TDMS No. ADENO-ASSOCIATED VIRAL VECTOR … › ntp-db › ntp_reports › ntp...BALB/C MICE MALE 0 0...

TDMS No. 20305 - 01

Test Type: 18-33 DAYS

Route: INTRADUCTAL CANNULATION

Species/Strain: MICE/BALB/C

P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL ADENO-ASSOCIATED VIRAL VECTOR (HEPO)

CAS Number: AAVIRVECEPO

Pathologist: LANNING, L.

D_MW_core_allgrp

Date Report Reqsted: 09/07/2005

Time Report Reqsted: 13:31:00

First Dose M/F: 02/02/04 / 02/09/04

Lab: MBA

C Number: C20305

Lock Date: 08/29/2005

Cage Range: ALL

Date Range: ALL

Reasons For Removal: 25021 TSAC 25020 NATD

Removal Date Range: ALL

Treatment Groups: Include ALL

TDMS No. 20305 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 09/07/2005

Test Type: 18-33 DAYS ADENO-ASSOCIATED VIRAL VECTOR (HEPO) Time Report Reqsted: 13:31:00

Route: INTRADUCTAL CANNULATION CAS Number: AAVIRVECEPO First Dose M/F: 02/02/04 / 02/09/04

Species/Strain: MICE/BALB/C Pathologist: LANNING, L. Lab: MBA

0 0 0 0 0 0 0 0 DAY ON TEST 0 0 1 9 9 9 9 9

2 2 7 2 2 2 2 1 .................................................................................................................................................................

0BALB/C MICE MALE 0 ANIMAL ID 0

ISORMCONSALINE 0 1

0 0 0 0 2

0 0 0 1 4

0 0 0 1 5

0 0 0 1 6

0 0 0 1 9

0 0 0 2 0

0 0 0 2 1 * TOTALS

ALIMENTARY SYSTEM .........................................................................................................................................................................................................

Esophagus + M M + + + + + 6 .........................................................................................................................................................................................................

Gallbladder + + A + + + + I 6 .........................................................................................................................................................................................................

Intestine Large, Cecum + + A + + + + A 6 .........................................................................................................................................................................................................

Intestine Large, Colon + + A + + + + + 7 .........................................................................................................................................................................................................

Intestine Large, Rectum + + A + + + + + 7 .........................................................................................................................................................................................................

Intestine Small, Duodenum + + A + + + + A 6 .........................................................................................................................................................................................................

Intestine Small, Ileum + + A + + + + A 6 .........................................................................................................................................................................................................

Intestine Small, Jejunum + + A + + + + A 6 .........................................................................................................................................................................................................

Liver + + A + + + + + 7 Centrilobular, Hepatocyte, Vacuolization 1 1.0 1Cytoplasmic, Focal

.........................................................................................................................................................................................................

Pancreas + + A + + + + + 7 .........................................................................................................................................................................................................

Salivary Glands + + + + + + + + 8 .........................................................................................................................................................................................................

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked





0 0 0 0 0 0 0 0 DAY ON TEST 0 0 1 9 9 9 9 9

2 2 7 2 2 2 2 1 .................................................................................................................................................................


ISORMCONSALINE 0 1

0 0 0 0 2

0 0 0 1 4

0 0 0 1 5

0 0 0 1 6

0 0 0 1 9

0 0 0 2 0

0 0 0 2 1 * TOTALS

Stomach, Forestomach + + A + + + + + 7 .........................................................................................................................................................................................................

Stomach, Glandular + + A + + + + + 7

CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................

Blood Vessel + + + + + + + + 8 .........................................................................................................................................................................................................

Heart + + + + + + + + 8 Epicardium, Mineralization, Focal 1 1 2 1.0

ENDOCRINE SYSTEM .........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + 8 Subcapsular, Hyperplasia, Focal 1 1 1 1 1 1 6 1.0

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + 8 .........................................................................................................................................................................................................

Islets, Pancreatic + + A + + + + + 7 .........................................................................................................................................................................................................

Parathyroid Gland + M M + + M M + 4 .........................................................................................................................................................................................................

Pituitary Gland + + A + + + + + 7 .........................................................................................................................................................................................................

Thyroid Gland + + M + + + + + 7 Ectopic Thymus 1 1 1.0






0 0 0 0 0 0 0 0 DAY ON TEST 0 0 1 9 9 9 9 9

2 2 7 2 2 2 2 1 .................................................................................................................................................................


ISORMCONSALINE 0 1

GENERAL BODY SYSTEM NONE

0 0 0 0 2

0 0 0 1 4

0 0 0 1 5

0 0 0 1 6

0 0 0 1 9

0 0 0 2 0

0 0 0 2 1 * TOTALS

GENITAL SYSTEM .........................................................................................................................................................................................................

Epididymis + + + + + + + + 8 .........................................................................................................................................................................................................

Penis + 1 .........................................................................................................................................................................................................

Preputial Gland + + A + + + + + 7 .........................................................................................................................................................................................................

Prostate + + + + + + + + 8 Inflammation, Focal, Chronic Active 2 1 2.0

.........................................................................................................................................................................................................

Seminal Vesicle + + A + + + + + 7 .........................................................................................................................................................................................................

Testes + + + + + + + + 8

HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................

Bone Marrow + + + + + + + + 8 .........................................................................................................................................................................................................

Lymph Node, Mandibular + M + + + + + + 7 .........................................................................................................................................................................................................






0 0 0 0 0 0 0 0 DAY ON TEST 0 0 1 9 9 9 9 9

2 2 7 2 2 2 2 1 .................................................................................................................................................................


ISORMCONSALINE 0 1

0 0 0 0 2

0 0 0 1 4

0 0 0 1 5

0 0 0 1 6

0 0 0 1 9

0 0 0 2 0

0 0 0 2 1 * TOTALS

Lymph Node, Mesenteric + + A + + + + + 7 Hyperplasia, Lymphoid 2 1 2.0

.........................................................................................................................................................................................................

Spleen + + A + + + + + 7 Hematopoietic Cell Proliferation 1 1 1 1 1 1 1 7 1.0

.........................................................................................................................................................................................................

Thymus + + A + + + + + 7

INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................

Mammary Gland M M M M M M M M 0 .........................................................................................................................................................................................................

Skin + + + + + + + + 8

MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................

Bone + + + + + + + + 8

NERVOUS SYSTEM .........................................................................................................................................................................................................

Brain + + A + + + + + 7

RESPIRATORY SYSTEM .........................................................................................................................................................................................................

Lung + + + + + + + + 8






0 0 0 0 0 0 0 0 DAY ON TEST 0 0 1 9 9 9 9 9

2 2 7 2 2 2 2 1 .................................................................................................................................................................


ISORMCONSALINE 0 1

0 0 0 0 2

0 0 0 1 4

0 0 0 1 5

0 0 0 1 6

0 0 0 1 9

0 0 0 2 0

0 0 0 2 1 * TOTALS

Alveolus, Hemorrhage, Focal 1 1 1 3 1.0 .........................................................................................................................................................................................................

Nose + + A + + + + + 7 .........................................................................................................................................................................................................

Trachea M + M + + I + + 5

SPECIAL SENSES SYSTEM .........................................................................................................................................................................................................

Eye + + + + + + + + 8 .........................................................................................................................................................................................................

Harderian Gland + + A + + + + + 7

URINARY SYSTEM .........................................................................................................................................................................................................

Kidney + + + + + + + + 8 .........................................................................................................................................................................................................

Urinary Bladder + + A + + + + + 7






0 0 0 DAY ON TEST 9 9 9

1 2 2 .................................................................................................................................................................


