M ALE R EPRODUCTIVE S YSTEM Robert Scranton ©2009.

MALE REPRODUCTIVE SYSTEM

Robert Scranton ©2009

THE PARTS

• Testes• Excretory Ducts• Accessory Glands• Penis

TESTES

Name the layers covering the testes from outer to inner ____________

________________

_________________

______________

Scrotum

Tunica VaginalisTunica albuginea

Mediastinum


TESTES

The tunica vaginalis is made of a ________ and _______ ______ __________.

The tunica albuginea is a ________ __________ __________ ______.

Mediastinum

Where is it found? __________________________

What does it contain? ________

parietalmembraneserous


visceral

denseirregular connective tissue

Posterior expansion of tunica albuginea

Rete testes

Identify•Mediastinum•Seminiferous tubules•Testicular Septae•Testicular Lobule•Tunica albuginea

TESTES

The testicular parenchyma is composed of the:

___________________

_______________


Seminiferous tubules

Leydig Cells

Spermatozoa

Androgens (testosterone)

The main functions of the testes, a compund _________ gland, are ___________& _________________.

tubularreproduction hormone production

SEMINIFEROUS TUBULES


Composed of __________ & ___________germ cells sertoli cellsGerm Cells

SpermatogoniaDivide mitotically Spermatogonia (spermatocytogenesis)

Divide meiotically primary spermatocytes




Spermatogonia 1° Spermatocyte 2° Spermatocyte Spermatids

Spermatids:• Post-meiotic• Haploid cells•In process of spermiogenesis




Spermatogonia 1° Spermatocyte 2° Spermatocyte Spermatids

Process of Spermiogenesis:1. 2. 3. 4.

Condensation of the nucleusReduction of cytoplasm volumeFormation of an acrosomeFormation of the flagellum




Spermatogonia 1° Spermatocyte 2° Spermatocyte SpermatidsSpermatozoa (male gamete)

Q:What is the significance of the syncytium between the germ cells from a single spermatogonium?

A: These small intercellular bridges allow for the synchronization of meiotic division of these cells.

Germ Cells


Leydig Cells


(interstitial)

Describe the morphology:

• Eosinophilic cytoplasm• lots of mitochondria• Reinke crystals

Tubular cristi and lots of smooth ER

• Cytoplasmic location• increase with age• found in 50% of leydig cell tumors

Stimulated by: LH

Sertoli Cells


Sertoli Cells


The Facts- Short & SweetDescribe the morphology: • On the outside of the seminiferous tubule • Basal end lines the basement membrane• Apical surfaces form the luminal margin• Nucleus located basally, triangular shape, prominent nucleolus

Describe the hormone interactions: • Produce mullerian inhibiting factor (MIF)• Stimulated by follicle stimulating hormone (FSH)

Describe the functions: • Blood-testis barrier• Phagocytosis• Synthesis and secretion of inhibin• Synthesis of androgen-binding protein• Aromatization of androgen to estrogen


Tubili recti Rete testes Efferent ductulesEpididymus Vas deferens Ejaculatory ducts Urethra

Starting with the seminiferous tubules, trace the ducts to the external environment


Tubili recti

sertoli cells only

Describe each segment


Tubili recti Rete testes


• Simple Cuboidal cells• within the mediastinum


Tubili recti Rete testes Efferent ductules


• 10-12 short ducts• Simple cuboidal cells• Columnar cells • thin band of circular smooth muscle on outside

Secretory actionCiliated


Tubili recti Rete testes Efferent ductulesEpididymus


• Proximally • Distally • Circular smooth muscle becomes thicker• Sympathetic innervation• Spermatozoa become functionally mature• Decapacitation of spermatozoa

Tall pseudostratified columnar w/ stereociliaShort pseudostratified columnar w/ stereocilia


Tubili recti Rete testes Efferent ductulesEpididymus Vas deferens

• Short pseudostratified columnar epithelium w/ stereocilia• inner longitudinal, middle circular, outer longitudinal smooth muscle layers• mucosal folds• distal dilation • sympathetic innervation


ampulla of vas deferens



• found within the prostate gland• simple cuboidal epithelium


Ejaculatory ducts



• Part of reproductive and urinary system• Three sections:


Ejaculatory ducts Urethra

1. Prostatic 2. Membraneous 3. Penile

Transitional epitheliumPseudostratified columnar epithelium

Pseudostratified columnar epithelium changes to stratified squamous epithelium in the glans

1. Seminiferous Tubules 2. Straight Tubules 3. Rete Testes

4. Efferent Ductules 5. Epididymus

6. Vas Deferens (20x below)

7. Ejaculatory Duct (no image)8. Urethra (no image)


1. Seminal Vesicles2. Prostate gland3. Bulbourethral glands4. Glands of Littre

Name the accessory glands



Drain into the _________________. Lined by __________ ______ _______. Epithelium secretion is composed of ______, _______, and ________. The secretion is ____% of the volume of ejaculate. The vesicles have a smooth muscle wall and sympathetic innervation.

ampulla of the vas deferens

Pseudostratified columnarepithelium

fructose fibrinogen

ascorbic acid 70



Central and peripheral zones

AKA “periurethral”- Benign prostatic hypertrophy

Prostatic adenocarcinoma



Parenchyma _______________, draining into the ______ ______. Secretion contains _____, ______, and ___________. PSA- responsible for _______ of semen. Production is stimulated by sex steroids (____)Stroma- __________ + __________

branched tubuloalveolar glands

Prostatic urethracholine citric acid

acid phosphataseliquifaction

DHTFibroelastic CT

smooth muscle



For those that got a little lost on the last slide……

PSA implies _____ or ____________

Prostatic (serum) acid phosphatase implies ___________

BPH Prostatic Cancer

Prostatic Cancer



• Paired glands secreting _____• Found in the ___________• Drain into _________________

mucusUG diaphragm

Proximal penile urethra



• Branched tubuloalveolar glands• Secrete lubricating mucus into penile urethra


Penis__ masses of erectile tissue covered by ____________

__ Corpora cavernosa__ Corpus spongiosum

3 Fibroelastic CT

+ Glans Penis21

Erectile tissue = Fibrous network of trabeculaeVenous sinusoids AKA lacunaHelicine arterioles

M ALE R EPRODUCTIVE S YSTEM Robert Scranton ©2009.

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