Module 6Module 6Making a CaseMaking a Case

Review

Linde, 2005

Moderate improvements for mild or temp depression ONLY

Table of Evidence

# studies/part

Study types

Valid?

Litsearch?

Results consistent?

Outcome

26/3320 RCTs Yes Yes Yes

Whiskey, 2001

Moderate improvements for mild or temp depression ONLY

14/1296 RCTs Yes No Yes

Study Intervention Duration Study Type Sample Outcome

Casper, 2006 600mg/daily 6-week RCT n= 205 Mean score (HMD)

123 I decreases: 82 C 11.6 for SJW 6.0 for placebo

Table of Evidence

A – Recommendation based on consistent and good quality (level 1 study quality) patient-oriented evidence

SORT

Study Quality Diagnosis Scenarios Therapy/Prevention Scenarios Harm/Etiology Scenarios

A – Recommendation based on consistent and good quality (level 1 study quality) patient-oriented evidence B – Recommendation based on inconsistent and limited quality (level 2 study quality) patient-oriented evidence

SORT

Study Quality Diagnosis Scenarios Therapy/Prevention Scenarios Harm/Etiology Scenarios

A – Recommendation based on consistent and good quality (level 1 study

quality) patient-oriented evidence B – Recommendation based on inconsistent and limited quality (level 2 study quality) patient-oriented evidence C – Recommendation based on consensus, usual practice, opinion (level 3)

study quality) disease-oriented evidence

SORT

Study Quality All Scenarios

Patient-oriented evidence measures outcomes that matter to patients: morbidity, mortality, symptom improvement, cost reduction, and quality of life.

Disease-oriented evidence measures intermediate, physiologic, or surrogate end points that may or may not reflect improvements in patient outcomes (e.g., cholesterol levels, blood chemistry, physiologic function, pathologic findings).

SORT

Ebell MH, et al. 2004. Strength of Recommendation Taxonomy (SORT): A Patient-Centered Approach to Grading Evidence in the Medical Literature. American Family Physician 69(3):548-556.

SORT

Form a clinical question (PICO, search query)

Find evidence (research)

Make a case

Three simple steps

Module 6Module 6Making a CaseMaking a Case