TRTRMCONSALINE 3 1

0 0 0 0 0 0 3 3 2 3 * TOTALS


Esophagus + + + 3 .........................................................................................................................................................................................................

Gallbladder A + + 2 .........................................................................................................................................................................................................

Intestine Large, Cecum + + + 3 .........................................................................................................................................................................................................

Intestine Large, Colon + + + 3 .........................................................................................................................................................................................................

Intestine Large, Rectum + + + 3 .........................................................................................................................................................................................................

Intestine Small, Duodenum + + + 3 .........................................................................................................................................................................................................

Intestine Small, Ileum + + + 3 .........................................................................................................................................................................................................

Intestine Small, Jejunum + + + 3 .........................................................................................................................................................................................................

Liver + + + 3 Centrilobular, Hepatocyte, Vacuolization 1 1.0 1Cytoplasmic, Focal

.........................................................................................................................................................................................................

Pancreas + + + 3 .........................................................................................................................................................................................................

Salivary Glands + + + 3 .........................................................................................................................................................................................................






0 0 0 DAY ON TEST 9 9 9

1 2 2 .................................................................................................................................................................


TRTRMCONSALINE 3 1

0 0 0 0 0 0 3 3 2 3 * TOTALS

Stomach, Forestomach + + + 3 .........................................................................................................................................................................................................

Stomach, Glandular + + + 3


Blood Vessel + + + 3 .........................................................................................................................................................................................................

Heart + + + 3


Adrenal Cortex + + + 3 Subcapsular, Hyperplasia, Focal 1 1 1 3 1.0

.........................................................................................................................................................................................................

Adrenal Medulla + + + 3 .........................................................................................................................................................................................................

Islets, Pancreatic + + + 3 .........................................................................................................................................................................................................

Parathyroid Gland + M + 2 .........................................................................................................................................................................................................

Pituitary Gland + I + 2 .........................................................................................................................................................................................................

Thyroid Gland + + + 3






0 0 0 DAY ON TEST 9 9 9

1 2 2 .................................................................................................................................................................


TRTRMCONSALINE 3 1


0 0 0 0 0 0 3 3 2 3 * TOTALS

GENITAL SYSTEM .........................................................................................................................................................................................................

Epididymis + + + 3 .........................................................................................................................................................................................................

Preputial Gland + + + 3 .........................................................................................................................................................................................................

Prostate + + + 3 .........................................................................................................................................................................................................

Seminal Vesicle + + + 3 .........................................................................................................................................................................................................

Testes + + + 3


Bone Marrow + + + 3 .........................................................................................................................................................................................................

Lymph Node, Mandibular + + + 3 .........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + 3 .........................................................................................................................................................................................................

Spleen A + + 2 Hematopoietic Cell Proliferation 1 1 2 1.0






0 0 0 DAY ON TEST 9 9 9

1 2 2 .................................................................................................................................................................


TRTRMCONSALINE 3 1

0 0 0 0 0 0 3 3 2 3 * TOTALS

.........................................................................................................................................................................................................

Thymus + + + 3


Mammary Gland M M M 0 .........................................................................................................................................................................................................

Skin + + + 3


Bone + + + 3

NERVOUS SYSTEM .........................................................................................................................................................................................................

Brain + + + 3


Lung + + + 3 .........................................................................................................................................................................................................

Nose + + + 3 .........................................................................................................................................................................................................

Trachea + + + 3






0 0 0 DAY ON TEST 9 9 9

1 2 2 .................................................................................................................................................................


TRTRMCONSALINE 3 1

0 0 0 0 0 0 3 3 2 3 * TOTALS


Eye + + + 3 .........................................................................................................................................................................................................

Harderian Gland + + + 3

URINARY SYSTEM .........................................................................................................................................................................................................

Kidney + + + 3 .........................................................................................................................................................................................................

Urinary Bladder + + + 3






0 0 0 0 0 0 0 0 0 0 DAY ON TEST 0 0 0 2 9 9 9 9 9 9

2 2 2 9 2 2 2 2 2 2 .................................................................................................................................................................


1-7 SALINE 3 4

0 0 0 3 5

0 0 0 3 6

0 0 0 3 9

0 0 0 4 7

0 0 0 4 8

0 0 0 4 9

0 0 0 5 2

0 0 0 5 3

0 0 0 5 4 * TOTALS


Esophagus + + + + + + + + + + 10 .........................................................................................................................................................................................................

Gallbladder + + + + + + + + M + 9 .........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + 10 .........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + + + 10 .........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + 10 .........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + + + 10 .........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + + + + + 10 .........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + + + + 10 .........................................................................................................................................................................................................

Liver + + + + + + + + + + 10 Hepatocyte, Inflammation, Focal, Chronic 1 1.0 1Active Centrilobular, Hepatocyte, Vacuolization 1 1.0 1Cytoplasmic, Focal

.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + 10 .........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + 10






0 0 0 0 0 0 0 0 0 0 DAY ON TEST 0 0 0 2 9 9 9 9 9 9

2 2 2 9 2 2 2 2 2 2 .................................................................................................................................................................


1-7 SALINE 3 4

0 0 0 3 5

0 0 0 3 6

0 0 0 3 9

0 0 0 4 7

0 0 0 4 8

0 0 0 4 9

0 0 0 5 2

0 0 0 5 3

0 0 0 5 4 * TOTALS

.........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + 10 .........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + 10


Blood Vessel + + + + + + + + + + 10 .........................................................................................................................................................................................................

Heart + + + + + + + + + + 10 Epicardium, Mineralization, Focal 1 1 1 3 1.0


Adrenal Cortex + + + + + + + + + + 10 Subcapsular, Hyperplasia, Focal 1 1 1 1 1 1 1 7 1.0

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + 10 .........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + 10 .........................................................................................................................................................................................................

Parathyroid Gland M M M M + + M + + + 5 .........................................................................................................................................................................................................

Pituitary Gland + + + + + M + + + + 9 .........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + 10






0 0 0 0 0 0 0 0 0 0 DAY ON TEST 0 0 0 2 9 9 9 9 9 9

2 2 2 9 2 2 2 2 2 2 .................................................................................................................................................................


1-7 SALINE 3 4

0 0 0 3 5

0 0 0 3 6

0 0 0 3 9

0 0 0 4 7

0 0 0 4 8

0 0 0 4 9

0 0 0 5 2

0 0 0 5 3

0 0 0 5 4 * TOTALS

Ectopic Thymus 1 1 1.0


GENITAL SYSTEM .........................................................................................................................................................................................................

Epididymis + + + + + + + + + + 10 .........................................................................................................................................................................................................

Preputial Gland + + + + + + + + + + 10 .........................................................................................................................................................................................................

Prostate + + + + + + + + + + 10 .........................................................................................................................................................................................................

Seminal Vesicle + + + + + + + + + + 10 .........................................................................................................................................................................................................

Testes + + + + + + + + + + 10


Bone Marrow + + + + + + + + + + 10 .........................................................................................................................................................................................................

Lymph Node, Mandibular + + + + + + M M M + 7 .........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + + + 10 .........................................................................................................................................................................................................






0 0 0 0 0 0 0 0 0 0 DAY ON TEST 0 0 0 2 9 9 9 9 9 9

2 2 2 9 2 2 2 2 2 2 .................................................................................................................................................................


1-7 SALINE 3 4

0 0 0 3 5

0 0 0 3 6

0 0 0 3 9

0 0 0 4 7

0 0 0 4 8

0 0 0 4 9

0 0 0 5 2

0 0 0 5 3

0 0 0 5 4 * TOTALS

Spleen + + + + + + + + + + 10 Hematopoietic Cell Proliferation 1 1 1 1 1 2 1 2 1 1 10 1.2 Congestion, Diffuse 2 1 2.0

.........................................................................................................................................................................................................

