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![Page 1: Nanocellulose in a given medical application Short introduction to biomedical applications of nanocellulose and wound healing Panu Kajander1.](https://reader036.fdocuments.us/reader036/viewer/2022081512/56649d315503460f94a09f79/html5/thumbnails/1.jpg)
Panu Kajander 1
Nanocellulose in a given medical application
Short introduction to biomedical applications of nanocellulose and
wound healing
![Page 2: Nanocellulose in a given medical application Short introduction to biomedical applications of nanocellulose and wound healing Panu Kajander1.](https://reader036.fdocuments.us/reader036/viewer/2022081512/56649d315503460f94a09f79/html5/thumbnails/2.jpg)
Introduction
• Natural polymers: alginate, chitosan, gelatin, collagen, elastin, starch and cellulose
• Bacterial nanocellulose, BNC (or microbial cellulose, MC)• Low cost, biodegradability, biocompatibility, mechanical
properties, availability, sustainability, and low cytotoxicity
• Applications: Implants, drug delivery, wound healing, tissue engineering, antibacterial/antimicrobial activity, cardiovascular tissue replacement, cancer targeting, cornea replacement and biological detection.
![Page 3: Nanocellulose in a given medical application Short introduction to biomedical applications of nanocellulose and wound healing Panu Kajander1.](https://reader036.fdocuments.us/reader036/viewer/2022081512/56649d315503460f94a09f79/html5/thumbnails/3.jpg)
Properties of ideal wound dressing (Czaja et al. 2007)
![Page 4: Nanocellulose in a given medical application Short introduction to biomedical applications of nanocellulose and wound healing Panu Kajander1.](https://reader036.fdocuments.us/reader036/viewer/2022081512/56649d315503460f94a09f79/html5/thumbnails/4.jpg)
Gauze dressings
• Topical application in wound healing
• Burns and chronic wounds
• Increase in tissue generation, capillary formation and proliferation in wound area
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Advantages
• Confortability to various body counters
• Maintains proper water balance
• Reduces wound pain• Faster tissue
regeneration• Better healing effect• Lower inflammatory
response
![Page 6: Nanocellulose in a given medical application Short introduction to biomedical applications of nanocellulose and wound healing Panu Kajander1.](https://reader036.fdocuments.us/reader036/viewer/2022081512/56649d315503460f94a09f79/html5/thumbnails/6.jpg)
Main conclusions
Numbers of publications in the period 2000–2013 on cellulose materials for biomedical applications. The topic keywords (SciFinder): cellulose, implants, tissue engineering, drug delivery, antibacterial/antimicrobial, cardiovascular, and wound healing.(Jorfi & Foster, 2014)
• BNC has morphological similarities with collagen attractive for cell immobilization and cell support
• Due to durability and compatibility, BNCs are suitable for tissue engineering
Outlook:• Surface functionalization
with bioactive molecules (eg pharmaceuticals, growth factors ect.)
• Interactions between biomaterial and living tissue can be tuned by the form (eg hydrogel, solid film..)
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References• Mehdi Jorfi, E. Johan Foster. 2014. Recent advances in nanocellulose for
biomedical applications. Journal of Applied Polymer Science. Vol 132, issue 14, pp. 1097-4628. DOI: 10.1002/app.41719. http://dx.doi.org/10.1002/app.41719
• Lina Fu,ad Yue Zhang,a Chao Li,b Zhihong Wu,c Qi Zhuo,e Xia Huang,b Guixing Qiu,c Ping Zhou and Guang Yang. 2012. Skin tissue repair materials from bacterial cellulose by a multilayer fermentation method. J. Mater. Chem., 2012, 22, 12349 DOI: 10.1039/c2jm00134a
• Czaja WK, Young DJ, Kawecki M, Brown RM Jr..2007. The future prospects of microbial cellulose in biomedical applications. Biomacromolecules. 2007 Jan;8(1):1-12.
• http://www.fibrocellscience.com/technology/technology-overview/