distalis, Carcinoma X
Thyroid Gland + + + + + + + + + + + + + + + + + + +C-cell, Adenoma X XC-cell, Carcinoma XFollicular Cell, Adenoma X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 135
DAY ON TEST
FISCHER 344 RATS FEMALE
0731
0471
0729
0731
0298
0735
0091
0732
0731
0366
0735
0448
0735
0464
0729
0669
0091
0091
0731
0722
0366
0366
0735
0731
0652
3.0 MG/KGANIMAL ID
00456
00457
00458
00459
00460
00461
00462
00463
00464
00465
00466
00467
00468
00469
00470
00471
00472
00473
00474
00475
00476
00477
00478
00479
00480
females(cont...)
Follicular Cell, Carcinoma
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + + + + + + + + + +Adenoma X XCarcinoma X X
Ovary + + + + + + + + + + + + + + + + + + +
Uterus + + + + + + + + + + + + + + + + + + +Polyp Stromal X X
Vagina +Polyp
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear
Lymph Node +
Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 136
DAY ON TEST
FISCHER 344 RATS FEMALE
0731
0471
0729
0731
0298
0735
0091
0732
0731
0366
0735
0448
0735
0464
0729
0669
0091
0091
0731
0722
0366
0366
0735
0731
0652
3.0 MG/KGANIMAL ID
00456
00457
00458
00459
00460
00461
00462
00463
00464
00465
00466
00467
00468
00469
00470
00471
00472
00473
00474
00475
00476
00477
00478
00479
00480
females(cont...)
Lymphoma Malignant
Spleen + + + + + + + + + + + + + + + + + + +HemangiosarcomaLeukemia Mononuclear X X XLymphoma Malignant
Thymus + + + + + + + + + + + + + + + + + + +Leukemia MononuclearThymoma Benign X
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + +Carcinoma XFibroadenoma X X X X X XFibroadenoma, Multiple X X X X
Skin + + + + + + + + + + + + + + + + + + +Keratoacanthoma XTrichoepithelioma
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + +
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + +Carcinoma, Metastatic, Pituitary Gland X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 137
DAY ON TEST
FISCHER 344 RATS FEMALE
0731
0471
0729
0731
0298
0735
0091
0732
0731
0366
0735
0448
0735
0464
0729
0669
0091
0091
0731
0722
0366
0366
0735
0731
0652
3.0 MG/KGANIMAL ID
00456
00457
00458
00459
00460
00461
00462
00463
00464
00465
00466
00467
00468
00469
00470
00471
00472
00473
00474
00475
00476
00477
00478
00479
00480
females(cont...)
Peripheral Nerve + +
Spinal Cord + +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + +Carcinoma, Metastatic, Thyroid Gland XLeukemia Mononuclear
Nose + + + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + + + +
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + +
Urinary Bladder + + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X XLymphoma Malignant
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 138
DAY ON TEST
FISCHER 344 RATS FEMALE
0732
0366
0091
0417
0729
0625
0015
0731
0731
0379
0731
0729
0729
0735
0732
0091
0606
0729
0732
0735
0690
0366
0691
0731
0704
3.0 MG/KGANIMAL ID
00481
00482
00483
00484
00485
00486
00487
00488
00489
00490
00491
00492
00493
00494
00495
00496
00497
00498
00499
00500
00501
00502
00503
00504
00505
females(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + M + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + +
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + I + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + +
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + +
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + +
Liver + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X X
Mesentery + + + + + + + + +Schwannoma Malignant X
Pancreas + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
Salivary Glands + + + + + + + + + + + + + + + + + + + +
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + +Squamous Cell Papilloma
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 139
DAY ON TEST
FISCHER 344 RATS FEMALE
0732
0366
0091
0417
0729
0625
0015
0731
0731
0379
0731
0729
0729
0735
0732
0091
0606
0729
0732
0735
0690
0366
0691
0731
0704
3.0 MG/KGANIMAL ID
00481
00482
00483
00484
00485
00486
00487
00488
00489
00490
00491
00492
00493
00494
00495
00496
00497
00498
00499
00500
00501
00502
00503
00504
00505
females(cont...)