Thymus + + + + + + + + + + 10


Mammary Gland M M M M M M M M M M 0 .........................................................................................................................................................................................................

Skin + + + + + + + + + + 10


Bone + + + + + + + + + + 10 .........................................................................................................................................................................................................

Skeletal Muscle + 1 Hemorrhage, Focal 3 1 3.0 Inflammation, Focal, Acute 2 1 2.0

NERVOUS SYSTEM .........................................................................................................................................................................................................

Brain + + + + + + + + + + 10







0 0 0 0 0 0 0 0 0 0 DAY ON TEST 0 0 0 2 9 9 9 9 9 9

2 2 2 9 2 2 2 2 2 2 .................................................................................................................................................................


1-7 SALINE 3 4

0 0 0 3 5

0 0 0 3 6

0 0 0 3 9

0 0 0 4 7

0 0 0 4 8

0 0 0 4 9

0 0 0 5 2

0 0 0 5 3

0 0 0 5 4 * TOTALS

Lung + + + + + + + + + + 10 Alveolus, Hemorrhage, Focal 1 1 1 3 1.0 Alveolar Epithelium, Bronchiole, 1 2.0 2Hyperplasia, Focal

.........................................................................................................................................................................................................

Nose + + + + + + + + + + 10 .........................................................................................................................................................................................................

Trachea + + I I + + + + + + 8


Eye + + + + + + + + + + 10 .........................................................................................................................................................................................................

Harderian Gland + + + + + + + + + + 10

URINARY SYSTEM .........................................................................................................................................................................................................

Kidney + + + + + + + + + + 10 .........................................................................................................................................................................................................

Urinary Bladder + + + + + + + I + + 9






0 0 0 0 0 0 0 0 DAY ON TEST 0 0 9 9 9 9 9 9

2 2 2 2 2 2 2 2 .................................................................................................................................................................


1-8 SALINE 5 6

0 0 0 5 7

0 0 0 6 8

0 0 0 6 9

0 0 0 7 0

0 0 0 7 3

0 0 0 7 4

0 0 0 7 5 * TOTALS


Esophagus + + + + + + M + 7 .........................................................................................................................................................................................................

Gallbladder A A + + + + + + 6 .........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + 8 .........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + 8 .........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + 8 .........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + 8 .........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + + + 8 .........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + + 8 .........................................................................................................................................................................................................

Liver + + + + + + + + 8 .........................................................................................................................................................................................................

Pancreas + + + + + + + + 8 .........................................................................................................................................................................................................

Salivary Glands + + + + + + + + 8 .........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + 8 .........................................................................................................................................................................................................






0 0 0 0 0 0 0 0 DAY ON TEST 0 0 9 9 9 9 9 9

2 2 2 2 2 2 2 2 .................................................................................................................................................................


1-8 SALINE 5 6

0 0 0 5 7

0 0 0 6 8

0 0 0 6 9

0 0 0 7 0

0 0 0 7 3

0 0 0 7 4

0 0 0 7 5 * TOTALS

Stomach, Glandular + + + + + + + + 8


Blood Vessel + + + + + + + + 8 .........................................................................................................................................................................................................

Heart + + + + + + + + 8 Ventricle, Thrombosis, Focal 4 1 4.0


Adrenal Cortex + + + + + + + + 8 Subcapsular, Hyperplasia, Focal 1 1 1 1 1 5 1.0

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + 8 .........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + 8 .........................................................................................................................................................................................................

Parathyroid Gland M M + + M + + + 5 .........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + 8 .........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + 8







0 0 0 0 0 0 0 0 DAY ON TEST 0 0 9 9 9 9 9 9

2 2 2 2 2 2 2 2 .................................................................................................................................................................


1-8 SALINE 5 6

0 0 0 5 7

0 0 0 6 8

0 0 0 6 9

0 0 0 7 0

0 0 0 7 3

0 0 0 7 4

0 0 0 7 5 * TOTALS

GENITAL SYSTEM .........................................................................................................................................................................................................

Epididymis + + + + + + + + 8 .........................................................................................................................................................................................................

Preputial Gland + + + + + + + + 8 .........................................................................................................................................................................................................

Prostate + + + + + + + + 8 .........................................................................................................................................................................................................

Seminal Vesicle + + + + + + + + 8 .........................................................................................................................................................................................................

Testes + + + + + + + + 8


Bone Marrow + + + + + + + + 8 .........................................................................................................................................................................................................

Lymph Node, Mandibular M + + + + + + + 7 .........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + 8 .........................................................................................................................................................................................................

Spleen + + + + + + + + 8 Hematopoietic Cell Proliferation 1 1 1 1 2 1 1 1 8 1.1

.........................................................................................................................................................................................................

Thymus + + + + + + + + 8






0 0 0 0 0 0 0 0 DAY ON TEST 0 0 9 9 9 9 9 9

2 2 2 2 2 2 2 2 .................................................................................................................................................................


1-8 SALINE 5 6

0 0 0 5 7

0 0 0 6 8

0 0 0 6 9

0 0 0 7 0

0 0 0 7 3

0 0 0 7 4

0 0 0 7 5 * TOTALS



Skin + + + + + + + + 8


Bone + + + + + + + + 8

NERVOUS SYSTEM .........................................................................................................................................................................................................

Brain + + + + + + + + 8


Lung + + + + + + + + 8 Alveolus, Hemorrhage, Focal 1 1 1 1 1 1 6 1.0 Alveolar Epithelium, Bronchiole, 1 2.0 2Hyperplasia, Focal

.........................................................................................................................................................................................................

Nose + + + + + + + + 8 .........................................................................................................................................................................................................

Trachea + + + + + + + + 8






0 0 0 0 0 0 0 0 DAY ON TEST 0 0 9 9 9 9 9 9

2 2 2 2 2 2 2 2 .................................................................................................................................................................


1-8 SALINE 5 6

0 0 0 5 7

0 0 0 6 8

0 0 0 6 9

0 0 0 7 0

0 0 0 7 3

0 0 0 7 4

0 0 0 7 5 * TOTALS


Eye + + + + + + + + 8 .........................................................................................................................................................................................................

Harderian Gland + + + + + + + + 8

URINARY SYSTEM .........................................................................................................................................................................................................

Kidney + + + + + + + + 8 .........................................................................................................................................................................................................

Urinary Bladder A + + + + + + + 7






0 0 0 0 0 0 0 0 DAY ON TEST 2 7 9 9 5 9 9 9

9 6 2 2 4 2 2 2 .................................................................................................................................................................


1-9 SALINE 8 1

0 0 0 8 9

0 0 0 9 0

0 0 0 9 1

0 0 0 9 3

0 0 0 9 4

0 0 0 9 5

0 0 0 9 6 * TOTALS


Esophagus + A + + + + + + 7 .........................................................................................................................................................................................................

Gallbladder + M + + + + + + 7 .........................................................................................................................................................................................................

Intestine Large, Cecum + A + + + + + I 6 .........................................................................................................................................................................................................

Intestine Large, Colon + A + + + + + + 7 .........................................................................................................................................................................................................

Intestine Large, Rectum + A + + + + + + 7 .........................................................................................................................................................................................................

Intestine Small, Duodenum + A + + + + + + 7 .........................................................................................................................................................................................................

Intestine Small, Ileum + A + + + + + + 7 .........................................................................................................................................................................................................

