Metabolisme Protein [Autosaved]
-
Upload
melisa-novitasari -
Category
Documents
-
view
232 -
download
1
Transcript of Metabolisme Protein [Autosaved]
-
8/12/2019 Metabolisme Protein [Autosaved]
1/31
METABOLISME PROTEIN
Dr. I Dewa Ayu Susilawati, drg. M. Kes
-
8/12/2019 Metabolisme Protein [Autosaved]
2/31
Protein Diet
Asam amino
Urea
NH3
Asetil-KoANitrogen amino
glutamat
Benda ketonKarbohidrat(glukosa)
Derivat nitrogen(nonprotein)Protein jaringan
SIKLUSKREBS
2CO2
T R A N S A M I N A S I
D E A M I N A S IGARIS BESAR
METABOLISMEPROTEIN
-
8/12/2019 Metabolisme Protein [Autosaved]
3/31
Proteins are organic compounds made ofamino acids (polymers of -amino acids)
Kinds of amino acids: 20
Amount of amino acids > 50
http://en.wikipedia.org/wiki/Organic_compoundhttp://en.wikipedia.org/wiki/Amino_acidhttp://en.wikipedia.org/wiki/Amino_acidhttp://en.wikipedia.org/wiki/Organic_compound -
8/12/2019 Metabolisme Protein [Autosaved]
4/31
AMINO ACIDS
Amino acids are molecules containing anamine group, a carboxylic acid group and oneof the twenty R-groups.
http://en.wikipedia.org/wiki/Moleculehttp://en.wikipedia.org/wiki/Aminehttp://en.wikipedia.org/wiki/Carboxylic_acidhttp://en.wikipedia.org/wiki/Carboxylic_acidhttp://en.wikipedia.org/wiki/Aminehttp://en.wikipedia.org/wiki/Molecule -
8/12/2019 Metabolisme Protein [Autosaved]
5/31
Peptide bond A peptide bond is a chemical bond formed between two moleculeswhen the carboxyl group of one molecule reacts with the aminogroup of the other molecule, thereby releasing a molecule of water(H2O).
-
8/12/2019 Metabolisme Protein [Autosaved]
6/31
-
8/12/2019 Metabolisme Protein [Autosaved]
7/31
-
8/12/2019 Metabolisme Protein [Autosaved]
8/31
KATABOLISME PROTEIN
-
8/12/2019 Metabolisme Protein [Autosaved]
9/31
Asam amino: Amonia urea ekskresi Karbon glikolisis atau SAS energi
-
8/12/2019 Metabolisme Protein [Autosaved]
10/31
-
8/12/2019 Metabolisme Protein [Autosaved]
11/31
Katabolisme treonin, glisin, serin, alanin
-
8/12/2019 Metabolisme Protein [Autosaved]
12/31
-
8/12/2019 Metabolisme Protein [Autosaved]
13/31
Jalur masuk asam amino ke Siklus Krebs
-
8/12/2019 Metabolisme Protein [Autosaved]
14/31
Pembentukan urea
-
8/12/2019 Metabolisme Protein [Autosaved]
15/31
The aromatic rings of tryptophan are precursors ofnicotinate, indoleacetate, and serotonin.
-
8/12/2019 Metabolisme Protein [Autosaved]
16/31
ASAM AMINO GLUKOGENIK
Glycine
Serine Valine Histidine
Arginine Cysteine Proline
Alanine Glutamate Glutamine
Aspartate Asparagine
A glucogenic amino acid is an amino acid that can beconverted into glucose through gluconeogenesis
http://en.wikipedia.org/wiki/Glycinehttp://en.wikipedia.org/wiki/Serinehttp://en.wikipedia.org/wiki/Valinehttp://en.wikipedia.org/wiki/Histidinehttp://en.wikipedia.org/wiki/Argininehttp://en.wikipedia.org/wiki/Cysteinehttp://en.wikipedia.org/wiki/Prolinehttp://en.wikipedia.org/wiki/Alaninehttp://en.wikipedia.org/wiki/Glutamatehttp://en.wikipedia.org/wiki/Glutaminehttp://en.wikipedia.org/wiki/Aspartatehttp://en.wikipedia.org/wiki/Asparaginehttp://en.wikipedia.org/wiki/Amino_acidhttp://en.wikipedia.org/wiki/Glucosehttp://en.wikipedia.org/wiki/Gluconeogenesishttp://en.wikipedia.org/wiki/Gluconeogenesishttp://en.wikipedia.org/wiki/Glucosehttp://en.wikipedia.org/wiki/Amino_acidhttp://en.wikipedia.org/wiki/Amino_acidhttp://en.wikipedia.org/wiki/Amino_acidhttp://en.wikipedia.org/wiki/Asparaginehttp://en.wikipedia.org/wiki/Aspartatehttp://en.wikipedia.org/wiki/Glutaminehttp://en.wikipedia.org/wiki/Glutamatehttp://en.wikipedia.org/wiki/Alaninehttp://en.wikipedia.org/wiki/Prolinehttp://en.wikipedia.org/wiki/Cysteinehttp://en.wikipedia.org/wiki/Argininehttp://en.wikipedia.org/wiki/Histidinehttp://en.wikipedia.org/wiki/Valinehttp://en.wikipedia.org/wiki/Serinehttp://en.wikipedia.org/wiki/Glycine -
8/12/2019 Metabolisme Protein [Autosaved]
17/31
ASAM AMINO KETOGENIKA ketogenic amino acid is an amino acid that can be converted into ketone
bodies through ketogenesis
Ketogenic amino acids are unable to be converted to glucose as bothcarbon atoms in the ketone body are ultimately degraded to carbondioxide in the citric acid cycle .
