Neurological Disorders Lesson 3.3
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Transcript of Neurological Disorders Lesson 3.3
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Neurological DisordersLesson 3.3
Why does applying pressure relieve some of our pain?
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Ca2+
Do Now: Review the steps of synaptic transmission with a partner
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Synaptic Transmission2. Voltage-gated Ca2+
channels open. 6. NTs bind to postsynaptic
receptors. 4. Ca2+ sensitive proteins fuse synaptic vesicles to
membrane.
Ca2+
7. Ion channels open on postsynaptic membrane,
allowing ions to flow into cell.
8. Excess NTs are degraded by enzymes or pumped
back into presynaptic cell.
3. Ca2+ flows into cell
5. NTs are released into synaptic cleft
1. Action Potential
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Student Model of Pain Pathway
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Why would you ever want to decrease the activity of neurons?
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How could you decrease the activity of neurons?
Sodium (Na+) Calcium (Ca2+)
Positive Positive
Chloride (Cl-)
Negative
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Getting to Threshold
Inhibitory Postsynaptic potentials (IPSP) caused by entry of negative ions
Threshold – Voltage at which Na+ channels open
Excitatory Postsynaptic potentials (EPSP) caused by entry of positive ions
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Excitatory and Inhibitory Synapses
Excitatory Synapse:Neurotransmitters open Na+ channels producing EPSPs.
Inhibitory Synapse:Neurotransmitters open Cl- channels producing IPSPs.
Axon hillock reaches threshold and action potential is fired.
IPSPs encounter EPSPs. Threshold is not reached and no action potential is fired.
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Decreasing Neuronal Activity:
Why do we instinctively apply pressure to something that is
painful?
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Projection Neuron
Pressure neuron
Pain neuron
Build the Circuit in the Spinal Cord
To the Brain
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Pain neuron
Projection neuron
To BrainInterneuron
+Pain
Build the Circuit in the Spinal Cord
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Pain neuron
Pressure neuron
Projection neuron
To BrainInterneuron
Add the Pressure Neuron
+PainPain
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