Intestine Small, Jejunum + A + + + + + + 7 .........................................................................................................................................................................................................

Liver + A + + + + + + 7 Hepatocyte, Necrosis, Focal 1 1 1.0 Vacuolization Cytoplasmic, Focal 1 1 1.0 Centrilobular, Hepatocyte, Vacuolization 2 1.0 1 1Cytoplasmic, Focal

.........................................................................................................................................................................................................

Pancreas + A + + + + + + 7 .........................................................................................................................................................................................................

Salivary Glands + A + + + + + + 7






0 0 0 0 0 0 0 0 DAY ON TEST 2 7 9 9 5 9 9 9

9 6 2 2 4 2 2 2 .................................................................................................................................................................


1-9 SALINE 8 1

0 0 0 8 9

0 0 0 9 0

0 0 0 9 1

0 0 0 9 3

0 0 0 9 4

0 0 0 9 5

0 0 0 9 6 * TOTALS

.........................................................................................................................................................................................................

Stomach, Forestomach + A + + + + + + 7 .........................................................................................................................................................................................................

Stomach, Glandular + A + + + + + + 7


Blood Vessel + A + + + + + + 7 .........................................................................................................................................................................................................

Heart + + + + + + + + 8 Epicardium, Mineralization, Focal 2 1 2.0


Adrenal Cortex + A + + + + + + 7 Subcapsular, Hyperplasia, Focal 1 1 1 1 1 1 6 1.0

.........................................................................................................................................................................................................

Adrenal Medulla + A + + + + + + 7 .........................................................................................................................................................................................................

Islets, Pancreatic + A + + + + + + 7 .........................................................................................................................................................................................................

Parathyroid Gland + M + M + + + + 6 .........................................................................................................................................................................................................

Pituitary Gland + I I + + + + + 6 .........................................................................................................................................................................................................

Thyroid Gland + A + + + + + + 7






0 0 0 0 0 0 0 0 DAY ON TEST 2 7 9 9 5 9 9 9

9 6 2 2 4 2 2 2 .................................................................................................................................................................


1-9 SALINE 8 1

0 0 0 8 9

0 0 0 9 0

0 0 0 9 1

0 0 0 9 3

0 0 0 9 4

0 0 0 9 5

0 0 0 9 6 * TOTALS

Ectopic Thymus 1 1 1.0


GENITAL SYSTEM .........................................................................................................................................................................................................

Epididymis + + + + + + + + 8 .........................................................................................................................................................................................................

Preputial Gland + A + + + + + M 6 .........................................................................................................................................................................................................

Prostate + A + + + + + + 7 .........................................................................................................................................................................................................

Seminal Vesicle + A + + + + + + 7 .........................................................................................................................................................................................................

Testes + + + + + + + + 8


Bone Marrow + A + + + + + + 7 .........................................................................................................................................................................................................

Lymph Node, Mandibular + A M + + + + + 6 .........................................................................................................................................................................................................

Lymph Node, Mesenteric + A + + + + + + 7 .........................................................................................................................................................................................................






0 0 0 0 0 0 0 0 DAY ON TEST 2 7 9 9 5 9 9 9

9 6 2 2 4 2 2 2 .................................................................................................................................................................


1-9 SALINE 8 1

0 0 0 8 9

0 0 0 9 0

0 0 0 9 1

0 0 0 9 3

0 0 0 9 4

0 0 0 9 5

0 0 0 9 6 * TOTALS


.........................................................................................................................................................................................................

Thymus + A + + + + + + 7



Skin + + + + + + + + 8


Bone + + + + + + + + 8

NERVOUS SYSTEM .........................................................................................................................................................................................................

Brain + A + + + + + + 7


Lung + A + + + + + + 7 Alveolus, Hemorrhage, Focal 1 1 1 3 1.0

.........................................................................................................................................................................................................

Nose + A + + + + + + 7






0 0 0 0 0 0 0 0 DAY ON TEST 2 7 9 9 5 9 9 9

9 6 2 2 4 2 2 2 .................................................................................................................................................................


1-9 SALINE 8 1

0 0 0 8 9

0 0 0 9 0

0 0 0 9 1

0 0 0 9 3

0 0 0 9 4

0 0 0 9 5

0 0 0 9 6 * TOTALS

.........................................................................................................................................................................................................

Trachea + A + + + + + + 7


Eye + A + + + + + + 7 .........................................................................................................................................................................................................

Harderian Gland + A + + + + + + 7

URINARY SYSTEM .........................................................................................................................................................................................................

Kidney + + + + + + + + 8 Right, Infarct, Multiple 3 1 3.0

.........................................................................................................................................................................................................

Urinary Bladder + A + + + + + + 7






0 DAY ON TEST 2

9

0 0 2

0 0 2

0 5 0

0 9 2

0 9 2

0 9 2

0 9 2

0 9 2

0 9 2

................................................................................................................................................................. 0BALB/C MICE MALE 0

ANIMAL ID 1 1-10 SALINE 0

1

0 0 1 0 3

0 0 1 0 4

0 0 1 0 7

0 0 1 1 0

0 0 1 1 1

0 0 1 1 2

0 0 1 1 5

0 0 1 1 6

0 0 1 1 7 * TOTALS


Esophagus + + + + + + + + + + 10 .........................................................................................................................................................................................................

Gallbladder + + + + + + + + + + 10 .........................................................................................................................................................................................................

Intestine Large, Cecum + + + A + + + + + + 9 .........................................................................................................................................................................................................

Intestine Large, Colon + + + A + + + + + + 9 .........................................................................................................................................................................................................

Intestine Large, Rectum + + + A + + + + + + 9 .........................................................................................................................................................................................................

Intestine Small, Duodenum + + + A + + + + + + 9 .........................................................................................................................................................................................................

Intestine Small, Ileum + + + A + + + + + + 9 .........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + + + + 10 .........................................................................................................................................................................................................

Liver + + + + + + + + + + 10 Hematopoietic Cell Proliferation 3 1 3.0

.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + 10 .........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + 10

2Submandibular Gland, Degeneration, 1 2.0 Diffuse

Submandibular Gland, Inflammation, 2 1 2.0






0 0 0 0 0 0 0 0 0 0 DAY ON TEST 2 0 0 5 9 9 9 9 9 9

9 2 2 0 2 2 2 2 2 2 .................................................................................................................................................................


1-10 SALINE 0 1

0 0 1 0 3

0 0 1 0 4

0 0 1 0 7

0 0 1 1 0

0 0 1 1 1

0 0 1 1 2

0 0 1 1 5

0 0 1 1 6

0 0 1 1 7 * TOTALS

Diffuse, Acute .........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + 10 .........................................................................................................................................................................................................

Stomach, Glandular + + + A + + + + + + 9


Blood Vessel + + + + + + + + + + 10 .........................................................................................................................................................................................................

Heart + + + + + + + + + + 10 Epicardium, Mineralization, Focal 1 1 1 1 4 1.0


Adrenal Cortex + + + + + + + + + + 10 Subcapsular, Hyperplasia, Focal 1 1 1 1 1 1 1 7 1.0

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + 10 .........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + 10 .........................................................................................................................................................................................................

Parathyroid Gland M + M + + + + + + + 8 .........................................................................................................................................................................................................

Pituitary Gland + + + I M + I I + I 5 .........................................................................................................................................................................................................






0 0 0 0 0 0 0 0 0 0 DAY ON TEST 2 0 0 5 9 9 9 9 9 9

9 2 2 0 2 2 2 2 2 2 .................................................................................................................................................................


