MB&B 208: Molecular Biology Fall 2006 MWF, 10-11 Hall-Atwater 84
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Transcript of MB&B 208: Molecular Biology Fall 2006 MWF, 10-11 Hall-Atwater 84
MB&B 208: Molecular Biology
Fall 2006
MWF, 10-11
Hall-Atwater 84
http://sholmes.web.wesleyan.edu/wescourses/2006f/mbb208/01/
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The “Central Dogma” of Molecular Biology
Gene definition:
Classical genetics: The functional unit of inheritance.
Molecular genetics: The nucleic acid sequence that is necessary for the synthesis of a functional polypeptide (protein) or RNA.
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Transcription initiation in eukaryotes
RNA polymerase: CTD = carboxy terminal domain
GTF’s = general transcription factors
TFIID: includes TBP, binds TATA box
TFIIH: helicase and CTD kinase
Initiation: phosphorylation of CTD by TFIIH
GTF’s do not remain associated with transcribing polymerase
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TBP (TATA binding protein)
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Gene transcription: role of transcription factors1. Recruitment of RNA polymerase2. Overcome inhibition by chromatin structure
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