Mr Ben Challacombe MS FRCS - Guy's and St Thomas · 2020. 9. 7. · 44% Judge et al. BJUi 2007...
Transcript of Mr Ben Challacombe MS FRCS - Guy's and St Thomas · 2020. 9. 7. · 44% Judge et al. BJUi 2007...
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Mr Ben Challacombe MS FRCS
Consultant Urological Surgeon & Honorary Senior LecturerMDT Urological Cancer Lead, Robotic Fellowship Director
Guy's & St Thomas’ Hospitals and KCL, London, UKGuys Hospital 21st March 2016
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Intuitive SurgicalEthicon/J&JGSKTakedaSanofiAstellasLillyProstate Centre
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Sir Lancelot.mpg
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Gold standard Is it MORBID??
Mortality <1% Blood transfusion 20-30% Complications 9-30% Hospital stay 6.4 days Incontinence >10% Erectile dysfunction 14-
44% Judge et al. BJUi 2007Catalona et al. J Urol 2004Walsh et al. Urology 2000
Graefen et al Eur Urol 2006
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• 4 robotic arms enable Solo Surgery™
• Fingertip control
• 7º of freedom 90º of articulation
• Motion scaling and tremor reduction
• 4 robotic arms enable Solo Surgery™
• Fingertip control
• 7º of freedom 90º of articulation
• Motion scaling and tremor reduction
Enhanced Dexterity, Precision & ControlEnhanced Dexterity, Precision & Control
da Vinci Surgical System
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Superior Visualization
Enhanced Dexterity
Greater Precision
Ergonomic Comfort
da Vinci® Surgical Systemda Vinci® Surgical System
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Better vision- 3D binocular view Improved magnification, x3, x5, x10 7 Degrees of Freedom of movement Tremor filtering Delicate and precise instruments: ergonomic Teaching: perfect assistant view
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199920002001200220032004
Alaska
2005
Hawaii
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Puerto Rico
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© Copyright Bruce Jones Design Inc. 2003
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First UK Robot St Mary’s Hospital 2001 First active robotic programme Guy’s 2003 BAUS registry estimates 58% robotic
penetration in prostatectomy Many charity purchases: haphazard Vast majority in public system IOP Guidance: 50/yr, 5 min/surgeon
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Radical Prostatectomy +/- EPLND Radical Cystectomy
Extracorporeal/Intracorporeal reconstruction: Partial Nephrectomy Dismembered Pyeloplasty Ureteric Re-implant/diverticulectomy RRN, RNU RRPLND
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1st Robotic system 2003 Da Vinci Si dual console 2010- replacement da Vinci Xi dual console 2015- additional Fellowship programme: 14 independent 300 RARP annually (>3000) 60 RPN (220) 50 RARC (300) 50 other robotic procedures (nephrectomy,
nephro-ureterectomy, adrenalectomy)
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Lap prostate training: Declan Cahill 2007 Robotic Training Guy’s 2008 Robotic Fellowship Melbourne Prof Costello 2009 Royal Marsden Robotic 2010 Guy’s and St Thomas 2010-present 500 RARPs, 20 LRPs, 10 ORP 400 Upper Tract robotics: 230 partial nephrectomy Fellowship Director/MDM Lead Martini Klinik/ BAUS courses BAUS Oncology
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Vickers and Scardino, 2008
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Outcomes evaluatedOutcomes evaluated
•• PerioperativePerioperative-- operative time, blood loss, transfusion rate, operative time, blood loss, transfusion rate, overall complication ratesoverall complication rates
•• OncologicalOncological-- positive surgical margins, bDFSpositive surgical margins, bDFS
•• FunctionalFunctional-- urinary continence and potency recoveryurinary continence and potency recovery
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Operative time: RARP seriesOperative time: RARP series
Mean 138 min (90-180)
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Blood loss: RARP seriesBlood loss: RARP series
Mean 232 ml (69-534)
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Transfusion rate: RARP seriesTransfusion rate: RARP series
Mean 1.9% (0-5%)
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Blood loss and transfusion rate: Blood loss and transfusion rate: RARP Vs RRPRARP Vs RRP
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Blood loss and transfusion rate: Blood loss and transfusion rate: RARP Vs LRPRARP Vs LRP
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Overall complications: RARP seriesOverall complications: RARP series
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Overall complications: RARP Vs RRPOverall complications: RARP Vs RRP
Novara G, Ficarra V. et al (unpuplished data)
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Overall complications: RARP Vs LRPOverall complications: RARP Vs LRP
Novara G, Ficarra V. et al (unpuplished data)
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Outcomes evaluatedOutcomes evaluated
•• PerioperativePerioperative-- operative time, blood loss, transfusion rate, operative time, blood loss, transfusion rate, overall complication ratesoverall complication rates
•• OncologicalOncological-- positive surgical margins, bDFS, OS and CSSpositive surgical margins, bDFS, OS and CSS
•• FunctionalFunctional-- urinary continence and potency recoveryurinary continence and potency recovery
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Positive surgical margins: RALP Vs RRPPositive surgical margins: RALP Vs RRP
Novara G, Ficarra V.. et al (Eur Urol 2012)
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Positive surgical margins: RALP Vs RRPPositive surgical margins: RALP Vs RRP
Novara G, Ficarra V. et al (Eur Urol 2012)
Sensitivity analysis in pT2 prostate cancers
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Positive surgical margins: RALP Vs LRPPositive surgical margins: RALP Vs LRP
Novara G, Ficarra V.. et al (Eur Urol 2012)