1-10 SALINE 0 1

0 0 1 0 3

0 0 1 0 4

0 0 1 0 7

0 0 1 1 0

0 0 1 1 1

0 0 1 1 2

0 0 1 1 5

0 0 1 1 6

0 0 1 1 7 * TOTALS

Thyroid Gland + + + + + + + + + + 10 Ectopic Thymus 1 1 2 1.0


GENITAL SYSTEM .........................................................................................................................................................................................................

Epididymis + + + + + + + I + + 9 .........................................................................................................................................................................................................

Preputial Gland + + + + + + + + + + 10 .........................................................................................................................................................................................................

Prostate + + + + + + + + + + 10 .........................................................................................................................................................................................................

Seminal Vesicle + + + + + + + + + + 10 .........................................................................................................................................................................................................

Testes I + + + + + + + + + 9


Bone Marrow + + + + + + + + + + 10 .........................................................................................................................................................................................................

Lymph Node, Mandibular + + + + M + + M M + 7 .........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + A + + + + + + 9 .........................................................................................................................................................................................................






0 0 0 0 0 0 0 0 0 0 DAY ON TEST 2 0 0 5 9 9 9 9 9 9

9 2 2 0 2 2 2 2 2 2 .................................................................................................................................................................


1-10 SALINE 0 1

0 0 1 0 3

0 0 1 0 4

0 0 1 0 7

0 0 1 1 0

0 0 1 1 1

0 0 1 1 2

0 0 1 1 5

0 0 1 1 6

0 0 1 1 7 * TOTALS

Spleen + + + + + + + + + + 10 Hematopoietic Cell Proliferation 3 1 1 2 3 3 3 4 3 4 10 2.7

.........................................................................................................................................................................................................

Thymus + + + + + + + + + + 10


Mammary Gland M M M M M M M M M M 0 .........................................................................................................................................................................................................

Skin + + + + + + + + + + 10 Epidermis, Dermis, Subcutaneous Tissue, 1 4.0 4Inflammation, Focal, Acute


Bone + + + + + + + + + + 10

NERVOUS SYSTEM .........................................................................................................................................................................................................

Brain + + + + + + + + + + 10


Lung + + + + + + + + + + 10 Alveolus, Hemorrhage, Focal 1 1 1 1 1 5 1.0

.........................................................................................................................................................................................................






0 0 0 0 0 0 0 0 0 0 DAY ON TEST 2 0 0 5 9 9 9 9 9 9

9 2 2 0 2 2 2 2 2 2 .................................................................................................................................................................


1-10 SALINE 0 1

0 0 1 0 3

0 0 1 0 4

0 0 1 0 7

0 0 1 1 0

0 0 1 1 1

0 0 1 1 2

0 0 1 1 5

0 0 1 1 6

0 0 1 1 7 * TOTALS

Nose + + + + + + + + + + 10 .........................................................................................................................................................................................................

Trachea + + + + + I + + + I 8


Eye + + + + + + + + + + 10 .........................................................................................................................................................................................................

Harderian Gland + + + + + + + + + + 10

URINARY SYSTEM .........................................................................................................................................................................................................

Kidney + + + + + + + + + + 10 .........................................................................................................................................................................................................

Urinary Bladder + + + I + + + + + + 9

*** END OF MALE DATA ***






0 0 0 0 0 0 DAY ON TEST 9 9 9 9 9 9

2 2 2 2 2 2 .................................................................................................................................................................

0BALB/C MICE FEMALE 0 ANIMAL ID 1

ISORMCONSALINE 3 1

0 0 1 3 2

0 0 1 3 3

0 0 1 3 6

0 0 1 3 7

0 0 1 3 8 * TOTALS


Esophagus + + + + + + 6 .........................................................................................................................................................................................................

Gallbladder + + + + + + 6 .........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + 6 .........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + 6 .........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + 6 .........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + 6 .........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + 6 .........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + 6 .........................................................................................................................................................................................................

Liver + + + + + + 6 Infiltration Cellular, Focal, Mononuclear 1 1.0 1Cell

.........................................................................................................................................................................................................

Pancreas + + + + + + 6 .........................................................................................................................................................................................................

Salivary Glands + + + + + + 6 .........................................................................................................................................................................................................






0 0 0 0 0 0 DAY ON TEST 9 9 9 9 9 9

2 2 2 2 2 2 .................................................................................................................................................................


ISORMCONSALINE 3 1

0 0 1 3 2

0 0 1 3 3

0 0 1 3 6

0 0 1 3 7

0 0 1 3 8 * TOTALS

Stomach, Forestomach + + + + + + 6 .........................................................................................................................................................................................................

Stomach, Glandular + + + + + + 6


Blood Vessel + + + + + + 6 .........................................................................................................................................................................................................

Heart + + + M + + 5


Adrenal Cortex + + + + + + 6 Subcapsular, Hyperplasia, Focal 1 1 1 1 1 1 6 1.0 Zona Reticularis, Hypertrophy, Focal 1 1 1 1 1 5 1.0

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + 6 .........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + 6 .........................................................................................................................................................................................................

Parathyroid Gland M + + + + + 5 .........................................................................................................................................................................................................

Pituitary Gland I + + + + + 5 .........................................................................................................................................................................................................

Thyroid Gland + + + + + + 6 Ectopic Thymus 1 1 2 1.0






0 0 0 0 0 0 DAY ON TEST 9 9 9 9 9 9

2 2 2 2 2 2 .................................................................................................................................................................


ISORMCONSALINE 3 1


0 0 1 3 2

0 0 1 3 3

0 0 1 3 6

0 0 1 3 7

0 0 1 3 8 * TOTALS

GENITAL SYSTEM .........................................................................................................................................................................................................

Clitoral Gland + + M + M M 3 .........................................................................................................................................................................................................

Ovary + + I + + + 5 .........................................................................................................................................................................................................

Uterus + + + + + + 6 Endometrium, Hyperplasia, Diffuse, Cystic 1 1 2 1 4 1.3


Bone Marrow + + + + + + 6 .........................................................................................................................................................................................................

Lymph Node, Mandibular + + + + + + 6 .........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + 6 .........................................................................................................................................................................................................

Spleen + + + + + + 6 Hematopoietic Cell Proliferation 2 1 1 1 1 2 6 1.3

.........................................................................................................................................................................................................

Thymus + + + + + + 6






0 0 0 0 0 0 DAY ON TEST 9 9 9 9 9 9

2 2 2 2 2 2 .................................................................................................................................................................


ISORMCONSALINE 3 1

0 0 1 3 2

0 0 1 3 3

0 0 1 3 6

0 0 1 3 7

0 0 1 3 8 * TOTALS


Mammary Gland + + + + + + 6 .........................................................................................................................................................................................................

Skin + + + + + + 6


Bone + + + + + + 6

NERVOUS SYSTEM .........................................................................................................................................................................................................

Brain + + + + + + 6


Lung + + + + + + 6 Alveolus, Hemorrhage, Focal 1 1 1 3 1.0

.........................................................................................................................................................................................................

Nose + + + + + + 6 .........................................................................................................................................................................................................

Trachea I + I + I I 2

SPECIAL SENSES SYSTEM






0 0 0 0 0 0 DAY ON TEST 9 9 9 9 9 9

2 2 2 2 2 2 .................................................................................................................................................................


ISORMCONSALINE 3 1

0 0 1 3 2

0 0 1 3 3

0 0 1 3 6

0 0 1 3 7

0 0 1 3 8 * TOTALS

.........................................................................................................................................................................................................

Eye + + + + + + 6 .........................................................................................................................................................................................................

Harderian Gland + + + + + + 6

URINARY SYSTEM .........................................................................................................................................................................................................

