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N I H GUIDE - Vol. 19, N O . 27, J u l y 20 , 1990

NOTICES

RECEIPT DATES FOR AIDS COMPETING APPLICATIONS ............................... 1 d*Nat iona l I n s t i t u t e s o f Heal th Index: NATIONAL INSTITUTES OF HEALTH

NOTICES OF AVAILABILITY (RFPs AND RFAs)

SURVEILLANCE EPIDEMIOLOGY AND END RESULTS EXPANSION (RFP) ................... 1 Nat iona l Cancer I n s t i t u t e Index! CANCER

SYNTHESIS OF CONGENERS AND PRODRUGS OF ANTI-AIDS COMPOUNDS (RFP) ............ 2 Nat iona l Cancer I n s t i t u t e Index: CANCER

NATURAL PRODUCTS LEAD-BASED SYNTHESIS (RFP) ................................. 3 Nat iona l Cancer I n s t i t u t e Index: CANCER

PROXY MEASURES FOR SERIOUS CHILDHOOD INJURIES (RFA HD-90-11) ................ 3 Nat iona l I n s t i t u t e of Chi ld Heal th and Human DevelopmentIndex: CHILD HEALTH, HUMAN DEVELOPMENT

ERRATUM

UPDATE ON THE N I H POLICY REGARDING PROGRAM PROJECT, AND OTHER COMPLEX MULTIFACETED, UNSOLICITED GRANT APPLICATIONS ................................ 5 Nat iona l I n s t i t u t e s o f Heal th Index: NATIONAL INSTITUTES OF HEALTH

-#'

RECEIPT DATES FOR AIDS COMPETING APPLICATIONS

P.T. 34; K.W. 0715008, 1014006 I d

N a t i o n a l I n s t i t u t e s o f Heal th

I n t h e March 1 1 , 1988, N I H Guide f o r Grants and C o n t r a c t s (Vol. 17, No. 91,t h e N I H announced t h e e s t a b l i s h m e n t o f t h e d a t e s o f January 2, May 1 , and September 1 as r e c e i p t d a t e s ( f o r May, October, and February AdvisoryCounci l s , r e s p e c t i v e l y ) f o r i n v e s t i g a t o r - i n i t i a t e d Acquired Immune Def ic iencySyndrome (AIDS) r e s e a r c h g r a n t a p p l i c a t i o n s . These r e c e i p t d a t e s d i f f e r from t h o s e f o r o t h e r a p p l i c a t i o n s and have been e s t a b l i s h e d i n o r d e r t o accomplisht h e receipt- to-award p r o c e s s i n an a c c e l e r a t e d f a s h i o n , as mandated by l a w .

While t h a t announcement a l s o al lowed f o r submission o f AIDS-related a p p l i c a t i o n s on r e g u l a r r e c e i p t d a t e s , w i t h t h e r e c e n t c h a r t e r i n g of i n i t i a l review groups s p e c i f i c a l l y f o r t h e review o f AIDS a p p l i c a t i o n s it is now n e c e s s a r y f o r a l l a p p l i c a n t s s u b m i t t i n g i n v e s t i g a t o r - i n i t i a t e d AIDS-related a p p l i c a t i o n s t o adhere s t r i c t l y t o t h e AIDS r e c e i p t d a t e s .

It must b e s t r e s s e d t h a t t h e above r e c e i p t d a t e s a r e f o r competingc o n t i n u a t i o n (Type 2) and supplemental (Type 3) a p p l i c a t i o n s , as w e l l as f o r new (Type 1 ) a p p l i c a t i o n s . Thus, f o r example, whi le some c u r r e n t g r a n t e e s mayhave had t h e i r l a s t competing AIDS-related a p p l i c a t i o n p e e r reviewed by an i n i t i a l review group o t h e r t h a n one o f t h e r e c e n t l y e s t a b l i s h e d AIDS review groups, a l l subsequent competing c o n t i n u a t i o n a p p l i c a t i o n s must b e submi t ted for t h e r e c e i p t d a t e s l i s t e d above f o r review by t h e s e AIDS i n i t i a l review groups .

