NIGATA UNIVE SYLLABUS RSITY - MDS

SYLLABUS

NIIGATA UNIVERSITY

Graduate School of Medical and Dental Sciences

Course for Oral Life Science

2014SYLLABU

SN

IIGATA

UN

IVE

RSITY Graduate School of M

edical and Dental Sciences

Course for O

ral Life Science

Index

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Statement of purpose

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Course Day

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Course Requirements ------------------------------------------------------- 7

--------------------------------------------- 11 Designated Subjects (Required Subjects)

------- 23 Designated Subjects (Elective Subjects Course works for basic dentistry)

------- 57 Designated Subjects (Elective Subjects Course works for clinical dentistry)

--------------------------------------------- 97 Elective Subjects in a Related Discipline (Elective Subjects)

---------------------------------------------------- 97 Integrated Lectures on Basic and Clinical Dentistry

---------------------------------------------------- 107 Department of Oral Health Science

-------------------------------------------------- 245 Department of Oral Biological Science

---------------------------------------------------- 313 Department of Tissue Regeneration and Reconstruction

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The Graduate School program focuses both on education and research in

the field of advanced life sciences, incorporating the latest advancements in

life science technology and responding to a wide range of medical

challenges. The results of comprehensive research are applied to the

development of medical treatment for the benefit of society.

The University seeks to train its students with a high sense of integrity and

creativity, endeavoring to build a closer connection, not only with the local

community, but also in a global society.

These goals implement the philosophy of the Graduate School:

In Education

1. Training a team of researchers who will expand the field of advanced life

sciences

2. Generating medical discoveries that meet the needs of clinical disciplines

3. Equipping professionals to pursue academic activity and healthcare with

medical and intellectual integrity

4. Affirming lifelong learning and re-entry into academic life by accepting

persons in occupational undertakings, and with cooperation of the

University of the Air, whose study center for delivering broadcast lectures,

is located on the same campus.

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Course Day

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( ) + ( )

90 91 92 10 0 1 2 1 1 3 4

5

9211 7013

9013 9113

( 90 91)

9015 9115

9014 9114 9214

9015 9115 9215

2012

( + + ) ( + + ( )+ )

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( 30 )

1) (5 )

2) (4 )

3)

1 2

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Doctoral

Candidate

, 4

, 30 , ,

,

3

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The Course for Oral Life Science with new concept comprises the following two courses. Course for development of leaders has been established to develop researchers and leaders in the fields of dental and/or medical sciences. Another one, course for advancement in the main discipline focuses on education in the specialized field for general practitioners. Students are expected to take each of the above courses. 1. Course Requirements (a minimum of 30 credits including lectures,

seminars and exercises) 1) Designated Subjects (Required (5 credits)

The designated subjects are composed of the basic subject for practical statistics and English literacy one.

2) Selective Designated Subjects ( a minimum of 4 credits) Course works for basic dentistry and clinical dentistry are provided to develop fundamental knowledge and skills as graduate students. Students are able to select some of them with a minimum of 4 credits according to each interesting.

3) Subjects in Unrelated Disciplines Students are able to take subjects in unrelated disciplines comprising lectures, seminars and exercises.

2. Advisors and Research Program Students are supposed to belong to a certain research project, and then to take course works and specific seminars relevant to fundamental matter. After that, an advisory team consisting of one chief advisor and two supervisors is established and a research program is also determined.

3. Thesis and Evaluation The system of “Doctoral Candidate” is applied in the Graduate School. Marks are given to students based upon their educational, research, (clinical) activities and self-learning. Students will have the privilege to submit thesis after obtaining grades determined.

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Requirements for the PhD Degree

We can offer the doctoral degree medicine, dentistry, and academics. The

PhD degree must be completed within a minimum of four years and

following the completion of 30 graduate credit units in the program.

Students must complete their doctoral dissertation and pass the final

examination. Only students with a successful record of research will be

able to complete their degrees within three years.

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Designated Subject Required Subject

2009 Enrolled students after 2009

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In the first semester, students will be introduced to the reading skills in the first half of the

textbook. These will include scanning, skimming, context clues, and inferences.

Students will learn to find information from reading passages and become familiar with the

rhetoric of English writing.

Students will learn about the rhetoric of English writing and identify topics and supporting

ideas. When possible, they will work with authentic material.

Skills will be introduced in class, to be reviewed by students in homework assignments.

The limited class time requires students to be present each session. There will be a take-home

test with a study sheet at the end of the semester.

April 14 Introduction, vocabulary study, Part 2,

Unit 1. John Plagens

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April 21 Scanning, Part 3, Unit 1. John Plagens

May 12 Skimming, Part 3, Unit 6. John Plagens

May 26 Meaning from Context, Part 2, Unit 3. John Plagens

June 9 Making Inferences, Part 3, Unit 2.

John Plagens

June 23 Topics of Paragraphs, pp. 147-155. John Plagens

July 7 Main Ideas of Paragraphs, pp. 156- John Plagens

Attendance, homework assignments, and a take-home test.

The homework will comprise 70% of the grade; late homework will receive ½. The take-home

test will be 30% of the final grade.

More Reading Power (3rd Edition, Longman) by Beatrice S. Mikulecky and Linda Jeffries.

A comprehensive review of writing skills from the sentence level to paragraph and essay

construction.

Students will learn the writing skills necessary for composing a well written essay.

Students will learn the components of the English essay: general statements, thesis

statements, supporting paragraphs, and concluding paragraphs. Also included will be

outlining and self-editing. Each student will submit an essay at the end of the semester.

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Attendance in class is required as there will be in-class writing practice. There will also be

homework assignments each time. These will be submitted to the instructor by e-mail.

April 14 Introduction to sentence types, common errors in

English writing. Text, pp. 162-171 John Plagens

April 21 More on sentence types, introduction to the paragraph.

Text, pp. 172-177, 2-10 John Plagens

May 12 Further studies on the paragraph. Text, pp. 11-17 John Plagens

May 26 Unityand coherence in the paragraph. Text, pp. 18-25 John Plagens

June 9 Introduction to logical connectors. Text, pp. 25-38 John Plagens

June 23 Introduction to the essay. Text, pp. 54-67 John Plagens

July 7 Outlining, essay unity. Text, pp. 68-78 John Plagens

Attendance and homework assignments (75%; ½ for late homework), and final essay (25%)

1. Writing Academic English (Fourth Edition), by Alice Oshima and Ann Hogue, Longman

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Students will build on the reading skills acquired in the first semester and cover the rest of the

textbook.

Students will be introduced to common patterns of organization in reading as well as the

logical connectors employed. Participants will be able to choose reading topics.

Students will begin to acquire the ability to analyze authentic material for patterns of

organization. They will also gain an understanding of the organization of academic papers.

Attendance at each session is absolutely necessary. There will be homework assignments

each time. A final take-home test will be given.

October 6 Sentence patterns, Listing pattern, additive

connectors. Text, pp. 172-175 John Plagens

October 20 Sequence pattern, sequential connectors. John Plagens

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Text, pp. 175-178

November 10 Comparison/Contrast pattern, adversative

connectors. Text, pp. 179-181 John Plagens

December 1 Cause/Effect pattern, causal connectors.

Text, pp. 181-184 John Plagens

December 15 Problem/Solution pattern, pattern review.

Text, pp. 184-186; pp, 187-188 John Plagens

January 26 Summarizing, Reading Longer Passages, pp.

194- John Plagens

February 2 More on Longer Passages; Academic Papers John Plagens

Attendance, homework assignments, and final take-home test.

More Reading Power (3rd Edition, Longman) by Beatrice S. Mikulecky and Linda Jeffries.

Students will continue learning writing skills necessary for professional papers. The course

will cover such topics as patterns of organization and the composition of abstracts and

professional papers.

Students will be introduced to the rhetoric and writing skills necessary for professional papers.

The second semester will build on the writing skills acquired in the first semester. Students

will learn patterns of writing organization and rhetorical devices used in professional papers

and reports. Authentic examples will be used for reference.

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Attendance in class is required as there will be in-class writing practice. There will also be

homework for each class; these assignments will be submitted by e-mail before the next class..

October 6Ch. 3: Interpreting graphs: Narration, Description,

Exposition John Plagens

October 20 Ch. 5: Chronological Order: Process Essays John Plagens

November 10 Ch.7: Comparison/Contrast Essays John Plagens

December 1 Ch. 6: Cause/Effect Essays John Plagens

December 15Writing abstracts, summaries, and introductions: Ch.3

Summarizing, the “Moves” John Plagens

January 26 Rhetorical organization of research papers; Analyzing

Discussions John Plagens

February 2 Definitions in research topics and terminology John Plagens

Attendance and homework assignments, late homework will receive ½ credit.

1. Writing Academic English (Fourth Edition), by Alice Oshima and Ann Hogue, Longman

2.

