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Project PROSPER – Development of a PROactive Symptom and social Engagement Wearable trackeR for communities

Arun Sethuraman, Founder & CEO | arun@crely.ai | +1.617.520.4447 |+65.9119.2989

More than 11 million confirmed COVID-19 cases worldwide, and 500,000+ deaths

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About 2 in 3 patients are unaware of COVID-19 symptoms, and they receive medical attention significantly late

Yale New Haven Health: Influenza (Flu) vs Coronaviruses. (n.d.). Retrieved June 30, 2020, from https://www.ynhhs.org/patient-care/urgent-care/flu-or-coronavirus

1. Patients are most infectious during first week, when they are only mildly symptomatic

2. ~20% develop severe pneumonia

3. ~80% of patients who require intubation or mechanical ventilation eventually die

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Early identification of symptoms is crucial for isolating and treating COVID-19 patients. Unfortunately, long term care facilities are woefully inadequate to deal with the crisis

Yang, X., Yu, Y., Xu, J., Shu, H., Xia, J., Liu, H., . . . Shang, Y. (2020). Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: A single-centered, retrospective, observational study. The Lancet Respiratory Medicine, 8(5), 475-481. doi:10.1016/s2213-2600(20)30079-5

Covid-19 patients most infectious in 1st week of illness, but odds of transmission significantly reduced after 2nd week: S'pore study. (n.d.). Retrieved June 29, 2020, from https://www.todayonline.com/singapore/covid-19-patients-most-infectious-1st-week-illness-odds-transmission-significantly-reduced

Written by Josephine Moulds, F. (n.d.). People with mild or no symptoms could be spreading COVID-19. Retrieved June 29, 2020, from https://www.weforum.org/agenda/2020/03/people-with-mild-or-no-symptoms-could-be-spreading-covid-19/

Residents and staff live and work in small,

confined and crowded settings

A lot of staff work at multiple care facilities to

compensate for low wages

Nature of care work requires

physical contact

Elderly residents Residents with comorbidities+

~50%

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Reliable continuous patient monitoring system and a credible early warning method is an unmet need

Physiological, Social and Environmental factors form the basis of an effective early warning system.

Symptoms monitoring. Equivalent to, or better

than current standard of care

Rapid Contact Tracing and Enforcement of Quarantine

Orders

Identification Of Virus Clusters And Optimal Transmission

Conditions

+ +

Project PROSPER is the development of a PROactive Symptom and social Engagement Wearable trackeR for communities

A wearable device-enabled clinical decision support system to improve early detection and management of Infectious Disease epidemics like COVID-19

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Team Crely is an accomplished, diverse group of clinicians, scientists, engineers and MedTech executives who are passionate about our mission to make a difference to the patients

Prior to Crely, the team collectively has had 120 years of experience, 20 publications and 2 patents

Prof. Harry van Goor Dr. Kiran Agrawal-Harding Dr. Niki Kennedy

Scientific Advisory BoardCrely Leadership Team

Project PROSPER is an extension of Crely’s medical device enabled remote monitoring platform to improve surgical outcomes

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Purpose of EUREKA GlobalStars grant request is to complete Proof of Concept of the 360 degree clinical decision support system to improve early detection and management of COVID-19 and future Infectious Diseases.

Credits: CIMIT HealthTech Innovation Cycle

Technical

Regulatory

Market/ Bus.

Clinical

INVENTION TRANSLATION COMMERCIALIZATION

Need Idea PoC PoF PoV ICT VoS A&L Use SoC

Solid Line: Current State Dashed Line: Deliverables from Grant

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To accomplish our collective mission, we would like to have a dialog with a diverse group of potential partners to assess each other’s mission, motivation, strengths, synergies and gaps

# Partner Profile Role of Partner Desired Outcome1 Govt. bodies, Ministry of Health, Non-

profit foundations involved with population health and/or epidemic management

• Validate unmet need• Knowledge partner to customize solution

to the needs of the market• Integration of solution within existing

healthcare service delivery

• Conditional Letter of Intent (LoI) for joint commercialization

2 Universities, Research Centers, Healthcare Systems

• Validate unmet need• Knowledge partner to customize solution

to the clinical needs of the target indication

• Support with product development• Conduct Clinical Studies

• Development of joint IP from the project

• Clinical validation• Licensing agreement to

commercialize IP

3 Companies with Sensor and/or Machine Learning / AI related competencies

• Collaborate with Crely on technology and product development

• Rapid development of technology solutions

• Joint commercialization opportunity

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Crely won the award of Best Investment at the Harvard Business School 2019 New Venture

Competition-Asia Pacific

Potential to save tens of thousands of lives

With sensor data and clinical insights, additional business opportunities for data-related services

High barriers to entry for competition due to IP protection for sensors, and data acquisition lead

Exit options through robust M&A market with potential suitors from both healthcare and IT industries

Team Crely is at the right place, with the right people, and with the right solution to make an impact to the lives of patients and healthcare providers. We need your support.