AIDS-related a p p l i c a t i o n s i n c l u d e t h o s e which propose s t u d i e s on t h e e t i o l o g y ,epidemiology, n a t u r a l h i s t o r y , pathology, d i a g n o s i s , t r e a t m e n t o r p r e v e n t i o no f AIDS o r t h e v a r i o u s s e q u e l l a e s p e c i f i c a l l y a s s o c i a t e d w i t h t h e syndrome.Basic s t u d i e s o f t h e H I V v i r u s , such as v i r o l o g y , molecular g e n e t i c s ,immunology, and i n v ivo o r i n v i t r o models o f human H I V i n f e c t i o n aimed a t e l u c i d a t i n g t h e mechanism o f t h e AIDS i n f e c t i o u s p r o c e s s are d i r e c l ya p p l i c a b l e . P r e p a r a t i o n and s c r e e n i n g o f anti-AIDS a g e n t s as w e l l as v a c c i n e development i n both p r e c l i n i c a l and c l i n i c a l s t u d i e s are i n c l u d e d . Relevant

‘e s t u d i e s o f blood and blood products , n e u r o l o g i c a l effects o f H I V i n f e c t i o n ,b e h a v i o r a l r e s e a r c h , and p r e v e n t i o n o f h i g h - r i s k behaviors , and e d u c a t i o n p r o j e c t s a r e a l s o a c c e p t a b l e . The f i n a l d e t e r m i n a t i o n o f AIDS r e l a t e d n e s s is t h e r e s p o n s i b i l i t y of t h e D i v i s i o n o f Research Grants (DRG) , N I H . For f u r t h e r guidance, a p p l i c a n t s are a d v i s e d t o c o n t a c t t h e Referral Office, DRG, a t (301)496-7447.

NOTICES OF AVAILABILITY (RFPs AND R F A s )

SURVEILLANCE EPIDEMIOLOGY AND END RESULTS EXPANSION

RFP AVAILABLE: NCI-CN-05302-03

P.T. 34; K.W. 0785055, 0413001, 0715035, 0755018

N a t i o n a l Cancer I n s t i t u t e

The N a t i o n a l Cancer I n s t i t u t e , D i v i s i o n o f Cancer Prevent ion and Cont ro l , i s s o l i c i t i n g p r o p o s a l s f o r a n Expansion o f t h e S u r v e i l l a n c e , Epidemiology and End R e s u l t s (SEER) Program. The t h r u s t o f t h i s proposed p r o j e c t is t o : 1 )o b t a i n w i t h i n t h e geographic area o f coverage, d a t a on a l l newly diagnosed cases o f cancer beginning January 1 , 1990 forward; 2 ) o b t a i n cancer p a t i e n ts u r v i v a l d a t a on a l l cases diagnosed i n 1990 forward; 3) monitor t r e n d s i n t h e i n c i d e n c e o f s p e c i f i c forms o f cancer , p a r t i c u l a r l y w i t h r e s p e c t t o demographic and s o c i a l c h a r a c t e r i s t i c s o f t h e p o p u l a t i o n ; and 4 ) assess t h e completeness and accuracy o f a l l d a t a c o l l e c t e d . O f f e r o r s must providedocumentation o f a u t h o r i t y t o c o l l e c t d a t a f o r t h e i r i d e n t i f i e d coverage area and w i l l be r e q u i r e d t o have a Hispanic p o p u l a t i o n o f a t l eas t 3 0 0 , 0 0 0 i n t h e i r coverage area.

Requests f o r t h i s s o l i c i t a t i o n must b e i n w r i t i n g and reference RFP No. NCI-CN-05302-03. The RFP w i l l be a v a i l a b l e approximately J u l y 30, 1990, and

*,,,uu/ w i l l be due approximately September 13, 1990.

The N a t i o n a l Cancer I n s t i t u t e e x p e c t s t o make one award from t h i s s o l i c i t a t i o n .

N I H GUIDE - Vol. 19, No. 27, J u l y 20, 1990 - Page 1

Copies o f t h e RFP may be o b t a i n e d by sending a w r i t t e n r e q u e s t t o :

Mrs. S h i r l e y Kyle, C o n t r a c t i n g Officer N a t i o n a l I n s t i t u t e s o f Heal th N a t i o n a l Cancer I n s t i t u t e Research C o n t r a c t s Branch, PCCS Execut ive P l a z a South, Room 635 9000 R o c k v i l l e P ike Bethesda, MD 20892 Telephone: (301) 496-8603