In humans, the ketogenic amino acids are:
Leucine , lysine In humans, the amino acids which can be ketogenic or glucogenic are: Threonine , isoleucine , phenylalanine , tryptophan , Tyrosine
The three ketone bodies are: Acetoacetate , which, if not oxidized to form usable energy, Acetone , which is not used as an energy source, but is instead exhaled
or excreted as waste -hydroxybutyrate is synthesized in the liver and can be used as an
energy source by the brain when blood glucose is low. Each of these compounds is synthesized from acetyl-CoA molecules
http://en.wikipedia.org/wiki/Amino_acidhttp://en.wikipedia.org/wiki/Ketone_bodieshttp://en.wikipedia.org/wiki/Ketone_bodieshttp://en.wikipedia.org/wiki/Ketogenesishttp://en.wikipedia.org/wiki/Carbon_dioxidehttp://en.wikipedia.org/wiki/Carbon_dioxidehttp://en.wikipedia.org/wiki/Citric_acid_cyclehttp://en.wikipedia.org/wiki/Leucinehttp://en.wikipedia.org/wiki/Lysinehttp://en.wikipedia.org/wiki/Threoninehttp://en.wikipedia.org/wiki/Isoleucinehttp://en.wikipedia.org/wiki/Phenylalaninehttp://en.wikipedia.org/wiki/Tryptophanhttp://en.wikipedia.org/wiki/Tyrosinehttp://en.wikipedia.org/wiki/Acetoacetatehttp://en.wikipedia.org/wiki/Acetonehttp://en.wikipedia.org/wiki/Beta-hydroxybutyratehttp://en.wikipedia.org/wiki/Beta-hydroxybutyratehttp://en.wikipedia.org/wiki/Liverhttp://en.wikipedia.org/wiki/Glucosehttp://en.wikipedia.org/wiki/Glucosehttp://en.wikipedia.org/wiki/Liverhttp://en.wikipedia.org/wiki/Beta-hydroxybutyratehttp://en.wikipedia.org/wiki/Beta-hydroxybutyratehttp://en.wikipedia.org/wiki/Beta-hydroxybutyratehttp://en.wikipedia.org/wiki/Acetonehttp://en.wikipedia.org/wiki/Acetoacetatehttp://en.wikipedia.org/wiki/Tyrosinehttp://en.wikipedia.org/wiki/Tryptophanhttp://en.wikipedia.org/wiki/Phenylalaninehttp://en.wikipedia.org/wiki/Isoleucinehttp://en.wikipedia.org/wiki/Threoninehttp://en.wikipedia.org/wiki/Lysinehttp://en.wikipedia.org/wiki/Leucinehttp://en.wikipedia.org/wiki/Citric_acid_cyclehttp://en.wikipedia.org/wiki/Carbon_dioxidehttp://en.wikipedia.org/wiki/Carbon_dioxidehttp://en.wikipedia.org/wiki/Ketogenesishttp://en.wikipedia.org/wiki/Ketone_bodieshttp://en.wikipedia.org/wiki/Ketone_bodieshttp://en.wikipedia.org/wiki/Amino_acid -
8/12/2019 Metabolisme Protein [Autosaved]
18/31
-
8/12/2019 Metabolisme Protein [Autosaved]
19/31
GLUKONEOGENESIS
-
8/12/2019 Metabolisme Protein [Autosaved]
20/31
Biosintesis Protein
-
8/12/2019 Metabolisme Protein [Autosaved]
21/31
-
8/12/2019 Metabolisme Protein [Autosaved]
22/31
-
8/12/2019 Metabolisme Protein [Autosaved]
23/31
-
8/12/2019 Metabolisme Protein [Autosaved]
24/31
Transkripsi Pembentukan mRNA Dibutuhkan
- RNA polimerase
- DNA template (cetakan
- 4 macam ribonukleosida trifosfat:ATP, GTP, CTP, UTP
DNA templateRNA polimerase
Mg++
mRNA
ATP
GTPCTPUTP
-
8/12/2019 Metabolisme Protein [Autosaved]
25/31
Translasi
1 Pengaktifan asam amino dengan ATPasam amino + ATP
2. Pengikatan aminoasiladenilat dengan tRNA
3. Penggabungan antikodon pada tRNA dengan kodon tripletmRNA
4. Pembentukan polipeptida
Asam amino+ ATP
Amino asil adenilatAminoasil sintetase
Mg++
amino ASIL
ADENILAT+ t RNA
Amino asil -tRNAAminoasil sintetase
-
8/12/2019 Metabolisme Protein [Autosaved]
26/31
-
8/12/2019 Metabolisme Protein [Autosaved]
27/31
-
8/12/2019 Metabolisme Protein [Autosaved]
28/31
-
8/12/2019 Metabolisme Protein [Autosaved]
29/31
-
8/12/2019 Metabolisme Protein [Autosaved]
30/31
-
8/12/2019 Metabolisme Protein [Autosaved]
31/31