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Designated Subjects Elective Subjects

Course works for basic dentistry


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25

28

31

34

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Work Course on Related Biomaterials I

Assistant Prof. Mitsugu KANATANI Div. Biomimetics ext. 2852 e-mail: [email protected]

Associate Prof. Seigo OKAWA Div. Biomimetics ext. 2852 e-mail: [email protected]

PBL No.003 (1 ) PBL room 003 on the 1st floor

This course deals with ceramic biomaterials, medical polymers, metallic biomaterials and composite materials. We discuss biocompatibility and in vivo reactions of biomaterials. Moreover, we discuss the application of nano particles for biomaterial and the assessment of biomaterials.

In the course, students are required to understand characteristics and in vivo reactions of biomaterials and to consider methods for evaluation of biomaterials.

After successfully completing this course, students will be able to: Understand relationship between biomaterials and biological body. Explain characterization of biomaterials. Choose an appropriate biomaterial for a given implant design and use based on biomechanics. Discuss characterization and in vivo reactions of new biomaterials such as nano particles. Explain reason for applying composite materials for biomaterials. Discuss assessment of biomaterials.

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Students may discuss homework problems and assignments with fellow classmates.

Biomaterials and their existing state

Mitsugu Kanatani

Biological body and biomaterials

Mitsugu Kanatani

Characterization of biomaterials

Mitsugu Kanatani

Biomechanics

Mitsugu Kanatani

Ceramic biomaterials (part 1)

Mitsugu Kanatani


Mitsugu Kanatani


Mitsugu Kanatani

Biomedical polymers (part 1)

Seigo Okawa


Seigo Okawa


Seigo Okawa

Metallic biomaterials (part 1)

Seigo Okawa


Seigo Okawa

Composite biomaterials

Seigo Okawa

Nano particles and biomaterials

Seigo Okawa

Assessment criteria for biomaterials

Seigo Okawa

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(25%) (25%) 50% Homework (25%) and presentation (25%) and oral examination (50%)

No particular attention.

We will indicate research papers if required.

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Work Course on Related Biomaterials II

PBL No.003 (1 ) PBL room 003 on the 1st floor

This course deals with ceramic biomaterials, medical polymers, metallic biomaterials and composite materials. We discuss biocompatibility and in vivo reactions of biomaterials. Moreover, we discuss the application of nano particles for biomaterial and the assessment of biomaterials.

In the course, students are required to understand characteristics and in vivo reactions of biomaterials and to consider methods for evaluation of biomaterials.

After successfully completing this course, students will be able to: Understand relationship between biomaterials and biological body. Explain characterization of biomaterials. Choose an appropriate biomaterial for a given implant design and use based on biomechanics. Discuss characterization and in vivo reactions of new biomaterials such as nano particles. Explain reason for applying composite materials for biomaterials. Discuss assessment of biomaterials.

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Students may discuss homework problems and assignments with fellow classmates.

Biomaterials and their existing state

Mitsugu Kanatani

Biological body and biomaterials

Mitsugu Kanatani

Characterization of biomaterials

Mitsugu Kanatani

Biomechanics

Mitsugu Kanatani


Mitsugu Kanatani


Mitsugu Kanatani


Mitsugu Kanatani


Seigo Okawa


Seigo Okawa


Seigo Okawa


Seigo Okawa


Seigo Okawa

Composite biomaterials

Seigo Okawa

Nano particles and biomaterials

Seigo Okawa

Assessment criteria for biomaterials

Seigo Okawa

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(25%) (25%) 50% Homework (25%) and presentation (25%) and oral examination (50%)

No particular attention.

We will indicate research papers if required.

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& in situ

Ten Cate Nanci

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(Course No.) (Semester) (Data) (Credit)

1 (Thursday/6-7) I 4

(Thursday/6-7) II 4

Course

I II 9013

Instructor

Place

Division of Oral Pathology

I II

Course outline

This course deals with the methodology for research on pathogenesis of oral and maxillofacial diseases from the aspect of molecular pathology. Modern trends in molecular biology technology which should be applied in pathological research on oral and maxillofacial diseases will be lectured.

Course aim

In this course, students will understand the pathogenesis of oral and maxillofacial diseases, from their causative factors, molecular mechanism, clinical processes, to prognoses. Clinic-pathological aspects of their diagnostic criteria will be emphasized towards the end of their prevention and treatments.

Attainment target

Understanding various clinical characteristics of oral and maxillofacial diseases Distinguishing clinicopathological features for oral and maxillofacial diseases Understanding possible pathogenetic processes of oral and maxillofacial diseases Understanding clinical and pathological diagnostic issues on of oral and maxillofacial diseases

Understanding possible prevention strategies against of oral and maxillofacial diseases

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Study method attention

Nothing particular

Plan

No. Date Contents Instructor

1 04/17 1 Guidance Diseases of tooth and periodontal tissue 1 Takashi Saku, Jun Cheng

2 04/24 2 Diseases of tooth and periodontal tissue 2 Takashi Saku, Jun Cheng

3 05/01 1 Diseases of oral mucosa 1 Takashi Saku, Jun Cheng



6 05/22 1 Diseases of salivary gland 1 Takashi Saku, Jun Cheng



9 06/12 1 Diseases of odontogenic tissue 1 Takashi Saku, Jun Cheng



12 07/03 1 Diseases of jaw and temporomandibular joint 1 Takashi Saku, Jun Cheng

13 07/10 2 Diseases of jaw and temporomandibular joint 2 Takashi Saku, Jun Cheng

14 07/17 1 Diseases of mesenchymal soft tissue 1 Takashi Saku, Jun Cheng

15 07/24 2 Diseases of mesenchymal soft tissue 2 Takashi Saku, Jun Cheng

Evaluation

Handing in papers or oral or written examinations

Media

Related research papers

Reference book


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Designated Subjects Elective Subjects

Course works for clinical dentistry


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I II

Conference Room in Div. Reconstructive Surgery for Oral and Maxillofacial Region, Clinic of Oral and Maxillofacial Surgery

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Guidance

Kobayashi

Clinical examination for diagnosis

Kobayashi

Diagnostic imaging

Shingaki

Inflammation

Kobayashi

Trauma

Shingaki

Mucosal disease / disease of the salivary gland

Shingaki

Temporomandibular joint disease

Kobayashi

Developmental anomalies

Kobayashi

Benign tumor /

Shingaki

Malignant tumor

Shingaki

Surgical treatment techniques

Kobayashi

Reconstruction of the tissue defect

Shingaki

Dental implant therapy for the bone defect

Kobayashi

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Transplantation of teeth Kobayashi

Morphological and functional assessments

Kobayashi

Oral test and clinical presentation

3

1-3

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Elective Subjects in a Related Discipline Elective Subjects

Integrated Lectures on Basic and Clinical Dentistry

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102

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Department of Oral Health Science

A 111

A 111

B 111

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A 118,121

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A 128,131

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Guidance Takashi Okiji

Pathogenesis of pulpal diseases Takashi Okiji

Vital pulp therapy Takashi Okiji

Pathogenesis of apical periodontal diseases Takashi Okiji

Root canal instrumentation Takashi Okiji

Root canal irrigation/medication Takashi Okiji

Root canal filling Takashi Okiji

Prognosis of endodontic treatment Takashi Okiji

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In this course, we will discuss the clinical tests, diagnosis and treatment of pulpal and periapical diseases, and train current endodontic treatments using newly-developed materials and instruments.

To understand the clinical tests and diagnosis methods and treatments of pulpal and periapical diseases.

After completing this course, the student should be able to: 1. Describe the clinical tests and diagnosis methods of pulpal and periapical diseases. 2. Describe the vital pulp therapy.

Describe the properties and usage of pulp capping materials.

Nothing particular

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Guidance Kunihiko Yoshiba

Clinical tests and diagnosis methods of pulpal and periapical diseases

Kunihiko Yoshiba

Vital pulp therapy

Kunihiko Yoshiba

Properties and usage of pulp capping materials

Kunihiko Yoshiba

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Seminar on Endodontics IB IIB

Associate Prof. Kunihiko Yoshiba (Div. Cariology, Operative Dentistry & Endodontics) Ext. 2864 e-mail: [email protected]

Laboratory in Div. Cariology, Operative Dentistry & Endodontics

In this course, we will discuss the clinical tests, diagnosis and treatment of pulpal and periapical diseases, and train current endodontic treatments using newly-developed materials and instruments.

To understand the clinical tests and diagnosis methods and treatments of pulpal and periapical diseases.

After completing this course, the student should be able to: 1. Use a microscopy in endodontic treatment. 2. Prepare root canals with NiTi rotary instruments. 3. Obturate root canals with current techniques.