SYNTHESIS OF CONGENERS AND PRODRUGS OF ANTI-AIDS COMPOUNDS

RFP AVAILABLE: NCI-CM-17513-28

P.T. 34; K.W. 1003006, 1003012, 0755025, 0715008

N a t i o n a l Cancer I n s t i t u t e

The Drug S y n t h e s i s and Chemistry Branch (DS&CB), o f t h e Developmental T h e r a p e u t i c s Program (DTP), D i v i s i o n o f Cancer Treatment (DCT), N a t i o n a l Cancer I n s t i t u t e ( N C I ) , is seeking c o n t r a c t o r s w i t h e x p e r t i s e i n chemical s y n t h e s i s and drug d e s i g n , t o s y n t h e s i z e a v a r i e t y o f compounds f o r e v a l u a t i o n as p o t e n t i a l anti-AIDS a g e n t s . The a s s i g n e d o b j e c t i v e s o f t h i s p r o j e c t are t o d e s i g n and s y n t h e s i z e t h e f o l l o w i n g : ( a ) Congeners o f l e a d compounds having confirmed a c t i v i t y , t o enhance a c t i v i t y o r potency; ( b ) Prodrugs w i t h s t r u c t u r a l m o d i f i c a t i o n s t h a t may provide a l t e r e d pharmacokine t ics , a l t e r e d drug t r a n s p o r t , improved b i o - a v a i l a b i l i t y th rough i n c r e a s e d water s o l u b i l i t y , o r i n c r e a s e d chemical s t a b i l i t y ; ( c ) Other a l t e r e d s t r u c t u r e s t h a t p o s s e s s elements of b o t h congener and prodrug; and ( d ) Compounds r e l a t e d t o n a t u r a l p r o d u c t s , e . g . , a l k a l o i d s , h e t e r o c y c l e s , n u c l e o s i d e s , p e p t i d e s , e t c . Each c o n t r a c t o r should have a v a i l a b l e a f u l l y o p e r a t i o n a l f a c i l i t y , i n c l u d i n g a l l n e c e s s a r y equipment and i n s t r u m e n t a t i o n for a l l a s p e c t s of t h e con t r ac t . The n a t u r e o f t h i s p r o j e c t r e q u i r e s t h a t t h e f o l l o w i n g r e s t r i c t i o n be a p p l i e d : The N C I s i g n s l e g a l l y b i n d i n g agreements w i t h c e r t a i n s u p p l i e r s ( o f t e n pharmaceut ica l o r chemical companies) which s t a t e t h a t a l l i n f o r m a t i o n on compounds submi t ted by t h e s u p p l i e r w i l l be h e l d c o n f i d e n t i a l . The s u c c e s s f u l o f f e r o r w i l l b e expec ted t o s y n t h e t i c a l l y modify such commercially c o n f i d e n t i a l ( d i s c r e e t ) materials. Thus, pharmaceut ica l o r chemical companies could o b t a i n v a l u a b l e d a t a on new l e a d compounds. Therefore , i n o r d e r t o honor t h e c o n f i d e n t i a l i t y agreement w i t h t h e o r i g i n a l s u p p l i e r , t h e N C I b e l i e v e s t h a t t h e compounds cannot be s e n t t o p o t e n t i a l c o m p e t i t o r s o f t h e s u p p l i e r , and t h u s pharmaceut ica l and chemical compounds must b e excluded from t h e c o m p e t i t i o n . For purposes o f t h i s r e s t r i c t i o n , a pharmaceut ica l o r chemical company is d e f i n e d as an o r g a n i z a t i o n which sells d r u g s and chemica ls t o t h e g e n e r a l p u b l i c f o r p r o f i t .

T h i s is a r e c o m p e t i t i o n o f c o n t r a c t s c u r r e n t l y h e l d by t h e U n i v e r s i t y o f Alabama, Georgia Tech Research Corp. (Georgia I n s t . o f Technology), Purdue Research Foundation, and t h e Research Foundation o f S t a t e U n i v e r s i t y o f N e w York a t B u f f a l o . It i s a n t i c i p a t e d t h a t t h r e e cost-reimbursement c o n t r a c t s w i l l b e awarded f o r a p e r i o d o f t h r e e y e a r s beginning on o r about May 30, 1991.

RFP No. NCI-CM-17513-28 was i s s u e d on J u l y 16 and i s a v a i l a b l e upon r e q u e s t t o Carolyn Barker , C o n t r a c t S p e c i a l i s t , and p r o p o s a l s w i l l be due approximately n i n e weeks t h e r e a f t e r .