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Oncological Results: 5Oncological Results: 5--year bDFSyear bDFS
Menon M et al Eur Urol 2010; 58: 838-846
95% 91%86%
81%
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Oncological Results: 5Oncological Results: 5--year bDFSyear bDFS
Drouin SJ et al World J Urol 2009; 27: 599-605Oncological outcomes of robotic-assisted radical prostatectomy after more than 5 years.Billia M1, Elhage O, Challacombe B, Cahill D, Popert R, Holmes K, Kirby RS, Dasgupta P. WJ Urol 2014
239 patients having RRP, LRP or RARP at Pitie-Salpetriere, Paris
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Oncological Results: bDFSOncological Results: bDFS
Sooriakumaran P. et al J Urol 2011; 165: 4 (suppl 1); e 263
20,166 patients having surgery in 15 Centers
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Outcomes evaluatedOutcomes evaluated
•• PerioperativePerioperative-- operative time, blood loss, transfusion rate, operative time, blood loss, transfusion rate, overall complication ratesoverall complication rates
•• OncologicalOncological-- positive surgical margins, bDFS, OS and CSSpositive surgical margins, bDFS, OS and CSS
•• FunctionalFunctional-- urinary continence and potency recoveryurinary continence and potency recovery
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Urinary continence recovery: non comparative RALP series
Mean 92% (83 – 98%)
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Urinary continence: RARP Vs RRPUrinary continence: RARP Vs RRP
Novara G, Ficarra V., et al (unpuplished data)
12-mo continence rate
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Urinary continence: RARP Vs LRPUrinary continence: RARP Vs LRP
Novara G, Ficarra V., et al (unpuplished data)
12-mo continence rate
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Potency recovery: non comparative RALP series
Mean 78% (62– 94%)
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Potency recovery: RARP Vs RRPPotency recovery: RARP Vs RRP
Novara G, Ficarra V. et al (Eur Urol 2012)
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Potency recovery: RARP Vs LRPPotency recovery: RARP Vs LRP
Novara G, Ficarra V. et al (Eur Urol 2012)
12-mo potency rate
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Functional Outcomes limitationsFunctional Outcomes limitations
•• Major methodological and surgical issues may affect Major methodological and surgical issues may affect continence rates (definition, use of questionnaires, continence rates (definition, use of questionnaires, time of assessment, surgical details)time of assessment, surgical details)
•• Most of the available studies do not report Most of the available studies do not report erectile function recovery in the appropriate wayerectile function recovery in the appropriate way
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•• Excellent (better than RRP) perioperative Excellent (better than RRP) perioperative outcomesoutcomes
•• Equivalent (early and intermediate) oncologic Equivalent (early and intermediate) oncologic outcomesoutcomes
•• Significantly bSignificantly better functional (continence and etter functional (continence and potency) outcomespotency) outcomes
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Porpiglia Eur Urol 2013 60 vs 60 pts 3/12 Continence 80% RARP group & 61.6% in
LRP group (p=0.044) 1 yr continence rate 95.0% & 83.3%, respectively
(p=0.042) Erection recovery was 80.0% and 54.2%,
respectively (p=0.020)
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National Institute for Health Care and Excellence
UK Body
Initial Prostate Cancer Guidance 2008
contentious
New Prostate Cancer Guidance 2014
Prostate cancer: diagnosis and treatment Issued: January 2014 NICE clinical guideline 175 guidance.nice.org.uk/cg175
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Commissioners of urology services should consider providing robotic surgery to treat localised prostate cancer. [new 2014]
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QALY (quality adjusted years) threshold for NHS/NICE £30,000, for 10 year timespan.
Incremental cost per QUALY for RARP <£30,000
Provided number procedures/year >150. When 100/yr £47,822 When 50/yr >£66,000
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Centralisation For cost effectiveness For quality For trials
First time robotics recognised by a national body.
Based on health economic study showing reduced positive margins in RARP vs LRP.
12 robots installed in 6/12 Now acquisitions stopped.
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1/1/14- 31/12/14 6161 cases 5814 England HES- England 6,651 cases (87%) 147 consultants, 62 sites 58.5% Robotic assisted 26.7% Laparoscopic 13.4% Open
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Median no of cases/consultant: 32 (range 1 - 157) Median no of cases/centre: 85 (range 1 - 250) Transfusion rate was 2.7% - 5,174 of the entries recorded whether there had
been adverse events. The total post-operative complication rate was 9.5% (491 / 5174).
Of these 491 cases, 364 recorded the Clavien Grade: ≥3 = 1.6%
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Easier does not mean easy! Simulation Observing Assisting Modular console training Fellowship? Full Console surgeon
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Melbourne, Australia 2008, supported by TUF grant
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Only One system, one company Others in evolution High Cost in NHS Non‐technical skills RCT provable outcomes? Availability
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50 UK systems 6-10 Irish systems High Volume Centres offering all treatments
Access to trials Imaging access: MRI, PSMA PET MDM: specialist radiology/pathology Pre-surgical briefing Data collection: measurement Improvement
Structured Training and Mentorship programmes
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Robotics in urology has raised the bar Patients demand it High volume results excellent Can we afford it? Can we afford not to?
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@benchallacombe