Nothing particular

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Guidance Kunihiko Yoshiba

Microscopy in endodontic treatment

Kunihiko Yoshiba

Root canal preparation with NiTi rotary instruments

Kunihiko Yoshiba

Root canal filling

Kunihiko Yoshiba

Reports (50%) and oral examination (50%)

Original prints and related papers

Textbook of Endodontology 2nd ed. (Bergenholtz G et al., Wiley-Blackwell, 2010)

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Clinic of Cariology, Operative Dentistry & Endodontics

Nothing particular

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Guidance

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Clinic of Cariology, Operative Dentistry & Endodontics

Nothing particular

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Laboratory in Div. Preventive Dentistry

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(Course No.) (Semester) (Date) (Credit)

Course

Instructor

Place

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IA IIA Plan

No. Date

Contents Instructor

IB IIB Plan

No. Date

Contents Instructor

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1 2

Course

IA IIA 9114

Instructor

Place

Course outline

. Although, dental implant is one of the very effective treatment option of prosthetic dentistry, it is at higher risk

of serious accident in compared with conventional prosthetic treatment. For leading dental implant treatment to a success, it is necessary to perform appropriately diagnosis and treatment planning. Among the necessary knowledge and technique regarding the dental implant treatment, this course focusing on the acquirement of treatment planning and computer aided simulation.

Course aim

The aim of this course is to acquire the rudimentary knowledge and treatment planning of dental implant.

Attainment target

1. (To explain the pros and cons of dental implants)

2. (To explain the dangers of dental implants)

3. (To explain the clinical procedures of dental implant)

4. (To explain the computer aided simulation system of dental implant)


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Clinical skill will be acquired according to the recognition system of Oral Implant Clinic in Niigata University Medical and Dental Hospital.

10

11

12

13

14

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15

Evaluation (Attendance)(20 )

(Reports imposed during the course)(20 ) (Written examination)(60 )

Media

The handout will be provided in each lecture.

Reference book

J Lindhe, T Karring, NP Lang, Clinical periodontology and implant dentistry, John Wiley & Sons, Apr 15, 2009

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2 2

Course

IB IIB 9115

Instructor

Place

Course outline

. Although, dental implant is one of the very effective treatment option of prosthetic dentistry, it is at higher risk

of serious accident in compared with conventional prosthetic treatment. Furthermore, usage of dental implant make the treatment planning more complicated. For leading dental implant treatment to a success, it is necessary no only to perform appropriately diagnosis and treatment planning, but also selection of superstructure and occlusal adjustment are important. Among the necessary knowledge and technique regarding the dental implant treatment, this course focusing on the treatment planning from the prosthodontics point of view.

Course aim

Attainment target

1. (To explain the pros and cons of dental implants)

2. (To explain the dangers of dental implants)

3. (To explain the clinical procedures of dental implant)

4. (To explain the superstructure of dental implant)

5. (To explain the occlusion of dental implant)

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6. (To explain the factors affecting the prognosis of dental implant)


Clinical skill will be acquired according to the recognition system of Oral Implant Clinic in Niigata University

Medical and Dental Hospital.

10/7

10/14

10/21

10/28

11/4

11/11

11/18

11/25

12/2

10 12/9

11 12/16

12 1/13

13 1/20

14 1/27

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15 2/3

Evaluation (Attendance)(20 )

(Reports imposed during the course)(20 ) (Written examination)(60 )

Media

The handout will be provided in each lecture.

Reference book

J Lindhe, T Karring, NP Lang, Clinical periodontology and implant dentistry, John Wiley & Sons, Apr 15, 2009

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The procedure and the attention of the dental implant installation

The prosthodontical method for the dental implant

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The cource is designed to learn functional reconstructive procedure using implant-supported prosthesis after surgery of oral tumor through lecture, trial practical training and model practice.

To explain the diagnosis and treatment for oral benign tumor.

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To explain the diagnosis and treatment for oral malignant tumor. To explain the surgical approach for oral malignant tumor. To explain the multidisciplinary therapy for oral cancer. To explain the reconstructive surgery after resection for oral tumor. To explain the complication with surgery for oral tumor. To explain the oral function of reconstruction by implant-supported prosthesis. To explain the bone augmentation for oral implant. To explain the clinical procedure of oral implant. To explain the superstructure of oral implant. To explain the evaluation of functional reconstruction by implant-supported prosthesis. To explain the longterm prognosis of reconstruction by implant-supported prosthesis.

Lecture The guidance or this course using slide and DVD. Simulation: To master the basic technique of oral surgery using trial practical training and model practice. Presentation and discussion of some cases

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Minimal Intervention Dentistry

1) 2) 3) 4) 5) I comment on the main points of basic and clinical cariology to understand five following principles based on

Minimal Intervention Dentistry.

1) remineralization of early lesions 2) reduction in cariogenic bacteria, in order to eliminate the risk of further demineralization and cavitation 3) minimum surgical intervention of cavitated lesions 4) repair rather than replacement of defective restorations 5) disease control

This course is mainly focusing on the clinical epidemiology, biological aspects of dental caries, non-operative therapy, operative intervention and caries control in order to understand the concept of MID.

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After completion of this course, the students will be able to; 1) explain an etiology and pathology of the caries. 2) explain the detection of dental caries, a diagnosis and an assessment. 3) explain a classification of the dental caries and epidemiology in Japan. 4) explain a role of the saliva. 5) explain a non-operative treatment of the dental caries 6) explain the decision making of operative intervention of the dental caries. 7) explain the caries control of the patient

Study methods are the lecture and reading of the textbook of cariology.

Introduction M. Fukushima

Etiology of dental caries M. Fukushima

Clinical pathology of dentin caries M. Fukushima

5/12 16 Detection of dental caries (5/12 16; participation in oral health examination for freshman students in Niigata University)

M. Fukushima

Diagnosis and assessment of caries risk M. Fukushima

Classifications of dental caries M. Fukushima

Epidemiology of dental caries M. Fukushima

Role of saliva M. Fukushima

Non-operative treatments of dental caries, Remineralization of early caries

M. Fukushima

Decision making of surgical intervention M. Fukushima

Management of root surface caries in elderly people

M. Fukushima

Caries control and monitoring M. Fukushima

Self search of updated caries research and systematic review (1)

M. Fukushima


M. Fukushima

Summery M. Fukushima

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Introduction M. Fukushima

Etiology of dental caries M. Fukushima

Clinical pathology of dentin caries M. Fukushima

5/12 16 Detection of dental caries (5/12 16; participation in oral health examination for freshman students in Niigata University)

M. Fukushima

Diagnosis and assessment of caries risk M. Fukushima

Classifications of dental caries M. Fukushima

Epidemiology of dental caries M. Fukushima

Role of saliva M. Fukushima

Non-operative treatments of dental caries, Remineralization of early caries

M. Fukushima

Decision making of surgical intervention M. Fukushima

Management of root surface caries in elderly people

M. Fukushima

Caries control and monitoring M. Fukushima


M. Fukushima


M. Fukushima

Summery M. Fukushima

Reports (100%)

Fejerskov O, Kidd EAM ; Dental Caries –The disease and its clinical management- Second edition, 2008, Blackwell-Munksgaard 13,528

Pitts N.: Detection, Assessment, Diagnosis and Monitoring of Caries, 2009, Karger Kidd EAM: Essentials of Dental Caries 3rd edition, 2005,Oxford

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2000 FDI Minimal intervention dentistry MIMI

MI

The importance of conservation of tooth substances is recognized since minimal intervention dentistry (MI) was proposed by FDI in 2000. The concept of MI on caries treatment was derived from the development of adhesive dentistry and clinical cariology. And recently, social demands for esthetic dentistry are increasing, and tooth colored restoration are getting more significant. However, the success of adhesive treatment depends on the clinical technique. In this seminar, tooth colored restoration applying the adhesive technology will be lectured and practiced on the manikin models to achieve a clinical success of MI.

The aim of this seminar is to understand the adhesive dentistry based on MI and clinical practices.

The students will be able to; 1. explain MI concepts 2. explain the importance of conservation of tooth substances in the restorative treatments

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3. explain the bonding mechanism to tooth and restorative materials. 4. remove the caries lesion by MI concept. 5. place a matrix for class and adhesive resin restoration and avoid the contamination of preparations during a

bonding procedure. 6. understand the chair-side CAD/CAM fabrication process.

1. Study methods are lecture and preclinical practice. 2. Study materials for which students provide themselves will be announced in advance. (Ex. extracted human teeth, jaw model etc.)

