Metabolismo de Nucleotidos
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Transcript of Metabolismo de Nucleotidos
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UNIVERSIDAD TECNICA DE ORUROFACULDAD DE CIENCIAS DE LA
SALUD“Carrera de Medicina”
Dr. Freddy V. García Morales.
BIOQUIMICA
Metabolismo de nucleótidos de purinas y
pirimidinas
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1. Importancia medica.2. No son necesarias en la
dieta (Se biosintetizan.)
INTRODUCCION
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BIOSINTESIS DE NUECLEOTIDOS DE PURINA
1. Síntesis de intermediarios anfibolicos.
2. Fosforilacion de purinas. 3. Fosforilacion de nucleótidos de
purina.
Purina
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Biosíntesis de 5-fosforibosil-1-firofosfato
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5-fosforibosil-1-firofosfato + Glutamina (grupo amino)
5 FOSFO 5 - B – D RIBOSILAMINA
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5 fosfo 5 - b – d – ribosilamina + GlicinaGILINAMINA RIBOSIL -5 – FOSFATO
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Transaminación
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Cierre del anillo
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CO2
Carboxilasa
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Se condensa con un aspartato
H2O
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H2O
IMP ciclohidrolaza
Cierre de anillo
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Reacciones de recuperación
① Fosforribosilación. por la PRPP
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① Fosforilacion directa.② Fosforilacion directa.
ATP
ADP
Ribonucleocido de purina IMP
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Regulación
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Regulación
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BIOSINTESIS DE NUECLEOTIDOS DE PIRIMIDINA
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Reacciones de recuperación.
A partir de algunas pimidinas libres. Uridina y citidina. Tiamidina y de desoxicitidina.
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Regulación
① Regulación alosterica.
② Regulación a genético.
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Regulación
① Regulación alosterica.
② Regulación a genético.
PRPP
ATP
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Regulación
① Regulación alosterica.
② Regulación a genético.
PRPP
ATP
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CATABOLISMO DE PURINAS
Se utilizan para tratamiento de gota y hiperuricemia.
Normalmente se elimina 400 a 600 mg/24 hrs. AU.
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CATABOLISMO DE PURINAS
Xantina oxidasa
Se utilizan para tratamiento de gota y hiperuricemia.
Normalmente se elimina 400 a 600 mg/24 hrs. AU.
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FISIOPATOLOGIA
Hiperuricemia
> 600 mg/24hrs. Defectos enzimáticos. Cáncer o psoriasis.
Gota
Hiperuricemia Tofos:
• Articulaciones • Riñones y TB.
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FISIOPATOLOGIA
Síndrome de Lesh - Nyhan
Defecto una enzima importante en el metabolismo de la purinas (HGPT).
Hipouricemia
Deficit de la enzima XA. Defecto
• Genetico • Daño hepatico.
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CATABOLISMO DE PIRIMIDINAS
Aciduria orotico
① Tipo I: Deficiencia de 2 enzimasreaccion 5,6.
② Tipo II:deficiencia de 1 enzimareaccion 6
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CATABOLISMO DE PIRIMIDINAS
Aciduria orotico
① Tipo I: Deficiencia de 2 enzimasreaccion 5,6.
② Tipo II:deficiencia de 1 enzimareaccion 6
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GRACIAS!!!!!!!!...
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