Copies o f t h e RFP may be o b t a i n e d by sending a w r i t t e n r e q u e s t t o :

M s . Carolyn E . Barker , C o n t r a c t S p e c i a l i s t N a t i o n a l I n s t i t u t e s o f Heal th N a t i o n a l Cancer I n s t i t u t e Research C o n t r a c t s Branch, TCS Execut ive P l a z a South, Room 603 9000 R o c k v i l l e P ike Bethesda, MD 20892 Telephone: (301) 496-8620

N I H GUIDE - Vol. 19, No. 27, J u l y 20, 1990 - Page 2

NATURAL PRODUCTS LEAD-BASED SYNTHESIS

RFP AVAILABLE : NCI-CM-17502-19

P.T. 34; K.W. 0750025, 1003006, 1003012, 0715008, 0715035

’d N a t i o n a l Cancer I n s t i t u t e

The Drug S y n t h e s i s and Chemistry Branch o f t h e Developmental T h e r a p e u t i c s Program, D i v i s i o n o f Cancer Treatment ( D C T ) , N a t i o n a l Cancer I n s t i t u t e ( N C I ) , i s s e e k i n g c o n t r a c t o r s w i t h e s t a b l i s h e d e x p e r t i s e i n t h e f i e l d o f e n a n t i o - and s t e r e o s e l e c t i v e s y n t h e s i s o f complex molecules t o p r e p a r e n a t u r a l p r o d u c t s and t h e i r d e r i v a t i v e s f o r e v a l u a t i o n as an t i tumor and AIDS a n t i v i r a l a g e n t s . The N C I s i g n s l e g a l l y b i n d i n g agreements w i t h some s u p p l i e r s ( o f t e n pharmceut ica l o r chemical companies) which s t a t e t h a t a l l in format ion on compounds donated by t h o s e s u p p l i e r s w i l l be h e l d c o n f i d e n t i a l . The s u c c e s s f u l o f f e r o r may b e a s s i g n e d a c o n f i d e n t i a l compound as a s y n t h e s i s o r m o d i f i c a t i o n t a r g e t . If t h e c o n t r a c t o r were a chemical o r pharmaceut ica l company t h e y could g a i n v a l u a b l e d a t a on c o n f i d e n t i a l new l e a d compounds. The N C I b e l i e v e s t h a t i n o r d e r t o honor t h e c o n f i d e n t i a l i t y agreement w i t h s u p p l i e r s and i n o r d e r t o avoid any chance o f t r a n s m i t t i n g p r i v i l e g e d d a t a t o a compet i tor , pharmaceut ica l and chemical companies must b e excluded from t h i s c o m p e t i t i v e procurement .

RFP No. NCI-CM-17502 w i l l be i s s u e d , upon w r i t t e n r e q u e s t t o Z e t h e r i n g Gore,Contrac t S p e c i a l i s t , t h e week o f J u l y 16, 1990. P r o p o s a l s w i l l be due approximate ly seven weeks t h e r e a f t e r . The c o n t r a c t p e r i o d is t o be f o r t h r e e y e a r s , beginning approximate ly March 1991.

Copies o f t h e RFP may b e o b t a i n e d by sending a w r i t t e n r e q u e s t t o :

M s . Z e t h e r i n g Gore, Cont rac t S p e c i a l i s t N a t i o n a l I n s t i t u t e o f H e a l t h N a t i o n a l Cancer I n s t i t u t e Research C o n t r a c t s Branch, TCS Execut ive P l a z a South, Room 603 9000 R o c k v i l l e P ike Bethesda, MD 20892

“ I d PROXY MEASURES FOR SERIOUS CHILDHOOD INJURIES

RFA AVAILABLE: HD-90-11

P.T. 34; K . W . 0715027, 0770005, 0413001, 0404000, 0775000

N a t i o n a l I n s t i t u t e o f C h i l d Heal th and Human Development

A p p l i c a t i o n Rece ip t Date: November 30, 1990

The Human Learning and Behavior Branch (HLB) of t h e Center f o r Research �or Mothers and C h i l d r e n (CRMC), N a t i o n a l I n s t i t u t e o f Chi ld Heal th and Human Development ( N I C H D ) , i n v i t e s g r a n t a p p l i c a t i o n s f o r r e s e a r c h t o develop measures which are proxy o r s u b s t i t u t e s f o r s e r i o u s , p o t e n t i a l l y f a t a l , o r handicapping i n j u r i e s i n c h i l d r e n and youth . These measures are needed t o develop and e v a l u a t e i n t e r v e n t i o n s f o r s e r i o u s i n j u r i e s wi thout depending on t h e a c t u a l occur rence o f t h e s e i n j u r i e s . Such measures used i n l i e u o f f a t a l o r handicapping i n j u r i e s are c o n s i d e r e d proxy measures f o r s e r i o u s i n j u r i e s .