Caries detection and removal of carious lesion (lecture)

Caries detection and removal of carious lesion (Preclinical practice )


Direct bonded restoration lecture

Direct bonded restoration- management of polymerization shrinkage (lecture)

Direct bonded class restoration Preclinical practice



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CAD/CAM CAD/CAM restoration lecture

CAD/CAM Tooth preparation for CAD/CAM all ceramic crown (Preclinical practice)

CAD/CAM Demonstration of CAD/CAM restoration fabrication (Preclinical practice)

Clinical case presentations by students

Caries detection and removal of carious lesion (lecture)



Direct bonded restoration lecture

Direct bonded restoration- management of polymerization shrinkage (lecture)




CAD/CAM CAD/CAM restoration lecture

CAD/CAM Tooth preparation for CAD/CAM all ceramic crown (Preclinical practice)

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CAD/CAM Demonstration of CAD/CAM restoration fabrication (Preclinical practice)

Clinical case presentations by students

40 20 20 Attendance (40%) , practice products (20%) and oral examination (20%)

No particular textbook

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Course No. Semester Data Credit

1 A Mon 5 2

A Mon 6 2

Course Seminar on Social work practice A A

9214

Instructor

Prof. Hideki Takahashi

Department of Oral Health and Welfare, Division of Welfare

Ext. 0550 E-mil:[email protected]

Place

Course outline

The subject of this seminar is mainly social work practice for senior citizens and persons with

disabilities fields. The study of social work will be performed through the following steps: examination

and analysis of the main practice models that are presently in use, deduction of the implications from

these models and practical feedback.

Course aim

Students shall understand availability of social work in public health and welfare.

Attainment target

Based on the practice model of social work, students can explain a case in exemplification.


Lecture and discussion. To prepare for seminar, students need to read reference books.

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Plan


1 4/14

Guidance Takahashi. H

2-7 4/21-6/2 Psycho-social approach. Person in his situation. Takahashi. H

8-13 6/9-7/14 Generalist approach. Holistic viewpoint. Takahashi. H

14-15 7/23-7/28

Feedback Takahashi. H

Evaluation

Reports as formative estimation (50%) and Oral examination (50%).

Media

We indicate Research paper if required.

Reference book


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Course No. Semester Data Credit

2 B Mon 5 2

B Mon 6 2

Course Seminar on Social work practice B B

9215

Instructor

Prof. Hideki Takahashi

Department of Oral Health and Welfare, Division of Welfare

Ext. 0550 E-mil:[email protected]

Place Laboratory in the Department of Health and Welfare

Course outline

The subject of this seminar is mainly social work practice for senior citizens and persons with

disabilities fields. The study of social work will be performed through the following steps: examination

and analysis of the main practice models that are presently in use, deduction of the implications from

these models and practical feedback.

Course aim

Students shall understand availability of social work in public health and welfare.

Attainment target

Based on the practice model of social work, students can explain a case in exemplification.


Lecture and discussion. To prepare for seminar, students need to read reference books.

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Plan


1 10/6

Guidance Takahashi. H

2-7 10/20-12/8 Empowerment approach. Liberation from oppression. Takahashi. H

8-13 12/-2/2 Narrative approach. Social constructionism. Takahashi. H

14-15 2/9-2/16

Feedback Takahashi. H

Evaluation

Reports as formative estimation (50%) and Oral examination (50%).

Media


Reference book


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( )

1 1 Thu 1 IA 2

Thu 5 IIA 2

2 1 Thu 1 IB 2

Thu 5 IIB 2

IA IIA 9214 IB IIB 9215

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( )

/ Fri/5 A

/ Fri/6 A

Examination social health and welfare planning of local government

A A

9214

Ext. 2021 Email:[email protected]

This course deals practice social health and welfare planning of local government.

This course aim is to understand the role of the local government in health and welfare.

To understand the planning what is devised to develop the legal plan according to the field of

health and welfare service user.

To explain a local government and administration.

To explain social health and welfare planning of local government.

Participants read contents-relevant papers before attending.

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Guidance

Local autonomy and welfare

Social health and welfare planning of local

government

background, significance, summary)

Public and private collaboration and welfare pluralism

(social-welfare-council,social-welfare-corporation,

Citizen-participation)

planning

process relation between other plans )

70% 30%

Report(70%) and oral examination(50%)

2005

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( )

/ Fri/5 B

/ Fri/6 B

Examination social health and welfare planning of local government

B B

9215

Ext. 2021 Email:[email protected]

This course deals social health and welfare planning of local government.

This course aim is to learn how legal plans according to the field of health welfare service user

attribute are unified in health and welfare planning of local government.

To explain the association between planning of local government and legal plans.

Read contents-relevant papers before attending.

Search a homepage of Ministry of health-labour and welfare,prefectures and city towns

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Guidance

Guidance of central government for province

Plan (elderly disability next generation support)

Prefectural Plan

(elderly disability next generation support)

Municipal Plan

(elderly disability next generation support)

70%, 30%

Report(70%) and oral examination(50%)

Show at all times.

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( )

2

2

Seminar on Regulatory Sciences

Seminar on Regulatory Sciences 9214 9215

Associate Prof. Kouichi Kurokawa (Dept. of Oral Health and Welfare, Div. of Welfare) Ext. 0549 E-mail: [email protected]

Laboratory in the Dept. of Oral Health and Welfare

Advanced Seminar of Oral Biological Science

Regulatory science seminar is academic discipline to adjust the relationship between regulatory and science evaluation, and learn drug and medical devices development This seminar deals with the drug legislation and related rules, which are necessary for the development and application of biomaterials, and the design of clinical protocols for biomaterial evaluations based on evaluation guidelines.

Student will gain understanding of important drug legislation and legal guidelines for biomaterial development and application. They will also get basic knowledge needed for safe and effective research and development of biomaterials and devices.

Students will understand the outlines of specific guidelines under the drug legislation. Though the study of these guidelines, they will also acquire knowledge needed to design clinical protocols.

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Basic knowledge on drug legislation will be delivered by lectures. Specific guidelines will be used to practice the preparation of application documents in hypothetical clinical development research.


Guidance

1-3 Drug legislation and related rules 1-3

1-3 Various guidelines in biomaterial development 1

1-3 Biological safety guideline 1-3

1-4 Clinical evaluation guideline 1-4

Summary and conclusions


Guidance

Drug legislation and related rules

Various guidelines in biomaterial development

1-2 Clinical evaluation guideline 1-2

1-8 Exercise on clinical protocol design 1

1-2 Discussion on clinical protocol design 1-2

Summary and conclusions

Oral test or written examination.

PMDA web site http://www.pmda.go.jp/operations/shonin/info/iryokiki.html http://www.pmda.go.jp/english/service/regulation.html

10 Guideline on application for medical devices (10th edition) ISBN978-4-8408-1118-7

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‘ ’

‘ ’

‘ ’

‘’

At the end of the course, the students will be able to:

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( )

2

2

Seminar on Biomechanics Applied to Prosthodontics A A

9114

Associate Prof. Roxana Stegaroiu (Dept. of Oral Health and Welfare, Div. of Oral Science for Health Promotion

Ext. 0547 E-mail: [email protected]

Seminar room in the Dept. of Oral Health and Welfare

This seminar will be focused on the basic biomechanical principals and research methods

with applications in prosthodontics and implant dentistry. Also, we will discuss the various

post and core systems from the point of view of retention and tooth fracture prevention.

This seminar aims to provide basic knowledge on biomechanical principals and research

methods with applications in prosthodontics and implant dentistry. Also, through case studies

of fixed prosthesis using posts and cores, students will learn how to apply those principles in

basic case studies.


- explain the basic principals of biomechanics with applicability to prosthodontics;

- explain the usability of finite element analysis, strain gauge measurements and fatigue testing in

prosthodontic research;

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- explain how to select post and core types from a biomechanical viewpoint.

After a concise lecture on each class topic, related articles will be discussed in seminar style.

Guidance Roxana Stegaroiu

Biomechanical principles with relevance for

prosthodontics

Roxana Stegaroiu

Research methods in biomechanics 1: Fatigue

testing

Roxana Stegaroiu

Research methods in biomechanics 2: Strain

gauge measurements

Roxana Stegaroiu

Research methods in biomechanics 3: 3D finite

element method (3D FEM)

Roxana Stegaroiu

Case study 1:Post and core types and their

retention

Roxana Stegaroiu

Case study 2: Post and core types and tooth

fracture

Roxana Stegaroiu

ConclusionsRoxana Stegaroiu

Oral test or report.

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Related papers and reprints will be provided.

1) “Fundamentals of Fixed Prosthodontics” 3rd Edition (Herbert T. Shillingburg, Jr. et al,

Quintessence books, 1997) and related articles from prosthodontic journals.

2) “Osseointegration: on continuing synergies in surgery, prosthodontics, and biomaterials”

(George A. Zarb et al, Quintessence, 2008) and related articles from implant journals

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( )

2 2

2

Seminar on Biomechanics Applied to Prosthodontics B B

9115

Associate Prof. Roxana Stegaroiu (Dept. of Oral Health and Welfare, Div. of Oral Science for Health Promotion

Ext. 0547 E-mail: [email protected]

Seminar room in the Dept. of Oral Health and Welfare

Based on biomechanical principles, the graduate students will review the types, designs,

materials and dimensions of different prosthetic restorations, including implant

superstructures, and they will debate about their appropriate selection for typical clinical

cases.

