Molecular Developmental Biology II 2011

Friedrich-Schiller-Universität JenaBiologisch-Pharmazeutische Fakultät

Institut für SpezielleZoologie und Evolutionsbiologie

Direktor: Prof. Dr. Martin Fischer

Prof. Dr. Lennart Olsson

1. Limb Development

What can be more curious than that the hand of a man, formed for grasping, that of a mole for digging, the leg of a horse, the paddle of the porpoise, and the wing of a bat should all be constructed on the same pattern ans should include similar bons, and in the same relative positions?

Charles Darwin (1859)

BMP concentration in IDS and digit identityBeads with BMP inhibitor nogginDeletion of both shh and gli3

Ichthyostega

Acanthostega

Early”Amphibians”