Morteza Naghavi, M.D. Founder Society for Heart Attack Prevention and Eradication (SHAPE) SHAPE...
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Transcript of Morteza Naghavi, M.D. Founder Society for Heart Attack Prevention and Eradication (SHAPE) SHAPE...
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- Morteza Naghavi, M.D. Founder Society for Heart Attack Prevention and Eradication (SHAPE) SHAPE Guidelines Prevention of Fatal Cardiovascular Events (Heart Attack & Stroke) based on the Detection and Treatment of Subclinical Atherosclerosis (Hidden Plaque Build-up in Coronary and Carotid arteries)
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- The Problem
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- > 15 Million Heart Attacks Each Year Source: World Heart Federation The AEHA 2005 VP Summit
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- Unpredicted
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- In >50% of victims, the first symptom of asymptomatic atherosclerosis is a sudden cardiac death or acute MI.
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- Men Women 010203040506070 Patients Diagnosed with CHD (%) Murabito et al Circulation 1993 Sudden Cardiac Death or Acute MI as Initial Presentation of CHD 62% 42%
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- Of 136,905 patients hospitalized with CAD, 77% had normal LDL levels below 130 mg/dl Modified from Sachdeva et al. AHJ, Vol 157, 111-117 Jan 2009 Chapter 1: Preventive Cardiology; the SHAPE of the Future in Naghavi et al. Asymptomatic Atherosclerosis: Pathophysiology, Detection and Treatment. Humana Press, 2009
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- Modified from Sachdeva et al. AHJ, Vol 157, 111-117 Jan 2009 Chapter 1: Preventive Cardiology; the SHAPE of the Future in Naghavi et al. Asymptomatic Atherosclerosis: Pathophysiology, Detection and Treatment. Humana Press, 2009 Of 136,905 patients hospitalized with CAD, 45.4% had normal HDL levels above 40 mg/dl
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- Of 136,905 patients hospitalized with CAD, 61.8% had normal triglyceride levels below 150 mg/dl Modified from Sachdeva et al. AHJ, Vol 157, 111-117 Jan 2009 Chapter 1: Preventive Cardiology; the SHAPE of the Future in Naghavi et al. Asymptomatic Atherosclerosis: Pathophysiology, Detection and Treatment. Humana Press, 2009
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- Slide Source: Lipids Online www.lipidsonline.org 1998 2002. 222 patients with 1 st acute MI, no prior CAD, no DM. Men 20% Goal LDL
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- Relying on risk factors of atherosclerosis (i.e. cholesterol & blood pressure) mislead physicians and patients. A direct assessment of atherosclerosis is needed. CONCLUSION:
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- Sir Winston Churchill, 91 Sir Winston Churchill, 91 Jim Fixx, 53 Jim Fixx, 53 Who Has More Cardiovascular Risk Factors?
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- Philip Alexander Poole-Wilson death with 66 years March 4, 2009 Two weeks after Update in Cardiology In Davos Helmut Drexler death with 58 years Unexpected Sudden Death of Famous Cardiologists
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- Status Quo IS Unacceptable Bottom Line:
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- CVD Genotyping? Naghavi et al. Circulation. 2003;108:1664 ~50% Apparently Healthy People (New) ~50% CHD Patients (Recurrent)
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- CVD Genotyping? Naghavi et al. Circulation. 2003;108:1664 ~50% Apparently Healthy People (New) ~50% CHD Patients (Recurrent)
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- Naghavi et. al. Circulation Journal Vol108, No14; October 7, 2003 The Vulnerable Patient Consensus Statement Preceding the SHAPE Initiative
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- Naghavi et. al. Circulation Journal Vol108, No14; October 7, 2003 The Vulnerable Patient Consensus Statement Preceding the SHAPE Initiative
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- First SHAPE Symposium
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- SHAPE Task Force Meeting
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- SHAPE Guidelines Published
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- Existing Guidelines (Status Quo): Screen for Risk Factors of Atherosclerosis Treat Risk Factors of Atherosclerosis The SHAPE Guidelines: Screen for Atherosclerosis (the Disease) Regardless of Risk Factors Treat based on the Severity of the Disease and its Risk Factors SHAPE v.s. Status Quo
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- Based on the paper by Pepe e. al. Am J Epidemiol 2004; 159:882-890. ROC Curve, its AUC and Corresponding Odds Ratio hs-CRP LDL HDL Smoking Hypertension Diabetes etc. Risk Factors
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- Based on the paper by Pepe e. al. Am J Epidemiol 2004; 159:882-890. ROC Curve, its AUC and Corresponding Odds Ratio hs-CRP LDL HDL Smoking Hypertension Diabetes etc. CAC +FRS IMT+FRS Structural Risk Factors
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- Based on the paper by Pepe e. al. Am J Epidemiol 2004; 159:882-890. ROC Curve, its AUC and Corresponding Odds Ratio hs-CRP LDL HDL Smoking Hypertension Diabetes etc. CAC +FRS IMT+FRS Structural Risk Factors Combined structural & functional?
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- 1: No history of angina, heart attack, stroke, or peripheral arterial disease. 2: Population over age 75y is considered high risk and must receive therapy without testing for atherosclerosis. 3: Must not have any of the following: Chol>200 mg/dl, blood pressure >120/80 mmHg, diabetes, smoking, family history, metabolic syndrome. 4: Pending the development of standard practice guidelines. 5: High cholesterol, high blood pressure, diabetes, smoking, family history, metabolic syndrome. 6: For stroke prevention, follow existing guidelines.
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- Some of the Members of the SHAPE Task Force (left to right): Drs Budoff, Falk, Rumberger, Naghavi, Fayad, Hecht, and Berman
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- Current National Preventive Care Reimbursement Policies Do Not Match the Burden of the Problem Inadequate & Disproportionate
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- Why do we screen for asymptomatic cancers but ignore asymptomatic CVD?
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- $1000 for # 2 Killer
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- Number (per year) Estimated Impact of SHAPE (Sensitivity Analysis Range) Estimated Change in Cost CVD Deaths910,60010% (5%-25%) ($1.2 b) MI (prevalence)7,200,000 25% (5%-35%) ($18.0 b) Chest Pain Symptoms (ER visits)6,500,000 5% (2.5%-25%) ($4.1 b) Hospital Discharge for Primary Diagnosis of CVD6,373,000 10% (5%-25%) $3.8 b Hospital Discharge for Primary Diagnosis of CHD970,000 10% (5%-25%) ($9.9 b) Cholesterol Lowering Therapy 50 % (50%-65%) 8.00 b CV Imaging8,700,000 10% (5%-25%) $358 m Angiography6,800,000 15% - CTA (2.5%-25%) $600 m PCI (percutaneous coronary interventions per year)657,000 10% (5%-50%) ($580 m) CABS (coronary artery bypass surgeries per year)515,000 5% (2.5%-50%) ($672 m) Total in Cost ($21.5 b) Cost Effectiveness of the SHAPE Guidelines
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- poly pills
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- WWW.SHAPESOCIETY.ORG
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- The SHAPE Textbook Released at American College of Cardiology Conference