Through various case studies, students will learn about basic applications of biomechanical

principles in prosthodontics and implant dentistry.


- explain how the type and dimensions of the dental arch restoration will influence mechanical stresses

and strains in the abutment teeth;

- explain how dental implant and superstructure types, dimensions, and materials will influence

mechanical stresses and strains in the bone around implants;

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After a concise lecture on each class topic, related articles will be discussed in seminar style.

Case study 3: Biomechanical principles and

dental arch reconstruction

Roxana Stegaroiu

Case study 4: Bone adaptation to mechanical

stress/strain

Roxana Stegaroiu

Case study 5: Superstructure type and stress

in/around implants

Roxana Stegaroiu

Case study 6: Superstructure material and

stress/strain in/around implants

Roxana Stegaroiu

Case study 7: Implant type and dimensions and

stress in/around implants

Roxana Stegaroiu

Case study 8: 3D finite element analysis of

precisely simulated trabecular bone

Roxana Stegaroiu

Case study 9: Conventional prostheses vs.

implants (selection of the appropriate treatment

option)

Roxana Stegaroiu

ConclusionsRoxana Stegaroiu

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Oral test or report.

Related papers and reprints will be provided.

1) “Fundamentals of Fixed Prosthodontics” 3rd Edition (Herbert T. Shillingburg, Jr. et al,

Quintessence books, 1997) and related articles from prosthodontic journals.

2) “Osseointegration: on continuing synergies in surgery, prosthodontics, and biomaterials”

(George A. Zarb et al, Quintessence, 2008) and related articles from implant journals

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Department of Oral Biological Science

IA 247

A 247

IB 247

B 247

A 250

A 250

B 250

B 250

A

A

B

B

A 253

A 253

B 256

B 256

A 259

A 259

B 262

B 262

A 265

A 265

B 265

B 265

A 267

A 267

B 267

B 267

A 271

A 271

B 271

B 271

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A 273

A 273

B 273

B 273

A 276

A 276

B 276

B 276

A 279

A 279

B 279

B 279

A 282

A 282

B 285

B 285

A 288

A 288

B 290

B 290

A 293

A 293

B 296

B 296

A 299

A 299

B 302

B 302

A 305

A 305

B 305

B 305

A 309

A 309

B 309

B 309

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’

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― ―249

― ―250

― ―251

― ―252

“ ”“ ” “ ”

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“ ”“ ” “ ”

“ ” “”

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(Fri/6) I A

(Fri/7) II A

(Fri/6) I B

(Fri/7) II B

IA IIA IB IIB Dentofacial Orthodontics IA IIA, IB IIB


Prof. Isao Saito (Div. Orthodontics) Ext. 2902 EE-mail: [email protected]

This course will provide information on normal occlusion, etiology of dental/skeletal malocclusion and changes in dentofacial complex and occlusion with orthodontic treatment. The differences in orthodontic treatment effects between individual cases will be also discussed.

Basic knowledge of orthodontics will be provided to participants for orthodontic analysis and diagnosis.

Participants can: Explain definition of normal occlusion Explain methods for cephalometric analysis Describe various types of malocclusion and their characteristics Diagnose various types of malocclusion and show adequate treatment plan in respective case Explain treatment methods for various types of malocclusion

Participants will be required to read the textbook and/or references designated before attending.

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Orientation

Saito

Normal occlusion

Saito

Etiology of malocclusion

Saito

Diagnosis of malocclusion

Saito

Changes in dentofacial complex and occlusion with treatment

Saito

Methods for orthodontic correction

Saito

Presentation of various cases treated by orthodontic treatment alone or with orthognathic surgery

Saito

Overall discussion Saito

100 The students will be evaluated by interviews (100%) for contents of the lecture provided or case analysis.

The textbook of CONTEMPORARY ORTHODONTICS (5th edition; W. Proffit, ed., Mosby Year Book, Inc.) 15,108 and relevant papers in each content.Edgewise system 1 42,000

27,000 13,000 30,000

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IA IIA, IB IIBIA IIA, IB IIB

Seminar room for practice or cephalometric analysis, or orthodontic clinic

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Department of Tissue Regeneration and Reconstruction

A 317

A 317

317

317

A 322

A 322

B 322

B 322

A 326

A 326

B 326

B 326

A 330

A 330

B 330

B 330

A 334

A 334

B 334

B 334

A 337

A 337

B 337

B 337

A 340

A 340

B 340

B 340

A 343

A 343

B 343

B 343

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A

A

B

B

A 346

A 346

B 346

B 346

A

A

B

B

A 350

A 350

B 353

B 353

A 355

A 355

B 355

B 355

A 358

A 358

358

358

A 361

A 361

B 361

B 361

A 365

A 365

B 365

B 365

A 369

A 369

B 369

B 369

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A 373

A 373

B 373

B 373

A 376

A 376

B 376

B 376

A 382

A 382

B 382

B 382

A 388

A 388

B 388

B 388

A 393

A 393

395

395

A 397

A 397

B 397

B 397

A 401

A 401

B 401

B 401

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Seminar on morphology of hard tissues IA, IIA

Seminar on morphology of hard tissues IB, IIB

Associate. Prof. Hiroko Ida (Div. Anatomy and Cell Biology of the Hard Tissue) ext. 2813 e-mail: [email protected]

Laboratories in Div. Anatomy and Cell Biology of the Hard Tissue

This course will offer a practical training to observe hard tissues morphologically. The students shall practice a series of experimental techniques of tooth germ research from histological analysis and organ culture system to gene analysis.

The students shall learn a series of experimental techniques of hard tissue research from preparation of the samples to soft X ray, µCT and microscopic analysis. The students are required to understand the histological features of tooth germs, and shall learn in vivo and in vitro experimental techniques to analyze murine tooth germs.

The students can

perform different types of analysis to observe hard tissues depending on the purpose. perform some histological and immunohistochemical stainings and understand the findings. explain the development and histology of tooth germs. prepare paraffin sections to observe tooth germs. perform the organ culture of tooth germs.

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Lecture and practice. The students have to study the printed synopses beforehand.

Guidance Hiroko Ida

Methods for analysis of hard tissue

Hiroko Ida

Methods for sample preparation 1 (Fixation)

Hiroko Ida

Soft X ray analysis

Hiroko Ida

Micro CT analysis

Hiroko Ida

Methods for sample preparation 2 (Decalcification)

Hiroko Ida

Methods for sample preparation 3 (dehydration, Embedding)

Hiroko Ida

Methods for sample preparation 4 (paraffin section)

Hiroko Ida

Methods for sample preparation 5 (frozen section)

Hiroko Ida

Methods for histological stainings-1

Hiroko Ida

Methods for histological stainings-2

Hiroko Ida

Methods for immunohistochemical stainings-1

Hiroko Ida


Hiroko Ida


Hiroko Ida

Summary of hard tissue research

Hiroko Ida

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Guidance, summary of tooth germ research

Histological features of the tooth germ

The molecular mechanisms during tooth morphogenesis

Preparation of paraffin sections for tooth germ research

Staining of paraffin sections for tooth germ research (embryonic tooth germ)

Staining of paraffin sections for tooth germ research (postnatal tooth germ)

Staining of paraffin sections for tooth germ research

Organ culture of the tooth germ Lecture

Organ culture of the tooth germ Practice

Organ culture of the tooth germ Practice

Gene analysis of the tooth germ I (RT-PCR method)

Gene analysis of the tooth germ II (RT-PCR method)

Gene analysis of the tooth germ III (The methods of regulating gene expression)

The topics of tooth regeneration research

Summary of tooth germ research

Attendance, Oral examination

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Printed synopses will be distributed beforehand.

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In 1st semester, you will learn about structure and function of protein that are responsible for expression of biological function of various cells by lectures and seminars, and acquire knowledge necessary for understanding of academic research papers. In 2nd semester, you will learn about molecular mechanisms and disorders related to the life of protein, from translation to degradation.

1st semester

Knowledge about protein is essential not only for research on basic cell biology but also for understanding

mechanisms of diseases and action of the drugs at the molecular level. In order to understand academic research papers

on molecular cell biology, you will learn about structure and function of protein, mechanism of its functional regulation,

and research methods.