Stomach, Glandular + + + + + + + + + + + + + + + + + + + +
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X
Adrenal Medulla + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear XPheochromocytoma BenignPheochromocytoma Complex
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + +Adenoma X
Parathyroid Gland + M + + + + + + + + + + + + + + + + + +
Pituitary Gland + + + + + + + + + + + + + + + + + + + +Pars Distalis, Adenoma X X X X X X X X X X X XPars Distalis, Adenoma, Multiple X X X XPars Distalis, Carcinoma X
Thyroid Gland + + + + + + + + + + + + + + + + + + + +C-cell, Adenoma X X XC-cell, CarcinomaFollicular Cell, Adenoma
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 140
DAY ON TEST
FISCHER 344 RATS FEMALE
0732
0366
0091
0417
0729
0625
0015
0731
0731
0379
0731
0729
0729
0735
0732
0091
0606
0729
0732
0735
0690
0366
0691
0731
0704
3.0 MG/KGANIMAL ID
00481
00482
00483
00484
00485
00486
00487
00488
00489
00490
00491
00492
00493
00494
00495
00496
00497
00498
00499
00500
00501
00502
00503
00504
00505
females(cont...)
Follicular Cell, Carcinoma X
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + + + + + + + + + + +Adenoma XCarcinoma X
Ovary + + + + + + + + + + + + + + + + + + + +
Uterus + + + + + + + + + + + + + + + + + + + +Polyp Stromal X X X X X
Vagina + + +Polyp X
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X
Lymph Node + + +
Lymph Node, Mandibular M M M M M M M M M M M M M M M M M M M M
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 141
DAY ON TEST
FISCHER 344 RATS FEMALE
0732
0366
0091
0417
0729
0625
0015
0731
0731
0379
0731
0729
0729
0735
0732
0091
0606
0729
0732
0735
0690
0366
0691
0731
0704
3.0 MG/KGANIMAL ID
00481
00482
00483
00484
00485
00486
00487
00488
00489
00490
00491
00492
00493
00494
00495
00496
00497
00498
00499
00500
00501
00502
00503
00504
00505
females(cont...)
Lymphoma Malignant X
Spleen + + + + + + + + + + + + + + + + + + + +HemangiosarcomaLeukemia Mononuclear X X X X XLymphoma Malignant X
Thymus + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear XThymoma Benign
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + +Carcinoma XFibroadenoma X X X XFibroadenoma, Multiple X X X X X
Skin + + + + + + + + + + + + + + + + + + + +Keratoacanthoma XTrichoepithelioma X
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + +
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + +Carcinoma, Metastatic, Pituitary Gland X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 142
DAY ON TEST
FISCHER 344 RATS FEMALE
0732
0366
0091
0417
0729
0625
0015
0731
0731
0379
0731
0729
0729
0735
0732
0091
0606
0729
0732
0735
0690
0366
0691
0731
0704
3.0 MG/KGANIMAL ID
00481
00482
00483
00484
00485
00486
00487
00488
00489
00490
00491
00492
00493
00494
00495
00496
00497
00498
00499
00500
00501
00502
00503
00504
00505
females(cont...)
Peripheral Nerve +
Spinal Cord +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + +Carcinoma, Metastatic, Thyroid GlandLeukemia Mononuclear X X
Nose + + + + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + + + + +
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + +
Urinary Bladder + + + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + +Leukemia Mononuclear X X X X XLymphoma Malignant X
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 143
DAY ON TEST
FISCHER 344 RATS FEMALE
0729
0015
0015
0731
0715
0731
0735
0721
0015
0735
0594
0731
0552
0735
0015
3.0 MG/KGANIMAL ID
00506
00507
00508
00509
00510
00511
00512
00513
00514
00515
00516
00517
00518
00519
00520 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + 49
Intestine Large, Cecum + + + + + + + + + + + 50
Intestine Large, Colon + + + + + + + + + + + 50
Intestine Large, Rectum + + + + + + + + + + + 49
Intestine Small, Duodenum + + + + + + + + + + + 50
Intestine Small, Ileum + + + + + + + + + + + 49
Intestine Small, Jejunum + + + + + + + + + + + 49
Liver + + + + + + + + + + + 50Leukemia Mononuclear X X 10
