Michael A. Mussallem Michael A. Mussallem

Chairman and CEOChairman and CEOEdwards LifesciencesEdwards Lifesciences

Leading the fight against advancedLeading the fight against advancedcardiovascular diseasecardiovascular disease

Edwards HistoryEdwards History

• Founded by Miles “Lowell” Edwards Founded by Miles “Lowell” Edwards in in 19581958

– Inventor and visionary, held 60+ patentsInventor and visionary, held 60+ patents

• Partnered with physicians to introduce Partnered with physicians to introduce breakthrough medical devices to the worldbreakthrough medical devices to the world

• Changes in ownershipChanges in ownership– 19581958 Edwards LaboratoriesEdwards Laboratories– 19681968 American Hospital Supply Corp.American Hospital Supply Corp.– 19841984 Baxter International Inc.Baxter International Inc.– 20002000 Edwards Lifesciences (NYSE:EW)Edwards Lifesciences (NYSE:EW)

Edwards Leads Growth IndustryEdwards Leads Growth Industry

• A leader in treating advanced A leader in treating advanced cardiovascular diseasecardiovascular disease

– Cardiovascular disease is Cardiovascular disease is progressive; leading killer and health progressive; leading killer and health expenseexpense

• 2007 Sales: $1.091 billion2007 Sales: $1.091 billion– 2008 projected sales ~ $1.2+ billion2008 projected sales ~ $1.2+ billion

• Broad global presenceBroad global presence– Products sold in ~100 countriesProducts sold in ~100 countries

– 5,600+ employees5,600+ employees

Infectious Disease

19%Cancer

12%

Chronic Respiratory

7%

All Other32%

Cardiovascular Disease

30%

World’s Leading Killers

Japan16%

R.O.W.11%

Europe28%

U.S.45% 2007 Sales

By Region

St.-Prex, SwitzerlandSt.-Prex, SwitzerlandHorw, SwitzerlandHorw, Switzerland

Añasco, Puerto RicoAñasco, Puerto Rico

IrvineIrvineSalt Lake CitySalt Lake City

Mississauga, CanadaMississauga, Canada

Haina, Dominican RepublicHaina, Dominican Republic

Sao Paulo, BrazilSao Paulo, Brazil

Mumbai, IndiaMumbai, India

Tokyo, JapanTokyo, Japan

Edwards’ Global OperationsEdwards’ Global Operations

SingaporeSingapore

40+ offices in 35 countries40+ offices in 35 countries

Edwards’ Robust Core BusinessesEdwards’ Robust Core Businesses

• 90% of sales from products with #1 90% of sales from products with #1 global positionsglobal positions

– Leader in heart valve therapyLeader in heart valve therapy

– Leader in hemodynamic monitoringLeader in hemodynamic monitoring

• High barriers to entry High barriers to entry

• Strong brand recognitionStrong brand recognition

• Trusted partner with leading Trusted partner with leading cliniciansclinicians

• Strong base from which Strong base from which innovation can flourishinnovation can flourish

Edwards

MDT

STJOther

2007 Global Heart Valve Sales*

*Estimated

Edwards

HSP

Other

2007 Global Hemodynamic Monitoring Sales*

$435 million

$1.1 billion

Edwards’ Global StrategyEdwards’ Global Strategy

• A patient focusA patient focus– Targeted populations are large and growingTargeted populations are large and growing– Cardiovascular disease remains the leading cause Cardiovascular disease remains the leading cause

of death and largest healthcare expenseof death and largest healthcare expense

• Sizable growth opportunitiesSizable growth opportunities– Targeting transformational technologies in Targeting transformational technologies in

Structural Heart Disease and Critical Care MedicineStructural Heart Disease and Critical Care Medicine

• A product leadership strategyA product leadership strategy– Clinical superiority remains our primary basis of Clinical superiority remains our primary basis of

differentiation and competitive advantagedifferentiation and competitive advantage

Global Challenges/OpportunitiesGlobal Challenges/Opportunities

• Business practice scrutinyBusiness practice scrutiny

• Reimbursement pressureReimbursement pressure

• Regulatory timelinesRegulatory timelines

• Global and local competitorsGlobal and local competitors

• Price transparencyPrice transparency

Helping Patients is Our Life’s Work, andHelping Patients is Our Life’s Work, and