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2nd semester

Proper post-translational translocation, folding, modification and assembly are required for the expression of

biological functions of proteins. Mutations, incorrect protein modification or inappropriate aqueous environment (pH,

temperature, ionic strength, presence of chaotropic agents) may lead to misfolding which precludes the expression of

protein function. This misfolding has the potential to be rescued by "quality control mechanism". If this mechanism

cannot diminish the pool of misfolded protein, a part of the misfolded protein would be harmful to the cell. Diverse

diseases such as Alzheimer’s disease, prion disease and Parkinson’s disease have been shown to arise from protein

misfolding and aggregation. We will study the molecular mechanisms and disorders related to “the life of protein”

from translation to degradation.

Upon successful completion of 1st semester, you will understand

hierarchy to build the structure of the protein.

physicochemical interactions involved in the formation of higher order structure of a protein and specific

molecular recognition.

qualitative regulation of protein function.

quantitative regulation of protein function.

methods for protein purification.

methods for analyzing specific interaction and function of protein.

methods for analyzing the structure and function of proteins by molecular biological techniques.

Upon successful completion of 2nd semester, you will understand

molecular mechanisms related to the life of protein, from translation to degradation.

diseases arising from protein misfolding and aggregation.

In the seminar, you should prepare a presentation, and explain papers for the problem.

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Lecture: introduction to protein

Amaya

Lecture: structure and function of enzyme

Amaya

Lecture: qualitative regulation of protein function

Amaya

Lecture: quantitative regulation of protein function

Amaya

Lecture: protein explorer

Amaya

Lecture: analysis of the structure and function of proteins by molecularbiological methods

Amaya

Lecture: proteins involved in intracellular signal transduction

Amaya

Lecture: proteins involved in the regulation of gene expression

Amaya

Lecture: proteins involved in the regulation of cell cycle

Amaya

Seminar: intracellular signal transduction

Amaya

Seminar: regulation of gene expression

Amaya

Seminar: regulation of cell cycle

Amaya

Lecture: birth of protein (translation) Amaya

Lecture: molecular mechanism of protein localization

Amaya

Lecture: folding and quality control of protein

Amaya

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Lecture: protein folding disease

Amaya

Seminar: current topics of structure and function of ribosome

Amaya

Seminar: current topics of protein translocation across the endoplasmic reticulum membrane

Amaya

Seminar: current topics of molecular chaperones and protein quality control mechanism

Amaya

Seminar: current topics of prion disease

Amaya

Presentation and discussion 70%, Report 30%

Alberts, B., Johonson, A., Lewis, J., Raff, M., Roberts, K. and Walter, P.

Molecular Biology of the Cell 5th ed. Garland Science

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1 (Wednesday/5) IA

2 (Wednesday/5) IIA

2 (Wednesday/6) IB

2 (Wednesday/6) IIB

Course Oral pathology diagnostics


Instructor Prof. Takashi Saku (Division of Oral Pathology) Ext. 2832 e-mail: [email protected]

Place


Course outline

This course deals with the pathological concept of oral and maxillofacial tumors from their pathogenesis based on the modern pathological methodology to their diagnostic issues based on the correlation between pathological and clinical findings.

Course aim

In this course, students will understand the pathogenesis of oral and maxillofacial tumors from their causative factors, molecular mechanism, clinical processes, to prognoses. Clinic-pathological aspects of their diagnostic criteria will be emphasized towards the end of their prevention and treatments.

Attainment target

Understanding various clinical characteristics of oral and maxillofacial tumors Distinguishing clinicopathological features between benign and malignant oral and maxillofacial

tumors Understanding possible pathogenetic processes of oral and maxillofacial tumors Understanding clinical and pathological diagnostic issues on oral and maxillofacial tumors Understanding possible prevention strategies against oral and maxillofacial tumors


Nothing particular

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IA IIA Plan

No.

Date Contents Instructor

1 04/11 Guidance

Takashi Saku

2 04/18 Varieties of precancerous lesions of oral mucosa

Takashi Saku

3 04/25 Clinical features of precancerous lesions of oral mucosa

Takashi Saku

4 05/09 Histopathological features of precancerous lesions of oral mucosa

Takashi Saku

5 05/16

Corresponds to the clinical diagnosis of pathology of precancerous lesions of oral mucosa

Takashi Saku

6 05/23 Varieties of oral mucosal carcinomas

Takashi Saku

7 05/30 Clinical features of oral mucosal carcinomas

Takashi Saku

8 06/06 Histopathological features of oral mucosal carcinomas

Takashi Saku

9 06/13

Corresponds to the clinical diagnosis of pathology of oral mucosal carcinomas

Takashi Saku

10 06/20

Screening and prevention of precancerous lesions of oral mucosa and oral mucosal carcinomas

Takashi Saku

11 06/27 Varieties of salivary gland tumors

Takashi Saku

12 07/04 Clinical features of salivary gland tumors

Takashi Saku

13 07/11 Histopathological features of salivary gland tumors

Takashi Saku

14 07/18

Corresponds to the clinical diagnosis of pathology of salivary gland tumors

Takashi Saku

15 07/25

Screening and prevention of precancerous lesions of salivary gland tumors

Takashi Saku

IB IIB Plan

No.


1 10/03 Varieties of odontogenic tumors

Takashi Saku

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2 10/10 Clinical features of odontogenic tumors

Takashi Saku

3 10/17 Histopathological features of odontogenic tumors

Takashi Saku

4 10/24

Corresponds to the clinical diagnosis of pathology of odontogenic tumors

Takashi Saku

5 10/31 Screening and prevention of precancerous lesions of odontogenic tumors

Takashi Saku

6 11/07 Varieties of jaw and temporomandibular joint tumors

Takashi Saku

7 11/14 Clinical features of jaw and temporomandibular joint tumors

Takashi Saku

8 11/28 Histopathological features of jaw and temporomandibular joint tumors

Takashi Saku

9 12/05

Corresponds to the clinical diagnosis of pathology of jaw and temporomandibular joint tumors

Takashi Saku

10 12/12

Screening and prevention of precancerous lesions of jaw and temporomandibular joint tumors

Takashi Saku

11 12/19 Varieties of soft tissue tumors

Takashi Saku

12 01/09 Clinical features of soft tissue tumors

Takashi Saku

13 01/23 Histopathological features of soft tissue tumors

Takashi Saku

14 01/30 Corresponds to the clinical diagnosis of pathology of soft tissue tumors

Takashi Saku

15 02/06 Screening and prevention of precancerous lesions of soft tissue tumors

Takashi Saku

Evaluation


Media


Reference book


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1 (Friday/6) A

2 (Friday/6) A

2 (Friday/6) B

2 (Friday/6) B

Course

The molecular biological experimental methods for oral pathological research AA B B


Instructor Assoc. Prof. Jun Cheng Division of Oral Pathology Ext. 2835 e-mail: [email protected]

Place


Course outline

This course deals with the essential knowledge and research technique on molecular pathology for elucidating the mechanism of the pathogenesis, progresses and outcomes of various diseases in oral and maxillofacial region by lectures and practices.

Course aim

(PCR) (RT-PCR) DNA in situin situ (FISH)

In this course, students will acquire the fundamental methodology of molecular pathology research. Furthermore, they will learn additional techniques of collection and preservation of the cell and fresh tissue samples, the nucleic acid extraction and purification, laser-capture microdissection, polymerase chain reaction (PCR) and reversed transcriptase-PCR (RT-PCR), DNA sequencing, in situ hybridization, fluorescence in situ hybridization (FISH), and immunohistochemistry.

Attainment target

(PCR) (RT-PCR)DNA ( )

(FISH)

be able to collect and preserve for the cell and fresh tissue samples be able to extract and purify the nucleic acid from cell and tissue samples be able to work on laser-capture microdissection be able to do PCR and RT-PCR be able to understand DNA sequencing be able to do in situ hybridization be able to understand fluorescence in situ hybridization (FISH) be able to do immunohistochemical staining and immunofluorescence staining


Nothing particular

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IA IIA Plan

No.


1 04/11 Guidance

Jun Cheng

2 04/18 1

Collection and preservation of the cell and fresh tissue samples, and the nucleic acid extraction and purification 1

Jun Cheng

3 04/25 2


Jun Cheng

4 05/09 3


Jun Cheng

5 05/16 4


Jun Cheng

6 05/23 5


Jun Cheng

7 05/30 1 Laser-capture microdissection (LCM) 1

Jun Cheng


Jun Cheng


Jun Cheng


Jun Cheng

11 06/27 (PCR) PCR(RT-PCR) 1 Polymerase chain reaction (PCR) and reverse transcriptase-PCR 1

Jun Cheng


Jun Cheng


Jun Cheng


Jun Cheng

15 07/25 DNA ( ) 1 DNA sequencing 1

Jun Cheng

IB IIB Plan

No.