Kidney + + + + + + 6 .........................................................................................................................................................................................................

Urinary Bladder + + + + + + 6






0 0 0 DAY ON TEST 9 9 9

2 2 2 .................................................................................................................................................................


TRTRMCONSALINE 4 8

0 0 0 0 1 1 4 5 9 0 * TOTALS


Esophagus + + + 3 .........................................................................................................................................................................................................

Gallbladder + + + 3 .........................................................................................................................................................................................................

Intestine Large, Cecum + + + 3 .........................................................................................................................................................................................................

Intestine Large, Colon + + + 3 .........................................................................................................................................................................................................

Intestine Large, Rectum + + + 3 .........................................................................................................................................................................................................

Intestine Small, Duodenum + + + 3 .........................................................................................................................................................................................................

Intestine Small, Ileum + + + 3 .........................................................................................................................................................................................................

Intestine Small, Jejunum + + + 3 .........................................................................................................................................................................................................

Liver + + + 3 .........................................................................................................................................................................................................

Pancreas + + + 3 .........................................................................................................................................................................................................

Salivary Glands + + + 3 .........................................................................................................................................................................................................

Stomach, Forestomach + + + 3 .........................................................................................................................................................................................................






0 0 0 DAY ON TEST 9 9 9

2 2 2 .................................................................................................................................................................


TRTRMCONSALINE 4 8

0 0 0 0 1 1 4 5 9 0 * TOTALS

Stomach, Glandular + + + 3


Blood Vessel + + + 3 .........................................................................................................................................................................................................

Heart + + + 3 Epicardium, Mineralization, Focal 1 1 1.0


Adrenal Cortex + + + 3 Subcapsular, Hyperplasia, Focal 1 1 1 3 1.0 Zona Reticularis, Hypertrophy, Focal 1 1 1.0

.........................................................................................................................................................................................................

Adrenal Medulla + + + 3 .........................................................................................................................................................................................................

Islets, Pancreatic + + + 3 .........................................................................................................................................................................................................

Parathyroid Gland M M + 1 .........................................................................................................................................................................................................

Pituitary Gland I + + 2 .........................................................................................................................................................................................................

Thyroid Gland + + + 3 Ectopic Thymus 1 1 2 1.0






0 0 0 DAY ON TEST 9 9 9

2 2 2 .................................................................................................................................................................


TRTRMCONSALINE 4 8


0 0 0 0 1 1 4 5 9 0 * TOTALS

GENITAL SYSTEM .........................................................................................................................................................................................................

Clitoral Gland + M M 1 .........................................................................................................................................................................................................

Ovary + + + 3 .........................................................................................................................................................................................................

Uterus + + + 3


Bone Marrow + + + 3 .........................................................................................................................................................................................................

Lymph Node, Mandibular + + + 3 .........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + 3 .........................................................................................................................................................................................................

Spleen + + + 3 Hematopoietic Cell Proliferation 1 2 1 3 1.3

.........................................................................................................................................................................................................

Thymus + + + 3

INTEGUMENTARY SYSTEM






0 0 0 DAY ON TEST 9 9 9

2 2 2 .................................................................................................................................................................


TRTRMCONSALINE 4 8

0 0 0 0 1 1 4 5 9 0 * TOTALS

.........................................................................................................................................................................................................

Mammary Gland + + + 3 .........................................................................................................................................................................................................

Skin + + + 3


Bone + + + 3

NERVOUS SYSTEM .........................................................................................................................................................................................................

Brain + + + 3


Lung + + + 3 Alveolus, Hemorrhage, Focal 1 1 1 3 1.0

.........................................................................................................................................................................................................

Nose + + + 3 .........................................................................................................................................................................................................

Trachea + + I 2


Eye + + + 3






0 0 0 DAY ON TEST 9 9 9

2 2 2 .................................................................................................................................................................

BALB/C MICE FEMALE ANIMAL ID

TRTRMCONSALINE

0 0 1 4 8

.........................................................................................................................................................................................................

Harderian Gland + + + 3

0 0 0 0 1 1 4 5 9 0 * TOTALS

URINARY SYSTEM .........................................................................................................................................................................................................

Kidney + + + 3 .........................................................................................................................................................................................................

Urinary Bladder + + + 3






0 0 0 0 0 0 0 0 DAY ON TEST 0 0 9 9 9 9 9 9

2 2 2 2 2 2 2 2 .................................................................................................................................................................


1-7 SALINE 5 3

0 0 1 5 7

0 0 1 6 4

0 0 1 6 5

0 0 1 6 6

0 0 1 6 9

0 0 1 7 0

0 0 1 7 1 * TOTALS


Esophagus + + + + + + + + 8 .........................................................................................................................................................................................................

Gallbladder + + + + + + + + 8 .........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + 8 .........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + 8 .........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + 8 .........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + 8 .........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + + + 8 .........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + + 8 .........................................................................................................................................................................................................

Liver + + + + + + + + 8 Hepatocyte, Necrosis, Focal 1 1 1.0

.........................................................................................................................................................................................................

Pancreas + + + + + + + + 8 .........................................................................................................................................................................................................

Salivary Glands + + + + + + + + 8 .........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + 8






0 0 0 0 0 0 0 0 DAY ON TEST 0 0 9 9 9 9 9 9

2 2 2 2 2 2 2 2 .................................................................................................................................................................


1-7 SALINE 5 3

0 0 1 5 7

0 0 1 6 4

0 0 1 6 5

0 0 1 6 6

0 0 1 6 9

0 0 1 7 0

0 0 1 7 1 * TOTALS

.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + 8


Blood Vessel + + + + + + + + 8 .........................................................................................................................................................................................................

Heart + + + + + + + + 8 Epicardium, Mineralization, Focal 2 1 2 1.5


Adrenal Cortex + + + + + + + + 8 Subcapsular, Hyperplasia, Focal 1 1 1 1 1 1 1 1 8 1.0 Zona Reticularis, Hypertrophy, Focal 1 1 1 1 4 1.0

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + 8 .........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + 8 .........................................................................................................................................................................................................

Parathyroid Gland + M + M + + M + 5 .........................................................................................................................................................................................................

Pituitary Gland + + + + I + + + 7 .........................................................................................................................................................................................................

Thyroid Gland + + + + + + M + 7 Ectopic Thymus 1 1 1.0






0 0 0 0 0 0 0 0 DAY ON TEST 0 0 9 9 9 9 9 9

2 2 2 2 2 2 2 2 .................................................................................................................................................................


1-7 SALINE 5 3


0 0 1 5 7

0 0 1 6 4

0 0 1 6 5

0 0 1 6 6

0 0 1 6 9

0 0 1 7 0

0 0 1 7 1 * TOTALS

GENITAL SYSTEM .........................................................................................................................................................................................................

Clitoral Gland + + + M M I + M 4 .........................................................................................................................................................................................................

Ovary + + + + + + + + 8 .........................................................................................................................................................................................................

Uterus + + + + + + + + 8 Endometrium, Hyperplasia, Diffuse, Cystic 1 2 1 3 1.3


Bone Marrow + + + + + + + + 8 .........................................................................................................................................................................................................

Lymph Node, Mandibular + + + + + + + + 8 .........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + M + 7 .........................................................................................................................................................................................................


.........................................................................................................................................................................................................

Thymus + + + + + + + + 8






0 0 0 0 0 0 0 0 DAY ON TEST 0 0 9 9 9 9 9 9

2 2 2 2 2 2 2 2 .................................................................................................................................................................