I n t h e United S t a t e s , i n j u r i e s are t h e l e a d i n g cause o f d e a t h and d i s a b i l i t y among c h i l d r e n and young a d u l t s . They account f o r about h a l f o f a11 d e a t h s i n c h i l d r e n under 15 y e a r s and almost 8 0 p e r c e n t o f d e a t h s i n t h e 15 t o 24 age group. C l e a r l y , i n j u r y is one o f t h e most impor tan t c h a l l e n g e s f a c i n g t h e h e a l t h and s c i e n t i f i c community i n reducing m o r t a l i t y and s u f f e r i n g i n ch i ldhood. However d e a t h and d i s a b i l i t y due t o i n j u r y is s t i l l a r e l a t i v e l y uncommon e v e n t . S t u d i e s aimed a t development and e v a l u a t i o n of i n t e r v e n t i o n s t r a t e g i e s are compl ica ted by t h e l a r g e samples r e q u i r e d and dependence on t r a g i c e v e n t s as outcome measures. Therefore , measures are needed which p r e d i c t t h e p r o b a b i l i t y o f s e r i o u s i n j u r y more a c c u r a t e l y t h a n e x i s t i n g measures and can be used as dependent measures wi thout depending on a c t u a l occur rence of t h e s e i n j u r e s . Such measures must be o b s e r v a b l e and measurable . They may c o n s i s t o f sociodemographic, b e h a v i o r a l , p h y s i o l o g i c a l o r even g e n e t i c v a r i a b l e s o r combinat ions o f such v a r i a b l e s . They could comprise a set of v a r i a b l e s which d e s c r i b e s t h e p r o c e s s f o r s e r i o u s i n j u r i e s as a model

Wn#& and as d i s t i n c t from t h a t f o r minor i n j u r i e s . The r e l a t i o n s h i p o f t h e occurrence o f s e r i o u s i n j u r i e s t o minor i n j u r i e s i s a c e n t r a l i s s u e f o r t h i s r e s e a r c h .

N I H G U I D E - Vol. 19, No. 27, J u l y 20, 1990 - Page 3

The major i n j u r i e s exper ienced by c h i l d r e n va ry by age , l o c a t i o n , and o t h e r f a c t o r s . The re fo re , no one measure o r s e t o f measures is l i k e l y t o p r e d i c t a l l i n j u r i e s o f c h i l d r e n . However, t h i s r e s e a r c h must focus on a t l eas t one major t y p e o r cause o f i n j u r y f o r a t l ea s t one age group and should apply o r g e n e r a l i z e t o more t h a n one i n j u r y o r age group.

It is a n t i c i p a t e d t h a t t h e development and v a l i d a t i o n o f such measures may llI(L.

r e q u i r e t h e u s e o f l a r g e p o p u l a t i o n s o r d a t a b a s e s w i t h s u f f i c i e n t i n fo rma t ion r e g a r d i n g ch i ldhood i n j u r i e s . However, development o f proxy measures f o r s e r i o u s i n j u r y would a l s o r e q u i r e l o n g i t u d i n a l follow-up and a d d i t i o n a l i n fo rma t ion t h a n is c u r r e n t l y a v a i l a b l e w i t h c r o s s - s e c t i o n a l samples . Linkages between e x i s t i n g d a t a b a s e s may prove u s e f u l .

The product o f t h i s r e s e a r c h should be a measure o r s e t o f measures which would p r e d i c t t h e p r o b a b i l i t y o f s e r i o u s i n j u r y wi th g r e a t e r accuracy t h a n anyo t h e r c u r r e n t l y e x i s t i n g measure. The proxy measure(s1 must a l s o be s u f f i c i e n t l y a c c u r a t e so t h a t w i th e v a l u a t i o n o f i n t e r v e n t i o n s , changes i n t h e measure w i l l r e f lec t changes i n t h e a c t u a l rates o f s e r i o u s i n j u r y wi th s u f f i c i e n t power t o be used f o r t h i s purpose . Suggested examples o f p o s s i b l e proxy measures f o r s e r i o u s i n j u r y i n c l u d e : minor i n j u r i e s ( i f s t r o n g c o r r e l a t i o n wi th s e r i o u s i n j u r i e s i s demons t r a t ed ) , s a f e t y o r i n j u r y r e l a t e d behav io r , o r a se t o f demographic and/or o t h e r d e s c r i p t i v e v a r i a b l e s which h i g h l y p r e d i c t t h e p r o b a b i l i t y o f i n j u r y .

