NORMAL SEXUALNORMAL SEXUALDIFFERENTIATIONDIFFERENTIATION

Suganda Tanuwidjaja

IDENTITAS GENDERIDENTITAS GENDER

1. Genotype

2. Gonadale Sex

3. Phenotype Sex

4. Social Gender

GENOTYPEGENOTYPE

Chromosomal(Genetic) Sex

Gonadale Sex

Ovary-DeterminingGenes

Testis-DeterminingGenes

Phenotypic Sex

Gonadale SteroidsAnd Peptidas

(T.DHT.AMH)(Gonadale Steroids)

XY XX

♂ ♀

• Male : 46 XY

• Female : 46 XX

Y Chromosome (SRY Gene)

Diff. of The Bipotential Gonad

Testis

X Chromosome

One Dose Active

CHROMOSOMAL SEXCHROMOSOMAL SEX

• Gonadal Sex is determined by SRY

• Indiff. Gonad (SRY) Ovary

(+SRY) Testis

GONADAL SEXGONADAL SEX

1 X Chromosome : SRY

Gonad Ovary (Fetal Periode)

Ova Atrophy

(Only 1 Chr)

Cholesterol

STEROID METABOLISM OF GONADSTEROID METABOLISM OF GONAD

Androgen

Estrogen

Enzim

• Internal Ducts

• External Genital Appearance

• Peran Androgen

PHENOTYPE SEXPHENOTYPE SEX

Masculine

Wolffian Ducts

INTERNAL SEX DUCTS BIPOTENTIALINTERNAL SEX DUCTS BIPOTENTIAL

Feminine

Mullerian Ducts

Mullerian Duct Inhibitory Factor (MIF)

TESTICULAR PEPTIDE PRDCTTESTICULAR PEPTIDE PRDCT(SERTOLI CELL)(SERTOLI CELL)

Mullerian Duct Atrophy

Wolffian Duct Developed

MIF

WITHOUT...WITHOUT...

Developed :

• Uterus

• Oviduct

• Upper 2/3 of Vagina

LEYDIG CELL

Testosteron

Wolffian Ducts

• Epididymis• Vas Deferens• Seminal Vesicle

• Bipotential 8 Weeks

• Genital Tubercle Clitoris

• Urogenital Fold Labia Minora

• Labioscrotal Swelling Labia Majora

EXTERNAL GENITALIAEXTERNAL GENITALIA

TestosteroneDihydrotestosterone

(DHT)

5α Reductase Enzyme

Androgen Receptor (ARs)

Genital Tubercle Penis

DHT

ARs

Urogenital Slit Penile Urethra

Labioscrotal Fold Scrotum

Maternal Human Chorionic Gonadotropin(hCG)

11stst TRIMESTER TRIMESTER

Fetal Testes

Testosterone

Male Development

Fetal Pituitary Gonadotropin

22ndnd TRIMESTER TRIMESTER

Testicular Activity

Further Normal Growth

of The Penis

• Gender Development :

1. Gender Identity

2. Gender Role

3. Sexual Orientation

4. Desire & Capacity for Parenting

SOCIAL GENDERSOCIAL GENDER

• Surrounding

• Physical Differentiation

• Interaction

• Prenatal Androgen

DETERMINED FACTORSDETERMINED FACTORS

Thank YouThank You