1-7 SALINE 5 3

0 0 1 5 7

0 0 1 6 4

0 0 1 6 5

0 0 1 6 6

0 0 1 6 9

0 0 1 7 0

0 0 1 7 1 * TOTALS


Mammary Gland + + + + + + + + 8 .........................................................................................................................................................................................................

Skin + + + + + + + + 8


Bone + + + + + + + + 8

NERVOUS SYSTEM .........................................................................................................................................................................................................

Brain + + + + + + + + 8


Lung + + + + + + + + 8 Alveolus, Hemorrhage, Focal 1 1 1 1 1 5 1.0

.........................................................................................................................................................................................................

Nose + + + + + + + + 8 .........................................................................................................................................................................................................

Trachea + I + I + + + + 6







0 0 0 0 0 0 0 0 DAY ON TEST 0 0 9 9 9 9 9 9

2 2 2 2 2 2 2 2 .................................................................................................................................................................


1-7 SALINE 5 3

0 0 1 5 7

0 0 1 6 4

0 0 1 6 5

0 0 1 6 6

0 0 1 6 9

0 0 1 7 0

0 0 1 7 1 * TOTALS

.........................................................................................................................................................................................................

Eye + + + + + + + + 8 .........................................................................................................................................................................................................

Harderian Gland + + + + + + + + 8

URINARY SYSTEM .........................................................................................................................................................................................................

Kidney + + + + + + + + 8 .........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + 8






0 0 0 0 0 0 DAY ON TEST 9 9 9 9 9 9

2 2 2 2 2 2 .................................................................................................................................................................


1-8 SALINE 8 5

0 0 1 8 6

0 0 1 8 7

0 0 1 9 0

0 0 1 9 1

0 0 1 9 2 * TOTALS


Esophagus + + + + + + 6 .........................................................................................................................................................................................................

Gallbladder + + + + + + 6 .........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + 6 .........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + 6 .........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + 6 .........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + 6 .........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + 6 .........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + 6 .........................................................................................................................................................................................................

Liver + + + + + + 6 .........................................................................................................................................................................................................

Pancreas + + + + + + 6 .........................................................................................................................................................................................................

Salivary Glands + + + + + + 6 Submandibular Gland, Infiltration Cellular, 1 1.0 1Focal, Mononuclear Cell

.........................................................................................................................................................................................................






0 0 0 0 0 0 DAY ON TEST 9 9 9 9 9 9

2 2 2 2 2 2 .................................................................................................................................................................


1-8 SALINE 8 5

0 0 1 8 6

0 0 1 8 7

0 0 1 9 0

0 0 1 9 1

0 0 1 9 2 * TOTALS

Stomach, Forestomach + + + + + + 6 .........................................................................................................................................................................................................

Stomach, Glandular + + + + + + 6


Blood Vessel + + + + + + 6 .........................................................................................................................................................................................................

Heart + + + + + + 6 Epicardium, Mineralization, Focal 1 1 1.0


Adrenal Cortex + + + + + + 6 Subcapsular, Hyperplasia, Focal 1 1 1 1 1 1 6 1.0 Zona Reticularis, Hypertrophy, Focal 1 1 1 1 1 5 1.0

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + 6 .........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + 6 .........................................................................................................................................................................................................

Parathyroid Gland M + + + + + 5 .........................................................................................................................................................................................................

Pituitary Gland + + + + + + 6 .........................................................................................................................................................................................................

Thyroid Gland + + + + + + 6






0 0 0 0 0 0 DAY ON TEST 9 9 9 9 9 9

2 2 2 2 2 2 .................................................................................................................................................................


1-8 SALINE 8 5


0 0 1 8 6

0 0 1 8 7

0 0 1 9 0

0 0 1 9 1

0 0 1 9 2 * TOTALS

GENITAL SYSTEM .........................................................................................................................................................................................................

Clitoral Gland M + + + I + 4 .........................................................................................................................................................................................................

Ovary + + + + + I 5 .........................................................................................................................................................................................................

Uterus + + + + + + 6 Endometrium, Hyperplasia, Diffuse, Cystic 2 2 1 2 1 5 1.6


Bone Marrow + + + + + + 6 Depletion Cellular, Diffuse 2 1 2.0

.........................................................................................................................................................................................................

Lymph Node, Mandibular + + + + + + 6 .........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + 6 .........................................................................................................................................................................................................


.........................................................................................................................................................................................................

Thymus + + + + + + 6






0 0 0 0 0 0 DAY ON TEST 9 9 9 9 9 9

2 2 2 2 2 2 .................................................................................................................................................................


1-8 SALINE 8 5

0 0 1 8 6

0 0 1 8 7

0 0 1 9 0

0 0 1 9 1

0 0 1 9 2 * TOTALS


Mammary Gland + + + + + + 6 .........................................................................................................................................................................................................

Skin + + + + + + 6


Bone + + + + + + 6

NERVOUS SYSTEM .........................................................................................................................................................................................................

Brain + + + + + + 6


Lung + + + + + + 6 Alveolus, Hemorrhage, Focal 1 1 1 1 4 1.0

.........................................................................................................................................................................................................

Nose + + + + + + 6 .........................................................................................................................................................................................................

Trachea + + + + + + 6






0 0 0 0 0 0 DAY ON TEST 9 9 9 9 9 9

2 2 2 2 2 2 .................................................................................................................................................................


1-8 SALINE 8 5

0 0 1 8 6

0 0 1 8 7

0 0 1 9 0

0 0 1 9 1

0 0 1 9 2 * TOTALS


Eye + + + + + + 6 .........................................................................................................................................................................................................

Harderian Gland + + + + + + 6

URINARY SYSTEM .........................................................................................................................................................................................................

Kidney + + + + + + 6 .........................................................................................................................................................................................................

Urinary Bladder + + + + + + 6






0 0 0 0 0 0 0 DAY ON TEST 9 9 9 0 9 9 9

2 2 2 1 2 2 2 .................................................................................................................................................................


1-9 SALINE 0 6

0 0 2 0 7

0 0 2 0 8

0 0 2 0 9

0 0 2 1 1

0 0 2 1 2

0 0 2 1 3 * TOTALS


Esophagus + + + + + + + 7 .........................................................................................................................................................................................................

Gallbladder + + + + I + + 6 .........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + 7 .........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + 7 .........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + 7 .........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + 7 .........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + + 7 .........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + 7 .........................................................................................................................................................................................................

Liver + + + + + + + 7 .........................................................................................................................................................................................................

Pancreas + + + + + + + 7 .........................................................................................................................................................................................................

Salivary Glands + + + + + + + 7 .........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + 7 .........................................................................................................................................................................................................






0 0 0 0 0 0 0 DAY ON TEST 9 9 9 0 9 9 9

2 2 2 1 2 2 2 .................................................................................................................................................................


1-9 SALINE 0 6

0 0 2 0 7

0 0 2 0 8

0 0 2 0 9

0 0 2 1 1

0 0 2 1 2

0 0 2 1 3 * TOTALS

Stomach, Glandular + + + + + + + 7


Blood Vessel + + + + + + + 7 .........................................................................................................................................................................................................

Heart + + + + + + + 7 Epicardium, Mineralization, Focal 1 1 1 3 1.0


Adrenal Cortex + + + + + M + 6 Subcapsular, Hyperplasia, Focal 1 1 1 1 1 1 6 1.0

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + M + 6 .........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + 7 .........................................................................................................................................................................................................

Parathyroid Gland + + + M + + + 6 .........................................................................................................................................................................................................

Pituitary Gland + + + + + + + 7 .........................................................................................................................................................................................................

Thyroid Gland + + + + + + + 7







0 0 0 0 0 0 0 DAY ON TEST 9 9 9 0 9 9 9

2 2 2 1 2 2 2 .................................................................................................................................................................