Jun Cheng

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Jun Cheng


Jun Cheng

4 10/24 1 in situ hybridization 1

Jun Cheng


Jun Cheng


Jun Cheng


Jun Cheng

8 11/28 (FISH) 1 Fluorescence in situ hybridization 1

Jun Cheng


Jun Cheng


Jun Cheng


Jun Cheng

12 01/09 1 Immunohistochemical staining and immunofluorescence staining 1

Jun Cheng


Jun Cheng


Jun Cheng


Jun Cheng

Evaluation


Media

The molecular biology served for pathological diagnosis (Y. Kaneyi, S. Ishikawa, E. Ikeda, BUNKODO) and related research papers

Reference book


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1 (Tuesday/6) A

2 (Tuesday/6) A

2 (Tuesday/6) B

2 (Tuesday/6) B

Course Clinical oral pathology diagnostics exercises A B A B


Instructor Lecture Satoshi Maruyama (Medical and dental hospital, Oral pathology section) Ext. 2834 e-mail: [email protected]

Place


Course outline

This course deals with the methodology for research on pathogenesis of oral and maxillofacial diseases from the aspect of clinical pathology diagnostics. Modern trends in molecular biology technology which should be applied in pathological research on oral and maxillofacial diseases will be lectured.

Course aim

In this course, students will understand the pathogenesis of oral and maxillofacial diseases, from their causative factors, generation mechanism, clinical processes, to prognoses. Clinic-pathological aspects of their diagnostic criteria will be emphasized towards the end of their prevention and treatments.

Attainment target

Understanding various clinical characteristics of oral and maxillofacial diseases Distinguishing clinicopathological features for oral and maxillofacial diseases Understanding possible pathogenetic processes of oral and maxillofacial diseases Understanding clinical and pathological diagnostic issues on of oral and maxillofacial diseases Understanding possible prevention strategies against of oral and maxillofacial diseases


Nothing particular

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IA IIA Plan

No.


1 04/15 Guidance

Satoshi Maruyama

2 04/22 1 Practice for tooth and periodontal tissue lesions 1

Satoshi Maruyama


Satoshi Maruyama


Satoshi Maruyama


Satoshi Maruyama

6 05/27 1 Practice for oral mucosal lesions 1

Satoshi Maruyama


Satoshi Maruyama


Satoshi Maruyama


Satoshi Maruyama


Satoshi Maruyama

11 07/01 1 Practice for salivary gland lesions 1

Satoshi Maruyama


Satoshi Maruyama


Satoshi Maruyama


Satoshi Maruyama


Satoshi Maruyama

IB IIB Plan

No.


1 10/07 1 Practice for odontogenic lesions 1

Satoshi Maruyama

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Satoshi Maruyama


Satoshi Maruyama


Satoshi Maruyama


Satoshi Maruyama

6 11/11 1 Practice for jaw and temporomandibular lesions 1

Satoshi Maruyama


Satoshi Maruyama


Satoshi Maruyama


Satoshi Maruyama


Satoshi Maruyama

11 12/16 1 Practice for mesenchymal soft tissue lesions 1

Satoshi Maruyama


Satoshi Maruyama


Satoshi Maruyama


Satoshi Maruyama


Satoshi Maruyama

Evaluation


Media


Reference book


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Prof. Makio Saito (Div.Dental Pharmacology) Ext. 2844 EE-mail: [email protected]

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This course provides basic knowledge and techniques required for tissue engineering and regenerative therapies performed in periodontology and related oral medicine.

The primary purpose is to help students understanding our periodontal regenerative therapy using autologous cultured periosteal sheets. The secondary purpose is to help students mastering how to practice this therapy. This would be basis for skeletal tissue engineering.

Students should understand the basic concept of tissue engineering and then learn how to approach. Concrete targets are to master how to: (1) maintain experimental animals and perform surgical procedure, (2) isolate cells from animals for culture, (3) distinguish cleanliness from uncleanliness, (4) analyze and evaluate data from cell cultures, (5) use and apply biomaterials to tissue engineering.

Based on our edited textbook, our lectures and practices are performed. Students should study prior to the

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lecture/practice, and thoroughly discuss the results with literature. In this course, students are required to have the habit of evaluating the individual achievements by themselves.

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Oral exam and presentation 40%, Report 20%, Attitude 20%, Technical exam 20%

“Practice in Tissue Engineering” edited by Div. of Oral Bioengineering

“Tissue Engineering 2008” edited by the Japanese Society for Tissue Engineering

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/6 (Mon/6) A

/6 (Mon/6) A

/6 (Wed/6) B

/6 (Wed/6) B

Seminar on the Reconstruction of Occlusal Functioning A IIA IB IIB

A A 9014 B B 9015

Lecturer Mikako Tanaka (Medical and Dental Hospital, Clinic / Div. of Comprehensive Prosthodontics ) Ext. 2892 E-mail:[email protected]

Morphometry Lab or Lab of Comprehensive Prosthodontics Div.

Students will learn the relationships between the aging of the jaw bones and the systemic bone

metabolism, and then master several methods to examine jaw morphology.

Students will become familiar with methods of examining jaw bone morphology, taking into

consideration the characteristics of the jaw bones and their relationship to the systemic bone metabolism.

Students will be able to explain the differences between the jaw bones and other bones.

Students will be able to explain changes in the jaw bones due to aging.

Students will be able to explain the systemic bone metabolism and its age-related changes.

CT

Students will be able to use MicroCT to observe the microstructures of jaw bones

Students will be able to measure the bone mineral density of the jaw bones.

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Students will be able to quantify the jaw bone tissues using bone histomophometry.

This course will be presented in lecture, group-seminar and workshop formats, with suitable

homework assigned as necessary.

10 6 ( ) October 6 Introduction (lecture) M.Tanaka

10 8 ( ) October 8

Characteristics of the jaw bones compared with other bones (lecture) M.Tanaka

10 15 ( ) October 15 Age-related changes in the jaw bones (lecture) M.Tanaka

10 20 ( ) October 20

Age-related changes in the jaw bones (group seminar) M.Tanaka

10 22 ( ) October 22

The systemic bone metabolism and age-related changes (lecture) M.Tanaka

10 27 ( ) October 27 The systemic bone metabolism and age-related changes (group seminar) M.Tanaka

10 29 ( ) October 29 1 6

Review of lessons 1 to 6, discussion and suggested papers (group seminar) M.Tanaka

11 4 ( ) November 4

Principles and methods of using the microCT (lecture) M.Tanaka

11 5 ( ) November 5 11 10 ( ) November 10 11 12 ( ) November 12 11 17 ( ) November 17

Bone observation with microCT (workshop) M.Tanaka

11 19 ( ) November 19

11 26 ( ) November 26

9 12

Discussion of data obtained in lessons 9 to 12 (group seminar)

M.Tanaka

12 1 ( ) December 1

Principles and methods of using the peripheral quantitative CT (pQCT) (lecture)

M.Tanaka

12 3 ( ) December 3 12 8 ( ) December 8 12 10 ( ) December 10 12 15 ( ) December 15

Measurement of bone mineral density with pQCT (workshop)

M.Tanaka

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12 17 ( ) December 17

17 19

Discussion of data obtained in lessons 17 to19 (group seminar)

M.Tanaka

12 22 ( ) December 22 8 21

Review of lessons 8 to 21, discussion and suggested papers (group seminar)

M.Tanaka

27 1 14 ( ) January 14

Principles of bone histomorphometry (lecture) M.Tanaka

1 19 ( ) January 19 1 21 ( ) January 21 1 26 ( ) January 26 1 28 ( ) January 28

Observation of bone tissues with bone histomorphometry (workshop) M.Tanaka

2 2 ( ) February 2

24 27

Discussion of data obtained in lessons 24 to 27 (group seminar)

M.Tanaka

2 4 ( ) February 4 23 28

Review of lessons 23 to 28, discussion and suggested papers (group seminar) M.Tanaka

2 9 ( ) February 9 Summary M.Tanaka

50% 50%

Oral tests (50%) and written examinations (50%).

Suitable research papers will be distributed in class as required.

Suitable reference materials will be suggested as required.

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This course deals with the care for edentulous patient by dental implant.

The student will understand the therapeutic planning for edentulous patient by dental implant.

Abele to understand the implant treatment for edentulous patient and the characteristic.

Able to diagnosis a jaw bone of edentulous patient

Able to make a therapeutic implant planning for edentulous patient.

Able to

Analysis of data and learns diagnosis and planning methods.

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Guidance

Implant treatment for edentulous patient

Implant treatment for edentulous patient 2

Implant over denture (IOD)

Characteristics of

Concept of All-on-4

structure of All-on-4

Examination of edentulous patient

Diagnosis of edentulous patient

Diagnosis of CT images for edentulous patient

Summary

Computer simulation

Computer simulation

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Computer simulation

Complications

Case Presentation 1

Case Presentation 2

Case Presentation 3

Summary

Attendance situation to a class (50%), presentation and discussion results (50%).