Mesentery + + 18Schwannoma Malignant 1
Pancreas + + + + + + + + + + + 50Leukemia Mononuclear 1
Salivary Glands + + + + + + + + + + + 50
Stomach, Forestomach + + + + + + + + + + + 50Squamous Cell Papilloma 1
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 144
DAY ON TEST
FISCHER 344 RATS FEMALE
0729
0015
0015
0731
0715
0731
0735
0721
0015
0735
0594
0731
0552
0735
0015
3.0 MG/KGANIMAL ID
00506
00507
00508
00509
00510
00511
00512
00513
00514
00515
00516
00517
00518
00519
00520 * TOTALS
Stomach, Glandular + + + + + + + + + + + 50
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + 50Leukemia Mononuclear 1
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + 50Leukemia Mononuclear 2
Adrenal Medulla + + + + + + + + + + + 50Leukemia Mononuclear 1Pheochromocytoma Benign X 1Pheochromocytoma Complex 1
Islets, Pancreatic + + + + + + + + + + + 50Adenoma X 2
Parathyroid Gland + + + + + + + + + + M 46
Pituitary Gland + + + + + + + + + + + 50Pars Distalis, Adenoma X X X X X X 25Pars Distalis, Adenoma, Multiple 5Pars Distalis, Carcinoma 2
Thyroid Gland + + + + + + + + + + + 50C-cell, Adenoma 5C-cell, Carcinoma 1Follicular Cell, Adenoma 1
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 145
DAY ON TEST
FISCHER 344 RATS FEMALE
0729
0015
0015
0731
0715
0731
0735
0721
0015
0735
0594
0731
0552
0735
0015
3.0 MG/KGANIMAL ID
00506
00507
00508
00509
00510
00511
00512
00513
00514
00515
00516
00517
00518
00519
00520 * TOTALS
Follicular Cell, Carcinoma 1
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland M + + + + + + + + + + 49Adenoma X 4Carcinoma 3
Ovary + + + + + + + + + + + 50
Uterus + + + + + + + + + + + 50Polyp Stromal X X X 10
Vagina + 5Polyp 1
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + 50Leukemia Mononuclear 2
Lymph Node 4
Lymph Node, Mandibular M M M M M M M M M M M 0
Lymph Node, Mesenteric + + + + + + + + + + + 50Leukemia Mononuclear 5
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 146
DAY ON TEST
FISCHER 344 RATS FEMALE
0729
0015
0015
0731
0715
0731
0735
0721
0015
0735
0594
0731
0552
0735
0015
3.0 MG/KGANIMAL ID
00506
00507
00508
00509
00510
00511
00512
00513
00514
00515
00516
00517
00518
00519
00520 * TOTALS
Lymphoma Malignant 1
Spleen + + + + + + + + + + + 50Hemangiosarcoma X 1Leukemia Mononuclear X X 10Lymphoma Malignant 1
Thymus + + + + + + + + + + + 50Leukemia Mononuclear 1Thymoma Benign 1
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + 50Carcinoma X 3Fibroadenoma X X X 13Fibroadenoma, Multiple X X X 12
Skin + + + + + + + + + + + 50Keratoacanthoma 2Trichoepithelioma 1
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + 50
NERVOUS SYSTEM
Brain + + + + + + + + + + + 50Carcinoma, Metastatic, Pituitary Gland 2
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 147
DAY ON TEST
FISCHER 344 RATS FEMALE
0729
0015
0015
0731
0715
0731
0735
0721
0015
0735
0594
0731
0552
0735
0015
3.0 MG/KGANIMAL ID
00506
00507
00508
00509
00510
00511
00512
00513
00514
00515
00516
00517
00518
00519
00520 * TOTALS
Peripheral Nerve + 4
Spinal Cord + 4
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + 50Carcinoma, Metastatic, Thyroid Gland 1Leukemia Mononuclear 2
Nose + + + + + + + + + + + 50
Trachea + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + 50
Harderian Gland + + + + + + + + + + + 50
URINARY SYSTEM
Kidney + + + + + + + + + + + 50
Urinary Bladder + + + + + + + + + + + 50
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + 50Leukemia Mononuclear X X 10Lymphoma Malignant 1
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 148
*** END OF REPORT ***
TDMS No. 88133 - 07 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 03/31/2010Test Type: CHRONIC Trimethylolpropane triacrylate Time Report Requested: 13:41:41
Route: SKIN APPLICATION CAS Number: 15625-89-5 First Dose M/F: 01/18/05 / 01/18/05Species/Strain: RATS/F 344/N Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue
Page 149
