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COURSE MBT 401: Nanobiotechnology: Elective Course I4 Credits, Level II, 3 L, 1T)

Unit 1 15L1. Introduction to nanoscience

Introduction to nanoscience; History and scope, interdisciplinary nature,

structure of nanomaterials, length scales de Broglie wavelength & exciton

Bohr radius, quantum wires, quantum dots, fullerenes, graphite, carbon

nanotubes, inorganic nanowires, nanoparticles, core-shell nanoparticles2. Nanomaterials synthesis

Top-down and bottom-up approaches, chemical precipitation, vapor deposition,

hydrothermal method, pyrrolysis, Sputtering, laser ablation, electric-arc, sol-gel

processing, lithography, natural synthesis in organism, natural inorganic,

micelle, bio-based protocol

Unit 2 15L1. Nanomaterials characterization

Electron microscopy SEM, TEM, EDAX, X-ray diffraction atomic force

microscopy, confocal microscopy, UV-Visible spectroscopy, photoluminescence

spectroscopy, FTIR spectroscopy, UV and X-ray photoelectron spectroscopy,

particle size analysis, charge distribution analysis (charge on the surface,

estimation).

2. Nanotechnology Applications Materials domainNanoscale materials, fabrication at the nanoscale, Molecular Beam Epitaxy,

Nano transfer printing, Scanning probe based techniques for nanomaterial

synthesis, MEMS and NEMS, selforganization, nanoscale (opto)electronics and

magnetic Fullerenes, Nanosensors: characterization, perception,

electrochemical sensors, physical sensors, thin-films nanoscale devices

Transistors, FETs, quantum dots, lasers and others, Microfluidics, Nanofuel

cell, Nanoemulsions and coatings, Microcastings

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Unit 3 15L1. Nanotechnology Applications Biology domain

Bionanomachines composed of protein, nucleic acids, lipids, polysaccharides,

recombinant DNA technology, protein folding, self assembly, biomolecular

motors, traffic across membranes, biomolecular sensing, self replication,

nanobiosensors, nanoimplants, biorobotics, functionalization of nanoparticles

for biological applications.

2. Applications of AFM, SEM and Raman Spectroscopy in biologyScanning tunneling microscopy, atomic force microscopy, magnetic- force

microscopy (MFM), scanning near field optical microscopy (SNOM), etc.

Applications: microscopy, AFM/FFM and various measurement techniques,

friction and adhesion, self assembled monolayers

Unit 4 15L1. Applications in cancer biology

Characteristics of tumor tissues, drug delivery to tumors, physicochemical

properties of nanoparticles in cancer therapy, surface treatment of coating of

nanoparticle polymers for encapsulation, site specific delivery of

chemotherapeutic agents using nanoparticles, passive targeting, targeting

lymph nodes with nanoparticles, increasing bioavailability of a compound,

active targeting, magnetically directed targeting to tumor tissue, ligand

directed active targeting, targeted drug delivery using magnetic nanoparticles,

nanoviral gene therapy, hyperthermia, computer aided drug design, anti-AIDS

drugs, general medicine to personalized medicine, immunotoxinstargeted cell

killers, drugs delivered with liposomes, artificial blood, gene therapy

2. Applications in Food IndustryNano-food, food processing, packaging and safety, nano-capsules and

nanocomposites used in food industry.

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3. Applications in Environment ProtectionEnvironmental benefits of nanotechnology, nanotechnology in water treatment.

4. Applications in MicrobiologyMicrobial synthesis of nanoparticles, nanomaterial enabled microbial control,

application of nanotechnology in the study of cell structure; bacteria and virus.

5. Applications in AgricultureCrop improvement, nanoagrochemicals, nanosensors for on-farm monitoring,

plant disease monitoring, plant disease diagnosis.

References1. T. Pradeep, Nano, The Essentials, Understanding Nanoscience and

Nanotechnology, Tata McGraw-Hill Publishing Company Limited, 2007

2. J. W. M. Bulte, M.M.J. Modo, Nanoparticles in Biomedical Imaging: EmergingTechnologies and Applications, Springer Science Business Media, LLC, 2008

3. C.A. Mirkin and C.M. Niemeyer, Nanobiotechnology- II, More Concepts andApplications, WILEY-VCH, Verlag Gmb H&Co, 2007

4. V. Renugopalakrishnan and R. V. Lewis Eds. BionanotechnologyProteins toNanodevices, Springer.

5. D. S. Goodsell, Bionanotechnology Lessons from Nature John Wiley & Sons,Inc

6. Bhushan Ed.,Handbook of nanotechnology, Springer.7. A C. Yih and I. Talpasanu Eds. Micro and Nano Manipulations for Biomedical

Applications

8. Tuan VoDinh. Ed. Nanotechnology in Biology and Medicine: methods, deviceand applications. CRC Press.