$155.44

$84.31

, 2011 ¥12600

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Seminar on Oral and Maxllofacial Tissue Reconstructive Surgery , IA IIA IB IIB

Lecturer Michiko Yoshizawa (Div Oral Reconstructive Surgery) Exit. 2877 E-mail: [email protected]


The course is designed to learn diagnosis, surgery of tumor in oral and maxillofacial region and reconstructive surgery for tissue defect including application of regenerative medicine.

The aim of this course is to obtain the basic knowledge and skills to surgical resection and reconstruction of tumor in oral and maxillofacial region for oral and maxillofacial surgeons.

To explain and evaluate biopsy, imaging and the laboratory data for diagnosis and planning the

treatments for tumor in oral and maxillofacial region. To explain indication and methods of tumor resection. To explain materials for reconstruction, advantages and disadvantages of reconstructive methods. To explain surgical methods and postoperative complications of reconstructive surgery To explain application of regenerative medicine to reconstructive surgery in oral and maxillofacial

region.

This course consists of lecture and setting task of report and presentation. Students have to research beforehand using textbook or any academic resources.

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Diagnosis of tumor in oral and maxillofacial region Yoshizawa

Planning the treatments for tumor in oral and maxillofacial region Yoshizawa

Surgical resection of tumor in oral and maxillofacial region Yoshizawa

Fundamental procedures and methods of tumor resection Yoshizawa

Preoperative evaluation of tissue defect and function caused by tumor resection

Yoshizawa

Methods of reconstruction in oral and maxillofacial region Yoshizawa

Selection of materials for reconstruction Yoshizawa

Materials of reconstruction Local flap Yoshizawa

Materials of reconstruction Pedicle flap Yoshizawa

Materials of reconstruction Vascularized free flap Yoshizawa

Materials of reconstruction Biomaterial Yoshizawa

Planning of reconstructive surgery Yoshizawa

Presentation (1) Yoshizawa



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Reconstructive surgery (tongue) Yoshizawa

Reconstructive surgery (oral floor) Yoshizawa

Reconstructive surgery (mandible) Yoshizawa

Reconstructive surgery (maxilla and palate) Yoshizawa

Reconstructive surgery and neck dissection Yoshizawa

Postoperative complications of reconstructive surgery Yoshizawa

Evaluation by imaging after reconstructive surgery Yoshizawa

Evaluation of function after reconstructive surgery Yoshizawa

Application of regenerative medicine to oral and maxillofacial region Yoshizawa

Application of regenerative medicine (oral mucosa) Yoshizawa

Application of regenerative medicine (bone) Yoshizawa

Application of other tissue regenerative methods (distraction osteogenesis, tooth transplantation)

Yoshizawa




50 50 Report (50%) and Presentation (50%)

An Atlas of Head and Neck Surgery, Lore JM and Medina JE, Elsevier Saunders.

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Atlas of Regional and Free Flaps for Head and Neck Reconstruction , Urken ML, Cheney ML, Blackwell KE, Harris JR, Hadlock TA, Futran N, Wolters Kluwer / Lippincott Williams&Wilkins.

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IA IIA IB IIB

IA IIA IB IIB

Prof. Susumu SHINGAKI

Out and /or In-patient floors

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Diagnosis and Treatment of Developmental Maxillofacial Anomalies, IA IIA IB IIB

IA IIA IB IIB

Tadaharu Kobayashi (Div. Reconstructive Surgery for Oral and Maxillofacial Region) Exit. 2876 E-mail: [email protected]


The course is designed to learn diagnostic methods, treatment planning, techniques of orthognathic surgeries and postoperative evaluation for developmental maxillofacial anomalies.

The aim of this course is to obtain basic knowledge and technique to diagnose and treat developmental maxillofacial anomalies as oral and maxillofacial surgeon.

To collect necessary materials and data for adequate diagnosis of developmental maxillofacial anomalies. To diagnose dentofacial morphology and malalignment of teeth from many materials and data. To make a plan of surgical orthodontic treatment. To explain techniques of orthognathic surgeries and the indications. To assist orthognathic surgeries and manage the patients. To make a postoperative assessment of surgical orthodontic treatment.

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This cause consists of lecture using some documents, slides and moving images. Students have to do research beforehand using textbooks or any source materials.

Clinical condition of developmental maxillofacial anomalies

Kobayashi

Pathogenesis of developmental maxillofacial anomalies

Kobayashi

Collection of necessary materials and data for diagnosis

Kobayashi

X 1 Cephalometric analysis 1

Kobayashi

X 2 Cephalometric analysis 2

Kobayashi

CT 1 Computed tomography imaging 1

Kobayashi

CT 2 Computed tomography imaging 2

Kobayashi

Analysis of facial photograph

Kobayashi

Analysis of dental cast

Kobayashi

1 Analysis of stomatognathic functions 1

Kobayashi

2 Analysis of stomatognathic functions 2

Kobayashi

Planning of surgical orthodontic treatment

Kobayashi

1 Simulation of orthognathic surgery 1

Kobayashi

2 Simulation of orthognathic surgery 2

Kobayashi

Presentation and conclusion

Kobayashi

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1 Le Fort I Orthognathic surgery 1 (Le Fort I osteotomy)

Kobayashi

2 Orthognathic surgery 2 (sagittal split ramous osteotomy)

Kobayashi

3 Orthognathic surgery 3 (segmental maxillary osteotomies and subapical mandibular osteotomies)

Kobayashi

4 Orthognathic surgery 4 (genioplasty)

Kobayashi

5 Orthognathic surgery 5 (distraction osteogenesis)

Kobayashi

1 Perioperative management 1 (respiratory management)

Kobayashi

2 Perioperative management 2 (intermaxillary fixation and nutritional management)

Kobayashi

3 Perioperative management 3 (paresthesia and eustachian tube function)

Kobayashi

1 Postoperative assessment 1 (postoperative maxillomandibular stability)

Kobayashi

2 Postoperative assessment 2 (temporomandibular joint function)

Kobayashi

3 Postoperative assessment 3 (masticatory function)

Kobayashi

4 Postoperative assessment 4 (respiratory function during sleep)

Kobayashi

5 Postoperative assessment 5 (psychological assessment)

Kobayashi

6 Postoperative assessment 6 (subjective evaluation)

Kobayashi

Presentation and conclusion

Kobayashi

Oral test and clinical presentation

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Modern practice in orthognathic and reconstructive surgery Edited by William H Bell W.B. Saunders Company

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Seminar on Diagnosis and Treatment of Disease of Oral Mucosa, IA IIA IB IIB

IA IIA IB IIB

Ichiro SUZUKI (Medical and Dental Hospital, Div. Community Health Promotion)

Seminar Room (Dental Hospital Div.)

The course is designed to study biological nature, diagnostic procedure and treatment of disease of oral mucosa.

The aim of I,IIA course is to learn pathogenesis of various diseases and abnormalities of oral mucosa from the point of view of anatomical specificities, mucosal immunity and dermatosis. The aim of I,IIB course is to learn recent evidence and trend of diagnosis and treatment of disease of oral mucosa, based on seminar I,IIA.

To explain anatomical characteristics and immunity of oral mucosa. To describe outline of major dermatosis. To describe biological nature of disease of oral mucosa based on recent evidence and trend of basic research. To explain diagnostic procedure of disease of oral mucosa. To describe treatment of disease of oral mucosa based on recent clinical evidence and trend.

This course consists of lecture and setting task of report and presentation. Students have to research beforehand using any academic resources.(e.g. online journals)

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Ichiro SUZUKI

Ichiro SUZUKI

Ichiro SUZUKI

Ichiro SUZUKI

Ichiro SUZUKI

Ichiro SUZUKI

Ichiro SUZUKI

Ichiro SUZUKI

Ichiro SUZUKI

Ichiro SUZUKI

Ichiro SUZUKI

Ichiro SUZUKI

Ichiro SUZUKI

Ichiro SUZUKI

Ichiro SUZUKI

Ichiro SUZUKI

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Ichiro SUZUKI

Ichiro SUZUKI

Ichiro SUZUKI

Ichiro SUZUKI

Ichiro SUZUKI

Ichiro SUZUKI

Ichiro SUZUKI

Ichiro SUZUKI

Ichiro SUZUKI

Ichiro SUZUKI

Ichiro SUZUKI

Ichiro SUZUKI

Ichiro SUZUKI

Ichiro SUZUKI

Report(50%) and Presentation(50%)

Online medical resources.(No textbook is required.)

David E. Elder “Lever's Histopathology of the Skin” Lippincott Williams & Wilkins

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SYLLABUS

NIIGATA UNIVERSITY

Graduate School of Medical and Dental Sciences

Course for Oral Life Science

2014SYLLABU

SN

IIGATA

UN

IVE

RSITY Graduate School of M

edical and Dental Sciences

Course for O

ral Life Science

NIGATA UNIVE SYLLABUS RSITY - MDS

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