Newly-formed endothelial cells regulate myeloid cell activity ...

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Accepted manuscripts are peer-reviewed but have not been through the copyediting, formatting, or proofreading process. Copyright © 2016 the authors This Accepted Manuscript has not been copyedited and formatted. The final version may differ from this version. Research Articles: Development/Plasticity/Repair Newly-formed endothelial cells regulate myeloid cell activity following spinal cord injury via expression of CD200 ligand Merav Cohen 1,§ , Hila Ben-Yehuda 1,§ , Ziv Porat 2 , Catarina Raposo 1 , Siamon Gordon 3 and Michal Schwartz 1 1 Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel. 2 Department of Biological Services, Weizmann Institute of Science, Rehovot, Israel. 3 Sir William Dunn School of Pathology, The University of Oxford, Oxford, UK. DOI: 10.1523/JNEUROSCI.2199-16.2016 Received: 11 July 2016 Revised: 18 November 2016 Accepted: 29 November 2016 Published: 19 December 2016 Author contributions: M.C., H.B.-Y., S.G., and M.S. designed research; M.C., H.B.-Y., and C.R. performed research; M.C., H.B.-Y., Z.P., and M.S. analyzed data; M.C., H.B.-Y., and M.S. wrote the paper; S.G. and M.S. contributed unpublished reagents/analytic tools. Conflict of Interest: The authors declare no competing financial interest. § These authors contributed equally to this work. We thank S. Schwarzbaum for proofreading and M. Azoulay for handling the animals. This work was supported by the EU Seventh Framework Program HEALTH-2011 given to M.S. (Grant no. 279017). M. Schwartz holds the Maurice and Ilse Katz Professorial Chair in Neuroimmunology. Corresponding authors: Prof. Michal Schwartz; Weizmann Institute of Science, 76100 Rehovot, Israel, Tel: +972-89342467; Fax:+972-89346018; E-mail: [email protected]; Dr. Merav Cohen; Weizmann Institute of Science, 76100 Rehovot, Israel, Tel: +972-89346975; Fax: +972-89346018; E-mail: [email protected] Cite as: J. Neurosci 2016; 10.1523/JNEUROSCI.2199-16.2016 Alerts: Sign up at www.jneurosci.org/cgi/alerts to receive customized email alerts when the fully formatted version of this article is published.

Transcript of Newly-formed endothelial cells regulate myeloid cell activity ...

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Accepted manuscripts are peer-reviewed but have not been through the copyediting, formatting, or proofreadingprocess.

Copyright © 2016 the authors

This Accepted Manuscript has not been copyedited and formatted. The final version may differ from this version.

Research Articles: Development/Plasticity/Repair

Newly-formed endothelial cells regulate myeloid cell activity following spinal cordinjury via expression of CD200 ligand

Merav Cohen1,§, Hila Ben-Yehuda1,§, Ziv Porat2, Catarina Raposo1, Siamon Gordon3 and Michal Schwartz1

1Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.2Department of Biological Services, Weizmann Institute of Science, Rehovot, Israel.3Sir William Dunn School of Pathology, The University of Oxford, Oxford, UK.

DOI: 10.1523/JNEUROSCI.2199-16.2016

Received: 11 July 2016

Revised: 18 November 2016

Accepted: 29 November 2016

Published: 19 December 2016

Author contributions: M.C., H.B.-Y., S.G., and M.S. designed research; M.C., H.B.-Y., and C.R. performedresearch; M.C., H.B.-Y., Z.P., and M.S. analyzed data; M.C., H.B.-Y., and M.S. wrote the paper; S.G. and M.S.contributed unpublished reagents/analytic tools.

Conflict of Interest: The authors declare no competing financial interest.

§These authors contributed equally to this work.

We thank S. Schwarzbaum for proofreading and M. Azoulay for handling the animals. This work was supportedby the EU Seventh Framework Program HEALTH-2011 given to M.S. (Grant no. 279017). M. Schwartz holds theMaurice and Ilse Katz Professorial Chair in Neuroimmunology.

Corresponding authors: Prof. Michal Schwartz; Weizmann Institute of Science, 76100 Rehovot, Israel,Tel: +972-89342467; Fax:+972-89346018; E-mail: [email protected]; Dr. Merav Cohen;Weizmann Institute of Science, 76100 Rehovot, Israel, Tel: +972-89346975; Fax: +972-89346018; E-mail:[email protected]

Cite as: J. Neurosci 2016; 10.1523/JNEUROSCI.2199-16.2016

Alerts: Sign up at www.jneurosci.org/cgi/alerts to receive customized email alerts when the fully formattedversion of this article is published.

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in vitro in vivo,

Tnf Il1

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in vitro

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In vitro

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in vitro

Ppia

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Tnfα

Il-β

Il-6

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in vitro in vivo

Tnf Il-1

Il-6

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in vivo

in vivo

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ex vivo

in vitro

in vitro

Tnf Il-1 Il-6

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Il-6

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Tnf

Il-1 Il-6

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