T h i s Request f o r A p p l i c a t i o n s (RFA) i s in t ended t o be one component o f a program o f ch i ldhood i n j u r y r e s e a r c h w i t h i n N I C H D and o t h e r P u b l i c Hea l th S e r v i c e a g e n c i e s . The f o c u s o f t h i s announcement i s t o develop measures which are proxy f o r s e r i o u s i n j u r i e s t o c h i l d r e n . Based upon unde r s t and ing ga ined from t h i s and o t h e r r e s e a r c h , i n t e r v e n t i o n s can be developed and e v a l u a t e d as p a r t o f f u t u r e planned funding i n i t i a t i v e s .

The PHS u r g e s a p p l i c a n t s f o r g r a n t s t o g i v e added a t t e n t i o n (where f e a s i b l e and a p p r o p r i a t e ) t o t h e i n c l u s i o n o f m i n o r i t i e s and females i n s t u d y p o p u l a t i o n s f o r research i n t h e behavioral and soc ia l s c i e n c e s . If m i n o r i t i e s and females are not inc luded i n a g iven s tudy , a clear r a t i o n a l e f o r t h e i r e x c l u s i o n should be p rov ided . I n v e s t i g a t o r s are reminded t h a t merely i n c l u d i n g a r b i t r a r y numbers o f m i n o r i t y group and females p a r t i c i p a n t s i n a g iven s tudy is i n s u f f i c i e n t t o gua ran tee g e n e r a l i z a t i o n o f r e s u l t s .

A p p l i c a t i o n s should be submi t t ed on Form PHS-398 ( r e v . 10 /88) , which is a v a i l a b l e i n t h e b u s i n e s s o r g r a n t s and c o n t r a c t s o f f i c e a t most academic and r e s e a r c h i n s t i t u t i o n s o r from t h e D i v i s i o n o f Research Grants , N I H . A p p l i c a t i o n s p repa red i n r e sponse t o t h i s RFA should be r e c e i v e d by November 3 0 , 1990. The RFA l a b e l a v a i l a b l e i n t h e 10/88 r e v i s i o n o f A p p l i c a t i o n Form 398 must be a f f i x e d t o t h e bottom o f t h e face page. F a i l u r e t o u s e t h i s l a b e l cou ld r e s u l t i n de layed p r o c e s s i n g o f t h e a p p l i c a t i o n , such t h a t it may n o t r e a c h t h e review committee i n t i m e f o r rev iew.

It is a n t i c i p a t e d t h a t two awards w i l l be made as a r e s u l t o f t h i s announcement th rough t h e g ran t - in -a id (Ro l l mechanism used by t h e N I C H D . For a copy o f t h e d e t a i l e d RFA f u l l y d e s c r i b i n g t h e s p e c i f i c areas o f r e s e a r c h sought , c o n t a c t t h e fo l lowing :

P e t e r C . S c h e i d t . M . D . , M.P.H. Human Learn ing and Behavior Branch Nat iona l I n s t i t u t e o f Ch i ld Hea l th and Human DevelopmentRoom 633, EPN 9000 R o c k v i l l e P ike Bethesda, MD 20892 Telephone: (301) 496-6591

N I H GUIDE - Vol. 19, No. 2 7 , J u l y 20, 1990 - Page 4

ERRATUM

-UPDATE ON THE N I H POLICY REGARDING PROGRAM PROJECT, AND OTHER COMPLEX MULTIFACETED, UNSOLICITED GRANT APPLICATIONS

P.T. 34; K.W. 0710030, 1014006

Na t iona l I n s t i t u t e s o f Heal th

T h i s announcement as pub l i shed i n t h e N I H Guide f o r Grants and Con t rac t s on June 11, 1990, Vol. 19, No. 23, con ta ined an i n c o r r e c t addres s f o r D r . J u d i t h V a i t u k a i t i s of t h e Na t iona l Center �or Research Resources . The fo l lowing is t h e c o r r e c t addres s :

Nat iona l Center f o r Research Resources 5333 Westbard Avenue Westwood Bui ld ing , Room 8A16 Bethesda, MD 20892 A t t : D r . J u d i t h V a i t u k a i t i s Telephone: (301) 496-6023

*U.S.GOVERNMENT P R I N T I N G OFFICE:1990-261-138:20007

N I H GUIDE - Vol. 19, No. 27, J u l y 20, 1990 - Page 5