NeuroborreliosisName: Khalid Al-Kuwity

ID:213119354

Tutor: DR. Ansari

Objectives

• Neuroborreliosis • Epidemiology • Complication • Multiple Sclerosis • Neuroborreliosis v.s M.S• Diagnosis• Clinical features • Treatment• Prevention

Neuroborreliosis

Lyme disease (Neuroborreliosis ) is an infectious disease caused by the bacterium Borrelia burgdorferi .

Lyme disease can be transmitted to humans by the bite of an infected tick.

What is Borreliosis?

• The genus Borrelia is a member of the larger family of spiral-shaped bacteria called Spirochaetes and the bacteria can be termed as a Borreliosis.

Cont…

• There are many species of Borrelia bacteria worldwide, but not all of them cause the disease.

• There are only 3 species that known to cause the disease:

1-  Borrelia burgdorferi.

2- Borrelia afzelii. 

3-  Borrelia garinii.

Symptoms

• Flu-like.•  Erythema migrans (EM)

Rash.• Headache.• Stiff neck.• Muscle pain.• Tender glands • sensitivity to temperature

,sound and light levels

Con…

• Extreme tiredness.• Muscle weakness.• Joint pain.• Upset digestive system.• Disturbances of the central nervous

system• Sleep problems.

Con…

Epidemiology

Risk Factors

• Spending time in wooded or grassy areas.

• Having exposed skin.• Not removing ticks promptly or properly.

Complications

• Chronic joint inflammation (Lyme arthritis) commonly in the knee.

• Neurological symptoms, such as facial palsy and neuropathy.

• Cognitive defects, such as impaired memory.

• Heart rhythm irregularities

Multiple Sclerosis

Neuroborreliosis v.s M.S

*Golden Key

Mutable Sclerosis Lyme Disease

Effect only the CNS UMN

IgG oligoclonal band in the CSF

Parathesia (transit) not sever pain and not persist

Effect the CNS,PNS UMN, LMN

Present with organism antibody ( IgM, IgG) in the

CSF

Sever burning pain

Diagnosis

• Clinical features.• IgM antibodies detected in the 1st

month.• IgG late in the disease.• Enzyme-linked immunosorbent assay

(ELISA).• CSF (cerebrospinal fluid). • Polymerase chain reaction (PCR).

Clinical Features

Skin stage :present with erythmea

migrans. Associate with fever and

headache

Neurologic and cardiac

stage

Chronic Arthritis stage

Several day to weeks or months

If not treated

Treatment

• Antibacterial tablet ( Amoxicillin, doxycycline)

• Intravenous administration of ceftriaxone, cefotaxim or benzyl-pienicillin.

Prevention

• Wear long pants and long sleeves.• Use insect repellents.• Do your best to tick-proof your yard. • Check yourself, your children and your

pets for ticks.• Don't assume you're immune.• Remove a tick as soon as possible.

References

• 111-120, 130 1478-1481 352

156-161• http://www.mayoclinic.org/diseases-conditi

ons/lyme-disease/basics.

• http://www.lymediseaseaction.org.uk

Thank You