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ND Pharma & BiotechDEMINARELIZATED BONE MATRIXMATRIZ OSEA DESMINERALIZADAND Pharma & Biotech is the leading provider of sterile biological implants forsurgeries around the world. ND Pharma & Biotech prepares human donatedtissue and bovine tissue for transplantation through extensive testing andscreening, precision shaping and proprietary, validated sterilization processes.

2010

ND Pharma & BiotechDepartamento Cientfico

2010

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These allograft and xenograft implants are used in dental,head and neck, ophthalmology, spine, sports medicine,urology and other specialty surgeries. Our innovationscontinuously raise the bar of science and safety forbiologics from being the first company to offer precision-

tooled bone implants and assembled technology tomaximize each gift of donation, to inventing fully validatedsterilization processes that include viral inactivation steps.

Two such processes, the Totalcleanse Tissue Sterilization

Process and the Allplast process, sterilize tissue, areclinically successful and are scientifically proven toeliminate donor-to-recipient disease transmission riskwhile preserving tissue strength and biocompatibility.These processes have a proven record of more than amillion implants distributed with zero incidence of infection.

In addition, ND pastes are sterilized through thedemineralization process; a validated viral inactivationstep. The company is leading the evolution of biologicsonce again by offering a bovine based biological matrix,providing surgeons an expanded supply of safe, sterile

tissue for their patients.

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Biologic Implants

There are five categories of implants that we prepare for implantation:

Sports Medicine

ACL repair and other knee procedures

Foot and ankle procedures

Shoulder repair

Joint repair

Spinal Implants

Cervical and Lumbar procedures

Dental

Dental Bone Grafting

Dental Implant procedures

Bone Graft Subst itutes

General Orthopedic procedures

Trauma repair

Oncology procedures

Surgical Specialties

General Orthopedic procedures

Hernia repair

Breast reconstruction

Ophthalmology

Urology

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Allografts

The source of all allografts is tissue that has been donated by people upontheir death, with the consent of their family or loved ones. ND PHARMA &BIOTECH processes donated tissue for implantation by surgeons intopatients who are in need of tissue regeneration and healing. ND PHARMA& BIOTECH honors the gift of tissue donation by:

finding new ways to utilize the tissue to help patients,

increasing the use of the tissue that has been donated, and

helping as many patients as possible from each donation.

Xenografts

ND PHARMANATURALBiological Matrix provides surgeons an expandedsupply of safe, sterile tissue. Bovine bone sterilized through theAllcleanse process can be used in any application where a natural biologicscaffold is needed and provides an option for procedures previouslylimited by tissue availability and material constraints.

Natural Biological Matrix is a safe and natural alternative to autograft,

allograft and synthetic resorbable materials. Studies show Sterling graftsare equivalent to allograft biomechanically and remodel with patients' ownbone comparably to allograft.

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Biologics vs. other materials

Allograft vs. other options:

When you recommend surgery for your patients, in most cases you haveoptions. Will you use allograft, autograft or metal/synthetic implants?

Autograft: While autograft is osteoconductive (provides a scaffold for new bone toattach to) and osteoinductive (stimulates growth of new bone), it must beharvested from the patients body in a painful and potentially dangeroussecond surgery. In some cases, the patient may not even have sufficientquantities of tissue suitable for transplant; when they do and autograft isharvested, complications may occur such as morbidity at the harvest site,infection, nerve and artery damage, joint instability acute or recurrentpain. In addition, this second surgery means additional time underanesthesia.

Metals/synthetics: Metals can be tooled for specific applications and are designed for use withinstrument sets for faster and more precise surgeries. The patient spendsless time on the operating table, and the surgeon has a uniform processthat can be repeated easily. However, metals and synthetics do not

promote bone remodeling and since the material is stiffer than theadjoining bone, can actually cause weakening and fragility of surroundingbone or even cause it to disappear in these areas. In many cases, there isno metal or synthetic option, such as for tendons or other soft tissue usedin sports medicine repair.

Allograft: When properly processed, the patients body remodels with allograft the

same way it does with autograft. There is no rejection of allograft, and notyping required. Allograft has all the advantages of autograft, such asremodeling, without the complications and danger of a second surgerysite. Additionally, unlike autograft, which must be shaped in the operatingroom, allograft can be pre-shaped and precision tooled like metals,decreasing the amount of time required in surgery.

Great strides have been made in allograft safety with the invention of technologies such as ND PHARMA & BIOTECH Totalcleanse, the risk of disease transmission through allograft transmission is essentially

eliminated.

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ND Pharma & Biotech

2010

POLIGONO DE VALDREDO

33157

CUDILLERO, ASTURIAS

SPAIN