Naranjo canine neoplasia 2016 - cvm.ncsu.edu · – Pigmented (DDX. melanocytic neoplasia)...
Transcript of Naranjo canine neoplasia 2016 - cvm.ncsu.edu · – Pigmented (DDX. melanocytic neoplasia)...
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Canine neoplasia
Carol Naranjo, LV, DACVP, DECVP, PhDIDEXX Laboratories
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IRIDOCILIARY EPITHELIAL TUMORS
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Iridociliary epithelial tumors – dogs
• 2nd most common primary intraocular neoplasm
• Middle-aged dogs
• Retrievers
• Origin:
– Pigmented or non-pigmented CB epithelium
– Posterior iris epithelium (pigmented)
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Iridociliary epithelial neoplasia
• Adenoma
– Non uveo-invasive
– Uveo-invasive
• Adenocarcinoma (scleral invasion)
• Pleomorphic adenocarcinoma
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Iridociliary adenoma/carcinoma – Gross
• Well-delineated
• PC >>> AC
• Cradling lens
• 90% non-pigmented (light tan – pink)
– Pigmented (DDX. melanocytic neoplasia)
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Iridociliary epithelial neoplasms – Micro
• Ribbons, trabeculae, cords, papillae, acini
• Asteroid hyalosis
• 60% thick PAS-positive membranes
• 50% hyaluronic acid (Alcian blue +ive)
– DDx w/ metastastic neoplasia
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Iridociliary epithelial neoplasms – IHC
• Vimentin, NSE +ive
• S100 variable
• Cytokeratin:
– Benign tumors –ive
– Increasing staining w/ invasiveness
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Courtesy R. Dubielzig (COPLOW)
Vimentin Cytokeratin
Iridociliary epithelial neoplasms – IHC
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Iridociliary epithelial neoplasms –Prognosis
• Benign despite variable invasiveness
• Secondary glaucoma
– Directly
– PIFM
• No metastatic dz
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Pleomorphic adenocarcinoma
• Infrequent
• History of chronic ocular dz / trauma: 44%
– Trauma/uveitis
– Glaucoma
• Intraocular gentamicin injection: 25%
Zarfoss et al., 2007; Bell and Dubielzig, 2009 (ACVP abstract)
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Pleomorphic adenocarcinoma
• Gross:
– Poorly defined mass diffuse
– Filling the globe
• Histo: irregular cords, nests, anaplastic cells
• Poor prognosis (local recurrence, mets)
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Pleomorphic adenocarcinoma – Gross
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Pleomorphicadenocarcinoma – Histo
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Pleomorphic adenocarcinoma – IHCVimentin
100% positive (n = 16)
Pancytokeratin
75% positive (n = 16)
Bell & Dubielzig, ACVP abstracts, 2009
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PNET
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Neoplasia w/ neural differentiation
• PNET:
– Primitive neuroectodermal tumors
• Neuroblastoma, ependimoblastoma, retinoblastomas,
medulloepithelioma
• Eye:
– PNET: peripheral retina / CB
– Medulloepiteliomas: CB (dog) or ON (horse) >>> retina
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Medulloepithelioma
• PNET
• Shared features with iridociliary tumors
• Rare in dogs, horses >>> others
• Not always young dogs
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Medulloepithelioma – Gross
• CB: filling PC
• Can infiltrate retina
• Light tan
• Solid or papillary
Dubielzig et al., Veterinary Ocular Pathology; A Comparative Review, 2010.
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Medulloepithelioma – Micro
• Necrosis w/ survival around blood vessels
• Rosettes
• Teratoid: muscle, bone, cartilage, neuropil
• IHC:
– TERT +ive
– Vimentin and cytokeratin: limited +ivity
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Dubielzig et al., Veterinary Ocular Pathology; A Comparative Review, 2010.
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Medulloepithelioma – Prognosis
• Locally invasive
– Enucleation
• Mets very infrequent
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¿Retinoblastoma?
• Sparse reports, some arguable
• Tumors with neural differentiation (PNET) but
do not meet all the criteria
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Flexner-Wintersteiner rosettes Homer-Wright rosettes
Fleurettes Yanoff and Sassani’s Ocular Pathology, 2015
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Courtesy of Dr. Dubielzig, COPLOW
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Retinoblastoma in dogs?