1-9 SALINE 0 6

0 0 2 0 7

0 0 2 0 8

0 0 2 0 9

0 0 2 1 1

0 0 2 1 2

0 0 2 1 3 * TOTALS

GENITAL SYSTEM .........................................................................................................................................................................................................

Clitoral Gland + + + + + + M 6 .........................................................................................................................................................................................................

Ovary + + + + M + + 6 .........................................................................................................................................................................................................

Uterus + + + + + + + 7 Endometrium, Hyperplasia, Diffuse, Cystic 1 1 2 1 4 1.3


Bone Marrow + + + + + + + 7 .........................................................................................................................................................................................................

Lymph Node, Mandibular + + + + M + + 6 .........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + 7 .........................................................................................................................................................................................................

Spleen + + + + + + + 7 Hematopoietic Cell Proliferation 3 3 3 1 3 3 3 7 2.7

.........................................................................................................................................................................................................

Thymus + + + + + + + 7







0 0 0 0 0 0 0 DAY ON TEST 9 9 9 0 9 9 9

2 2 2 1 2 2 2 .................................................................................................................................................................


1-9 SALINE 0 6

0 0 2 0 7

0 0 2 0 8

0 0 2 0 9

0 0 2 1 1

0 0 2 1 2

0 0 2 1 3 * TOTALS

Mammary Gland + + + + + + + 7 .........................................................................................................................................................................................................

Skin + + + + + + + 7


Bone + + + + + + + 7

NERVOUS SYSTEM .........................................................................................................................................................................................................

Brain + + + + + + + 7


Lung + + + + + + + 7 Alveolus, Hemorrhage, Focal 2 1 1 1 1 2 6 1.3

.........................................................................................................................................................................................................

Nose + + + + + + + 7 .........................................................................................................................................................................................................

Trachea + + I I + + I 4


Eye + + + + + + + 7 .........................................................................................................................................................................................................






0 0 0 0 0 0 0 DAY ON TEST 9 9 9 0 9 9 9

2 2 2 1 2 2 2 .................................................................................................................................................................


1-9 SALINE 0 6

0 0 2 0 7

0 0 2 0 8

0 0 2 0 9

0 0 2 1 1

0 0 2 1 2

0 0 2 1 3 * TOTALS

Harderian Gland + + + + + + + 7

URINARY SYSTEM .........................................................................................................................................................................................................

Kidney + + + + + + + 7 .........................................................................................................................................................................................................

Urinary Bladder + + + + + + + 7






0 0 0 0 0 0 DAY ON TEST 9 9 9 6 9 6

2 2 2 9 2 2 .................................................................................................................................................................


1-10 SALINE 2 7

0 0 2 2 8

0 0 2 2 9

0 0 2 3 2

0 0 2 3 3

0 0 2 3 4 * TOTALS


Esophagus + + + + + A 5 .........................................................................................................................................................................................................

Gallbladder + + + A + A 4 .........................................................................................................................................................................................................

Intestine Large, Cecum + + + A + A 4 .........................................................................................................................................................................................................

Intestine Large, Colon + + + A + A 4 .........................................................................................................................................................................................................

Intestine Large, Rectum + + + A + A 4 .........................................................................................................................................................................................................

Intestine Small, Duodenum + + + A + A 4 .........................................................................................................................................................................................................

Intestine Small, Ileum + + + A + A 4 .........................................................................................................................................................................................................

Intestine Small, Jejunum + + + A + A 4 .........................................................................................................................................................................................................

Liver + + + + + A 5 Cyst, Focal 3 1 3.0

.........................................................................................................................................................................................................

Pancreas + + + A + A 4 .........................................................................................................................................................................................................

Salivary Glands + + + A + A 4 .........................................................................................................................................................................................................

Stomach, Forestomach + + + A + A 4






0 0 0 0 0 0 DAY ON TEST 9 9 9 6 9 6

2 2 2 9 2 2 .................................................................................................................................................................


1-10 SALINE 2 7

0 0 2 2 8

0 0 2 2 9

0 0 2 3 2

0 0 2 3 3

0 0 2 3 4 * TOTALS

.........................................................................................................................................................................................................

Stomach, Glandular + + + A + A 4


Blood Vessel + + + + + + 6 .........................................................................................................................................................................................................

Heart + + + + + + 6


Adrenal Cortex + + + + + A 5 Subcapsular, Hyperplasia, Focal 1 1 1 1 1 5 1.0

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + A 5 .........................................................................................................................................................................................................

Islets, Pancreatic + + + A + A 4 .........................................................................................................................................................................................................

Parathyroid Gland + + + A + A 4 Angiectasis 1 1 1.0

.........................................................................................................................................................................................................

Pituitary Gland I + + + + M 4 .........................................................................................................................................................................................................

Thyroid Gland + + + A + A 4






0 0 0 0 0 0 DAY ON TEST 9 9 9 6 9 6

2 2 2 9 2 2 .................................................................................................................................................................


1-10 SALINE 2 7


0 0 2 2 8

0 0 2 2 9

0 0 2 3 2

0 0 2 3 3

0 0 2 3 4 * TOTALS

GENITAL SYSTEM .........................................................................................................................................................................................................

Clitoral Gland + + + + + A 5 .........................................................................................................................................................................................................

Ovary + + + + + A 5 .........................................................................................................................................................................................................

Uterus + + + A + A 4 Endometrium, Hyperplasia, Diffuse, Cystic 2 1 2.0


Bone Marrow + + + + + A 5 .........................................................................................................................................................................................................

Lymph Node, Mandibular + + + A + A 4 .........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + A + A 4 .........................................................................................................................................................................................................


.........................................................................................................................................................................................................

Thymus + + + A + M 4






0 0 0 0 0 0 DAY ON TEST 9 9 9 6 9 6

2 2 2 9 2 2 .................................................................................................................................................................


1-10 SALINE 2 7

0 0 2 2 8

0 0 2 2 9

0 0 2 3 2

0 0 2 3 3

0 0 2 3 4 * TOTALS


Mammary Gland + + + A + A 4 .........................................................................................................................................................................................................

Skin + + + + + A 5


Bone + + + + + + 6

NERVOUS SYSTEM .........................................................................................................................................................................................................

Brain + + + A + + 5


Lung + + + + + A 5 Alveolus, Hemorrhage, Focal 1 1 2 3 1.3

.........................................................................................................................................................................................................

Nose + + + + + A 5 .........................................................................................................................................................................................................

Trachea + I + A + A 3







0 0 0 0 0 0 DAY ON TEST 9 9 9 6 9 6

2 2 2 9 2 2 .................................................................................................................................................................


1-10 SALINE 2 7

0 0 2 2 8

0 0 2 2 9

0 0 2 3 2

0 0 2 3 3

0 0 2 3 4 * TOTALS

.........................................................................................................................................................................................................

Eye + + + A + A 4 .........................................................................................................................................................................................................

Harderian Gland + + + A + A 4

URINARY SYSTEM .........................................................................................................................................................................................................

Kidney + + + A + A 4 Renal Tubule, Bilateral, Dilatation 2 1 2.0

.........................................................................................................................................................................................................

Urinary Bladder + + + A + A 4

*** END OF REPORT ***


TDMS No. ADENO-ASSOCIATED VIRAL VECTOR … › ntp-db › ntp_reports › ntp...BALB/C MICE MALE 0 0...

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Transcript of TDMS No. ADENO-ASSOCIATED VIRAL VECTOR … › ntp-db › ntp_reports › ntp...BALB/C MICE MALE 0 0...