• Retinoblastoma-like:– Fleurettes / rosettes (1 layer)
• Medulloepithelioma– Pseudorosettes
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Regan et al., 2013IHC IRBP
Retinoblastoma – like Medulloepithelioma
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UVEAL SCHWANNOMA OF BLUE EYED DOGS
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Uveal schwannoma of blue-eyed dogs
• SCTBED
• Blue-eyed / partially blue-eyed
• Siberian huskies, Border Collies, Catahoula hound
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Uveal schwannoma BED – Gross
• Anterior uvea (iris > CB) >>>> choroid
• Thickening of iris >> mass
– Confused with uveitis
– Only 50% neopl suspected
Courtesy of Dr. Dubielzig (COPLOW)
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Case material from COPLOW
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Uveal schwannoma BED – Histo
• Poorly demarcated
• Slender to plump spindle cells
• Bland to markedly atypical cells
• Loose fascicles to tight bundles and whorls
• May invade sclera
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Uveal schwannoma BED – IHC
• Vimentin +
• S100 +
• GFAP +
– Schwann cells of nonmyelinated nerves of iris stroma
Courtesy of Dr. Dubielzig (COPLOW)
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Uveal schwannoma BED – EM
• Long interdigitating cytoplasmic processes
• Intermittent basal laminae at plasma mb
• Peripheral nerve sheath origin
Zarfoss et al., 2007
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Uveal schwannoma BED – Prognosis
• Invasive: recurrence w/in orbit / scleral shell
• Mets rarely reported:
– Lungs, liver, mesenteric LN
– Path features linked to malignancy? (scleral invasion?)
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METASTATIC TUMORS
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Metastatic tumors to the globe (uvea)
• Dogs
– Lymphoma > histiocytic sarcoma
– Carcinoma, melanoma, hemangiosarcoma, OSA,…
– Carcinoma: mammary
– Extraskeletal OSA or chondrosarcoma
• Search for primary tumor!
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Uveal lymphoma
• Most common metastatic neoplasm
• 37% dogs w/ lymphoma have uveal involvement
– Preceding systemic signs, presenting complaint
• 2nd clinical sign (after lymphadenopathy)
• Bilat (not always)
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Uveal lymphoma – Gross
• Anterior > posterior uvea
• Mass-like lesion or diffuse (DDx. uveitis)
• Light tan
• Hematological abnormalities (hemorrhage)
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Uveal lymphoma – Micro
• Monomorphic round cells
– Iris, CB > retina, choroid, limbus, ON, peripheral n.
• DDx. melanoma / histiocytic sarcoma
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Uveal lymphoma – IHC
• B cell: CD20, CD79a, PAX5
• T cell: CD3
• Both described in the eye
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Uveal lymphoma – Prognosis
• Guarded
• Systemic: stage V if associated w/ hemorrhage
• ¿Primary? (Wiggans et al., 2014)
– Neurologic signs indep of ON involvement
– ¿Staging?
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Histiocytic sarcoma
• Metastatic
• Not infreq presented for ocular dz first
• Rottweiler > Retrievers > BMD
• Adult to senile
• Unilat (typically)
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Histiocytic sarcoma – Gross• Light tan • Anterior uvea
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Histiocytic sarcoma – Micro
• Round cells w/ abundant cytoplasm
– DDx. amelanotic melanoma
• Multinucleation, karyomegaly
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Histiocytic sarcoma – IHC
• Vimentin +
• CD18 +
• Melan A –
• CD3/CD20 –
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Histiocytic sarcoma – Prognosis • Grave, survival 0-6 mo post-enucleation
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• Unilat bilat
• Anterior > posterior uvea
• Neoplastic cells w/in blood vessels
• 2 patterns:
– Discrete mass
– Diffuse infiltrates lining the inner aspect of uvea
Metastatic tumors to the globe
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Primary vs. metastatic carcinomas
Primarybenign
Primarymalignant
Metastatic
Cytokeratin - +/- + Vimentin + + -
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Metastatic malignant melanoma